Skip to Content
You are currently on the new version of our website. Access the old version .

58,452 Results Found

  • Review
  • Open Access
129 Citations
28,981 Views
17 Pages

Modelling the Complexity of Human Skin In Vitro

  • Elisabeth Hofmann,
  • Anna Schwarz,
  • Julia Fink,
  • Lars-Peter Kamolz and
  • Petra Kotzbeck

The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and functi...

(This article belongs to the Special Issue Researches on Biomaterials for Tissue Engineering and Tissue Regeneration 2.0)
  • Article
  • Open Access
7 Citations
6,560 Views
15 Pages

Modelling the Influence of Regional Identity on Human Migration

  • Willem R. J. Vermeulen,
  • Debraj Roy and
  • Rick Quax

Human migration involves the relocation of individuals, households or moving groups between geographical locations. Aggregate spatial patterns of movement reflect complex interactions among motivations (such as distance, identity, economic opportunit...

  • Article
  • Open Access
6 Citations
4,097 Views
17 Pages

Data-Driven Modelling of Human-Human Co-Manipulation Using Force and Muscle Surface Electromyogram Activities

  • Ali Al-Yacoub,
  • Myles Flanagan,
  • Achim Buerkle,
  • Thomas Bamber and ,
  • Pedro Ferreira,
  • Ella-Mae Hubbard and
  • Niels Lohse
  • + 2 authors+ 0 author

With collaborative robots and the recent developments in manufacturing technologies, physical interactions between humans and robots represent a vital role in performing collaborative tasks. Most previous studies have focused on robot motion planning...

(This article belongs to the Special Issue Advances in Human-Machine Interaction, Artificial Intelligence, and Robotics)
  • Article
  • Open Access
9 Citations
5,243 Views
21 Pages

Modelling the Trust Value for Human Agents Based on Real-Time Human States in Human-Autonomous Teaming Systems

  • Chin-Teng Lin,
  • Hsiu-Yu Fan,
  • Yu-Cheng Chang,
  • Liang Ou and ,
  • Jia Liu,
  • Yu-Kai Wang and
  • Tzyy-Ping Jung
  • + 2 authors+ 0 author

The modelling of trust values on agents is broadly considered fundamental for decision-making in human-autonomous teaming (HAT) systems. Compared to the evaluation of trust values for robotic agents, estimating human trust is more challenging due to...

(This article belongs to the Special Issue 10th Anniversary of Technologies—Recent Advances and Perspectives)
  • Review
  • Open Access
10 Citations
3,553 Views
10 Pages

Coastal and estuarine morphogenetic evolution has been affected by anthropogenic activities. Human activities have become an important external force for the future prediction of morphological evolution in ecosystem health. We have reviewed the exist...

(This article belongs to the Section Coastal Engineering)
  • Review
  • Open Access
31 Citations
11,432 Views
41 Pages

22 July 2014

International agreements on climate change have highlighted the role of land in climate and human dynamics, making it an issue of global importance. The modelling of land-related processes, sectors, and activities has recently become a central topic...

(This article belongs to the Special Issue Land Use Change Feedbacks with Climate)
  • Review
  • Open Access
15 Citations
4,426 Views
26 Pages

25 February 2022

Sustainability science strives to hone our ability to tackle problems that involve interconnected economic, social, and environmental systems. Addressing the root causes of these problems requires a more nuanced understanding of how human behaviour c...

(This article belongs to the Special Issue Towards Sustainable Land-Water Interactions in the Anthropocene: The Role of Stakeholder Engagement and Participatory Modelling)
  • Article
  • Open Access
5 Citations
2,948 Views
21 Pages

18 August 2024

Pedestrian bridges, which are essential in urban and rural infrastructures, are vulnerable to vibrations induced by pedestrian traffic owing to their low mass, stiffness, and damping. This paper presents a novel predictive model of Human-Structure In...

