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1,025 Results Found

  • Article
  • Open Access
1 Citations
972 Views
18 Pages

The Dietary Inflammatory Index and Incident Risk of Type 2 Diabetes Mellitus: Interactions with Obesity and Dyslipidemia in a Prospective Cohort Study

  • Jinliang Liang,
  • Xueru Fu,
  • Yuying Wu,
  • Taifeng Chen and ,
  • Yaqin Su,
  • Li Yang,
  • Minqi Gu,
  • Liuding Wen,
  • Yang Zhao and
  • Ming Zhang
  • + 10 authors+ 5 authors

25 February 2026

Objectives: To explore the association between the dietary inflammatory index (DII) and type 2 diabetes mellitus (T2DM) risk and to evaluate potential interactions of obesity and dyslipidemia in the context of this association. Methods: This cohort s...

(This article belongs to the Section Nutritional Epidemiology)
  • Article
  • Open Access
593 Views
17 Pages

Joint Association of Hydration Status and Sleep Quality with Type 2 Diabetes Mellitus in a Population-Based Study

  • Miaolin Han,
  • Yixi Zhang,
  • Na Zhang,
  • Changyou Zhao and ,
  • Limin He,
  • Jingyue Guo,
  • Qiuyun Cheng,
  • Guotian Lin and
  • Fan Zhang
  • + 4 authors+ 0 author

7 September 2026

Objectives: To examine the joint association of hydration status and sleep quality with prevalent type 2 diabetes mellitus (T2DM) and to quantify their additive and multiplicative interactions. Methods: This cross-sectional study included 4762 partic...

(This article belongs to the Special Issue Importance of Diet and Lifestyle in Type 2 Diabetes)
  • Article
  • Open Access
17 Citations
9,112 Views
15 Pages

15 July 2013

Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod...

(This article belongs to the Collection Bioactive Compounds from Marine Plankton)
  • Article
  • Open Access
1,011 Views
16 Pages

Drug Safety in Hospitalized Diabetes Patients: A Retrospective Analysis of Predictors and Clinical Relevance of Potential Drug–Drug Interactions

  • Muhammad Adil Khan,
  • Nadia Farhanah Syafhan,
  • Sidra Noor,
  • Mohammed S. Alshammari and ,
  • Meshal Alotaibi,
  • Waad Alrohily,
  • Abdulaziz H. Alanazi,
  • Wael A. Alsubhi,
  • Latifah Al Shammari and
  • Ashfaq Ahmad
  • + 6 authors+ 1 author

Background: Diabetes mellitus is frequently associated with complications and comorbidities that often require hospitalization and the use of multiple medications for effective management. However, the simultaneous use of these treatments significant...

  • Article
  • Open Access
2 Citations
959 Views
22 Pages

RdDM-Dependent Epigenetic Regulation Coordinates Systemic Immunity and Compatibility with Trichoderma atroviride in Arabidopsis thaliana

  • Maria Montserrat Rosendo-Vargas,
  • Valeria Ávila-Castillo,
  • Kumari Rashmi and
  • Sergio Casas-Flores

Epigenetic regulation plays a central role in modulating plant immune responses and interactions with beneficial microbes. In this study, we investigated the contribution of RNA-directed DNA methylation (RdDM) components—DCL3; AGO9; DCL1; and t...

(This article belongs to the Special Issue Endophytic Fungus as Producers of New and/or Bioactive Substances, Second Edition)
  • Review
  • Open Access
3 Citations
3,399 Views
21 Pages

Epigenetic and Epitranscriptomic Antiviral Responses in Plants for Disease Management

  • Islam Hamim,
  • Sadman Jawad Sakib,
  • Md. Readoy Hossain,
  • Jaima Noor Hia and ,
  • Maria Hasan,
  • Alvi Al Muhimine and
  • John S. Hu
  • + 2 authors+ 0 author

22 December 2025

Plant viral diseases cause significant agricultural losses worldwide and are shaped by complex virus-host and virus-virus interactions. Unlike fungal or bacterial pathogens, viruses cannot be directly controlled with chemicals, and their management r...

(This article belongs to the Special Issue Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition)
  • Article
  • Open Access
3 Citations
2,713 Views
16 Pages

Presence of Induced Weak Ferromagnetism in Fe-Substituted YFexCr1−xO3 Crystalline Compounds

  • Roberto Salazar-Rodriguez,
  • Domingo Aliaga Guerra,
  • Jean-Marc Greneche,
  • Keith M. Taddei and ,
  • Noemi-Raquel Checca-Huaman,
  • Edson C. Passamani and
  • Juan A. Ramos-Guivar
  • + 2 authors+ 0 author

8 October 2022

Fe-substituted YFexCr1−xO3 crystalline compounds show promising magnetic and multiferroic properties. Here we report the synthesis and characterization of several compositions from this series. Using the autocombustion route, various compositio...

