Special Issue "Epigenetic and Molecular Consequences of Early-Life Trauma"
Deadline for manuscript submissions: closed (15 February 2021).
Interests: behavioural epigenetics; molecular consequences of early life adversity; DNA methylation; HPA axis; glucocorticoid receptor; genetics and epigenetics of the stress response
The environment in the early life period has a significant long-term impact on health and disease. This early-life exposome includes socioeconomic conditions, trauma exposure, parental separation, maltreatment, and many other factors. In many cases, suboptimal early-life conditions are a major contributor, not only to the lifelong disease burden but also to the cost of acute and chronic care. There is growing evidence that the early life social environment affects both the parents and the offspring. The direct action of the environment on the early-life epigenome as well as the inheritance of parental epigenetic marks is a rapidly expanding area of research. New and emerging research in the areas of epigenetics, biomedicine, and neuro-endocrinology hold great promise in relation to the development of our understanding of the complexity of the early life (social) environment and the multiplicity of factors that result in the long-term phenotype.
In this Special Issue of the International Journal of Molecular Sciences, the developmental origins of health and disease will be explored in the context of the early-life (social) environment. Potential topics include but are not limited to the early life (social) environment; methods of conceptualizing the early life environment, including SES, trauma, parental illness, or PTSD; long-term health consequences of the early life environment; long-term pathophysiological and phenotypic differences; biological markers of early-life exposure; and epigenetic or immunological mechanisms encoding exposure. Manuscripts exploring the relative strengths and weaknesses of competing hypotheses such as but limited to the hygiene hypothesis/microbiome establishment vs. EPIIC (Epigenetic Impact of Childbirth) that may explain long term differences in immune response are particularly welcome.
Although the impetus for this Special Issue comes from the COST Action CA18211 (Perinatal Mental Health and Birth-Related Trauma: Maximising Best Practice and Optimal Outcomes” (DEVoTION)), submissions are encouraged from the wider scientific community as well as action members.
Dr. Jonathan Turner
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Early-life exposome
- Epigenetic mechanisms
- Behavioural epigenetics
- Social epigenetics