Special Issue "Cell Death in Cancer and Inflammation: From Pathogenesis to Treatment"
Deadline for manuscript submissions: closed (1 April 2021).
Interests: apoptotic bodies; cell clearance; extracellular vesicles; necrosis
Interests: apoptosis; infectious disease; cancer; cell clearance; apoptotic bodies
Interests: apoptosis; secondary necrosis; extracellular vesicles; inflammation; cell clearance; reproductive biology
Cell death plays a crucial role in maintaining homeostasis through the elimination of excessive, infected, malignant and damaged cells. Over the past decade, the field of cell death has been evolving at a rapid pace with the identification of novel mechanisms underpinning the complex molecular control of cell death. In addition to the classically studied mechanisms of intrinsic and extrinsic apoptosis, new forms of Programmed Cell Death (PCD) are being uncovered. PCD is defined by a controlled signal pathway which results in cellular demise through apoptosis, necroptosis or pyroptosis. Notably, cell death is not always executed in an organised fashion, as seen in primary necrotic and secondary necrotic cell death. Furthermore, the mechanism of cell death can be cell-type specific as seen in NETosis (a specialized form of PCD occurring in neutrophils), driven through specific organelles (lysosomal cell death) and cellular processes (autophagic cell death). Moreover, the cell death field continues to expand with research characterizing novel cell death pathways such as ferroptosis, linker cell death, and parthanatos.
It is important to decipher the complex and overlapping molecular control of dying cells, as defects in the cell death pathway has been linked to a variety of diseases such as cancer and inflammation. Importantly, understanding the molecular mechanisms of cell death and its impairment in many cancer types has led to the development of novel anti-cancer therapeutics. Moreover, many inflammatory disorders, including autoimmunity, asthma, inflammatory bowel disease and transplant rejections, can be a result of enhanced inflammatory cell death. Thus, it is imperative to dissect the relationship between cell death and disease in order to develop much needed therapeutics.
For this Special Issue of Biomolecules, “Cell Death in Cancer and Inflammation: From Pathogenesis to Treatment”, we encourage the submission of review and primary research articles that showcase both the role of cell death and therapeutic approaches targeting cell death pathways in cancer and inflammation.
Dr. Ivan Poon
Dr. Georgia Atkin-Smith
Dr. Rochelle Tixeira
Dr. Amy A. Baxter
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell death