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Open AccessReview

Tissue Transparency In Vivo

1
Department of Physiology, Universidad Central del Caribe, Bayamon, PR 00960, USA
2
Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg 194064, Russia
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(13), 2388; https://doi.org/10.3390/molecules24132388
Received: 23 May 2019 / Revised: 19 June 2019 / Accepted: 25 June 2019 / Published: 28 June 2019
In vivo tissue transparency in the visible light spectrum is beneficial for many research applications that use optical methods, whether it involves in vivo optical imaging of cells or their activity, or optical intervention to affect cells or their activity deep inside tissues, such as brain tissue. The classical view is that a tissue is transparent if it neither absorbs nor scatters light, and thus absorption and scattering are the key elements to be controlled to reach the necessary transparency. This review focuses on the latest genetic and chemical approaches for the decoloration of tissue pigments to reduce visible light absorption and the methods to reduce scattering in live tissues. We also discuss the possible molecules involved in transparency. View Full-Text
Keywords: in vivo transparency; imaging depth; optical tissue clearing; deep-tissue optogenetics; genetically modified animals; model organisms with transparent tissues in vivo transparency; imaging depth; optical tissue clearing; deep-tissue optogenetics; genetically modified animals; model organisms with transparent tissues
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MDPI and ACS Style

Inyushin, M.; Meshalkina, D.; Zueva, L.; Zayas-Santiago, A. Tissue Transparency In Vivo. Molecules 2019, 24, 2388. https://doi.org/10.3390/molecules24132388

AMA Style

Inyushin M, Meshalkina D, Zueva L, Zayas-Santiago A. Tissue Transparency In Vivo. Molecules. 2019; 24(13):2388. https://doi.org/10.3390/molecules24132388

Chicago/Turabian Style

Inyushin, Mikhail; Meshalkina, Daria; Zueva, Lidia; Zayas-Santiago, Astrid. 2019. "Tissue Transparency In Vivo" Molecules 24, no. 13: 2388. https://doi.org/10.3390/molecules24132388

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