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14.7
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Journals
Antioxidants
Special Issues
Redox Homeostasis in Poultry/Animal Production―2nd Edition
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Redox Homeostasis in Poultry/Animal Production―2nd Edition

A Special Issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2037

Editor

Prof. Dr. Peter F. Surai

E-Mail Website
Guest Editor
Vitagene and Health Research Centre, Bristol BS4 2RS, UK
Interests: vitamin E; Se; carotenoids; carnitine; betaine; vitagenes; stress adaptaion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Commercial animal/poultry production is associated with a range of stresses, including physiological, environmental, technological, nutritional, and internal/immunological stresses. Analysis of modern technologies of egg and meat production indicates that it is practically impossible to prevent stress, and the development of effective strategies for stress protection has become a hot topic in recent years. It is generally accepted that at the molecular level, most stresses are associated with overproduction of free radicals, compromised antioxidant defences, oxidative stress, and redox imbalance. Therefore, accumulating evidence indicates that maintenance of the optimal redox status is a key task for the integrated antioxidant defence network. In particular, the interplay between various transcription factors, including Nrf2 and NF-kB, and vitagenes provides important mechanisms of stress adaptation. In this contest, inflammation, as an important contributor to different metabolic disorders in farm animals and poultry, deserves more attention. Understanding molecular mechanisms of redox status regulation under various stress conditions and the development of effective nutritional strategies to prevent dysregulation of the redox homeostasis is a fast-developing area of current research.

Building upon the fruitful first edition (https://www.mdpi.com/journal/antioxidants/special_issues/3U4B8ZF017), this second edition will further focus on redox homeostasis maintenance in poultry/animal production to provide optimal health and high stress resistance under commercially relevant stress conditions.

This includes, but is not restricted to, topics such as the following:

  • Molecular mechanisms of redox homeostasis regulation under various stress conditions
  • Superoxide dismutase and its roles in redox homeostasis
  • Redox homeostasis and immunity, inflammation, microbiota, gut health, reproduction, and meat quality
  • Dietary manipulation to improve redox balance: Se, vitamin E, carotenoids, carnitine, taurine, polyphenolics, etc.
  • Transcription factors (Nrf2 and NF-kB) and vitagene in redox homeostasis

Prof. Dr. Peter F. Surai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox homeostasis
  • oxidative stress
  • antioxidants
  • transcription factors
  • immunity
  • inflammation
  • poultry
  • pigs
  • cattle

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Published Papers (3 papers)

