Avian pathogenic E. coli (APEC) can cause localized or systemic infection, resulting in large economic losses per year, and impact health of humans. Previous studies showed that RIP2 (receptor interacting serine/threonine kinase 2) and its signaling...
Colibacillosis is an acute and chronic avian disease caused by avian pathogenic E. coli (APEC). Previous studies have demonstrated that RIP2 plays a significant role in APEC infection. Moreover, increasing evidence indicates that microRNAs (miRNAs) a...
Amyloid aggregates play a major role in diseases as well as in normal physiological function. Receptor-interacting protein kinases 1 and 3 (RIP1/RIP3) aggregates complexes in cellular necroptosis is one example of protein aggregation in normal cellul...
Multiple submerged breakwaters (MSBWs) are commonly used coastal protection structures due to their specific advantages over the emerged ones. Rip currents, as the inevitable natural hazard in the gaps of these constructions, are investigated numeric...
To analyze the impacts of groins, sandbars, and channels on the three-dimensional features of rip currents, we conducted experimental investigations on the vertical distribution of rip currents under intersecting waves along barred beaches with chann...
Rip currents at featureless beaches (i.e., beaches lacking sandbars or channels) are often hydrodynamically controlled, exhibiting intermittent and unpredictable behaviors that pose significant risks to recreational beach users. This study assessed o...
Receptor-interacting protein 3 (RIP3) has been demonstrated to be a key regulator not only in cell death pathways including apoptosis and necroptosis but also in inflammation and host immune responses. In this study, a RIP3 ortholog named Lc-RIP3 is...
Rip currents are the strong narrow seaward current produced by waves breaking on the coast. Of the many types of rip currents, the present study investigates, experimentally and numerically, the rip current system produced by the wave reflection on a...
Type I ribosome-inactivating proteins (RIPs) are plant toxins that inhibit protein synthesis by exerting rRNA N-glycosylase activity (EC 3.2.2.22). Due to the lack of a cell-binding domain, type I RIPs are not target cell-specific. However once linke...
2 March 2023
Among many coastal hazards, rip currents have gradually become one of the most noticeable hazards. Studies have demonstrated that most drowning accidents at beaches around the world are related to rip currents. In this study, online and field questio...
A rip current is a strong, localized current of water which moves along and away from the shore. Recent studies have suggested that drownings due to rip currents are still a major threat to beach safety. Identification of rip currents is important fo...
Detecting rip currents from satellite imagery offers valuable information for the characterization and assessment of this coastal hazard. While recent advances in deep learning have enabled automatic detection from close-view beach images, the broade...
Rip currents are fast-moving, narrow channels of water that flow seaward from the shoreline, typically forming within the surf zone and extending beyond the wave-breaking region. These currents pose significant hazards to swimmers, contributing to nu...
Real-time and accurate longitudinal rip detection of a conveyor belt is crucial for the safety and efficiency of an industrial haulage system. However, the existing longitudinal detection methods possess drawbacks, often resulting in false alarms cau...
Rip currents are fast offshore currents generated during the breaking process of waves propagating nearshore, posing a potential life safety threat to coastal bathers. This study utilizes a Boussinesq phase-resolving model to investigate the formatio...
Glacial ripping is a newly recognized process sequence in which subglacial erosion is triggered by groundwater overpressure. Investigations in gneiss terrain in lowland Sweden indicate that ripping involves three stages of (i) hydraulic jacking, (ii)...
Regulated cardiomyocyte death is a central contributor to myocardial infarction (MI)-associated injury. Mixed lineage kinase domain-like protein (MLKL), a key effector of necroptosis, has been implicated in cardiovascular disease; however, its role i...
RIP140 is a major transcriptional coregulator of gut homeostasis and tumorigenesis through the regulation of Wnt/APC signaling. Here, we investigated the effect of RIP140 on Paneth cell differentiation and its interplay with the transcription factor...
Rip currents are strong water channels flowing away from the shoreline. They can occur on any shore with breaking waves. Rip currents play a significant role in changing the topography of shallow water regions by transporting large amounts of bed mat...
Saponin-mediated endosomal escape is a mechanism that increases the cytotoxicity of type I ribosome-inactivating proteins (type I RIPs). In order to actualize their cytotoxicity, type I RIPs must be released into the cytosol after endocytosis. Withou...
The diversity of livestock coat color results from human positive selection and represents an indispensable part of breed identity. As an important biodiversity resource, pigs have many special characteristics, including the most visualized feature,...
A XBeach surfbeat model is used to explore the dynamics of natural headland rip circulation under a broad range of incident wave conditions and tide level. The model was calibrated and extensively validated against measurements collected in the vicin...
Cancer cells switch their metabolism toward glucose metabolism to sustain their uncontrolled proliferation. Consequently, glycolytic intermediates are diverted into the pentose phosphate pathway (PPP) to produce macromolecules necessary for cell grow...
Rip currents pose a serious maritime safety hazard, as they can quickly carry swimmers away from the shore, often leading to drownings caused by panic. Traditional beach flags and signs often fall short due to the complexities involved in issuing rea...
