Background. Interferon is a marker of host antiviral immunity, which is disordered in COVID-19 patients. ERV can affect the secretion of interferon through the cGAS-STING pathway. In this study, we explored whether IFN-I and HERV-K (HML-2) were activ...
Human endogenous retroviruses (HERVs) comprise a significant portion of the human genome, making up roughly 8%, a notable comparison to the 2–3% represented by coding sequences. Numerous studies have underscored the critical role and importance...
Human endogenous retrovirus (HERV-K (HML-2)) proviruses are among the few endogenous retroviral elements in the human genome that retain coding sequence. HML-2 expression has been widely associated with human disease states, including different types...
This review investigates the intricate role of human endogenous retroviruses (HERVs) in cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper sheds light on the latest research advancements and potential treatment stra...
The HERV-K(HML-2) family contains the most recently integrated and best preserved endogenized proviral sequences in the human genome. All known elements have nevertheless been subjected to mutations or deletions that render expressed particles non-...
Background: HML-2 subgroup mobile genetic elements of the HERV-K family were described to participate in carcinogenesis processes, but their expression and epigenetic regulation in molecular subtypes of colorectal cancer (CRC) remain partly character...
Endogenous retroviruses (ERVs) are related to long terminal repeat (LTR) retrotransposons, comprising gene sequences of exogenous retroviruses integrated into the host genome and inherited according to Mendelian law. They are considered to have contr...
Endogenous Retroviruses (ERVs) are ancient relics of infections that affected the primate germ line and constitute about 8% of our genome. Growing evidence indicates that ERVs had a major role in vertebrate evolution, being occasionally domesticated...
Human endogenous retrovirus (HERV) expression is currently studied for its possible activation by HIV infection. In this context, the HERV-K(HML2) group is the most investigated: it has been proposed that HIV-1 infection can prompt HML2 transcription...
Among the different activities of the AEC (Architecture, Engineering, and Construction) sector, the documentation phase is pivotal and covers the entire lifecycle of a building or infrastructure. In the last decade, in the geomatic field, technology...
About 8% of our genome is composed of sequences from Human Endogenous Retroviruses (HERVs). The HERV-K (HML.2) family, here abbreviated HML.2, is able to produce virus particles that were detected in cell lines, malignant tumors and in autoimmune dis...
Chronic hepatitis C virus (HCV) infection is closely associated with a plethora of diseases, including cancers and autoimmune disorders. However, the distinct triggers and cellular networks leading to such HCV-derived diseases are poorly understood....
The pluripotent stem cell (PSC)-derived human primordial germ cell-like cells (PGCLCs) are a cell culture-derived surrogate model of embryonic primordial germ cells. Upon differentiation of PSCs to PGCLCs, multiple loci of HML-2, the hominoid-specifi...
Human endogenous retroviruses (HERVs), which are critical to normal embryologic development and downregulated during normal maturation, have been implicated in a variety of cancers. Abnormal persistent production of HERVs has been suggested to play a...
High-precision retrieval of rainfall over large areas is of great importance for the research of atmospheric detection and the social life. With the rapid development of communication satellite constellations and 5G communication networks, the use of...
Forests are invaluable natural resources that provide essential ecosystem services, and their carbon storage capacity is critical for climate mitigation efforts. Quantifying this capacity would require accurate estimation of forest structural attribu...
In this study, we evaluated the capability of an unmanned aerial vehicle with a LiDAR sensor (UAV-LiDAR) to classify and map fuel types based on the Prometheus classification in Mediterranean environments. UAV data were collected across 73 forest plo...
The exposure of Mediterranean forests to large wildfires requires mechanisms to prevent and mitigate their negative effects on the territory and ecosystems. Fuel models synthesize the complexity and heterogeneity of forest fuels and allow for the und...
The application of static terrestrial laser scanning (TLS) in forest inventories is becoming more effective. Nevertheless, the occlusion effect is still limiting the processing efficiency to extract forest attributes. The use of a mobile laser scanne...
This study aims to evaluate the feasibility of using non-contact data collection methods—specifically, UAV (unmanned aerial vehicle)-based and terrestrial laser scanning technologies—to assess forest stand passability, which is crucial fo...
Forests play a critical role in biodiversity and in the conservation of ecosystems. Reliable and efficient forest inventories are therefore essential for sustainable forest management. Handheld mobile laser scanning (HMLS) is operationally attractive...
In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from health...
HML6-c14, a long terminal repeat (LTR)-type retrotransposon identified by expressed sequence tag (EST) database screening, was found to undergo RNA processing resembling that of placental tissue by in vitro expression analysis. Previous in situ hybri...
Glioblastoma (GBM) is an exceedingly aggressive primary brain tumor defined by rapid growth, extensive infiltration, and resistance to standard therapies. A central factor driving these malignancies is the subpopulation of glioblastoma stem cells (GS...
Coastal environments are fragile ecosystems threatened by various factors, both natural and anthropogenic. The preservation and protection of these environments, and in particular, the sand dune systems, which contribute significantly to the defense...
