The Pivotal Role of Tumor Stem Cells in Glioblastoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 7230
Special Issue Editors
Interests: inflammation; glioma; cancer stem cells; tumor biology; cyclooxygenase-2; nitric oxide synthase 2
Special Issues, Collections and Topics in MDPI journals
Interests: dicarbonyl stress; oxidative stress; mitochondrial metabolism
Special Issue Information
Dear Colleagues,
We are delighted to announce the launch of a Special Issue of Cells on all aspects related to the theme of “The Pivotal Role of Tumor Stem Cells in Glioblastoma”. We invite you to contribute original research articles or reviews to share your cutting-edge research, insights, and innovation on new mechanistic, functional, cellular, biochemical, or general evidence of cancer stem cells in glioblastoma.
Glioblastoma is one of the most complex, fast-growing, aggressive, and treatment-resistant cancers with an extremely poor prognosis. The latest therapeutic approaches are rarely effective due to the presence of tumor stem cells (TSC) that play a crucial role in resistance and recurrence.
TSCs can also strongly affect the tumor microenvironment, influencing all neighboring resident cell fate by genetic reprogramming and inducing some key stemness features. The precise molecular mechanisms underlying the intricate scenario of TSC are not yet fully understood. A deeper understanding of the TSCs' molecular and biological features could certainly allow us to define new, targeted, and more effective therapeutic approaches to overcome cancer resistance to improve survival rate and treatment response.
We look forward to your contributions.
Dr. Paola Palumbo
Dr. Silvano J. Santini
Guest Editors
Manuscript Submission Information
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Keywords
- glioblastoma stem cells
- resistance
- cancer therapy
- signaling pathways
- tumor microenvironment
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