Background: Scattering of the sclera limits optical coherence tomography (OCT) imaging of deeper targets including lesions, malignancies, and other surgical targets. While existing applications of fluorescein dye are currently focused on fluorescence...
The penetration of optical clearing agents (OCAs) is restricted by the natural barrier function of the stratum corneum (SC) of the skin, which can be breached by physical and chemical methods to enhance the transcutaneous delivery of OCAs. To breach...
Background: Optical coherence tomography (OCT) is a non-invasive imaging technique based on the interferometry of backscattered light. However, strong light scattering hinders its applicability in clinical dermatology. The strength of scattering is e...
Optical clearing agents (OCAs) offer a promising approach to enhance skin transparency by reducing scattering and improving photon transmission, which is critical for non-invasive optical diagnostics such as glucose sensing and vascular imaging. Howe...
The rapid development of super-resolution microscopy (SRM) techniques opens new avenues to examine cell and tissue details at a nanometer scale. Due to compatibility with specific labelling approaches, in vivo imaging and the relative ease of sample...
Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this tissue. Here, an optical clearing agent (OCA) was applied topically to...
The 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers are mimetic to phospholipids, being widely used as biocompatible polymers. In our previous study, MPC polymer hydrogels proved more effective for optical tissue clearing compared to acrylami...
Mesenchymal stromal cells (MSCs) injected intravenously are trapped in the capillaries of the lungs and die within the first 24 h. Studying the biodistribution and fate of labelled therapeutic cells in the 3D pulmonary context is important to underst...
The catalytically inactive mutant of Cas9 (dCas9) endonuclease has multiple biomedical applications, with the most useful being the activation/repression of transcription. dCas9 family members are also emerging as potential experimental tools for gen...
The term “tissue optical clearing” (TOC) came into use at the end of the 20th century and is associated with the development of methods for controlling tissue scattering properties using the refractive index matching effect [...]
(1) Background: The intra-oral behavior of clear thermoplastic dental materials can be influenced by various intrinsic and extrinsic factors. Aim: The purpose of this in vitro study was to evaluate the optical properties, color changes and whiteness...
In solar resource assessment, the climatological environment of the target area is objectively quantified by the cloudiness or clear sky index, which is defined as the ratio of global horizontal irradiance to clear sky solar insolation. The clear sky...
It is difficult to find research papers collecting comparative results about characterization studies of clear aligners. Therefore, the aim of this paper is to provide the first comparative analysis of most commercial clear aligners, in terms of thei...
Polarization imaging is a label-free and non-invasive technique that is sensitive to microstructure and suitable for probing the microstructure of living tissues. However, obtaining deep-layer information from tissues has been a challenge for optical...
The aim of this study was to establish an accessible methodology for the objective identification and 3D morphological characterization of renal glomeruli in mice. 3D imaging of the renal cortex was performed by light sheet microscopy on iDISCO+ opti...
The method of immersion optical clearing reduces light scattering in tissues, which improves the use of optical technologies in the practice of clinicians. In this work, we studied the optical and molecular diffusion properties of cat ovarian tissues...
The quantification and distribution characteristics of spinal motor neurons play important roles in the study of spinal cord and peripheral nerve injury and repair. In most research, the sole retrograde labeling of each nerve or muscle could not simu...
In this work, we use the method of optical coherence elastography (OCE) to enable quantitative, spatially resolved visualization of diffusion-associated deformations in the areas of maximum concentration gradients during diffusion of hyperosmotic sub...
Plant-parasitic nematodes are a significant cause of yield losses and food security issues. Specifically, nematodes of the genus Meloidogyne can cause significant production losses in horticultural crops around the world. Understanding the mechanisms...
This paper presents a recently developed variant of phase-resolved Optical Coherence Elastography (OCE) enabling non-contact visualization of transient local strains of various origins in biological tissues and other materials. In this work, we demon...
The visualization of infection processes in relevant tissues and organs using microscopy methods reveals a unique link between the distribution, tropism, and abundance of pathogens and the physiological structure of the respective organ. To dissect v...
To simultaneously achieve the high visible transparency and enhance the ultraviolet (UV)-blocking performance of displays, inorganic–organic hybrid nanoparticles, comprising TiO2 as a core and poly(methyl methacrylate) (PMMA) as a shell, were u...
Three-dimensional (3D) culture of tumor spheroids (TSs) within the extracellular matrix (ECM) represents a microtumor model that recapitulates human solid tumors in vivo, and is useful for 3D multiplex phenotypic analysis. However, the low efficiency...
Breast cancer is the most common cancer affecting women worldwide. Although many analyses and treatments have traditionally targeted the breast cancer cells themselves, recent studies have focused on investigating entire cancer tissues, including bre...
The visualization of viral pathogens in infected tissues is an invaluable tool to understand spatial virus distribution, localization, and cell tropism in vivo. Commonly, virus-infected tissues are analyzed using conventional immunohistochemistry in...
Characterization of the cardiac capillary network structure is of critical importance to understand the normal coronary functional properties and coronary microvascular diseases. The aim of our study was to establish an accessible methodology for 3D...
