Cancer Therapy
A section of Cancers (ISSN 2072-6694).
Section Information
In the last decades, cancer therapies have substantially improved cancer care and patients’ survival. The introduction of targeted therapies had a major impact on the management of cancer. However, millions of people still die from cancer every year and cancer drug resistance remains the Achilles' heel of cancer chemotherapeutics. Thanks to our increasing knowledge and understanding of the pathology, new cancer cells phenotypes and drug targets have emerged in the last years. The role of the tumor microenvironment in cancer promotion and progression as well as the plastic and dynamic nature of the disease have been unraveled and now pave the way to the development of new and innovative therapeutic strategies. In this section of Cancers, we aim at rapidly publishing contributions on all aspects of Cancer Therapy. We encourage the submission of manuscripts providing new and innovative therapeutic approaches as well as papers describing technologies and models developed for the discovery and the delivery of anticancer drugs. Systematic and perspective reviews are also welcome. Topics include, but are not limited to:
- Cancer therapeutics
- Targeted therapy
- Drug discovery
- Drug repurposing
- Structure-based design
- Target-based design
- Tumor drug delivery
- Tumor drug distribution
- Drug resistance
- Precision medicine
- Gain/loss of function screening
- Cancer cell plasticity
- Cancer cell metabolism
- Cell cycle checkpoint
- DNA repair
- Tumor-microenvironment interactions
- Extracellular vesicles
- Tumor heterogeneity
- Combination therapies
- Adaptive therapy
- Rechallenge therapy
- Radiotherapy
Editorial Board
Topical Advisory Panel
Special Issues
Following special issues within this section are currently open for submissions:
- Liver Cancer: Improving Standard Diagnosis and Therapy (Deadline: 10 July 2022)
- Advances in Endometrial Cancer: From Pathogenesis, Pathology Diagnosis and Molecular Classification to Targeted Therapy (Deadline: 15 July 2022)
- Advances in Lung Cancer Therapy (Deadline: 15 July 2022)
- Advances in Chemotherapy and Innovative Treatment Approaches for Germ Cell Tumors (Deadline: 15 July 2022)
- Personalized Therapies in Oesophageal Cancer (Deadline: 15 July 2022)
- Oligometastatic Disease (Deadline: 20 July 2022)
- Metastatic Colorectal Cancer: Biological Features, Old and New Treatments (Deadline: 20 July 2022)
- Biomarkers, Diagnostic Tools, Treatment Outcomes, and Late Complications in Neuro-Oncology (Deadline: 30 July 2022)
- Neoadjuvant Therapy for Breast Cancer (Deadline: 30 July 2022)
- Optical Genome Mapping in Hematological Malignancies (Deadline: 31 July 2022)
- Targeted and Combination Therapy: Multi-Omic Approaches and Patient-Derived Models for Ultra-Precise Cancer Therapy (Deadline: 31 July 2022)
- Targeting Signal Transduction Pathways in Cancer (Deadline: 31 July 2022)
- The Up-to-Date of Endoscopic Submucosal Dissection (ESD) in Early Cancers (Deadline: 31 July 2022)
- Emerging Targets and Drug Modalities in Preclinical Cancer Drug Discovery (Deadline: 31 July 2022)
- Immunosuppression in Ovarian Cancer and the Path to Successful Immunotherapy (Deadline: 31 July 2022)
- Advances in Adrenocortical Carcinoma: Research and Clinical Treatment (Deadline: 31 July 2022)
- Regulation, Role and Targeting of Calcium Signaling Pathways in Cancer (Deadline: 15 August 2022)
- Endocrine Toxicities of Antineoplastic Therapy (Deadline: 15 August 2022)
