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3,603 Results Found

  • Article
  • Open Access
13 Citations
8,527 Views
20 Pages

The Nuclear Dense Fine Speckled (DFS) Immunofluorescence Pattern: Not All Roads Lead to DFS70/LEDGFp75

  • Evelyn S. Sanchez-Hernandez,
  • Greisha L. Ortiz-Hernandez,
  • Pedro T. Ochoa,
  • Michael Reeves,
  • Nicola Bizzaro,
  • Luis E. C. Andrade,
  • Michael Mahler and
  • Carlos A. Casiano

The monospecific dense fine speckled (DFS) immunofluorescence assay (IFA) pattern is considered a potential marker to aid in exclusion of antinuclear antibody (ANA)-associated rheumatic diseases (AARD). This pattern is typically produced by autoantib...

  • Review
  • Open Access
1 Citations
16,295 Views
13 Pages

14 November 2023

The diagnosis of systemic autoimmune rheumatic disease (SARD) or its exclusion is carried out taking into account the results of immunological studies, primarily antinuclear antibodies (ANA) and specific autoantibodies. Often, during ANA analysis via...

  • Article
  • Open Access
3 Citations
4,564 Views
10 Pages

Analysis of Ana/Dfs70 Pattern in a Large Cohort of Autoimmune/Autoinflammatory Diseases Compared with First Degree Relatives and Healthy Controls Evaluated from Colombia

  • Consuelo Romero-Sánchez,
  • Omar-Javier Calixto,
  • Veronica Romero-Alvarez,
  • Alejandra Vargas-Martin,
  • Luis Castro,
  • Julio Amador,
  • Daniela Marín-Acevedo,
  • Mónica Acevedo-Godoy,
  • Diana Rincón-Riaño and
  • Juan Manuel Bello-Gualtero

9 September 2022

Background: The presence of Antinuclear antibodies/Dense Fine Speckled 70 (ANA/DFS70) has been proposed as a negative biomarker in the process of exclusion of systemic autoimmune/autoinflammatory rheumatic diseases (SARD). The purpose was to evaluate...

  • Review
  • Open Access
54 Citations
15,974 Views
30 Pages

Design for Manufacturing and Assembly (DfMA) and Design for Deconstruction (DfD) in the Construction Industry: Challenges, Trends and Developments

  • Cheryl Lyne C. Roxas,
  • Carluz R. Bautista,
  • Orlean G. Dela Cruz,
  • Rhem Leoric C. Dela Cruz,
  • John Paul Q. De Pedro,
  • Jonathan R. Dungca,
  • Bernardo A. Lejano and
  • Jason Maximino C. Ongpeng

28 April 2023

A building faces several challenges across its lifecycle stages. Challenges such as production inefficiency and inadequate waste management hinder advancement in the construction industry. Furthermore, the sector has emerged as one of the largest pro...

  • Article
  • Open Access
1 Citations
2,538 Views
24 Pages

To select the optimal design alternative in off-site construction (OSC) projects, the building industry has turned to design for manufacturing and assembly (DfMA). However, most DfMA developments in the OSC field until now have been on improving the...

  • Article
  • Open Access
35 Citations
8,630 Views
18 Pages

BIM and DfMA: A Paradigm of New Opportunities

  • Sepehr Abrishami and
  • Rocío Martín-Durán

26 August 2021

The main goal of this study is to explore the adoption of a design for manufacturing and assembly (DfMA) and building information management (BIM) approach during the whole lifecycle of assets. This approach aims to tackle issues inherent in the desi...

  • Article
  • Open Access
12 Citations
5,217 Views
20 Pages

Developing a Construction-Oriented DfMA Deployment Framework

  • Sara Rankohi,
  • Mario Bourgault,
  • Ivanka Iordanova and
  • Carlo Carbone

17 April 2023

Applying design for manufacture and assembly (DfMA) principles in the construction industry has gained attention in recent years. Studies convey that the application of DfMA in construction projects can significantly enhance overall productivity. How...

  • Article
  • Open Access
807 Views
37 Pages

8 September 2025

Rapid urbanisation and population growth call for more Industrialised Construction (IC) as a swifter, safer, higher-quality and affordable means of delivering housing and infrastructure. Meanwhile, rising global temperatures and extreme weather patte...

  • Review
  • Open Access
37 Citations
10,861 Views
22 Pages

DfMA for a Better Industrialised Building System

  • Mohammed Izrai Abd Razak,
  • Muhamad Azry Khoiry,
  • Wan Hamidon Wan Badaruzzaman and
  • Afifuddin Husairi Hussain

To improve the performance of the construction industry, innovative methods were introduced to make them better. Industrialised building systems (IBS) and prefabrication construction are the popular methods used and studied. However, these methods ar...

