Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 31 May 2026
Special Issue Editors
Interests: arboviruses; emerging pathogens; viral-host interactions; functional virology; human virome
Special Issues, Collections and Topics in MDPI journals
Interests: human virome; viral metagenomics; molecular virology; genomic surveillance; viral diversity
Special Issues, Collections and Topics in MDPI journals
Interests: emerging viruses; viral-host interactions; in vitro viral infection; functional virology; human virome
Special Issue Information
Dear Colleagues,
The human virome constitutes a dynamic and integral component of the host ecosystem, continuously interacting with both the immune system and the microbiota. These interactions influence immune regulation, inflammation, and overall physiological homeostasis.
Recent advances in molecular and metagenomic technologies, together with functional virology and systems biology approaches, are providing unprecedented insights into the composition, evolution, and biological activity of viral communities.
This Special Issue aims to collect high-quality studies that explore the molecular and functional characterization of the human virome and its emerging components. We particularly welcome contributions that elucidate mechanistic virome–host and virome–microbiota interactions, immune-modulatory pathways, and functional assays that validate omics-based discoveries.
By integrating metagenomic profiling, molecular immunology, and experimental virology, this Special Issue seeks to advance a comprehensive understanding of viral dynamics and their impact on human health and disease.
Topics of Interest:
- Molecular and metagenomic characterization of the human virome;
- Functional analysis of virome–host and virome–microbiota interactions;
- Molecular mechanisms of immune modulation and signaling;
- Application of omics and bioinformatics to functional virology;
- Experimental models for studying viral persistence and host response;
- Pseudovirus and cell-based assays for mechanistic investigations;
- Molecular evaluation and screening of antiviral compounds;
- Integration of molecular, genomic, and immunological data in virome studies.
Dr. Luigi Rosa
Dr. Pietro Giorgio Spezia
Dr. Davide Mariotti
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- human virome
- molecular virology
- functional virology
- metagenomics
- virus–host interactions
- immune modulation
- pseudovirus assays
- antiviral screening
- omics integration
- molecular immunology
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