Many studies of axon regeneration in the lamprey focus on 18 pairs of large identified reticulospinal (RS) neurons, whose regenerative abilities have been individually quantified. Their axons retract during the first 2 weeks after transection (TX), a...
This study investigates the influences of air temperature (T), relative humidity (RH), wind speed (WS), clearance index (KT), particulate matter (PM) concentrations (PM10 and PM2.5), and aerosol optical depth (AOD) on ultraviolet (UV) radiation durin...
Aerosols in the atmosphere significantly reduce the solar radiation reaching the Earth’s surface through scattering and absorption processes. Knowing their properties becomes essential when we are interested in measuring solar radiation at a gi...
We introduce optically clear and resilient free-form micro-optical components of pure (non-photosensitized) organic-inorganic SZ2080 material made by femtosecond 3D laser lithography (3DLL). This is advantageous for rapid printing of 3D micro-/nano-o...
Optically clear adhesive (OCA) has been widely used in flexible devices, where wavy stripes that cause troublesome long-term reliability problems often occur. The complex mechanical behavior of OCA should be studied, as it is related to the aforement...
Directly 3D-printed clear aligners are increasingly adopted for orthodontic treatment, but lack intrinsic antibacterial properties. This study investigates the integration of silanized chitosan nanoparticles (CSNPs) into 3D-printed clear aligner resi...
The increasing demand for energy in the building sector is mostly due to heat, ventilation and air conditioning (HVAC) systems. In the absence of the clear sky beam optical depth (CSBOD) and clear sky diffuse optical depth (CSDOD), there is a challen...
UAVs and other low-altitude remote sensing platforms are proving very useful tools for remote sensing of river systems. Currently consumer grade cameras are still the most commonly used sensors for this purpose. In particular, progress is being made...
Directly printed clear aligners may streamline orthodontic workflows but must withstand intraoral aging. This in vitro study evaluated the effects of layer thickness (50, 100, and 150 µm) and thermocycling on mechanical, morphological, optical,...
This paper highlights the advantages of an affordable multi-wavelength ground-based camera, called WaltRCam, for monitoring Aerosol Optical Depth (AOD) in a clear case over a peri-urban area. To simulate the performance of this low-cost camera, for w...
This study assesses the performance of six global horizontal irradiance (GHI) clear sky models, namely: Bird, Simple Solis, McClear, Ineichen–Perez, Haurwitz and Berger–Duffie. The assessment is performed by comparing 1-min model outputs to correspon...
The effectiveness of a series of optically transparent aligners for orthodontic treatments depends on the anchoring of each tooth. In contrast with the roots, the crowns’ positions and orientations are measurable with intraoral scans, thus avoi...
Most tumors consume large amounts of glucose. Concepts to explain the mechanisms that mediate the achievement of this metabolic need have proposed a switch of the tumor mass to aerobic glycolysis. Depending on whether primarily tumor or stroma cells...
Visualizing biological events and states to resolve biological questions is challenging. Tissue clearing permits three-dimensional multicolor imaging. Here, we describe a pH-adjustable tissue clearing solution, Seebest (SEE Biological Events and Stat...
In vivo tissue transparency in the visible light spectrum is beneficial for many research applications that use optical methods, whether it involves in vivo optical imaging of cells or their activity, or optical intervention to affect cells or their...
In this study, novel silane acrylates, such as diethylene glycol diacrylate (DEGDA) and tetraethylene glycol diacrylate (TEGDA), containing ethylene glycol chains were synthesized and introduced into acrylic pressure-sensitive adhesives (PSAs) to reg...
With regard to the problem of current solar irradiation of the tracking surface by the tracker, this can be rationally assessed using a modeled flux with parameters close to the natural direct in accordance with the maximum transparent atmosphere. As...
The intrinsic opacity of the sclera limits ab externo visualization of deeper structures such as Schlemm’s canal, thereby constraining angle-based glaucoma surgery. Tartrazine, a US FDA-approved azo dye, transiently enhances tissue optical tran...
We report the design, fabrication, and experimental characterization of an optically transparent printed planar inverted-F antenna (PIFA) operating at 2.45 GHz using the aerosol jet (AJ) printing method. The proposed antenna was fabricated using a cl...
Bottom reflectance is a significant parameter characterizing the bottom types for clear optically shallow waters, typically in oceanic islands and reefs. However, there is not an effective physics-based method for inverting the bottom reflectance usi...
18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a widely used noninvasive imaging modality for assessing hypoxia. We describe the first spatial comparison of FMISO PET with an ex vivo reference standard for hypoxia across whole t...
To further study the electro-optical modulation characteristics of LiNbO3 crystals and analyze their modulation performance, a method for studying the modulation characteristics of LiNbO3 crystals, based on the three-dimensional ray tracing method, i...
Cutaneous melanoma is one of the most aggressive and deadliest cancers in human beings due to its invasiveness and other factors. Histopathological analysis is crucial for a proper diagnosis. Optical tissue clearing is a novel field that allows 3D im...
The effects of optical clearing of implantable collagen materials were studied using optical clearing agents (OCAs) based on aqueous glucose solutions of various concentrations. By measuring the kinetics of the collimated transmission spectra, the di...
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