- Urothelial Carcinoma of the Upper Urinary Tract: What Changed 2021? (Deadline: 15 August 2022)
- Precision Medicine in Breast Cancer Treatment (Deadline: 15 August 2022)
- Predictors, Presentation, and Treatment Outcomes in Hepatocellular Carcinoma and Cirrhosis (Deadline: 15 August 2022)
- Endometrial Cancer: Old Questions and New Perspectives (Deadline: 15 August 2022)
- EMT in Cancer (Deadline: 15 August 2022)
- Treatment Modalities for Non-small Cell Lung Cancer— a Clinical Survey (Deadline: 15 August 2022)
- Post-neoadjuvant Strategies in Breast Cancer (Deadline: 20 August 2022)
- Nanomedicine Progress in Tumor Treatment (Deadline: 20 August 2022)
- Management and Treatment of Endocrine Tumors (Deadline: 30 August 2022)
- Surgical Treatment of Bone Metastases (Deadline: 31 August 2022)
- Thymoma and Thymic Carcinoma: Therapy and Outcomes (Deadline: 31 August 2022)
- Ubiquitin: What It Is and Its Role in Targeted Cancer Therapy (Deadline: 31 August 2022)
- Adjuvant Therapy in Cancer (Deadline: 1 September 2022)
- Advances in Cytoreductive Surgery and Intraperitoneal Chemotherapy (Deadline: 10 September 2022)
- Treatment of Glioma (Deadline: 10 September 2022)
- New Insights of Ovarian Cancer Treatment (Deadline: 15 September 2022)
- Breast Diseases; De-escalating Treatment: Current Status and Future Directions (Deadline: 15 September 2022)
- (Deadline: 15 September 2022)
- New Diagnostic and Therapeutic Tools against Multidrug Resistant Tumors 2.0 (STRATAGEM Special Issue, EU-COST CA17104) (Deadline: 15 September 2022)
- Metastatic Breast Cancers (Deadline: 15 September 2022)
- Systemic Therapy of Metastatic Prostate Cancer: From Novel Androgen-Receptor Targeted Agents to Radiopharmaceuticals (Deadline: 20 September 2022)
- Cancer Stem Cells (CSCs) in Drug Resistance and Their Therapeutic Implications in Cancer Treatment (Deadline: 25 September 2022)
- Extracellular Matrix in the Tumor Microenvironment—Role in Immune Modulation and Impact on Cancer Therapy (Deadline: 30 September 2022)
- Biological Basis of Anti-tumor Therapies (Deadline: 30 September 2022)
- Novel Targeted Therapies for T-cell Malignancies (Deadline: 30 September 2022)
- Radiation Therapy for Breast Cancer: Recent Advances and Challenges (Deadline: 30 September 2022)
- Cancers Research in Adenocarcinoma, Adenoma, Adenomatous Polyposis Coli, Colitis-Associated Neoplasm (Deadline: 30 September 2022)
- Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (Deadline: 30 September 2022)
- Targeting Mechanisms of Protein Degradation for Cancer Therapy (Deadline: 30 September 2022)
- Advanced Squamous Cell Carcinoma (Deadline: 30 September 2022)
- Plant-Derived Targeted Strategies in Cancer (Deadline: 30 September 2022)
- Microbiome in Cancer: Role in Carcinogenesis and Impact in Therapeutic Strategies (Deadline: 30 September 2022)
- Multidisciplinary Approach to Oral Cancer: The Way to Improve Expectancy and Quality of Life (Deadline: 30 September 2022)
- Novel Targets and Approaches in Cancer Therapy (Deadline: 30 September 2022)
- Latest Basic, Translational and Clinical Advancements in HER2-Positive Breast Cancer (Deadline: 1 October 2022)
- Novel Strategy and Technologies in Local and Locoregional Treatment for Lung Cancer (Deadline: 15 October 2022)
- Application of Proton Beam Therapy in Cancer Treatment (Deadline: 15 October 2022)
- Updates on Mechanism and Management of Gynecological Cancer (Deadline: 15 October 2022)
- New Insights into Oropharyngeal Cancer (Deadline: 15 October 2022)