  • Article
  • Open Access
3 Citations
1,848 Views
16 Pages

19 February 2024

This study introduces a modified DF2016 criterion to model a ductile fracture of sheet metals from shear to equibiaxial tension. The DF2016 criterion is modified so that a material constant is equal to the fracture strain at equibiaxial tension, whic...

  • Article
  • Open Access
31 Citations
5,403 Views
22 Pages

1 February 2023

The integration of Design for Manufacture and Assembly (DfMA) into the design process of industrialized construction has the potential to reduce errors and changes occurring after the design has been finalized, ultimately improving overall productivi...

  • Article
  • Open Access
25 Citations
4,686 Views
19 Pages

14 June 2019

With the prevalence of a circular economy, extended producer responsibility, and the maturity of intelligent manufacturing technology, Design for Remanufacture (DfRem) has become a new driving force for the profitability of the modern supply chain. D...

  • Review
  • Open Access
21 Citations
9,121 Views
21 Pages

20 January 2024

The construction industry, despite its anticipated significant growth, has struggled with low productivity over the past two decades. Design for manufacturing and assembly (DfMA), a methodology with a history of success in other industries, presents...

  • Article
  • Open Access
372 Views
14 Pages

Engineering AQP1-Deficient DF-1 Suspension Cells for High-Yield IBDV Production and Vaccine Scale-Up

  • Bingmei Dong,
  • Ruonan Wang,
  • Yu Guan,
  • Xiubao Zhao,
  • Ronghua Li,
  • Qingqing Xu,
  • Hui Li,
  • Qingfang Gao,
  • Shengjie Yao and
  • Na Tang
  • + 2 authors

31 December 2025

Background: Large-scale production of poultry viral vaccines increasingly requires robust suspension cell platforms. However, most avian cell lines, including DF-1, are strictly anchorage-dependent, limiting scalability. Aquaporin-1 (AQP1) regulates...

  • Article
  • Open Access
10 Citations
4,192 Views
27 Pages

23 October 2024

Modular construction is emerging into the limelight in the construction industry as one of the front-running modern methods of construction, facilitating multiple benefits, including improved productivity. Meanwhile, Circular Economy (CE) principles...

  • Article
  • Open Access
95 Views
13 Pages

A Human β-Defensin-Based Recombinant Protein DF2-HSA Ameliorates Cytokine Storm

  • Yibo Du,
  • Zhuojun Yu,
  • Weijin Sheng,
  • Yi Li,
  • Lei Hou,
  • Yanbo Zheng,
  • Xiujun Liu and
  • Yongsu Zhen

21 January 2026

Cytokine storm is a critical driver of acute respiratory distress syndrome and multiple organ failure. Human β-defensin 2 (HBD-2) is the first inducible defensin discovered in human body. Defensin can resist pathogenic microorganisms invading th...

  • Article
  • Open Access
5 Citations
2,388 Views
18 Pages

7 July 2022

Heat stress seriously affects medicinal herbs’ growth and yield. Rubisco accumulation factor (Raf) is a key mediator regulating the activity of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), which plays important roles in carbon ass...

  • Article
  • Open Access
2 Citations
1,534 Views
21 Pages

Functional Identification and Regulatory Active Site Screening of the DfDXS Gene of Dryopteris fragrans

  • Hanxu Zhao,
  • Jiameng Su,
  • Zhaoxuan Zhong,
  • Tongyou Xiong,
  • Weicong Dai,
  • Dongrui Zhang and
  • Ying Chang

21 September 2024

Dryopteris fragrans (L.) Schott has anti-inflammatory and antioxidant properties, and terpenoids are important components of its active constituents. The methyl-D-erythritol 4-phosphate (MEP) pathway is one of the major pathways for the synthesis of...

  • Review
  • Open Access
63 Citations
10,724 Views
25 Pages

A growing interest has been expressed in the issue of building adaptability over the past decade, perceiving it as an intrinsic criterion for sustainability. In light of the circular economy (CE) and its application in the construction sector, more a...

  • Article
  • Open Access
4 Citations
4,118 Views
26 Pages

Enhancement of the LeanDfX Product Development Framework and Application to the Design of an AGV Structure

  • Tomás Carneiro,
  • João Oliveira,
  • António J. Baptista and
  • Paulo M. S. T. de Castro

15 November 2022

A product development framework called LeanDfX has been conceived at INEGI, aiming at organizing the product design and development process benefitting from lean thinking and DfX paradigms. The design of the metallic structure for an automated guided...

