Various gating modifier toxins partition into membranes and interfere with the gating mechanisms of biological ion channels. For example, GsMTx4 potentiates gramicidin and several bacterial mechanosensitive channels whose gating kinetics are sensitiv...
Gating modifier toxins (GMTs) isolated from venomous organisms such as Protoxin-II (ProTx-II) and Huwentoxin-IV (HwTx-IV) that inhibit the voltage-gated sodium channel NaV1.7 by binding to its voltage-sensing domain II (VSDII) have been extensively i...
Spider toxin SNX-482 is a cysteine-rich peptide that interferes with calcium channel activity by binding to voltage-sensing domains of the CaV2.3 subtype. Two mechanisms dominate the binding process of cysteine-rich peptides: direct binding from the...
Cx43 hemichannels (HCs) are electrically and chemically gated transmembrane pores with low open probability and multiple conductance states, which makes kinetic studies of channel gating in large datasets challenging. Here, we developed open access s...
Polymer-modified cementitious repair mortars improve adhesion and durability but usually increase cradle-to-gate (A1–A3) emissions. This study develops a performance-normalized embodied-carbon screening framework that compares repair materials...
Spider gating modifier toxins (GMTs) are potent modulators of voltage-gated ion channels and have thus attracted attention as drug leads for several pathophysiological conditions. GMTs contain three disulfide bonds organized in an inhibitory cystine...
Memristors, as new electronic elements, have been under rigorous study in recent years, owing to their good memory and switching properties, low power consumption, nano-dimensions and a good compatibility to present integrated circuits, related to th...
Toxins as channel probes, small guanidinium alkaloids, such as tetrodotoxin and saxitoxin, canonical pore occlusion in voltage-gated Na+ channels. Cystine-rich peptides from spiders, scorpions, cone snails, and sea anemones, which act as pore blocker...
The Yunnan province of China is a typical humid region but with several severe region-wide droughts. Drought indices are generally used to identify and characterize drought events, and then play a key role in drought prediction. Therefore, a novel pr...
Gate machines, such as ticket gates in stations and secure gates in office buildings, are very common in people’s daily lives. On the one hand, the passage between the gates is not wide enough for pedestrians to pass through, which may affect t...
An organic electrochemical transistor (OECT) with MoS2 nanosheets modified on the gate electrode was proposed for glucose sensing. MoS2 nanosheets, which had excellent electrocatalytic performance, a large specific surface area, and more active sites...
A new water-soluble poly(propylene imine) dendrimer (PPI) modified with 4-sulfo-1,8-naphthalimid units (SNID) and its related structure monomer analog (SNIM) has been prepared by a simple synthesis. The aqueous solution of the monomer exhibited aggre...
Studies on the interaction sites of peptide toxins and ion channels typically involve site-directed mutations in toxins. However, natural mutant toxins exist among them, offering insights into how the evolutionary process has conserved crucial sequen...
Spider venoms are complex mixtures of biologically active components with potentially interesting applications for drug discovery or for agricultural purposes. The spider Phoneutria nigriventer is responsible for a number of envenomations with someti...
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels). Studies of these toxins have focused on varied aspec...
Background/Objectives: BrdU (5′-bromo-2′-deoxyuridine), a synthetic thymidine (T) analog, is widely used to study cell proliferation and DNA synthesis. To precisely identify where and when DNA replication starts and terminates, it is esse...
Multiplication is the dominant operation for many applications implemented on field-programmable gate arrays (FPGAs). Although most current FPGA families have embedded hard multipliers, soft multipliers using lookup tables (LUTs) in the logic fabric...
NMDA receptors are glutamate-activated ion-channels involved in many essential brain functions including learning, memory, cognition, and behavior. Given this broad range of function it is not surprising that the initial attempts to correct NMDA rece...
Hanatoxin 1 (HaTx1) is a polypeptide toxin isolated from spider venoms. HaTx1 inhibits the voltage-gated potassium channel kv2.1 potently with nanomolar affinities. Its receptor site has been shown to contain the S3b-S4a paddle of the voltage sensor ...
The fast Fourier transform (FFT) is the most prevalent algorithm for the spectral analysis of acoustic emission signals acquired at ultra-high sampling rates to monitor the condition of rotary machines. The complexity and cost of the associated hardw...
An itch is a clinical complication that affects millions of patients. However, few treatment options are available. The voltage-gated sodium channel Nav1.7 is predominantly expressed in peripheral sensory neurons and is responsible for the rising pha...
In this paper, a facile modifying technique of source/drain regions conductivity was proposed for self-aligned top-gate In-Ga-Zn-O (IGZO) thin-film transistors (TFTs) by controlling the process parameter of the passivation layer at relatively low tem...
In one of the “classical” configurations of electrolyte-gated field effect transistors (EGOFETs) for biosensing, the planar gate electrode is functionalized by (a monolayer of) receptors, to which the analyte molecules of interest bind fr...
The carbon nanotube (CNT) field emitter is suitable for the high frequency pulsing of X-ray. Pulsing reduces 49% of the dose in grid-controlled fluoroscopy and improves the image of moving objects. Various structures and manufacturing processes are b...
In this paper, a novel 4H-SiC split heterojunction gate double trench metal-oxide-semiconductor field-effect transistor (SHG-DTMOS) is proposed to improve switching speed and loss. The device modifies the split gate double trench MOSFET (SG-DTMOS) by...