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Research

19 pages, 5099 KB  
Article
SOD1 Overexpression Alleviates H2O2-Induced Oxidative Stress and Reshapes Transcriptomic Responses in Chicken DF-1 Cells
by Yidan Wang, Penghao Wei, Tinghao Gao, Zhiwei Li, Caiqin Deng, Hanjing Chen, Jianliang Zhang, Fengcai Zou and Haiyang Song
Antioxidants 2026, 15(9), 1074; https://doi.org/10.3390/antiox15091074 - 27 Aug 2026
Viewed by 218
Abstract
Oxidative stress is a major consequence of environmental, metabolic, and disease-related challenges in poultry and can compromise cellular integrity and function. Although antioxidant defense mechanisms are broadly conserved across vertebrates, oxidative-stress responses in avian cells remain less well characterized than those in mammalian [...] Read more.
Oxidative stress is a major consequence of environmental, metabolic, and disease-related challenges in poultry and can compromise cellular integrity and function. Although antioxidant defense mechanisms are broadly conserved across vertebrates, oxidative-stress responses in avian cells remain less well characterized than those in mammalian systems. Superoxide dismutase 1 (SOD1) is a key antioxidant enzyme, but how elevated SOD1 expression influences both oxidative injury and stress-responsive transcription in chicken cells remains incompletely understood. In this study, we established a stable SOD1-overexpressing chicken DF-1 fibroblast cell line and induced acute oxidative stress using hydrogen peroxide (H2O2). Cellular responses were evaluated using CCK-8 viability assays and Hoechst 33342/propidium iodide staining, followed by RNA sequencing and transcriptomic analyses. SOD1 overexpression markedly improved cell viability under H2O2 challenge and substantially reduced necrotic cell death, whereas its effect on apoptosis-associated changes was comparatively limited. Transcriptomic profiling showed that H2O2 induced extensive transcriptional reprogramming, while SOD1 overexpression reshaped this response by attenuating a subset of stress-inducible gene programs. Trend clustering further identified an H2O2-responsive module associated mainly with basic amino acid transport and stress-related regulatory processes that was less strongly induced in SOD1-overexpressing cells. Collectively, these findings demonstrate that elevated SOD1 expression enhances resistance to acute oxidative injury and modifies stress-responsive transcription in chicken fibroblasts. This study extends our current understanding of SOD1-mediated antioxidant cytoprotection in an avian cellular model and provides a molecular basis for further investigation of oxidative-stress regulation in poultry. Full article
(This article belongs to the Special Issue Redox Homeostasis in Poultry/Animal Production―2nd Edition)
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19 pages, 9831 KB  
Article
Effect of Low-Temperature Plasma on Porcine Oocytes In Vitro Primary Culture
by Yuhan Wang, Panpan Guo, Haoyu Fang, Tingting Lu and Wencheng Song
Antioxidants 2026, 15(5), 609; https://doi.org/10.3390/antiox15050609 - 12 May 2026
Viewed by 694
Abstract
The effective growth and maturation of porcine oocytes in vitro are critical for advancing reproductive biotechnologies. In this study, we explored low-temperature plasma (LTP) treatment as a redox modulation strategy to enhance the survival and maturation of denuded porcine oocytes during in vitro [...] Read more.
The effective growth and maturation of porcine oocytes in vitro are critical for advancing reproductive biotechnologies. In this study, we explored low-temperature plasma (LTP) treatment as a redox modulation strategy to enhance the survival and maturation of denuded porcine oocytes during in vitro primary culture in order to improve animal cellular health through innovative interventions. Freshly isolated oocytes were exposed to plasma treatment for different lengths of time and subsequently cultured under established in vitro conditions. Morphological and redox-related analyses showed that LTP treatment was associated with increased oocyte diameter, a higher first polar body extrusion rate, mitochondrial membrane potential changes, and altered intracellular and extracellular redox-related parameters. These beneficial effects exhibited a distinct time-dependent dose–response pattern. Furthermore, Western blot analysis showed altered expression of the EGFR/ERK signaling cascade and proteins such as Nrf2, suggesting that LTP treatment might participate in the regulation of maturation-related responses in porcine oocytes cultured in vitro by inducing redox-associated changes, along with alterations in EGFR/ERK-related signaling, Nrf2 expression, and molecules involved in maturation and apoptosis. Collectively, these findings highlight the positive role of LTP in supporting porcine oocyte maturation during in vitro primary culture and provide a promising approach for optimizing the in vitro primary culture of porcine oocytes. Full article
(This article belongs to the Special Issue Redox Homeostasis in Poultry/Animal Production―2nd Edition)
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25 pages, 15036 KB  
Article
A Preliminary Study on the Effects of Low Doses of Purified Zearalenone in Weaned Female Piglets: A Multi-Organ Toxicity Investigation
by Ying Liu, Qiaomin Duan, Ruiqi Tan, Sunlin Luo, Wenjun He, Wenjun Yang and Yiqiang Chen
Antioxidants 2026, 15(4), 496; https://doi.org/10.3390/antiox15040496 - 16 Apr 2026
Viewed by 539
Abstract
Zearalenone (ZEA) is an estrogenic Fusarium mycotoxin widely contaminating feed and feedstuffs, and posing significant risks to animal health. This preliminary study aimed to evaluate the toxicological effects of dietary exposure to purified ZEA at doses ranging from below to above the Chinese [...] Read more.
Zearalenone (ZEA) is an estrogenic Fusarium mycotoxin widely contaminating feed and feedstuffs, and posing significant risks to animal health. This preliminary study aimed to evaluate the toxicological effects of dietary exposure to purified ZEA at doses ranging from below to above the Chinese regulatory limit (0.15 mg/kg) in weaned female piglets. Twenty piglets were randomly assigned to five groups (four piglets per group) receiving 0, 0.075, 0.15, 0.3, or 0.6 mg/kg ZEA for 42 days. Results suggested that ZEA promoted systemic oxidative stress, evidenced by decreased serum total antioxidant capacity (T-AOC) and increased malondialdehyde (MDA) content in liver across all doses, and in jejunal mucosa at ≥0.15 mg/kg (p < 0.01). Growth performance declined only at 0.6 mg/kg during days 29–42 (p < 0.01), while hemoglobin (HGB) levels (p < 0.01) and ileal villus height (p < 0.05) were reduced at all doses. ZEA also caused inflammatory dysregulation, as evidenced by decreased interleukin-4 (IL-4) levels in serum, liver, and intestinal tissues across all doses (p < 0.01), and disrupted reproductive hormones even at 0.075 mg/kg, as indicated by suppressed serum luteinizing hormone (LH) levels (p < 0.01), which progressed to histopathological damage in uterine and ovarian tissues at higher doses. These preliminary findings, together with significant correlations between oxidative stress markers and multi-organ parameters, suggest that low doses of purified ZEA may induce systemic oxidative stress and subclinical multi-organ toxicity in weaned female piglets, highlighting the need to incorporate redox status into risk assessment and to explore potential antioxidant-based mitigation strategies. However, given the small sample size, these results should be interpreted with caution and warrant validation in larger samples. Full article
(This article belongs to the Special Issue Redox Homeostasis in Poultry/Animal Production―2nd Edition)
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