- Gene Editing and Delivery for Cancer Therapy (Deadline: 15 October 2022)
- Advances in Multiple Myeloma Research and Treatment (Deadline: 15 October 2022)
- New Insights of Management of Hepatocellular Carcinoma (Deadline: 15 October 2022)
- Personalized Therapy of Hormone-Responsive Breast Cancer (Deadline: 15 October 2022)
- Advances in Adrenocortical Carcinoma Research: Diagnosis, Treatment and Prognosis (Deadline: 20 October 2022)
- Her2-Positive Cancers and Antibody-Based Treatment: State of the Art and Future Developments (Deadline: 20 October 2022)
- High Unmet Medical Needs in the Treatment of Renal Cell Carcinoma (Deadline: 20 October 2022)
- Peritoneal Surface Malignancies (PSM): The SICO (Italian Society of Surgical Oncology) PSM—Oncoteam Experience, Result Analysis, and Studies’ Purpose (Deadline: 20 October 2022)
- New Insight in the Targeted Drugs for Breast Cancer (Deadline: 25 October 2022)
- Palliative and Complementary Therapies in Neuro-Oncology: Surgical and Therapeutic Challenges (Deadline: 30 October 2022)
- Novel Therapeutics for Genitourinary Tumors (Deadline: 30 October 2022)
- New Insights in Biliary Tract Cancers Therapy (Deadline: 30 October 2022)
- Combined CAR T-cell Therapies: A Next Step towards Precision Oncology (Deadline: 31 October 2022)
- Current Strategies in Spine Tumor Treatment (Deadline: 31 October 2022)
- Advances in Treatment of Non-melanoma Skin Cancer (Deadline: 31 October 2022)
- Radiation Therapy for Breast Cancers (Deadline: 31 October 2022)
- Treatment Resistance and Predictive Biomarkers in Lymphoid Malignancies (Deadline: 31 October 2022)
- New Approaches with Precision Medicine in Brain Tumors (Deadline: 31 October 2022)
- Frontiers in Cancer Photomedicine (Deadline: 31 October 2022)
- Mechanisms of Acquired Resistance to Targeted Therapy (Deadline: 31 October 2022)
- Recent Advances in Precision Image-Guided Cancer Therapy (Deadline: 1 November 2022)
- Targeted Drugs in Chronic Lymphocytic Leukemia (Deadline: 1 November 2022)
- Current Challenge and Future Advances for Lung Cancer: Genetics, Instrumental Diagnosis and Treatment (Deadline: 10 November 2022)
- Place of Radiotherapy/Brachytherapy as an Adjuvant or Salvage Treatment in Genitourinary Cancer, Gynecologic Cancer, and Pelvic Sarcoma (Deadline: 15 November 2022)
- Treatment of Bone Metastases including Metastatic Spinal Cord Compression (Deadline: 15 November 2022)
- Current Management of Early and Advanced Rectal Cancer (Deadline: 15 November 2022)
- Circulating Tumor Cells in Precision Oncology (Deadline: 15 November 2022)
- Radiation Therapy in Lung Cancer: From a Technical Revolution to a Combination with New Systemic Approaches (Deadline: 15 November 2022)
- Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy (Deadline: 15 November 2022)
- Targeted Therapy for Bladder Cancer (Deadline: 15 November 2022)
- The Role of Genetic and Epigenetic Aberrations in Cancer (Deadline: 16 November 2022)
- Lung Cancer with KRAS/EGFR Mutations (Deadline: 20 November 2022)
- Combating Tumor Radioresistance (Deadline: 20 November 2022)
- Cellular Plasticity: Tumorigenesis and Therapy (Deadline: 20 November 2022)
- Advances for Sellar and Parasellar Tumours: Current Treatments and Future Directions (Deadline: 20 November 2022)
- Novel Strategies to Mitigate Cancer Therapy Side Effects (Deadline: 22 November 2022)
- Breast Cancer: From Pathophysiology to Prevention and Treatment (Deadline: 25 November 2022)
- Roles of MET in Cancer Development and Treatment (Deadline: 30 November 2022)
