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Unwinding BRAHMA Functions in Plants

Université Grenoble Alpes, unité de formation et de recherche de Chimie et Biologie, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAe), Centre National de la Recherche Scientifique (CNRS), Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Institut de recherche interdisciplinaire de Grenoble (IRIG), Laboratoire de Physiologie Cellulaire et Végétale, 38000 Grenoble, France
Author to whom correspondence should be addressed.
Genes 2020, 11(1), 90;
Received: 27 November 2019 / Revised: 2 January 2020 / Accepted: 7 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Epigenetic Mechanisms for Plant Gene Regulation)
The ATP-dependent Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodeling complex (CRC) regulates the transcription of many genes by destabilizing interactions between DNA and histones. In plants, BRAHMA (BRM), one of the two catalytic ATPase subunits of the complex, is the closest homolog of the yeast and animal SWI2/SNF2 ATPases. We summarize here the advances describing the roles of BRM in plant development as well as its recently reported chromatin-independent role in pri-miRNA processing in vitro and in vivo. We also enlighten the roles of plant-specific partners that physically interact with BRM. Three main types of partners can be distinguished: (i) DNA-binding proteins such as transcription factors which mostly cooperate with BRM in developmental processes, (ii) enzymes such as kinases or proteasome-related proteins that use BRM as substrate and are often involved in response to abiotic stress, and (iii) an RNA-binding protein which is involved with BRM in chromatin-independent pri-miRNA processing. This overview contributes to the understanding of the central position occupied by BRM within regulatory networks controlling fundamental biological processes in plants. View Full-Text
Keywords: BRAHMA; SWI2/SNF2; chromatin; transcription factor; remodeling; miRNAs BRAHMA; SWI2/SNF2; chromatin; transcription factor; remodeling; miRNAs
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MDPI and ACS Style

Thouly, C.; Le Masson, M.; Lai, X.; Carles, C.C.; Vachon, G. Unwinding BRAHMA Functions in Plants. Genes 2020, 11, 90.

AMA Style

Thouly C, Le Masson M, Lai X, Carles CC, Vachon G. Unwinding BRAHMA Functions in Plants. Genes. 2020; 11(1):90.

Chicago/Turabian Style

Thouly, Caroline, Marie Le Masson, Xuelei Lai, Cristel C. Carles, and Gilles Vachon. 2020. "Unwinding BRAHMA Functions in Plants" Genes 11, no. 1: 90.

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