(This article belongs to the Special Issue Nanoscale Ferroic Materials—Ferroelectric, Piezoelectric, Magnetic, and Multiferroic Materials)
  • Review
  • Open Access
16 Citations
6,142 Views
8 Pages

The Cajal Body in Plant-Virus Interactions

  • Yi Ding and
  • Rosa Lozano-Durán

23 February 2020

Cajal bodies (CBs) are nuclear membraneless bodies composed of proteins and RNA. Although it is known that CBs play a role in RNA metabolism and the formation of functional ribonucleoprotein (RNP) particles, the whole breadth of CB functions is far f...

(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
  • Article
  • Open Access
9 Citations
5,067 Views
9 Pages

3-Form Cosmology: Phantom Behaviour, Singularities and Interactions

  • João Morais,
  • Mariam Bouhmadi-López and
  • João Marto

The latest cosmological observations by the Planck collaboration (and combined with others) are compatible with a phantom-like behaviour ( w < − 1 ) for the dark energy equation of state that drives the current acceleration of the Universe....

(This article belongs to the Special Issue Varying Constants and Fundamental Cosmology)
  • Article
  • Open Access
4 Citations
3,818 Views
8 Pages

Spin Reorientation Transition and Negative Magnetoresistance in Ferromagnetic NdCrSb3 Single Crystals

  • Lei Chen,
  • Weiyao Zhao,
  • Zhaocai Wang,
  • Fang Tang and ,
  • Yong Fang,
  • Zhuo Zeng,
  • Zhengcai Xia,
  • Zhenxiang Cheng,
  • David L. Cortie and
  • Renkui Zheng
  • + 7 authors+ 2 authors

20 February 2023

High-quality NdCrSb3 single crystals are grown using a Sn-flux method, for electronic transport and magnetic structure study. Ferromagnetic ordering of the Nd3+ and Cr3+ magnetic sublattices are observed at different temperatures and along different...

  • Review
  • Open Access
15 Citations
5,917 Views
17 Pages

15 June 2024

In the field of human health research, the homeostasis of copper (Cu) is receiving increased attention due to its connection to pathological conditions, including diabetes mellitus (DM). Recent studies have demonstrated that proteins associated with...

(This article belongs to the Special Issue Small-Molecule Inhibitors: Synthesis, Cytotoxicity and Biological Activities)
  • Article
  • Open Access
12 Citations
4,829 Views
9 Pages

Health Behaviors as a Mediator of the Association Between Interpersonal Relationships and Physical Health in a Workplace Context

  • Maria Alzira Pimenta Dinis,
  • Helder Fernando Pedrosa Sousa,
  • Andreia de Moura,
  • Lilian M. F. Viterbo and
  • Ricardo J. Pinto

The etiology of diseases is multifactorial, involving genetic, environmental, and lifestyle-related behaviors. Considering the pathway that involves behavioral processes, a huge body of empirical evidence has shown that some healthy behaviors such as...

(This article belongs to the Special Issue Workplace Health and Wellbeing 2019)
  • Article
  • Open Access
10 Citations
3,443 Views
21 Pages

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy

  • Silvia Diviccaro,
  • Lucia Cioffi,
  • Rocco Piazza,
  • Donatella Caruso and ,
  • Roberto Cosimo Melcangi and
  • Silvia Giatti
  • + 1 author+ 0 author

29 August 2023

The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk of developing dementia. Although several factors have been...

(This article belongs to the Special Issue Role of Neuroactive Steroids in Health and Disease)
  • Article
  • Open Access
1,659 Views
21 Pages

14 February 2025

Thermal relics with masses in the GeV to TeV range remain possible candidates for the Universe’s dark matter (DM). These neutral particles are often assumed to have vanishing electric and magnetic dipole moments so that they do not interact wit...

(This article belongs to the Section High Energy Nuclear and Particle Physics)
  • Feature Paper
  • Article
  • Open Access
8 Citations
3,853 Views
16 Pages

10 November 2021

The etiologies of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) are similar. Genetic and environmental factors interact to influence the risk of both types of diabetes. We aimed to determine if the polygenetic risk scores (P...

(This article belongs to the Special Issue Pregnancy Complication and Precision Medicine)
  • Article
  • Open Access
1,687 Views
14 Pages

31 August 2023

This paper introduces a comprehensive methodology for examining the stability of dark matter (DM) halos, emphasizing the necessity for non-local inter-particle interactions, whether they are fundamental or effective in nature, to maintain halo stabil...