- New Concepts of Personalized Therapy in Salivary Gland Carcinomas (Deadline: 30 November 2022)
- Diagnostic and Treatment Pathways for Locally Advanced and Metastatic Prostate Cancer (Deadline: 30 November 2022)
- Personalized Radiation Therapy for Oncology (Deadline: 30 November 2022)
- New Markers in the Early Diagnosis and Prognostic Evaluation of Ovarian Cancer (Deadline: 30 November 2022)
- Diagnosis and Treatment of Brain Metastases (Deadline: 30 November 2022)
- Therapies of Uveal Melanoma (Deadline: 30 November 2022)
- New Insights in Neuroblastoma — From Tumor Evolution to New Precision Oncology Approaches (Deadline: 30 November 2022)
- Genetics and Therapeutic Opportunities in Urologic Oncology (Deadline: 1 December 2022)
- Gastrointestinal Stromal Tumors (GIST): Opportunity and Challenges in Diagnosis and Treatment (Deadline: 5 December 2022)
- Translational Therapies for Mesothelioma (Deadline: 5 December 2022)
- Targeted Therapy of Melanoma: Novel Mechanisms and Biomarkers of Drug Resistance (Deadline: 5 December 2022)
- Therapeutic Progress in Adult Acute Lymphoblastic Leukemia (Deadline: 5 December 2022)
- Prostate-Specific Membrane Antigen (PSMA) (Deadline: 10 December 2022)
- Radiotherapy for Lung Cancer: New Frontiers and Challenges (Deadline: 10 December 2022)
- Curative Prevention and Treatment for Hepatocellular Carcinoma (Deadline: 15 December 2022)
- Feature Reviews in Cancer Therapy (Deadline: 15 December 2022)
- Current Strategies in Pancreatic Cancer Management: Intense Systemic Treatment and Aggressive Local Tumor Control. When Shall We Do What? (Deadline: 15 December 2022)
- ALK in Cancer: Lessons from the Future (Deadline: 15 December 2022)
- Locoregional Treatment for Breast Cancer: Current Status and Future Perspectives (Deadline: 15 December 2022)
- Advances in Minimally Invasive Liver Resection for Cancer Therapies (Deadline: 16 December 2022)
- Recent Advances in Immunotherapy for Head and Neck Cancer (Deadline: 20 December 2022)
- New Perspectives in the Treatment of Local Advanced and Metastatic Melanoma (Deadline: 20 December 2022)
- Primary and Metastatic Acral and Mucosal Melanoma (Deadline: 20 December 2022)
- Orthopedic Oncology: Surgical Innovations in 2022 (Deadline: 31 December 2022)
- Proton Therapy for Cancer in the Era of Precision Medicine (Deadline: 31 December 2022)
- Adult Acute Lymphoblastic Leukemia (Deadline: 31 December 2022)
- Melanoma Metastasis: New and Evolving Concepts (Deadline: 31 December 2022)
- Analysis of Cancer Radiotherapy (Deadline: 31 December 2022)
- The Emerging Role of Ion Channels in Brain Cancer: Mechanisms of Action and Therapeutic Targets (Deadline: 31 December 2022)
- Targeted Therapy for Acute Myeloid Leukemia (Deadline: 31 December 2022)
- Emerging Therapies in Renal Cell Carcinoma (Deadline: 31 December 2022)
- CAR T-cell Therapy for Lymphoma Research (Deadline: 31 December 2022)
- Therapeutic Options in Metastatic Colorectal Cancer (Deadline: 31 December 2022)
- Diagnostics and Therapeutics in Early Stage Breast Cancer Receiving Neoadjuvant Systemic Therapy (Deadline: 10 January 2023)
- New Insights on Therapy in Hepatocellular Carcinoma (Deadline: 15 January 2023)
- Recent Advances in Myelodysplastic Syndromes: Diagnosis, Prognosis and Clinical Therapy (Deadline: 15 January 2023)
- Advances and Perspectives in Diagnosis and Treatment Strategies for Bladder Cancer (Deadline: 15 January 2023)
- Hyperthermia-Based Cancer Treatments (Deadline: 20 January 2023)
