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Review

Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis

1
Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin County 640, Taiwan
2
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City 100, Taiwan
3
Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City 300, Taiwan
4
Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Kevin V. Hackshaw
Diagnostics 2021, 11(9), 1592; https://doi.org/10.3390/diagnostics11091592
Received: 2 August 2021 / Revised: 26 August 2021 / Accepted: 30 August 2021 / Published: 1 September 2021
(This article belongs to the Special Issue Rheumatic Diseases: Diagnosis, Treatment and Management)
Anti-DFS70 antibodies have been proposed as a marker to exclude systemic autoimmune rheumatic disease (SARD). We conducted this systematic diagnostic test accuracy review and meta-analysis to determine the performance of anti-DFS70 antibodies in patients with a positive anti-nuclear antibody (ANA) test result to exclude SARD. We searched PubMed, Embase, Web of Science, Scopus and the Cochrane Library up to 22 February 2021, and included studies examining the diagnostic accuracy of anti-DFS70 antibodies in patients with a positive ANA test result. The results were pooled using a hierarchical bivariate model and plotted in summary receiver operating characteristic curves. R software and Stata Statistical Software were used for the statistical analysis. Eight studies with 4168 patients were included. The summary sensitivity was 0.19 (95% confidence interval: 0.12–0.28) and the specificity was 0.93 (95% confidence interval: 0.88–0.96). The area under the curve was 0.69 (95% confidence interval: 0.64–0.72). The meta-regression analysis showed that targeting only ANA-associated rheumatic disease was associated with higher specificity. In addition, the studies with a non-SARD prevalence of <80% and using a chemiluminescence assay were associated with higher specificity. Anti-DFS70 antibodies have high specificity for the exclusion of SARD among patients presenting with a positive ANA test, but the sensitivity is low. View Full-Text
Keywords: ANA-associated rheumatic disease; systemic autoimmune rheumatic disease; dense fine speckled ANA-associated rheumatic disease; systemic autoimmune rheumatic disease; dense fine speckled
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MDPI and ACS Style

Cheng, C.-F.; Shih, M.-C.; Lan, T.-Y.; Li, K.-J. Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis. Diagnostics 2021, 11, 1592. https://doi.org/10.3390/diagnostics11091592

AMA Style

Cheng C-F, Shih M-C, Lan T-Y, Li K-J. Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis. Diagnostics. 2021; 11(9):1592. https://doi.org/10.3390/diagnostics11091592

Chicago/Turabian Style

Cheng, Chiao-Feng, Ming-Chieh Shih, Ting-Yuan Lan, and Ko-Jen Li. 2021. "Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis" Diagnostics 11, no. 9: 1592. https://doi.org/10.3390/diagnostics11091592

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