Molecular Cancer Biology

Dysregulation of the complex biological processes that control cell and tissue homeostasis, growth and development under physiological conditions is the key driver of oncogenesis, tumor progression and therapy resistance of cancer. A better understanding of the pivotal molecular events underlying these three aspects of cancer biology will aid the identification of novel targets and the development of new therapeutic approaches for the treatment of this devastating disease. This section covers all aspects of molecular and cellular biology related to the development, progression and therapy of cancer. Topics of interest include:

• oncogenesis and cancer progression;
• cancer immunology;
• drug discovery and targeted therapy;
• tumor invasion and metastasis;
• cancer stem cell biology;
• genomic instability;
• DNA damage and repair;
• cell cycle regulation;
• hypoxia;
• cancer cell metabolism;
• mechanisms of therapy resistance;
• autophagy;
• apoptosis;
• necrosis;
• senescence;
• angiogenesis;
• inflammation and cancer