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Proceedings, Volume 50, Issue 1

Viruses 2020 2020 - 150 articles

Viruses 2020—Novel Concepts in Virology

Barcelona, Spain | 5–7 February 2020

Volume Editors:
Eric O. Freed, NCI-Frederick, USA
Albert Bosch, University of Barcelona, Spain

Cover Story: This volume of Proceedings aims to gather the papers presented at the Viruses 2020—Novel Concepts in Virology, held on 5–7 February 2020 in Barcelona, Spain. Viruses continue to play a central role in all aspects of biomedical research, ranging from molecular and cell biology, structural biology, and immunology to evolution, epidemiology, and bioinformatics. This conference brings together 240 leading virologists from around the world and across the broad field of virology to share results of their recent studies. Viruses 2020 allowed for an information exchange between experienced researchers, engineers, and young scientists who are taking their first steps toward innovation.
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Articles (150)

  • Abstract
  • Open Access
1,589 Views
1 Page

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

  • Shuo Zhang,
  • Harish N. Ramanathan,
  • Florian Douam,
  • Katrina B. Mar,
  • Jinhong Chang,
  • Priscilla L. Yang,
  • John W. Schoggins,
  • Alexander Ploss and
  • Brett D. Lindenbach

Flaviviruses are enveloped, arthropod-borne, positive-strand RNA viruses that cause significant human disease. While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA repl...

  • Abstract
  • Open Access
3 Citations
2,393 Views
1 Page

A Mycovirus Mediates the Virulence of an Insect-Killing Fungus against the Malaria Mosquito Vector

  • Andre N. Pitaluga,
  • Charalampos Filippou,
  • Josephine Blakiston,
  • Robert H.A. Coutts,
  • George K. Christophides and
  • Ioly Kotta-Loizou

The cosmopolitan insect-pathogenic fungus and popular biocontrol agent Beauveria bassiana can be used to control Anopheles mosquito populations and restrict the spread of malaria, the deadliest vector-borne infectious disease in the world caused by t...

  • Abstract
  • Open Access
2 Citations
1,838 Views
1 Page

A Genome-Wide CRISPR Activation Screen Identifies Genes Involved in Protection from Zika Virus Infection

  • Anna Dukhovny,
  • Kevin Lamkiewicz,
  • Qian Chen,
  • Markus Fricke,
  • Nabila Jabrane-Ferrat,
  • Manja Marz,
  • Jae U. Jung and
  • Ella Hava Sklan

Zika virus (ZIKV) is an arthropod-borne emerging pathogen causing febrile illness. ZIKV is associated with the Guillain–Barré syndrome and other neurological complications. The vertical transmission of ZIKV can cause fetus demise, stillb...

  • Proceeding Paper
  • Open Access
1,755 Views
1 Page

MicroRNAs Are Predicted to Control the Ubiquitin/Proteasome System in Carica papaya Plants Infected by the Papaya Meleira Virus Complex

  • Tathiana Ferreira Sá Antunes,
  • Silas Pessini Rodrigues and
  • Patricia Machado Bueno Fernandes

Papaya sticky disease (PSD) is a severe disease that can destroy papaya trees. PSD is associated with a complex formed between a toti-like virus, Papaya meleira virus (PMeV), and an umbra-like virus—Papaya meleira virus 2 (PMeV2). PSD symptoms...

  • Abstract
  • Open Access
1,591 Views
1 Page

Characterization of Glycoproteins from Insect-Specific Goutanap and Negev Viruses

  • Kathakali Das,
  • Miri Stolovich-Rain,
  • Leora Gidon,
  • Sujata Kumari,
  • Tomer Schlosser,
  • Manoj Kumar,
  • Reuven Wiener and
  • Alexander Rouvinski

Negeviruses (NVs) are a recently discovered taxon of enveloped, positive sense, single-stranded RNA viruses, infecting blood-sucking insects. While classical arthropod-borne (arbo)viruses like dengue and Chikungunya infect both insects and vertebrat...

  • Proceeding Paper
  • Open Access
1,718 Views
1 Page

Knock Out of Cell Death Pathway Components Results in Differential Caspase Expression in Response to HCV Infection

  • Hannah L. Wallace,
  • Lingyan Wang,
  • Cassandra Davidson,
  • Vipin Chelakkot,
  • Michael Grant,
  • John Pezacki,
  • Kensuke Hirasawa and
  • Rodney S. Russell

Introduction: Pyroptosis (inflammatory programmed cell death) is induced after the activation of an inflammasome, ultimately resulting in pore formation and cell lysis. One factor in the pathology associated with chronic hepatitis C virus (HCV) infec...

  • Abstract
  • Open Access
1,592 Views
1 Page

Unique Features of Immunity within the Immunoglobulin Heavy Chain Locus of Egyptian Rousette Bats

  • Maggie L. Bartlett,
  • Peter A. Larson,
  • Mariano Sanchez-Lockhart and
  • Gustavo Palacios

Marburg virus (MARV) presents with a hemorrhagic fever in primates but asymptomatically in its known reservoir, the Egyptian rousette bat (Rousettus aegyptiacus, ERB). Understanding the biological mechanisms that explain these differential outcomes c...

  • Abstract
  • Open Access
1,517 Views
1 Page

Induction of the Type I IFN Response by Human Metapneumovirus Lacking SH, G, or M2.2 Expression

  • Kevin Groen,
  • Stefan van Nieuwkoop,
  • Ron Fouchier and
  • Bernadette van den Hoogen

The human metapneumovirus (HMPV), a member of the Pneumoviridae family, is a major cause of respiratory illness, primarily in young children, the elderly, and immunocompromised individuals. Having a fundamental understanding of the viral evasion of i...

  • Abstract
  • Open Access
1,685 Views
1 Page

Many viruses transmitted by blood-sucking arthropods have emerged worldwide and cause serious human and animal diseases. Arthropod-borne (arbo-)viruses possess a peculiar capacity to replicate in very different hosts, such as mosquitoes and mammals (...

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Proceedings - ISSN 2504-3900