This study describes an innovative in-line near-infrared (NIR) process monitoring method for the quantification of the total polyphenolic content (TPC) of Ajuga genevensis dry extracts. The dry extract was obtained in a fluidized bed processor, by sp...
Most of the challenges and conflicts facing countries and groups today involve cyberspace. Therefore, military forces around the world are developing methods (doctrines) and weapon systems to conduct cyberspace operations in order to dominate cybersp...
Background/Objective: Abdominal examination by medical doctors is undertaken to observe abdominal shape and tenderness, but it is not typically quantified. Our goal was to explore the potential of physical metrics for identifying significant differen...
Introduction: Breast cancer is the most common cancer in women; its early detection plays a crucial role in improving patient outcomes. Ki-67 is a biomarker commonly used for evaluating the proliferation of cancer cells in breast cancer patients. The...
Background/Objective: Cardiac magnetic resonance (CMR) is the reference method for right ventricular (RV) volume and function analysis, but time-consuming manual segmentation and corrections of imperfect automatic segmentations are needed. This study...
Plinabulin, a new antitumor drug developed from marine natural products that targets microtubules in cancer cells, is currently being tested in a phase III clinical study. Plinabulin has been clinically proven to be effective on leukopenia. However,...
Orthosiphon stamineus Benth. (OS) is a traditional folk medicine for the treatment of kidney stones and other urinary tract diseases. In this study, a rapid and sensitive Ultra high-performance liquid chromatography (UHPLC)-MS/MS approach was establi...
The excessive expression of reactive oxygen species is closely connected to many diseases. Considerable studies have demonstrated dandelion as well as its ingredients exhibited antioxidant activity. However, specific material basis reflecting the ant...
This study addresses the challenge of quantifying spatially differential vertical surface deformation (SDVSD). Traditional approaches using persistent scatterer interferometry (PSI) data often focus on bulk vertical surface deformation (VSD) but over...
Chronic myeloid leukemia (CML) is a well-characterized oncological disease in which virtually all patients possess a translocation (9;22) that generates the tyrosine kinase BCR::ABL1 protein. This translocation represents one of the milestones in mol...
Background/Objectives: Multiple imaging modalities are available for non-invasive hepatic fat quantification. We performed a hypothesis-generating methods-comparison study to compare liver fat fraction (FF) measurements obtained using magnetic resona...
Background: Treatment monitoring in pulmonary tuberculosis increasingly requires assessment of residual inflammatory burden and structural lung damage beyond microbiologic response alone. High-resolution computed tomography (HRCT) can provide this in...
Amino acids (AAs) and their metabolites are important building blocks, energy sources, and signaling molecules associated with various pathological phenotypes. The quantification of AA and tryptophan (TRP) metabolites in human serum and plasma is the...
This study used bibliometric methods to systematically analyze the development trend, knowledge structure and evolution path of the field of “quantitative research on agricultural soil respiration based on machine learning” from 2021 to 2...
Delafloxacin (DLX) is a recently-approved fluoroquinolone antibiotic, which is recommended for the treatment of “acute bacterial skin and skin structure infections”. A thorough literature survey revealed only a single published method for...
A rapid and sensitive high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was developed for the quantification of Paclitaxel (PTX), 6α-hydroxypaclitaxel (6α-OHP), and p-3′-hydroxypaclitaxe...
DA-7010 is a new candidate for an antibacterial agent that targets Gram-negative pathogens by acting as a leucyl-tRNA synthetase inhibitor. In this study, a simple and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was develop...
Lignin is an aromatic biopolymer derived from lignocellulosic biomass. Providing a comprehensive structural analysis of lignin is the primary motivation for the quantification of various functional groups, with a view to valorizing lignin in a wide r...
The first goal of this paper is to verify the accuracy of four calculation methods of log volume. The tool to achieve this goal is to compare the results of the calculation of the log volume with the real log volume obtained from the three-dimensiona...
Background: While MRI is the gold standard for meniscal assessment, its cost and accessibility limitations have led to growing interest in ultrasound, though its validity for quantifying meniscal tissue remains unclear. To validate the use of ultraso...
Objectives: To validate a deep learning-based algorithm for automated detection, segmentation, and quantitative assessment of retinal fluid on optical coherence tomography (OCT) across multiple retinal diseases. Methods: In this retrospective validat...
Lipidomics aim to quantify lipid species in all kinds of samples, including tissues. To subject a fixed amount of sample to various workflows, tissue homogenates were frequently prepared at defined concentrations in water or by addition of organic so...
With rapid urbanization, rooftop photovoltaic (PV) systems play an important role in mitigating the energy crisis and reducing emissions, yet achieving scientific and cost-effective deployment at the urban block scale remains challenging. This study...
27 April 2021
OJT007 is a methionine aminopeptidase 1 (MetAP1) inhibitor with potent anti-proliferative effects against Leishmania Major. In order to study its pharmacokinetics as a part of the drug development process, a sensitive, specific, and reproducible ultr...
This pioneering study presents an in-depth biomechanical examinations of soccer’s diving header, aiming to quantify its impact on ball speed enhancement (BSE) and effective offensive range (EOR). Despite the diving header’s widespread acc...