  • Article
  • Open Access
25 Citations
6,429 Views
20 Pages

30 March 2022

Off-site construction (OSC) offers a promising means to improve the efficiency of construction projects. However, the lack of experience and knowledge regarding its use results in errors in design owing to conflicts and omissions of considerations fo...

  • Article
  • Open Access
1 Citations
2,268 Views
12 Pages

Face Detection Based on DF-Net

  • Qijian Tang,
  • Yanfei Li,
  • Yinhe Cai,
  • Xiang Peng and
  • Xiaoli Liu

24 September 2023

Face data have found increasingly widespread applications in daily life. To efficiently and accurately extract face information from input images, this paper presents a DF-Net-based face detection approach. A lightweight facial feature extraction neu...

  • Article
  • Open Access
7 Citations
2,532 Views
21 Pages

6 January 2025

Additive manufacturing (AM) has revolutionized the design and production of complex geometries by offering unprecedented creative freedom over traditional manufacturing. Despite its growing prominence, AM lacks automated and standardized design rules...

  • Article
  • Open Access
1 Citations
897 Views
35 Pages

2 December 2025

The objective of this article is to evaluate the viability of implementing the Design for Manufacturing and Assembly (DfMA) methodology in the design and construction of complex wooden structures with non-standard geometry. The present study incorpor...

  • Proceeding Paper
  • Open Access
869 Views
5 Pages

14 November 2024

The DFO, a special hexadentate chelator with three hydroxamate moieties, is a bifunctional 1-(4-isothiocyanatophenyl)-3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)- 6,11,17, 22- tetraazaheptaeicosine] thiourea (p-SCN-Bn-Df), a sign...

  • Article
  • Open Access
560 Views
41 Pages

11 November 2025

The persistent fragmentation of the architecture, engineering, and construction (AEC) industry drives the pursuit of advanced and unified construction solutions. This study investigated the limited understanding and adoption of one of these solutions...

  • Article
  • Open Access
1,919 Views
19 Pages

3 June 2025

This study investigates the environmental and operational performance of X-DF and ME-GI propulsion systems in large LNG carriers, focusing on key emission and transport efficiency metrics—CO2, the EEOI, and the CII—and their relationship...

  • Article
  • Open Access
4 Citations
2,568 Views
11 Pages

The Protective Effect of Lycium Ruthenicum Murr Anthocyanins in Cr (VI)-Induced Mitophagy in DF-1 Cells

  • Shuhua Guo,
  • Mengzhu Qi,
  • Hongyan Li,
  • Yukun Cui,
  • Changxi Qi,
  • Guodong Cheng,
  • Meiyun Lv,
  • Pimiao Zheng and
  • Jianzhu Liu

25 July 2022

Cr (VI) is an extremely toxic environment and professional pollutant that seriously damages mitochondrial dysfunction when it enters a cell. Anthocyanins possess anti-oxidant, antiaging, and antifatigue properties. The regulatory effect of Lycium rut...

  • Article
  • Open Access
15 Citations
5,086 Views
15 Pages

Mixed Topology of DF Relayed Terrestrial Optical Wireless Links with Generalized Pointing Errors over Turbulence Channels

  • George K. Varotsos,
  • Hector E. Nistazakis,
  • Argyris N. Stassinakis,
  • Christos K. Volos,
  • Vasileios Christofilakis and
  • George S. Tombras

This study investigated the outage performance of a terrestrial FSO communication system that uses mixed series and parallel decode-and-forward (DF) relay-assisted (i.e., cooperative diversity) configurations, taking into account the influence of bot...

  • Article
  • Open Access
7 Citations
5,623 Views
24 Pages

18 April 2019

This article studied the application of multiple protocol switching mechanism (PSM) over cooperating Non-Orthogonal Multiple Access (NOMA) networks to minimize the probability of outage and maximize the system throughput and energy efficiency (EE). T...

  • Article
  • Open Access
8 Citations
2,391 Views
20 Pages

Unraveling the Nrf2-ARE Signaling Pathway in the DF-1 Chicken Fibroblast Cell Line: Insights into T-2 Toxin-Induced Oxidative Stress Regulation

  • Suisui Gao,
  • Kaixin Wang,
  • Kuankuan Xiong,
  • Shuai Xiao,
  • Chujian Wu,
  • Mingxia Zhou,
  • Linfeng Li,
  • Guoxiang Yuan,
  • Lihuang Jiang and
  • Lingchen Yang
  • + 1 author

25 October 2023

The T-2 toxin (T2) poses a major threat to the health and productivity of animals. The present study aimed to investigate the regulatory mechanism of Nrf2 derived from broilers against T2-induced oxidative damage. DF-1 cells, including those with nor...

