Metabolic reprogramming is one of the hallmarks of a tumor. It not only promotes the development and progression of tumor but also contributes to the resistance of tumor cells to chemotherapeutics. The difference in the metabolism between drug-resist...
Cholangiocarcinoma (CCA) is a malignant tumor originating from cholangiocyte. Prolonged alcohol consumption has been suggested as a possible risk factor for CCA, but there is no information about alcohol’s mechanisms in cholangiocyte. This stud...
Secondary glaucoma is a typical normal tissue complication following radiation therapy involving ocular radiation exposure at high fractionated dose (several tens of Gy). In contrast, recent studies in acutely exposed Japanese atomic bomb survivors s...
The development of construction materials with the integration of phase change materials (PCMs) has been a topic of wide interest in the scientific community, especially in recent years, due to its positive impact on temperature regulation inside bui...
Hyperspectral imaging (HSI) is increasingly used in studies for medical applications as it provides both structural and functional information of biological tissue, enhancing diagnostic accuracy and clinical decision-making. Recently, HSI cameras (HS...
Highway–rail grade crossing (HRGC) safety research relies on federal incident and inventory datasets that span multiple decades. However, inconsistencies in geographic identifiers and incomplete reconstruction of crossing denominators can disto...
Highway–rail grade crossing (HRGC) safety analysis is often based on raw incident counts or site-level models that do not adequately control for regional crossing-density exposure and frequently ignore spatial dependence. This limits the abilit...
On 6 February 2023, an M7.8 devastating earthquake started rupturing the East Anatolian fault system in Turkey, resulting in intense shaking that lasted over a minute. A second earthquake of magnitude 7.5 struck near the city of Elbistan a few hours...
To address the difficulty that cross-domain morphing vehicles are prone to infeasibility in complex environments with dense hard-constraint no-fly zones, a three-dimensional no-fly zone modeling approach based on a soft-constraint normalized threat m...
The selection of a stably expressed reference gene is a critical step for the quantitation of gene expression by qRT-PCR. We tested the stability of expression of nine putative reference genes in normoxia and hypoxia in four different human cell type...
Microplastics are emerging pollutants that have garnered significant attention, with evidence suggesting their association with the pathogenesis of type 2 diabetes mellitus. In order to assess the impact of polystyrene microplastic exposure on altera...
High dynamic range (HDR) has wide applications involving intelligent vision sensing which includes enhanced electronic imaging, smart surveillance, self-driving cars, intelligent medical diagnosis, etc. Exposure fusion is an essential HDR technique w...
8 March 2019
Environmental health studies on green space may be affected by contextual uncertainties originating from the temporality of environmental exposures and by how the spatial context is delimitated. The Normalized Difference Vegetation Index (NDVI) is fr...
Urban heat exposure has become an increasingly critical environmental issue under the dual pressures of global climate warming and rapid urbanization, posing significant threats to public health and urban sustainability. However, conventional linear...
The daily path of the Sun across longitude yields night and day, but the Sun also travels across latitude on a belt 47° wide. The solar meridian declination explains the latitudinal budget of natural beam irradiance (NBI), which is defined as the...
Background: This up-to-date narrative review examines the associations of low environmental exposure to toxic trace elements—arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg)—on pregnancy. While high levels are known to be harmful,...
Young adults with normal hearing may exhibit risk factors for hearing loss. The purpose of this study was to evaluate how self-reported personal music (PM) system volume use, preferred listening level, and self-reported alcohol use affects distortion...
The QT interval occupies a pivotal role in drug development as a surface biomarker of ventricular repolarization. The electrophysiologic substrate for QT prolongation coupled with reports of non-cardiac drugs producing lethal arrhythmias captured wor...
3D sound propagation modeling in the context of acoustic noise monitoring problems is considered. A technique of effective source spectrum reconstruction from a reference single-hydrophone measurement is discussed, and the procedure of simulation of...
Some reinforced concrete structures must be repaired at an early stage in their life due to the oxidation processes suffered by their reinforcements; such processes involve serious pathologies that affect the stability and safety of buildings. Spanis...
Colorectal cancer is a common cancer with a poor prognosis in both males and females. The influence of bisphenol A (BPA), a widely used environmental contaminant, in colon cancer development and progression is not well identified, in spite of the fac...
1 April 2022
Patients with NTG or POAG with more than one outpatient or discharge diagnosis from the ophthalmology department were included in the study. These data were merged with the PM2.5 data from the Air Quality Monitoring Network for analysis. This was a c...
Fourier transform infrared micro-spectroscopy (μ-FT-IR) is nowadays considered a valuable tool for investigating the changes occurring in human cells after exposure to ionizing radiation. Recently, considerable attention has been devoted to the us...
In recent years, there has been an increasing number of fires in buildings. The methods for detecting residual properties of buildings after fires are commonly destructive and subjective. In this context, property prediction based on mathematical mod...