(This article belongs to the Section Cosmology)
  • Review
  • Open Access
82 Citations
26,189 Views
32 Pages

Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis

  • Genoveva Berná,
  • María Jesús Oliveras-López,
  • Enrique Jurado-Ruíz,
  • Juan Tejedo and ,
  • Francisco Bedoya,
  • Bernat Soria and
  • Franz Martín
  • + 2 authors+ 0 author

21 November 2014

Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not...

(This article belongs to the Special Issue Nutrient: Gene Interactions)
  • Review
  • Open Access
23 Citations
9,757 Views
20 Pages

Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors

  • Panagiotis Theofilis,
  • Evangelos Oikonomou,
  • Konstantinos Tsioufis and
  • Dimitris Tousoulis

10 February 2023

Diabetes mellitus (DM) and heart failure (HF) are frequently encountered afflictions that are linked by a common pathophysiologic background. According to landmark studies, those conditions frequently coexist, and this interaction represents a poor p...

(This article belongs to the Special Issue Cardiometabolic Disorders: From Pathophysiological Mechanism to Therapeutic Target)
  • Review
  • Open Access
67 Citations
17,165 Views
40 Pages

Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

  • Ángeles Ortega,
  • Genoveva Berná,
  • Anabel Rojas,
  • Franz Martín and
  • Bernat Soria

Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. Nutrients and dietary patter...

(This article belongs to the Special Issue Gene-Diet Interactions in Chronic Diseases)
  • Article
  • Open Access
1 Citations
1,732 Views
27 Pages

17 September 2025

Background/Objectives: Diabetic retinopathy is a leading cause of blindness in diabetic patients, with disease susceptibility influenced by both genetic and environmental factors. This study aimed to identify novel genetic variants associated with DR...

(This article belongs to the Section Nutrigenetics and Nutrigenomics)
  • Article
  • Open Access
35 Citations
5,266 Views
22 Pages

Association of Polygenic Variants with Type 2 Diabetes Risk and Their Interaction with Lifestyles in Asians

  • Haeng Jeon Hur,
  • Hye Jeong Yang,
  • Min Jung Kim,
  • Kyun-Hee Lee and ,
  • Myung-Sunny Kim and
  • Sunmin Park
  • + 1 author+ 0 author

6 August 2022

Over the last several decades, there has been a considerable growth in type 2 diabetes (T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low insulin secretion, β-cell mass, and inability to compensate for insuli...

(This article belongs to the Section Nutrigenetics and Nutrigenomics)
  • Article
  • Open Access
39 Citations
4,135 Views
19 Pages

T2DM etiology differs among Asians and Caucasians and may be associated with gut microbiota influenced by different diet patterns. However, the association between fecal bacterial composition, enterotypes, and T2DM susceptibility remained controversi...

(This article belongs to the Special Issue Microbiome and Metabolome in the Gastrointestinal Tract)
  • Article
  • Open Access
17 Citations
4,222 Views
18 Pages

An Insulin Receptor-Binding Multifunctional Protein from Tamarindus indica L. Presents a Hypoglycemic Effect in a Diet-Induced Type 2 Diabetes—Preclinical Study

  • Izael Costa,
  • Mayara Lima,
  • Amanda Medeiros,
  • Lucas Bezerra and ,
  • Paula Santos,
  • Alexandre Serquiz,
  • Maíra Lima,
  • Gerciane Oliveira,
  • Elizeu Santos and
  • Ana Heloneida Morais
  • + 7 authors+ 2 authors

25 July 2022

The objectives of this study were to evaluate the hypoglycemic effect of the trypsin inhibitor isolated from tamarind seeds (TTI) in an experimental model of T2DM and the in silico interaction between the conformational models of TTI 56/287 and the i...

(This article belongs to the Special Issue Advances in Diet and Human Nutrition)
  • Article
  • Open Access
22 Citations
4,439 Views
16 Pages

Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status

  • Lulu Wang,
  • Xue Liu,
  • Jian Hou,
  • Dandan Wei and ,
  • Pengling Liu,
  • Keliang Fan,
  • Li Zhang,
  • Luting Nie,
  • Xing Li and
  • Zhenxing Mao
  • + 9 authors+ 4 authors

30 December 2020

Numerous studies have investigated the associations between serum vitamin D or testosterone and diabetes; however, inconsistencies are observed. Whether there is an interaction between vitamin D and testosterone and whether the lipid profile (total c...

