7,987 Results Found

Variations in several nuclear genes predisposing humans to the development of MODY diabetes have been very well characterized by modern genetic diagnostics. However, recent reports indicate that variants in the mtDNA genome may also be associated wit...

Climate change is a major cause of changes in alpine and polar vegetation, particularly at the edges of distributions. In temperate regions, these changes are expected to occur at the timberline of alpine zones. On Mt. Fuji, the highest mountain in J...

Mitochondria are important organelles whose primary role is generating energy through the oxidative phosphorylation (OXPHOS) system. Cardiomyopathy, a common clinical disorder, is frequently associated with pathogenic mutations in nuclear and mitocho...

Bromodomains (BD) are epigenetic readers of histone acetylation involved in chromatin remodeling and transcriptional regulation of several genes including protooncogene cellular myelocytomatosis (c-Myc). c-Myc is difficult to target directly by agent...

Mitochondrial DNA (mtDNA) mutations are highly associated with cancer progression. The poor prognosis of hepatocellular carcinoma (HCC) is largely due to high rates of tumor metastasis. This emphasizes the urgency of identifying these patients in adv...

Human mitochondrial disease exhibits large variation of clinical phenotypes, even in patients with the same causative gene defect. We illustrate this heterogeneity by confronting clinical and biochemical data of two patients with the uncommon pathoge...

This paper presents an improved droop-based control strategy for the active and reactive power-sharing on the large-scale Multi-Terminal High Voltage Direct Current (MT-HVDC) systems. As droop parameters enforce the stability of the DC grid, and allo...

Mt. Munkhkhairkhan is the most crucial region for understanding climate and glaciation changes in Mongolia. This study investigated the relationship between glacial area changes and the climate elements of Mt. Munkhkhairkhan in the Mongolian-Altai Mo...

α-MT is a hallucinogenic and stimulant tryptamine that was involved in several overdose fatalities in the United States and Europe. Analytical toxicology, and particularly the identification of metabolite biomarkers in biological samples, often...

Grossular, a widely recognized colored gemstone in the market, attains premium quality when exhibiting pale-toned orange-yellow to golden-yellow hues with high transparency. Recently, our research team identified abundant gem-grade grossular associat...

The structural diversity of microbial communities plays a pivotal role in microbiological research and applications. However, the study of microbial transitions has remained challenging due to a lack of effective methods, limiting our understanding o...

Background: Asthenozoospermia is defined as a condition in which the total motility of sperm in a semen sample is less than 40%. Due to impairing sperm motility, asthenozoospermia was linked to different mitochondrial DNA (mtDNA) alterations. The cur...

The stabilization problem of multi-terminal high-voltage direct current (MT-HVDC) systems feeding constant power loads is addressed in this paper using an inverse optimal control (IOC). A hierarchical control structure using a convex optimization mod...

To date, molecular genetics and population studies in Tibetan sheep (Ovis aries) have been limited, and little is known about the phylogenetic evolution and phylogeography of Tibetan sheep populations. The aim of the present research was to explore p...

In this paper, improvement in the power transfer capacity of transmission lines (TLs) by utilizing a multi-terminal high voltage direct current (MT-HVDC) grid is discussed. A multi-terminal HVDC grid designed for wind power can be used as an extra tr...

The restoration of damaged or disrupted forests with genetically appropriate restoration planting material that can adapt to future environmental conditions will ensure the conservation of forest genetic resources. Abies koreana is endemic to the Rep...

The Sentinel-1A/B satellite launched by European Space Agency (ESA) in 2014 provides a huge amount of free Terrain Observation by Progressive Scans (TOPS) data with global coverage to the public. The TOPS data have a frame width of 250 km and have be...

Several studies have indicated a relationship between metallothionein (MT) polymorphisms and the development of different pathologies, including neoplastic diseases. However, no studies thus far have been conducted on the influence of MT polymorphism...

This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica) were prep...

One of the strategies to detect the precursors of an eruption is to define the background dynamical state of a volcano for a prompt recognition of deviations from the basic condition. Mt. Vesuvius (Italy), currently in a quiescent state, is one of th...

One of the major challenges toward the reliable and safe operation of the Multi-Terminal HVDC (MT-HVDC) grids arises from the need for a very fast DC-side protection system to detect, identify, and interrupt the DC faults. Utilizing DC Circuit Breake...

Specific genetic variants in the mitochondrially encoded 12S ribosomal RNA gene (MT-RNR1) cause aminoglycoside-induced irreversible hearing loss. Mitochondrial DNA is usually not included in targeted sequencing experiments; however, off-target data m...

The recent arrival on the market of high-performing neural MT engines will likely lead to a profound transformation of the translation profession. The purpose of this study is to explore how this paradigm change impacts the post-editing process, with...

Magma dynamics at Mt. Etna volcano are frequently recognized as the result of complex crystallization regimes that, at shallow crustal levels, unexpectedly change from H₂O-undersaturated to H₂O-saturated conditions, due to the impulsive and irregular...

The toxic effect and differences of Cr(VI) on superoxide dismutase (SOD) activity, MDA, and metallothionein (MT) content in the hepatopancreas and gill of Portunus trituberculatus were investigated during Cr(VI) enrichment (15 days) and release exper...

Pathogenic variants in the MT-ATP6 are a well-known cause for maternally inherited mitochondrial disorders associated with a wide range of clinical phenotypes. Here, we present a 31- year old female with insulin-dependent diabetes mellitus, recurrent...