The receptor-interacting protein kinase 3 (RIP3) has been reported to regulate programmed necrosis–necroptosis forms of cell death with important functions in inflammation. We investigated whether RIP3 translocates into mitochondria in response...
We develop the general reconstruction scheme in two scalar model. The quintom-like theory which may describe (different) non-singular Little Rip or de Sitter cosmology is reconstructed. The number of scalar phantom dark energy models (with Little Rip...
RipX of Ralstonia solanacearum is translocated into host cells by a type III secretion system and acts as a harpin-like protein to induce a hypersensitive response in tobacco plants. The molecular events in association with RipX-induced signaling tra...
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutat...
The aim of this study was to investigate the expression of two nuclear receptor transcriptional coregulators, namely RIP140 (receptor-interacting protein of 140 kDa) and LCoR (ligand-dependent corepressor) in unifocal versus multifocal breast cancers...
Bacterial wilt, caused by Ralstonia solanacearum, one of the most destructive phytopathogens, leads to significant annual crop yield losses. Type III effectors (T3Es) mainly contribute to the virulence of R. solanacearum, usually by targeting immune-...
Cancer-derived small extracellular vesicles (sEVs) serve as critical mediators of cell-to-cell communication. Manzamine A (MA), a unique marine-derived alkaloid with various bioactivities, exerts anticancer effects against several kinds of tumors, bu...
Headland rips, sometimes referred to as boundary rips, are rip currents flowing against natural or artificial obstructions extending seaward from the beach, such as headland or groynes. They can be driven either by the deflection of the longshore cur...
21 November 2022
Metabolic dysregulation of the retinal pigment epithelium (RPE) has been implicated in age-related macular degeneration (AMD). However, the molecular regulation of RPE metabolism remains unclear. RIP140 is known to affect oxidative metabolism and mit...
While clear cell renal cell carcinoma (ccRCC) is curable, advanced metastatic (mRCC) remains a clinical challenge. We analyzed clinical, pathohistological, and molecular data (Receptor Interacting Protein 5—RIP5 and Vestigial Like Family Member...
Background/Objectives: Necroptosis is a critical process in the pathogenesis of myocardial ischemia–reperfusion injury (MIRI). Tilianin (Til), a natural flavonoid glycoside derived from Dracocephalum moldavica L., exhibits significant therapeut...
RipP1 is a well-characterized avirulence effector that induces a hypersensitive response (HR) in three tobacco species. However, the molecular mechanisms by which host proteins recognize RipP1 to activate a defense response and modulate host–pa...
The environmental bacterium Pseudomonas mosselii produces antagonistic secondary metabolites with inhibitory effects on multiple plant pathogens, including Ralstonia solanacearum, the causal agent of bacterial wilt. In this study, an engineered P. mo...
This study aimed to explore the spatio-temporal expression patterns of congenital anomalies of kidney and urinary tract (CAKUT) candidate genes, Fibroblast Growth Factor Receptor 1 (FGFR1), Fibroblast Growth Factor Receptor 2 (FGFR2) and Receptor-Int...
Rip currents pose significant threats to coastal safety and to autonomous marine vehicles operating nearshore. However, deploying high-precision monitoring models on resource-limited platforms remains challenging. This paper proposes a comprehensive...
11 October 2022
Smac mimetics are a group of compounds able to facilitate cell death in cancer cells. TNF-related apoptosis-inducing ligand (TRAIL) is a death receptor ligand currently explored in combination with Smac mimetics. The molecular mechanisms determining...
Apoptosis and necroptosis overlap in their initial signaling but diverge to produce non-inflammatory and pro-inflammatory outcomes, respectively. High glucose pushes signaling in favor of necroptosis producing a hyperglycemic shift from apoptosis to...
In this work, we present a Big Rip scenario within the framework of the generalized Brans-Dicke (GBD) theory. In the GBD theory, we consider an evolving BD parameter along with a self-interacting potential. An anisotropic background is considered to...
Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the...
This study aimed to explore how Dab1 gene functional silencing influences the spatial and temporal expression patterns of fibroblast growth factor receptor 1 (FGFR1), fibroblast growth factor receptor 2 (FGFR2), receptor-interacting protein kinase 5...
To date, more than 170 chemical modifications have been identified in RNA. m6A (N6-methyladenine) RNA methylation is the most abundant form of mRNA modification in eukaryotes, playing an important role in RNA post-transcriptional processes. To invest...
This manuscript presents a novel scheme to achieve high-resolution laser-radar ranging with a small sample number under low signal-to-noise ratio (SNR) conditions. To reduce the sample number, the Restricted Isometry Property-based optimal multi-chan...
Background: The function and mechanism of N6-methyladenosine (m6A) methylation in pressure-overload cardiac fibrosis remains limited and unclear. This study aims to analyze and predict m6A modifications present in mouse hearts because of transverse a...
Computer network communication is quickly growing in this pandemic situation. Phone conferencing, video streaming and sharing file/printing are all made easier with communications technologies. Data transmitted in time with little interruption become...
Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help the design of novel and personalized therapies and prognostic assessments. Abnormal RNA modification is a recently discovered process...
Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially pr...
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