  • Article
  • Open Access
19 Citations
5,886 Views
30 Pages

Life Cycle Engineering 4.0: A Proposal to Conceive Manufacturing Systems for Industry 4.0 Centred on the Human Factor (DfHFinI4.0)

  • Susana Suarez-Fernandez de Miranda,
  • Francisco Aguayo-González,
  • Jorge Salguero-Gómez and
  • María Jesús Ávila-Gutiérrez

27 June 2020

Engineering 4.0 environments are characterised by the digitisation, virtualisation, and connectivity of products, processes, and facilities composed of reconfigurable and adaptive socio-technical cyber-physical manufacturing systems (SCMS), in which...

  • Article
  • Open Access
12 Citations
3,292 Views
9 Pages

RNA Sequencing Reveals circRNA Expression Profiles in Chicken DF1 Cells Infected with H5N1 Influenza Virus

  • Li Chen,
  • Guoqin Li,
  • Yong Tian,
  • Tao Zeng,
  • Wenwu Xu,
  • Tiantian Gu and
  • Lizhi Lu

10 January 2022

H5N1, a highly pathogenic avian influenza virus that is prevalent in Asia, seriously harms the poultry industry and global public health. However, its pathogenesis is still not well understood. Circular RNAs (circRNAs), a newly identified type of RNA...

  • Communication
  • Open Access
2 Citations
2,391 Views
11 Pages

2 March 2023

The results of detailed studies on the beam quality of a non-chain pulsed electric discharged DF laser based on a compact inner cavity confocal positive branch unstable resonator were presented herein. The theoretical and experimental divergence angl...

  • Article
  • Open Access
15 Citations
2,926 Views
13 Pages

Validation of the Mechanical Behavior of an Aeronautical Fixing Turret Produced by a Design for Additive Manufacturing (DfAM)

  • Fernando Veiga,
  • Trunal Bhujangrao,
  • Alfredo Suárez,
  • Eider Aldalur,
  • Igor Goenaga and
  • Daniel Gil-Hernandez

27 May 2022

The design of parts in such critical sectors as the manufacturing of aeronautical parts is awaiting a paradigm shift due to the introduction of additive manufacturing technologies. The manufacture of parts designed by means of the design-oriented add...

  • Article
  • Open Access
34 Citations
10,618 Views
16 Pages

5 July 2019

As a demountable structure, the structure with design for deconstruction (DfD) is considered as a key contribution on the promotion of current construction sustainability by directly reusing valuable components from old structures. As a preliminary s...

  • Review
  • Open Access
13 Citations
6,543 Views
11 Pages

1 September 2021

Anti-DFS70 antibodies have been proposed as a marker to exclude systemic autoimmune rheumatic disease (SARD). We conducted this systematic diagnostic test accuracy review and meta-analysis to determine the performance of anti-DFS70 antibodies in pati...

  • Proceeding Paper
  • Open Access
1 Citations
3,248 Views
7 Pages

Implementation of Design for Sustainability in Product Engineering

  • Yeturu Jaganmohan Reddy,
  • Gogulamudi Pradeep Reddy and
  • Yellapragada Venkata Pavan Kumar

22 November 2023

Product engineering involves the design and development of new products or the improvement of existing products to efficiently meet market needs and ensure high quality. Design for Excellence (DfX) concepts, such as Design for Manufacturing, Design f...

  • Article
  • Open Access
4 Citations
1,476 Views
14 Pages

Dendrocalamus farinosus bamboo shoots, a species with rich nutritional value, are important in Southwest China. Lignin is an important factor affecting the postharvest flavor quality of bamboo shoots; however, the underlying mechanism of lignin...

  • Article
  • Open Access
4 Citations
2,658 Views
24 Pages

(1) This paper, based on the characteristics of complex steel structures as well as difficult points in the process of their detailed design, introduces the product design concept of DfMA (Design for Manufacturing and Assembly) from the manufacturing...

  • Article
  • Open Access
10 Citations
6,857 Views
30 Pages

16 January 2019

The need for understanding the context of the case company during Design for Sustainability (DfS) implementation has been a long identified need among the researchers in the field. Yet, studies on company context have primarily focused on studying,...

