Special Issue "Animal Models for Viral Diseases"
Deadline for manuscript submissions: closed (31 October 2018).
Interests: papillomavirus; virus tropsim; cervical cancer; tumour viruses; cervical screening
While observational studies on clinical materials are essential if we are to properly understand virus-associated disease pathogenesis, it is clear that clinical analysis must be combined with experimental approaches, if we are to fully understand the mechanistic aspects of disease progression. In this scheme, the use of animal disease models lies between experiments that aim to reconstruct of aspects of disease and tissue architecture using in vitro tissue culture methodologies, and as far as it is possible, the clinical evaluation of disease in infected human patients. Historically, the utility of animal models has been restricted by the host and tissue specificity of the virus under investigation, and/or whether an appropriate animal virus, able to cause similar disease in an appropriate laboratory animal can be found. It has often been the case, that virus disease-associations seen in humans, do not extend unmodified to their animal virus counterparts. To use these models requires a clear appreciation of the limitations of the chosen approach. More recently, the use of humanised mice has allowed the direct analysis of human viruses in human cells in the context of a whole animal, and has also been used to understand interaction with a humanised immune system. The increasing sophistication of such models is providing new insight into disease mechanisms, and the development of therapeutic approaches to control infection.Prof. John Doorbar
Prof. Ian Goodfellow
Manuscript Submission Information
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- disease models
- virus infection
- drug discovery
- immune therapy
- disease mechanisms