(This article belongs to the Special Issue Advances in Foot Biomechanics and Gait Analysis)
  • Proceeding Paper
  • Open Access
3 Citations
3,092 Views
7 Pages

The issue of the quantification of thermal comfort or heat stress on humans is in vogue nowadays. This is evident for indices, which are trying to quantify these effects. Most known indices are PET, modified PET, SET*, PT and UTCI. All thermal indice...

(This article belongs to the Proceedings of The 4th International Electronic Conference on Atmospheric Sciences)
  • Article
  • Open Access
5 Citations
18 Views

31 December 2020

A novel model of heat and moisture transfer in human-chemical protective clothing-environment is proposed to predict the human physiological regulatory response wearing chemical protective clothing (CPC). The human thermal model is developed by divid...

  • Article
  • Open Access
11 Citations
7,893 Views
13 Pages

In recent years, there has been an increasing demand for portable power sources as people are required to carry more equipment for occupational, military, or recreational purposes. The energy harvesting backpack that moves relative to the human body,...

(This article belongs to the Special Issue Energy Harvesting and Storage Applications)
  • Systematic Review
  • Open Access
33 Citations
12,252 Views
41 Pages

28 February 2025

As collaborative robots (cobots) increasingly share workspaces with humans, ensuring safe physical human–robot interaction (pHRI) has become paramount. This systematic review addresses safety assessment in pHRI, focussing on the industrial fiel...

(This article belongs to the Section Industrial Robots and Automation)
  • Article
  • Open Access
3 Citations
1,010 Views
23 Pages

Risk Assessment of Dynamic Positioning Operations: Modelling the Contribution of Human Factors

  • Mykyta Chervinskyi,
  • Francis Obeng,
  • Sidum Adumene and
  • Robert Brown

28 February 2026

Dynamic positioning (DP) systems are essential to maritime operations, as they ensure precise station keeping. Yet human error remains a major contributor to DP incidents, often interacting with technical failures and environmental conditions. This s...

(This article belongs to the Special Issue Maritime Transportation Safety and Risk Management)
  • Article
  • Open Access
11 Citations
3,909 Views
15 Pages

Particle Deposition in Large-Scale Human Tracheobronchial Airways Predicted by Single-Path Modelling

  • Cuiyun Ou,
  • Jian Hang,
  • Jiajia Hua,
  • Yuguo Li and ,
  • Qihong Deng,
  • Bo Zhao and
  • Hong Ling
  • + 2 authors+ 0 author

The health effects of particles are directly related to their deposition patterns (deposition site and amount) in human airways. However, estimating the particle trajectory in a large-scale human lung airway model is still a challenge. In this work,...

(This article belongs to the Special Issue Meteorology/Air Pollution and Health Impact)
  • Editorial
  • Open Access
1 Citations
1,936 Views
7 Pages

22 September 2025

Human stem cell research is entering a stage where disease modeling, translational applications, and clinical therapies are increasingly connected. This editorial provides an overview of the contributions included in this Special Issue, titled &ldquo...

(This article belongs to the Special Issue Human Stem Cells in Disease Modelling and Treatment)
  • Review
  • Open Access
1 Citations
3,747 Views
31 Pages

Taxonomy and Survey of Current 3D Photorealistic Human Body Modelling and Reconstruction Techniques for Holographic-Type Communication

  • Radostina Petkova,
  • Ivaylo Bozhilov,
  • Desislava Nikolova,
  • Ivaylo Vladimirov and
  • Agata Manolova

19 November 2023

The continuous evolution of video technologies is now primarily focused on enhancing 3D video paradigms and consistently improving their quality, realism, and level of immersion. Both the research community and the industry work towards improving 3D...

(This article belongs to the Section Electronic Multimedia)
  • Article
  • Open Access
14 Citations
5,013 Views
14 Pages

Prevent Workers from Injuries in the Brewing Company via Using Digital Human Modelling Technology

  • Xiaoxu Ji,
  • Ranuki O. Hettiarachchige,
  • Alexa L. E. Littman,
  • Nicole L. Lavery and
  • Davide Piovesan

11 March 2023

A large percentage of musculoskeletal disorder cases occur in brewing companies. The aim of this research study is to evaluate the risk of injuries for workers in the local brewing industry by integrating the actual human motion, which was captured b...