  • Review
  • Open Access
2 Citations
4,731 Views
22 Pages

End-users can design personalized furnishing products using remote web-based CAD systems. However, if these designs fail to incorporate design for disassembly (DfD) principles, the furniture’s subsequent repair, reconfiguration, recycling, and...

  • Article
  • Open Access
9 Citations
2,876 Views
16 Pages

13 September 2023

With technological transformations such as big data, blockchain, artificial intelligence, and cloud computing, digital techniques are infiltrating the field of finance. Digital finance (DF) is a resource-saving and environmentally friendly innovative...

  • Article
  • Open Access
623 Views
18 Pages

Molecular Characterization and Antiviral Function Against GCRV of Complement Factor D in Barbel Chub (Squaliobarbus curriculus)

  • Yu Xiao,
  • Zhao Lv,
  • Yuling Wei,
  • Mengyuan Zhang,
  • Hong Yang,
  • Chao Huang,
  • Tiaoyi Xiao and
  • Yilin Li

2 August 2025

The barbel chub (Squaliobarbus curriculus) exhibits remarkable resistance to grass carp reovirus (GCRV), a devastating pathogen in aquaculture. To reveal the molecular basis of this resistance, we investigated complement factor D (DF)—a rate-li...

  • Article
  • Open Access
8 Citations
2,746 Views
22 Pages

Deep Forest-Based DQN for Cooling Water System Energy Saving Control in HVAC

  • Zhicong Han,
  • Qiming Fu,
  • Jianping Chen,
  • Yunzhe Wang,
  • You Lu,
  • Hongjie Wu and
  • Hongguan Gui

25 October 2022

Currently, reinforcement learning (RL) has shown great potential in energy saving in HVAC systems. However, in most cases, RL takes a relatively long period to explore the environment before obtaining an excellent control policy, which may lead to an...

  • Article
  • Open Access
6 Citations
3,607 Views
18 Pages

29 April 2018

This paper considers a hybrid relay network consisting of the source, the amplify-and-forward (AF) relay, the decode-and-forward (DF) relay, and the destination. In hybrid three-hop relay systems, the transmitted signal from source can be received at...

  • Article
  • Open Access
4 Citations
4,112 Views
15 Pages

Double Filtration Plasmapheresis with Polyvinyl Alcohol-Based Membrane Lowers Serum Inflammation and Toxins in Patients with Hyperlipidemia

  • Wen-Sheng Liu,
  • Chien-Hung Lin,
  • Ching-Yao Tsai,
  • Hsiang-Tsui Wang,
  • Szu-Yuan Li,
  • Tsung-Yun Liu,
  • Ann Charis Tan,
  • Han-Hsing Tsou,
  • Kuo-Hsien Tseng and
  • Chih-Ching Lin

Hyperlipidemia is increasing in prevalence and is highly correlated with cardiovascular disease (CVD). Lipid-lowering medications prevent CVD but may not be suitable when the side effects are intolerable or hypercholesterolemia is too severe. Double-...

  • Review
  • Open Access
66 Citations
10,810 Views
15 Pages

A Systematic Review and Meta-Analysis of Dengue Risk with Temperature Change

  • Jingchun Fan,
  • Wanxia Wei,
  • Zhenggang Bai,
  • Chunling Fan,
  • Shulan Li,
  • Qiyong Liu and
  • Kehu Yang

Dengue fever (DF) is the most serious mosquito-borne viral disease in the world and is significantly affected by temperature. Although associations between DF and temperatures have been reported repeatedly, conclusions have been inconsistent. Six dat...

  • Article
  • Open Access
2 Citations
2,836 Views
15 Pages

Analysis of Flow Characteristics of a Debris Filter in a Condenser Tube Cleaning System

  • Da-Woon Jung,
  • Chung-Won Seo,
  • Young-Chan Lim,
  • Dong-Sun Kim,
  • Seung-Yul Lee and
  • Hyun-Kyu Suh

1 June 2023

In a power plant that uses seawater as a coolant, a debris filter (DF) is required to remove foreign substances from the seawater, and differential pressure leads to a decrease in the coolant flow rate, leading to a decrease in the power generation e...

  • Article
  • Open Access
6 Citations
4,122 Views
21 Pages

Design and Optimization of a Distributed File System Based on RDMA

  • Qinlu He,
  • Pengze Gao,
  • Fan Zhang,
  • Genqing Bian,
  • Weiqi Zhang and
  • Zhen Li

27 July 2023

With the rapid development of computer and network technology, to deal with explosively growing mass data correctly, distributed file systems have come into being, and they have been applied in many enterprises. However, in the packet storage process...

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