Housefly maggot larvae (HML) have been identified as a potential alternative animal diet for the fattening process of the Chinese mitten crab (Eriocheir sinensis). However, the feasibility and potential impacts of HML supplementation require further...
Precise forest inventory is the key to sustainable forest management. LiDAR technology is widely applied to tree attribute extraction. Therefore, this study compared DBH and tree height derived from Handheld Mobile Laser Scanning (HMLS), Airborne Las...
The capybara, Hydrochoerus hydrochaeris, is the largest extant rodent of the world. To better understand the correlation between size and body mass, and biochemical parameters of capybaras from areas with different degrees of anthropization (i.e., di...
In this study, we evaluated the performance of GeoSLAM ZEB Horizon and Stonex X120GO SLAM handheld mobile laser scanners (HMLS) to address two primary objectives. First, we aimed to assess and compare the accuracy of positioning achieved using HMLS i...
Background/Objectives: Advancing information on the key physicochemical properties of biologically active substances enables the development of formulations with reduced dosing, lower toxicity, and minimal adverse effects. This work addresses the kno...
Human endogenous retroviruses (HERVs) originate from ancient retroviral integration into the primate germline. Although most are defective proviruses, the most recently endogenized groups, like the HERV-K family, retain intact ORFs encoding retrovira...
Soybean root rot is an important disease that has affected soybean crops in recent years, but the available control methods still do not provide good protection for soybeans. In this study, three biodegradable mulch films (HML@CMCS, HML@PVA, HML@CMCS...
Forest measurements using conventional methods may not capture all the important information required to properly characterize forest structure. The objective of this study was to develop a low-cost alternative method for forest inventory measurement...
The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelop...
Ensuring a reliable and uninterrupted supply of electricity is crucial for sustaining modern and advanced societies. Traditionally, power systems analysis was mostly dependent on formal commercial software, mathematical models produced via a mix of d...
Nowadays, forest inventories are frequently carried out using a combination of field measurements and remote sensing data, often acquired with light detection and ranging (LiDAR) sensors. Several studies have investigated how three-dimensional laser...
Accurate and efficient forest inventory methods are crucial for monitoring forest ecosystems, assessing carbon stocks, and supporting sustainable forest management. Traditional field-based techniques, which rely on manual measurements such as diamete...
The Oostvaardersplassen nature reserve in the Netherlands is grazed by large herbivores. Due to their increasing numbers, the area became dominated by short grazed grasslands and biodiversity decreased. From 2018, the numbers are controlled to create...
Handheld mobile laser scanning (HMLS) can quickly acquire point cloud data, and has the potential to conduct forest inventory at the plot scale. Considering the problems associated with HMLS data such as large discreteness and difficulty in classific...
Hybrid machine learning encompasses predefinition of rules and ongoing learning from data. Human organizations can implement hybrid machine learning (HML) to automate some of their operations. Human organizations need to ensure that their HML impleme...
There is limited information on the impact of dietary supplementation with separate rumen-protected (RP) amino acids (AA), or with their combination, on ewes’ oxidative status. Sixty ewes were divided into five groups; C: basal diet (control); M: bas...
This study aimed to determine the effect of deep-sea water (DSW)-derived mineral waters on intestinal health, using a cell model and a dextran sulfate sodium (DSS)-induced enteritis mouse model. DSW was desalted and minerals were added to generate mi...
In this paper, we give an efficient way to calculate the values of the Mittag–Leffler (h-ML) function defined in discrete time
Human endogenous retrovirus-K (HERV-K) is the most recently integrated retrovirus in the human genome, with implications for multiple disorders, including cancer. Although typically transcriptionally silenced in normal adult cells, dysregulation of H...
An eight-week feeding trial was conducted to investigate methionine and lysine supplementation on the growth performance, body composition, antioxidant index and protein synthesis-related gene expression of the FFCR No. 2 strain common carp (Cyprinus...
A handheld mobile laser scanning (HMLS) approach to forest inventory surveying allows virtual reconstructions of forest stands and extraction of key structural parameters from beneath the canopy, significantly reducing survey time when compared again...
The Hibiscus manihot L. (HML) Medic, an edible hibiscus of the Malvaceae family, is abundant with flavonoids. The study investigated how Rhizopus-arrhizus-31-assisted pretreatment affects the extraction and bioactivity of flavonoids from HML. The fib...
6 November 2023
Methotrexate (MTX) is the cornerstone of therapy in the treatment of rheumatoid arthritis (RA). However, its efficacy and toxicity are variable and remain unpredictable. Interindividual variation in the metabolism of MTX by the enzyme folyl polygluta...
This study investigated the effect of mineral-balanced deep-sea water (DSW) on kidney health using an animal model of kidney injury due to a high-sodium diet. High magnesium/low sodium (HMLS) and high magnesium/high calcium (HMHC) DSW samples with di...
Gastric ulcers are often exacerbated by factors such as nonsteroidal anti-inflammatory drugs (NSAIDs) and inflammation, and they have a substantial impact on a significant portion of the population. Notably, indomethacin is recognized as a prominent...
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