In this paper, we investigate the effect of lateral gate design on performance of a p-type double lateral gate junctionless transistors (DGJLTs) with an air gate gap. The impact of lateral gate length, which modifies the real channel length of the de...
We show that transfer hysteresis for a pentacene thin film transistor (TFT) with a low-temperature solution-processed zirconia (ZrOx) gate insulator can be remarkably reduced by modifying the ZrOx surface with a thin layer of crosslinked poly(4-vinyl...
This paper proposes a standard applications of Radio Frequency Identification (RFID) system to manage vehicles at electronic toll gate system without compromising the vehicle speed. The existing electronic toll gate system has low latency as each car...
In this study, a high-K material, aluminum oxide (AlOx), as the dielectric of organic field-effect transistors (OFETs) was used to reduce the threshold and operating voltages, while focusing on achieving high-electrical-stability OFETs and retention...
A compatible fabrication technology for integrating InGaAs nMOSFETs and Ge pMOSFETs is developed based on the development of the two-step gate oxide fabrication strategy. The direct wafer bonding method was utilized to obtain the InGaAs-Insulator-Ge...
NMOSFET, whose gate is on the top of the n-p-n junction with gate oxide in between, is called the n-channel transistor. This bipolar junction underneath the gate oxide may provide an n-n-n-conductive channel as the gate is applied with a positive bia...
Gallium Nitride (GaN) high-electron mobility transistors (HEMTs) are highly promising for high-frequency and high-power applications due to their superior properties, such as a wide energy bandgap and high carrier density. The performance of GaN HEMT...
Compared to single-gate CNTFET, dual-gate structures have better electrostatic control over nanowire conductive channels. However, currently, there is insufficient research on the back-gate effect in a compact model of dual-gate CNTFET. This paper pr...
An improved ultrahigh upper gate 4H-SiC metal semiconductor field effect transistor (IUU-MESFET) is proposed in this paper. The structure is obtained by modifying the ultrahigh upper gate height h of the ultrahigh upper gate 4H-SiC metal semiconducto...
Technological units of water reservoirs and power plants include sluice gates which are designed to completely seal the inflow or outflow of water in supply or discharge channels. This article describes the issue of technical assessment of a sluice g...
The fault tree analysis (FTA) method is an important analysis method for safety system engineering. Traditional accident analysis theory agrees that basic events lead to top events, but it does not fully consider that the accident process is accident...
We propose a terahertz (THz) antenna-coupled wire-channel field-effect transistor—modified EdgeFET (m-EdgeFET), formed by combining single-gate FinFET and dual-side-gate EdgeFET concepts, which is used for THz detection. The proposed hybrid des...
Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shap...
Low-voltage, solution-processed organic thin-film transistors (OTFTs) have tremendous potential to be key components in low-cost, flexible and large-area electronics. However, for these devices to operate at low voltage, robust and high capacitance g...
Quantum computing is an emergent field promising the improvement of processing speed in key algorithms by reducing their exponential scaling to polynomial, thus enabling solutions to problems that exceed classical computational capabilities. Gate-bas...
As a promising candidate for More Moore technology, InGaAs-based n-channel metal-oxide-semiconductor field-effect transistors (nMOSFETs) have attracted growing research interest, especially with InGaAs-on-insulator (InGaAs-OI) configurations aimed at...
Gated communities have been the popular form of housing around the world to address social and safety issues over the past decade, including in Chinese cities. However, gated communities, despite being a more efficient system (less congested), have b...
The increase of the switching speed in power semiconductors leads to converters with better efficiency and high power density. On the other hand, fast switching generates some consequences like overshoots and higher switching transient, which provoke...
13 September 2019
In this study, a life cycle assessment (LCA) was used to investigate the environmental benefits of using styrene-butadiene-styrene (SBS) to modify polylactide (PLA)-based wood plastic composites (WPCs), with a process-based and input–output hyb...
The mechanosensitive channel of large conductance, MscL, has been proposed as a triggered nanovalve to be used in drug release and other nanodevices. It is a small homopentameric bacterial protein that has the largest gated pore known: greater than 3...
Due to the influence of parasitic internal parameters and junction capacitance, the silicon carbide (SiC) power devices are frequently marred by significant overshoots in current and voltage, as well as high-frequency oscillations during the switchin...
Gold-nanoparticle (Au-NP) non-volatile memories (NVMs) with low-damage CF4 plasma treatment on the blocking oxide (BO) layer have been investigated to present the gate injection of the holes. These holes, injected from the Al gate with the positive g...
We have developed a Magnetic Resonance Imaging (MRI)-compatible system to enable gating of a scanner to the heartbeat of a foetus for cardiac, umbilical cord flow and other possible imaging applications. We performed radiofrequency safety testing pri...
Growing demand for renewable energy from biomass has prompted exploration of timber transportation concepts. This study evaluated the operational and regulatory boundaries of whole-tree hauling using a modified log trailer in the southeastern United...
Mixed-dimensional heterostructures integrating two-dimensional (2D) van der Waals magnets with conventional ferromagnetic films unify the versatile functionalities of both material classes and offer enormous potential for magnetic sensing, non-volati...
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