Molecular Advances in MAFLD

Dear Colleagues,

With the global rise of metabolic-associated fatty liver disease (MAFLD), previously termed nonalcoholic fatty liver disease (NAFLD), it is quickly becoming the leading indication for liver transplant and risk factor of hepatocarcinoma. This recent change in nomenclature to MAFLD refocuses on the metabolic underpinnings of this disease and a paradigm shift in the approach to its management. Despite the clinical burden of the disease, there is currently no FDA-approved treatment, highlighting a pressing need to understand its pathophysiology and underlying molecular mechanisms better. Hence, a concerted and interdisciplinary approach is required to delineate higher-order mechanisms in this complex disease.

In this Special Issue, we invite experimental studies and up-to-date review articles in MAFLD in these areas, but not limited to:

• Advancements in MAFLD modeling with animals or tissue organoids;
• Multi-organ crosstalk in MAFLD progression, e.g., gut–liver axis, immune–liver crosstalk;
• Systems-level investigation, e.g., single cell-bulk-, spatial-, integrative-omics of MAFLD-associated cellular landscape;
• Big data mining for drug target discovery.

Dr. Nguan Soon Tan
Guest Editor

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