Special Issue "Molecular Biology and Pathology of Breast Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2018).
Interests: breast cancer; diagnostic and prognostic markers; gene expression; transcriptional regulation; genomics and transcriptomics; polymorphisms; p53 pathway; hormone receptor pathways; epithelial–mesenchymal transition
Molecular alterations are causal to the genesis and progression of cancer. It is widely predicted that the molecular profile of a tumor, more than traditional clinical and histopathological characteristics or even the tissue of origin, will ultimately determine the specific personalized therapy in the future. Many steps in this ongoing molecular revolution have been pioneered in breast cancer research and treatment. Arguably, the first molecularly targeted therapy plus companion diagnostics was clinically established for breast cancer decades ago: Tamoxifen for estrogen receptor positive, but not negative patients. Hereditary breast cancer has been a paradigm for genetic cancer susceptibility syndromes ever since the discovery of the breast cancer genes BRCA1 and BRCA2 more than twenty years ago. Molecular subtypes of breast cancer based on genome-wide expression profiling were reported as early as 2000, and are still widely-used in breast cancer research and prognosis.
Along these lines, this Special Issue welcomes submissions of research articles and reviews covering molecular aspects of the biology and pathology of breast cancer in humans and model organisms, including diagnostic, prognostic and predictive molecular biomarkers; molecularly targeted therapies; hereditary breast cancer and genes, mutations and polymorphisms with a role in breast cancer risk and biology; breast cancer genomics and transcriptomics; epigenetics and epigenomics of breast cancer.
Prof. Martin Schreiber
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Molecular mechanisms;
- Diagnostic, prognostic and predictive molecular markers;
- Current and novel immunohistochemical markers;
- Molecular subtypes;
- Molecularly targeted therapies;
- Hereditary breast cancer;
- Mutations and polymorphisms;
- Breast cancer genomics and transcriptomics;
- Epigenetics and epigenomics;
- Preclinical models