  • Review
  • Open Access
1 Citations
1,093 Views
14 Pages

19 May 2026

Attention deficit hyperactivity disorder (ADHD) is a common and highly heterogeneous neurodevelopmental condition with complex biological underpinnings. Despite substantial progress in identifying genetic and neurobiological correlates, the cellular...

(This article belongs to the Section Stem Cells)
  • Article
  • Open Access
34 Citations
6,424 Views
24 Pages

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project

  • Nina Nauwelaerts,
  • Julia Macente,
  • Neel Deferm,
  • Rodolfo Hernandes Bonan and ,
  • Miao-Chan Huang,
  • Martje Van Neste,
  • David Bibi,
  • Justine Badee,
  • Frederico S. Martins and
  • Pieter Annaert
  • + 8 authors+ 3 authors

Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok...

(This article belongs to the Special Issue Physiologically-Based Pharmacokinetic Modeling in Pregnancy, Lactation, and in Neonates: Achievements, Challenges and Future Directions)
  • Article
  • Open Access
241 Views
36 Pages

24 October 2026

Hybrid frameworks combine structural modelling, machine learning, and explainable artificial intelligence (AI) to evaluate human–AI Strategic Decision Support Systems (SDSSs). However, their methodological reliability requires systematic assess...

(This article belongs to the Special Issue Intelligent Computing & Optimization)
  • Review
  • Open Access
10 Citations
10,185 Views
14 Pages

30 April 2024

The hair follicle is a specialized appendage of the skin that is critical for multiple functions, including thermoregulation, immune surveillance, and sebum production. Mammals are born with a fixed number of hair follicles that develop embryonically...

  • Article
  • Open Access
35 Citations
7,917 Views
21 Pages

9 October 2022

Green Human Resources Management (GHRM) is an alignment of traditional human resource practices such as strategies, policies, procedures, and rules to the latest green and sustainable environment responsive practices. Unlike corporates, the adoption...

(This article belongs to the Section Sustainable Education and Approaches)
  • Article
  • Open Access
2 Citations
4,909 Views
13 Pages

6 November 2019

The head is one of the most sun-exposed anatomical zones and its ultraviolet (UV) exposure is often underestimated. The goal of this research is to quantify the solar erythemal UV protection provided by human hair for different orientations and Solar...

  • Review
  • Open Access
18 Citations
8,271 Views
25 Pages

Mouse Models for Human Herpesviruses

  • Ivana Kutle,
  • Anne Dittrich and
  • Dagmar Wirth

More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investig...

(This article belongs to the Special Issue Animal Models for Human Viruses)
  • Article
  • Open Access
12 Citations
3,527 Views
13 Pages

The emergence and recent development of collaborative robots have introduced a safer and more efficient human–robot collaboration (HRC) manufacturing environment. Since the release of COBOTs, a great amount of research efforts have been focused...

(This article belongs to the Special Issue Intelligent Human-Robot Interaction)
  • Article
  • Open Access
22 Citations
6,954 Views
16 Pages

Using Digital Human Modelling to Evaluate the Risk of Musculoskeletal Injury for Workers in the Healthcare Industry

  • Xiaoxu Ji,
  • Ranuki O. Hettiarachchige,
  • Alexa L. E. Littman and
  • Davide Piovesan

3 March 2023

Background: Hospital nurses and caregivers are reported to have the highest number of workplace injuries every year, which directly leads to missed days of work, a large amount of compensation costs, and staff shortage issues in the healthcare indust...