- Lung Adenocarcinoma: Screening and Surgical Treatment (Deadline: 31 January 2023)
- Pediatric and AYA Sarcoma and Intermediate Tumors (Deadline: 31 January 2023)
- DNA Double Strand Break Repair in Prostate Cancer: From Mechanistic Regulation to Clinical Application (Deadline: 31 January 2023)
- The Surgical Management of Neuroendocrine Tumor (Deadline: 10 February 2023)
- Estrogens and Estrogen Receptor Modulators in Cancer Research and Therapy (Deadline: 15 February 2023)
- Research Progress in Esophageal Squamous Cell Carcinoma (Deadline: 15 February 2023)
- Proton and Radiation Therapy for Breast Cancer: Progress & Pitfalls (Deadline: 20 February 2023)
- Gastrointestinal Oncology: Clinical Management (Deadline: 28 February 2023)
- Radiation Biology of Glioblastoma—Defining Clinically Relevant Novel Targets and New Therapies for Improved Patient Outcomes (Deadline: 28 February 2023)
- Resistance to Apoptosis-Based Cancer Therapy—Induction of Non-apoptotic Cell Death to Overcome Chemoresistance (Deadline: 28 February 2023)
- Metabolic Hallmarks of Malignant Cells (Deadline: 1 March 2023)
- Topic on Immunotherapy and Tumor Microenvironment in Lymphoma (Deadline: 10 March 2023)
- Prostate Cancer Progression (Deadline: 15 March 2023)
- Neoadjuvant Therapies in Pancreatic Cancer (Deadline: 20 March 2023)
- Targeted Therapy for Androgen Receptor Signaling Inhibitors (ARSI)-Resistant Prostate Cancer (Deadline: 20 March 2023)
- Research in Spatially Fractionated Radiation Therapies for Cancers (Deadline: 31 March 2023)
- Tyrosine Kinase Inhibitors (TKIs) in Cancer Targeted Therapy (Deadline: 31 March 2023)
- Multimodality Treatment in Recurrent Metastatic Head and Neck Cancer (Deadline: 1 April 2023)
- CAR-T Cells: Past, Present, and Future (Deadline: 20 April 2023)
- Preoperative Radiotherapy in Cancers (Deadline: 30 April 2023)
- The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives (Deadline: 15 May 2023)
- Radiotherapy and New Biological Paradigms in Cancer Treatments (Deadline: 23 May 2023)
- Advances in Radiotherapy for Head and Neck Cancer (Deadline: 31 May 2023)
- New Approaches in Modulating Transcription Factors for Cancer Therapy (Deadline: 31 May 2023)
- Evolving Role of the Thoracic Oncologic Surgeon in the Era of Molecular and Immune-Targeted Therapies for Lung Cancer (Deadline: 15 June 2023)
- Advances in Brachytherapy in the Treatment of Tumors (Deadline: 30 June 2023)
- Meningioma Surgery and Functional Outcome (Deadline: 23 July 2023)
- Novel Predictive and Prognostic Biomarkers for Locoregionally Advanced Nasopharyngeal Carcinoma (Deadline: 31 July 2023)
- Breast Cancer: Tailored Rehabilitation Strategies to Address the Challenge of Survivorship Issues (Deadline: 3 July 2025)
Topical Collections
Following topical collections within this section are currently open for submissions:
- Acute Myeloid Leukemia (AML)
- Advances in Diagnostic and Interventional Radiology in Oncology
- Advances in Geriatric Oncology: Exploring Practical Ways to Optimize Treatment in Older Patients with Cancer 2.0
- Cancer Nanomedicine
- Drug Resistance and Novel Therapies in Cancers
- Innovative Concepts in the Diagnosis and Treatment of Gynecologic Malignancies
- Neuroendocrine Tumors: Treatment and Management
- New Treatment for Colorectal Cancer
- Novel Therapies for Hepatocellular Carcinoma
- Plasma Oncology
- Prostate Cancer: Pathophysiology, Pathology and Therapy
- Radiomics and Cancers
- Targeted Cancer Therapy
- Targeted Therapies and Immunotherapies in Metastatic Melanoma
- Urological Cancer
