Cell Targets and Toxicity

Dear Colleagues,

Cell toxicity plays an important role in many aspects in biomedicine; the nature and severity of toxicity constitute a very important role in helping to understand basic issues in biological and biomedical processes. Physiologically, cells may deliberately die when are damaged or when they have to be removed to protect a tissue from the accumulation of unwanted cells. In addition, cell toxicity constitutes the main objective in many medical therapies, particularly in cancer, including radiotherapy, chemotherapy, phototherapy or immunotherapy. However, molecular mechanisms of such therapies are not always fully elucidated. Cell response to a determined insult is also related with the mechanisms of endogenous protective systems and, therefore, understanding such mechanisms also improves knowledge of basic cell biology and cancer cell therapies.

This Special Issue is focused on cell toxicity and it would include original articles on aspects related with molecular mechanisms of cell toxicity induced by different insults, mainly cancer therapies, and the ways in which this can lead to cell death. Potential topics include, but are not limited to, physical and chemical insults, intracellular targets, reactive oxygen species, detoxication systems, cell response (cell death mechanisms) and stem cells in toxicity.

Prof. Dr. Ángeles Juarranz de la Fuente
Guest Editor

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