(This article belongs to the Special Issue Wearable and Unobtrusive Technologies for Healthcare Monitoring)
  • Review
  • Open Access
14 Citations
6,563 Views
17 Pages

Human Embryo Models and Drug Discovery

  • Margit Rosner,
  • Manuel Reithofer,
  • Dieter Fink and
  • Markus Hengstschläger

For obvious reasons, such as, e.g., ethical concerns or sample accessibility, model systems are of highest importance to study the underlying molecular mechanisms of human maladies with the aim to develop innovative and effective therapeutic strategi...

(This article belongs to the Special Issue hiPSC-Derived Cells as Models for Drug Discovery)
  • Article
  • Open Access
229 Views
33 Pages

27 September 2026

Stationary occupants modify the vibration of lightweight floors and grandstands, yet predicted responses depend on how the stationary human is represented. This study examines model-form effects among a conventional separative model (SM), a reduced i...

(This article belongs to the Special Issue High-Performance Buildings for Health and Comfort: Indoor Environment, Thermal Design, and Structural Integrity)
  • Review
  • Open Access
37 Citations
12,614 Views
28 Pages

Computational Modeling of the Human Microbiome

  • Shomeek Chowdhury and
  • Stephen S. Fong

The impact of microorganisms on human health has long been acknowledged and studied, but recent advances in research methodologies have enabled a new systems-level perspective on the collections of microorganisms associated with humans, the human mic...

(This article belongs to the Special Issue Genome-Scale Modeling of Microorganisms in the Real World)
  • Review
  • Open Access
40 Citations
10,797 Views
27 Pages

Human Cell Modeling for Cardiovascular Diseases

  • Melania Lippi,
  • Ilaria Stadiotti,
  • Giulio Pompilio and
  • Elena Sommariva

2 September 2020

The availability of appropriate and reliable in vitro cell models recapitulating human cardiovascular diseases has been the aim of numerous researchers, in order to retrace pathologic phenotypes, elucidate molecular mechanisms, and discover therapies...

(This article belongs to the Special Issue Cell Programming for Cardiovascular Disease Modeling and Therapy)
  • Article
  • Open Access
13 Citations
4,715 Views
17 Pages

A Co-Simulation Model Integrating a Musculoskeletal Human Model with Exoskeleton and Power Tool Model

  • Carla Molz,
  • David Scherb,
  • Christopher Löffelmann,
  • Johannes Sänger and ,
  • Zhejun Yao,
  • Andreas Lindenmann,
  • Sven Matthiesen,
  • Robert Weidner,
  • Sandro Wartzack and
  • Jörg Miehling
  • + 5 authors+ 0 author

19 March 2024

Working at and above head height with a power tool represents a common activity in craft and assembly applications. To assist and protect the user from overload and injuries in these situations, the development and use of application-specific support...

(This article belongs to the Special Issue Novel Approaches and Applications in Ergonomic Design III)
  • Review
  • Open Access
7 Citations
7,031 Views
29 Pages

Recent advancements in stem cell biology and tissue engineering have revolutionized the field of neurodegeneration research by enabling the development of sophisticated in vitro human brain models. These models, including 2D monolayer cultures, 3D or...

(This article belongs to the Special Issue Molecular Aspects of the Neurodegenerative Brain Diseases)
  • Article
  • Open Access
2,210 Views
17 Pages

Human Mediation of Wildfires and Its Representation in Terrestrial Ecosystem Models

  • Jiang Zhu,
  • Hui Tang,
  • Keyan Fang,
  • Frode Stordal and ,
  • Anders Bryn,
  • Min Gao and
  • Xiaodong Liu
  • + 2 authors+ 0 author

28 July 2025

Increasing wildfires are causing global concerns about ecosystem functioning and services. Although some wildfires are caused by natural ignitions, it is also important to understand how human ignitions and human-related factors can contribute to wil...

  • Article
  • Open Access
1 Citations
1,799 Views
16 Pages

Assessment of Surrogate Models for Research on Resistance and Deformation of Repairs of the Human Meniscal Roots: Porcine or Older Human Models?