Background/Objectives: Given the clinical limitations of azathioprine (AZA) in treating inflammatory bowel disease, this study developed an AZA-loaded microbiota-modulating and colon-targeted nanoparticle constructed from pectin, Zein, and Eudragit&r...
Background/Objectives: Semaglutide, a long-acting glucagon-like peptide-1 (GLP-1) analog for type 2 diabetes and obesity, requires sensitive and high-throughput bioanalytical methods to support pharmacokinetic studies. However, previously reported li...
Introduction: Ventricular pressure and arterial flow are commonly evaluated separately, although their instantaneous product represents hydraulic power. This study examined whether synchronized ventricular pressure and arterial flow recordings can be...
Human activity today produces a large number of pollutants that end up in the environment, such as soil, water, and airborne particles. The first objective of this work is to introduce a new third-order multivariate calibration approach called self-w...
Rotavirus remains a leading cause of acute gastroenteritis worldwide, particularly in young children, despite widespread vaccination efforts. This study aims to evaluate rotavirus circulation at the population level through wastewater-based epidemiol...
Digital polymerase chain reaction (dPCR) is a breakthrough technology based on the partitioning of the analytical sample and detection of individual end-point amplifications into the separate compartments. Among the numerous applications of this tech...
Background: The arterial switch operation (ASO) is the preferred treatment for d-transposition of the great arteries (TGA). Freedom from reintervention is mainly determined by the performance of the arterial outflow tracts, with variable incidence of...
Water irrigation systems are required to provide adequate pressure levels in any sort of network. Quite frequently, this requirement is achieved by using pressure reducing valves (PRVs). Nevertheless, the possibility of using hydraulic machines to re...
We investigated the time evolution of the symmetry of symbols constituting alphabets rooted in the Phoenician script. A diversity of quantitative measures of symmetry of graphemes appearing in Phoenician, Western Greek, Etruscan from Marsiliana, Arch...
Background: Dysregulation of adipokines is considered a key mechanism of chronic inflammation in metabolic syndrome. Some adipokines affect food intake by crossing the blood/brain barrier. The adipokine chemerin is associated with metabolic syndrome,...
The combination regimen targeting BRAF and MEK inhibition, for instance, encorafenib (Braftovi™, ENF) plus binimetinib (Mektovi®, BNB), are now recommended as first-line treatment in patients with unresectable or metastatic melanoma with a...
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle loss, leading to difficulties in movement. Mutations in the DMD gene that code for the protein dystrophin are responsible for the development of D...
Exploring tazarotene, a third-generation retinoid for potential hand osteoarthritis treatment, this study presents the development and validation of an ultra-performance liquid chromatography with quadrupole detector mass spectrometry (UPLC-QDa) meth...
This study aimed to elucidate stage-specific dynamics, assembly mechanisms, and functional roles of bacterial communities during Macrobrachium rosenbergii larval development through high-resolution microbiota profiling. A high-frequency sampling stra...
Cytological evaluation of lymph nodes (LN) in canine cutaneous mast cell tumors (MCT) has a key role in MCT staging. However, cytological discrimination between metastatic and reactive LNs is debated and diagnostic criteria inconsistent. The aim of t...
A rapid, simple, and sensitive gas chromatography–tandem mass spectrometry (GC–MS) method was established and validated for simultaneous determination of four volatile compounds, namely curzerene, methoxyfuranodiene, β-elemene, and &...
Household food waste accounts for the most significant part of total food waste in economically developed countries. In recent times, this issue has gained recognition in the international research community and policy making. In light of the Sustain...
Monitoring the quantity and quality of metals in lake water is a major part of assessing water toxicity. A fundamental aspect of geochemical monitoring studies is the evaluation of the equilibrium distribution of metal speciation in water and the inf...
Manual assembly operations are sensitive to human errors that can diminish the quality of final products. The paper shows an application of human reliability analysis in a realistic manufacturing context to identify where and why manual assembly erro...
The front-face fluorescence spectroscopy technique was used to establish a rapid prediction model of riboflavin concentration in milk without prior sample preparation. The prediction model developed was then compared with two conventional high perfor...
Urbanization proceeds globally and is often driven by migration. Simultaneously, cities face severe exposure to environmental hazards such as floods and heatwaves posing threats to millions of urban households. Consequently, fostering urban household...
Leakage is a common phenomenon in dams, and its early detection is critical for dam safety. In the present study, a new method based on tracer tests is applied to detect and quantify leakage in the Wanyao Dam, Jiangshan City, China. The objective is...
Type I interferons (IFNs) are cytokines with both antiviral properties and protective roles in innate immune responses to viral infection. They induce an antiviral cellular state and link innate and adaptive immune responses. Yet, viruses have evolve...
25 October 2022
Considering that the promotion of new-energy vehicles (NEVs) is a potential measure to address urban air pollution, the Chinese government has launched subsidy schemes to improve its market penetration. The purpose of this study is to quantify the ec...
After a mine water inrush occurs, it is crucial to quickly identify the source of the water inrush and the key control area, and to formulate accurately efficient water control measures. According to the differences in water chemical characteristics...
of 235