One of the major challenges on large-scale Multi-Terminal High Voltage Direct Current (MT-HVDC) systems is the steady-state interaction of the hybrid AC/DC grids to achieve an accurate Power Flow (PF) solution. In PF control of MT-HVDC systems, diffe...

Synthetic Aperture Radar Interferometry (InSAR), widely applied for the monitoring of land subsidence, has the advantage of high accuracy and wide coverage. High-resolution SAR data offers a chance to reveal impressive details of large-scale man-made...

Alveolar epithelial cell (AEC) mitochondrial (mt) DNA damage and fibrotic monocyte-derived alveolar macrophages (Mo-AMs) are implicated in the pathobiology of pulmonary fibrosis. We showed that sirtuin 3 (SIRT3), a mitochondrial protein regulating ce...

Velocity measurement by an incremental encoder is an important issue for advanced motion control applications such as robotics. In this paper, we deal with a kind of MT-type velocity estimation method. Though the conventional MT method is well known...

In early December 2015, a rapid sequence of strong paroxysmal events took place at the Mt. Etna crater area (Sicily, Italy). Intense paroxysms from the Voragine crater (VOR) generated an eruptive column extending up to an altitude of about 15 km abov...

The Orbiting Carbon Observatory-3 (OCO-3) mission provides a new perspective for studying atmospheric carbon dioxide (CO₂). Here we assess the potentiality of OCO-3 satellite acquisitions to analyse and monitor the CO₂ emissions from Mt. Etna volcano...

On 5 September 2022, a Mw 6.6 earthquake occurred in Luding, Sichuan Province, China. The epicenter of this earthquake was located in the vicinity of Mt. Gongga. The China Earthquake Administration employed the Global Navigation Satellite System (GNS...

In 2019, the National Geographic and Rolex Perpetual Planet Everest expedition successfully retrieved the greatest diversity of scientific data ever from the mountain. The confluence of geologic, hydrologic, chemical and microbial hazards emergent as...

Landslide susceptibility maps (LSMs) play an important role in landslide hazard risk assessments, urban planning, and land resource management. While states of motion and dynamic factors are critical in the landslide formation process, these factors...

Permafrost degradation can significantly affect vegetation, infrastructure, and sustainable development on the Qinghai-Tibet Plateau (QTP). The permafrost on the QTP faces a risk of widespread degradation due to climate change and ecosystem disturban...

This study documents the compositional variations of phenocrysts from a basaltic trachyandesitic sill emplaced in the Valle del Bove at Mt. Etna volcano (Sicily, Italy). The physicochemical conditions driving the crystallization and emplacement of th...

Background: Current studies indicate irisin role in carcinogenesis. The aim of the study was to investigate the expression of irisin in LSCCs and to determine its association with clinicopathological factors, as well as recognized markers of prolifer...

As the largest independent east–west-trending mountain in the world, Mt. Tianshan exerts crucial impacts on climate and pollutant distributions in central Asia. Here, the vertical structures of meteorological elements and black carbon (BC) were first...

Changes in stimuli and feeding in pregnant mothers alter the behavior of offspring. Since behavior is mediated by brain activity, it is expected that postnatal changes occur at the level of currents, receptors or soma and dendrites structure and modu...

Advanced motion control applications require smooth and highly accurate high-bandwidth velocity feedback, which is usually provided by an incremental encoder. Furthermore, high sampling rates are also demanded in order to achieve cutting-edge system...

The aerosol size distribution and cloud condensation nuclei (CCN) number concentration were measured using a wide-range particle spectrometer (WPS) and a cloud condensation nuclei counter (CCNC) on Mt. Tian from 31 July to 9 September, 2019. Combined...

This paper proposes a decoupled control of a dc-dc modular multilevel converter (MMC) based on a double-T topology intended for multi-terminal high voltage direct current (MT-HVdc) transmission systems or emerging distribution systems operating in me...

Mt. Baekdu is a volcano near the North Korea-Chinese border that experienced a few destructive eruptions over the course of its history, including the well-known 1702 A.D eruption. However, signals of unrest, including seismic activity, gas emission...

The aim of this study was to examine the impact of twenty honey samples, harvested in Mt. Olympus (Greece), on the virulence factors implicated in P. aeruginosa pathogenesis. Six key virulence factors (protease and elastase activity, pyocyanin and py...

Mammalian respiratory complex I (CI) biogenesis requires both nuclear and mitochondria-encoded proteins and is mostly organized in respiratory supercomplexes. Among the CI proteins encoded by the mitochondrial DNA, NADH-ubiquinone oxidoreductase chai...

Geological hazards often occur in mountainous areas and are sudden and hidden, so it is important to identify and assess geological hazards. In this paper, the western mountainous area of Beijing was selected as the study area. We conducted research...

On 16 February 2021, an eruptive paroxysm took place at Mt. Etna (Sicily, Italy), after continuous Strombolian activity recorded at summit craters, which intensified in December 2020. This was the first of 17 short, but violent, eruptive events occur...

Peptides from heptad repeat (HR1 and HR2) regions of gp41 are effective inhibitors of HIV-1 entry that block the fusion of viral and cellular membranes, but the generation of antibodies highly specific for these peptides is challenging. We have previ...

Estimation of fault classification and location in a multi-terminal high voltage direct current (MT–HVdc) transmission system is a challenging problem and is considered to be a fundamental maneuver of dc grid protection. This research paper cri...