  • Alejandro Peña-Trabalon,
  • Ana Perez-Blanca,
  • Salvador Moreno-Vegas,
  • M. Belen Estebanez-Campos and
  • Maria Prado-Novoa

12 January 2024

Meniscal root repair is not routinely recommended for patients over 75 years old, yet surrogate age-unrestricted human or porcine models are used for its evaluation. This study assesses the suitability of older human or porcine meniscus models for in...

(This article belongs to the Special Issue Biomechanics of Soft and Hard Tissues)
  • Article
  • Open Access
4,001 Views
14 Pages

A New Model for Human Running Micro-Doppler FMCW Radar Features

  • Yongqiang Zhang,
  • Xiaopeng Li,
  • Guilei Ma,
  • Jinlong Ma and ,
  • Menghua Man and
  • Shanghe Liu
  • + 1 author+ 0 author

15 June 2023

Human body detection is very important in the research of automotive safety technology. The extraction and analysis of human micro-motion based on frequency-modulated continuous wave (FMCW) radar is gradually receiving attention. Aimed at the modulat...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Review
  • Open Access
37 Citations
7,103 Views
16 Pages

Animal Models in Human Adenovirus Research

  • Luca D. Bertzbach,
  • Wing-Hang Ip and
  • Thomas Dobner

1 December 2021

Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
6 Citations
2,367 Views
24 Pages

ApOL-Application Oriented Workload Model for Digital Human Models for the Development of Human-Machine Systems

  • Johannes Sänger,
  • Lukas Wirth,
  • Zhejun Yao,
  • David Scherb and ,
  • Jörg Miehling,
  • Sandro Wartzack,
  • Robert Weidner,
  • Andreas Lindenmann and
  • Sven Matthiesen
  • + 4 authors+ 0 author

29 August 2023

Since musculoskeletal disorders are one of the most common work-related diseases for assemblers and machine operators, it is crucial to find new ways to alleviate the physical load on workers. Support systems such as exoskeletons or handheld power to...

(This article belongs to the Special Issue Digital Technologies to Support Human Factors Engineering in Manufacturing System Design: Theory and Applications)
  • Review
  • Open Access
23 Citations
7,703 Views
22 Pages

Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections

  • Vinodhini Krishnakumar,
  • Siva Sundara Kumar Durairajan,
  • Kalichamy Alagarasu,
  • Min Li and
  • Aditya Prasad Dash

13 March 2019

Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental fo...

(This article belongs to the Special Issue Animal Models for Viral Diseases)
  • Article
  • Open Access
5 Citations
6,974 Views
26 Pages

28 February 2019

Reconstructing three-dimensional (3D) human poses is an essential step in human body

animation. The purpose of this paper is to fill the gap in virtual reality research by reconstructing

postures in a high-precision human model. This paper presents a n...

  • Review
  • Open Access
1,391 Views
42 Pages

10 July 2026

Autoimmune diseases arise from a breakdown of immune tolerance and complex interplay of genetic susceptibility, environmental triggers, tissue-specific immune responses, microbiota, and regulatory pathways. Mouse models remain essential for dissectin...

(This article belongs to the Special Issue Animal Models of Autoimmune Diseases)
  • Proceeding Paper
  • Open Access
428 Views
18 Pages

A range of sensors are used by human activity recognition (HAR) to identify the activities that people complete each day. The recognition of human activities has benefited greatly from machine learning (ML), as it has made many human activities more...

(This article belongs to the Proceedings of The 1st International Conference on Emerging Tech & Innovation (ICETI))
  • Review
  • Open Access
22 Citations
7,151 Views
28 Pages

Advancements in MAFLD Modeling with Human Cell and Organoid Models

  • Shi-Xiang Wang,
  • Ji-Song Yan and
  • Yun-Shen Chan

6 October 2022

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is one of the most prevalent liver diseases and has no approved therapeutics. The high failure rates witnessed in late-phase MAFLD drug trials reflect the complexity of the disease, and h...