The utilization of sustainable cement replacement materials in concrete can control the emission of carbon dioxide and greenhouse gases in the construction industry, thus contributing significantly to the environment, society, and the global economy....
The objective of the study was to assess the safety of the HyperSound® Audio System (HSS), a novel audio system using ultrasound technology, in normal hearing subjects under normal use conditions; we considered preexposure and post-exposure test desi...
Background and Objectives: The relationship between depression in tinnitus patients without hearing loss remains elusive. This study aimed to investigate the association between tinnitus and normal hearing and depression. Materials and Methods: Parti...
Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major...
Transcription factors bind specific DNA motifs to regulate the expression of target genes in order to maintain normal hematopoiesis [...]
There is ongoing debate as to whether or not α-hydroxyisocaproic acid (HICA) positively regulates skeletal muscle protein synthesis resulting in the gain or maintenance of skeletal muscle. We investigated the effects of HICA on mouse C2C12 myotubes u...
Adolescence is hallmarked by two parallel processes of sexual maturation and adult patterning of the brain. Therefore, adolescence represents a vulnerable postnatal period for neurodevelopment where exogenous factors can negatively impact adult brain...
Background: The relationship between general anesthesia (GA) exposure and cognitive function remains controversial. This study aimed to investigate the association between GA exposure and cognitive severity, as measured using the Clinical Dementia Ra...
Reference genes are crucial in molecular biological studies as an internal control for gene re-search as they exhibit consistent expression patterns across many tissue types. In canines, radiation therapy is the most important therapeutic tool to cur...
With the increasing application of nanomaterials in aerospace technology, the long-term space exposure to nanomaterials especially in the space full of radiation coupled with microgravity condition has aroused great health concerns of the astronauts....
Several epidemiological studies concluded that inhalation of diesel exhaust particles (DEP) is associated with an increase in the relative risk of lung cancer. In vitro research evaluating the genetic damage and/or changes in gene expression have bee...
While light at night (LAN) and noise levels have been linked to suboptimal sleep outcomes, little is known about the link between these factors and long-term suboptimal sleep trajectories. The current study examined the association of neighborhood LA...
Synthetic amorphous silica is one of the most used nanomaterials, and numerous toxicological studies have studied its effects. Most of these studies have used an acute exposure mode to investigate the effects immediately after exposure. However, this...
Development of drugs that are selectively toxic to cancer cells and safe to normal cells is crucial in cancer treatment. Evaluation of membrane permeability is a key metric for successful drug development. In this study, we have used in silico molecu...
22 July 2026
Background: “Third-hand” exposure produced by “second-hand” environmental vaping aerosol (EVA) has been reported as a parallel analogue of “third-hand smoke” (THS) produced by residues of environmental tobacco smok...
The association between aluminum exposure and obesity remains uncertain. This study investigated whether aluminum exposure (dietary, serum, and urinary) is linked to obesity and whether dietary antioxidant capacity moderates this relationship. A tota...
It is unclear whether normal human skin tissue or abnormal scarring are photoreceptive. Therefore, this study investigated photosensitivity in normal skin tissue and hypertrophic scars. The expression of opsins, which are photoreceptor proteins, in n...
A substantial percentage of pregnant smokers stop using traditional cigarettes and switch to alternative nicotine-related products such as e-cigarettes. Prenatal exposure to tobacco increases the risk of psychiatric disorders in children. Adolescence...
Per-layer UV exposure during 3D printing may influence polymerization and the biological response of photocurable aligner resins. This study evaluated exposure-dependent cytotoxicity of Tera Harz TC-85 and NextDent Ortho Flex and performed an explora...
23 March 2015
Background: A few studies have suggested an association between prenatal exposure to methylmercury and decreased heart rate variability (HRV) related to autonomic heart function, but no study has examined this association using baroreflex sensitivity...
Transcription factors control genes to maintain normal hemopoiesis, and dysregulation of some factors can lead to acute lymphoblastic leukemia (ALL). Mycoviruses are known to alter the genetics of their fungal host. The present study evaluates the ef...
Cadmium accumulation in the body can damage a variety of organs and impair their development and functions. In the present study, we investigated the effect of cadmium on the stemness and proliferation of normal bovine mammary epithelial cells (BMECs...
The link between melanoma development and the use of oral combined contraceptives is not fully elucidated, and the data concerning this issue are scarce and controversial. In the present study, we show that the components of oral contraceptives, ethi...
The existence of considerable interpatient variability in pharmacokinetic exposure necessitates dose adjustment to avoid potential adverse events and suboptimal efficacy in targeted therapy. Exposure–response relationships for toceranib phospha...
Phthalates and bisphenol A are recognized as the predominant endocrine-disrupting substances (EDCs) in the environment, but their impact on sleep health remains unclear. Vitamin D has often been reported to play a role in sleep health and may be affe...
In this paper, the use of HVAC systems and non-HVAC control measures to reduce virus-laden bioaerosol exposure in a highly occupied indoor space is investigated. A simulation tool was used to model the fate and transport of bioaerosols in an indoor s...
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