(This article belongs to the Special Issue Molecular Advances in MAFLD)
  • Review
  • Open Access
5 Citations
5,691 Views
17 Pages

Developmental Toxicity Studies: The Path towards Humanized 3D Stem Cell-Based Models

  • Mariana A. Branco,
  • Tiago C. Nunes,
  • Joaquim M. S. Cabral and
  • Maria Margarida Diogo

Today, it is recognized that medicines will eventually be needed during pregnancy to help prevent to, ameliorate or treat an illness, either due to gestation-related medical conditions or pre-existing diseases. Adding to that, the rate of drug prescr...

(This article belongs to the Special Issue Organoids: The New 3D-Frontier to Model Different Diseases In Vitro)
  • Article
  • Open Access
9 Citations
3,348 Views
15 Pages

A Multi-Segmented Human Bioheat Model for Asymmetric High Temperature Environments

  • Jing Geng,
  • Yin Gu,
  • Wenguo Weng,
  • Ming Fu and ,
  • Shifei Shen and
  • Rui Zhou
  • + 1 author+ 0 author

In workplaces such as steel, power grids, and construction, firefighters and other workers often encounter non-uniform high-temperature environments, which significantly increase the risk of local heat stress and local heat discomfort for the workers...

  • Article
  • Open Access
6 Citations
4,197 Views
57 Pages

The intricate relationships between humans and animals have long shaped philosophical, cultural and scientific inquiry. This narrative review examines evolving conceptions of animal consciousness, agency and sentience within broader historical, ethic...

  • Review
  • Open Access
16 Citations
4,955 Views
24 Pages

In Vitro Human Cancer Models for Biomedical Applications

  • Jane Ru Choi,
  • Gül Kozalak,
  • Ighli di Bari,
  • Quratulain Babar and ,
  • Zahra Niknam,
  • Yousef Rasmi and
  • Kar Wey Yong
  • + 2 authors+ 0 author

3 May 2022

Cancer is one of the leading causes of death worldwide, and its incidence is steadily increasing. Although years of research have been conducted on cancer treatment, clinical treatment options for cancers are still limited. Animal cancer models have...

(This article belongs to the Section Cancer Therapy)
  • Article
  • Open Access
3 Citations
3,578 Views
22 Pages

Since human movement patterns are important for validating the performance of wireless networks, several traces of human movements in real life have been collected. However, collecting data about human movements is costly and time-consuming. Moreover...

(This article belongs to the Special Issue Opportunistic Networks)
  • Review
  • Open Access
24 Citations
7,490 Views
26 Pages

23 February 2022

The study of human–machine interaction as a unique control system was one of the first research interests in the engineering field, with almost a century having passed since the first works appeared in this area. At the same time, it is a cruci...

(This article belongs to the Special Issue Review Papers in Sensors and Sensing Technologies)
  • Article
  • Open Access
2 Citations
4,584 Views
21 Pages

4 February 2023

In the literature the value of the driver’s head acceleration has been widely used as an objective function for the modification of the suspension and/or the seat characteristics in order to optimize the ride comfort of a vehicle. For these opt...

  • Review
  • Open Access
4 Citations
3,616 Views
19 Pages

Can Humanized Immune System Mouse and Rat Models Accelerate the Development of Cytomegalovirus-Based Vaccines Against Infectious Diseases and Cancers?

  • Kaci Craft,
  • Athina Amanor,
  • Ian Barnett,
  • Clarke Donaldson and ,
  • Ignacio Anegon,
  • Srinivas Madduri,
  • Qiyi Tang and
  • Moses T. Bility
  • + 3 authors+ 0 author

Over the past three decades, immunodeficient mouse models carrying human immune cells, with or without human lymphoid tissues, termed humanized immune system (HIS) rodent models, have been developed to recapitulate the human immune system and associa...

(This article belongs to the Special Issue Advances and Challenges of Molecular Research on Disease in Animal Models in Biomedicine)

of 1,170