(This article belongs to the Special Issue Nutrition and Lipid Metabolism in Type 2 Diabetes)
  • Article
  • Open Access
37 Citations
4,955 Views
13 Pages

Exploring the Distribution and Impact of Bosonic Dark Matter in Neutron Stars

  • Davood Rafiei Karkevandi,
  • Mahboubeh Shahrbaf,
  • Soroush Shakeri and
  • Stefan Typel

3 March 2024

The presence of dark matter (DM) within neutron stars (NSs) can be introduced by different accumulation scenarios in which DM and baryonic matter (BM) may interact only through the gravitational force. In this work, we consider asymmetric self-intera...

  • Article
  • Open Access
1 Citations
1,441 Views
11 Pages

Diet–Gene Interaction Between Fruit Intake and CMIP rs2925979 Polymorphism in Relation to Type 2 Diabetes: A Family-Based Study in Northern China

  • Liangchun Kuo,
  • Yinxi Tan,
  • Yiqun Wu,
  • Xueying Qin and ,
  • Haiying Gong,
  • Yao Zhao,
  • Tao Wu,
  • Dafang Chen,
  • Mengying Wang and
  • Yonghua Hu
  • + 6 authors+ 1 author

24 May 2025

Background/Objectives: This study aimed to investigate the association between dietary intake and the risk of type 2 diabetes mellitus (T2DM) in a rural northern Chinese population, and to explore potential gene–diet interactions that may influ...

(This article belongs to the Section Nutritional Epidemiology)
  • Review
  • Open Access
13 Citations
6,332 Views
17 Pages

Gene–Diet Interactions in Diabetes Mellitus: Current Insights and the Potential of Personalized Nutrition

  • Angeliki Kapellou,
  • Effie Salata,
  • Dimitrios Miltiadis Vrachnos,
  • Sevastiani Papailia and
  • Spiros Vittas

14 May 2025

Type 2 diabetes mellitus (T2DM) remaina significant global health challenge, with its increasing prevalence and associated complications contributing to high morbidity and economic burden. Genetic factors play a crucial role in T2DM susceptibility, y...

(This article belongs to the Section Molecular Genetics and Genomics)
  • Article
  • Open Access
7 Citations
1,562 Views
14 Pages

We investigate the effects of dark matter (DM) on neutron star (NS) properties using the neutron decay anomaly model within the relativistic mean-field (RMF) framework. Three nucleonic models (HCD0–HCD2) are developed, satisfying astrophysical...

(This article belongs to the Section Compact Objects)
  • Article
  • Open Access
3 Citations
3,698 Views
16 Pages

Properties of Subhalos in the Interacting Dark Matter Scenario

  • Ángeles Moliné,
  • Jascha A. Schewtschenko,
  • Miguel A. Sánchez-Conde,
  • Alejandra Aguirre-Santaella and ,
  • Sofía A. Cora and
  • Mario G. Abadi
  • + 1 author+ 0 author

21 September 2019

One possible and natural derivation from the collisionless cold dark matter (CDM) standard cosmological framework is the assumption of the existence of interactions between dark matter (DM) and photons or neutrinos. Such a possible interacting dark m...

(This article belongs to the Special Issue The Role of Halo Substructure in Gamma-Ray Dark Matter Searches)
  • Article
  • Open Access
22 Citations
4,045 Views
14 Pages

13 November 2019

Deltamethrin (DM) is a toxic pesticide that is nonetheless widely used to control insect pests in agricultural production. Although the number of DM molecularly imprinted polymers (MIPs) is increasing in many scientific applications, the theoretical...

(This article belongs to the Special Issue Simulations of Polymers II)
  • Article
  • Open Access
37 Citations
5,456 Views
16 Pages

Dietary Copper and Selenium Intakes and the Risk of Type 2 Diabetes Mellitus: Findings from the China Health and Nutrition Survey

  • Zhixin Cui,
  • Haiyan Zhou,
  • Ke Liu,
  • Man Wu and ,
  • Shun Li,
  • Shuangli Meng and
  • Huicui Meng
  • + 2 authors+ 0 author

13 May 2022

The long-term associations between dietary copper (Cu) and selenium (Se) intakes and type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the prospective associations between dietary Cu and Se intakes and T2DM risk in Chinese adults....

(This article belongs to the Special Issue Minerals Metabolism and Human Health)
  • Article
  • Open Access
7 Citations
4,198 Views
16 Pages

18 January 2022

Protein kinases exert physiological functions through phosphorylating their specific substrates; however, the mode of kinase–substrate recognition is not fully understood. Rho-kinase is a Ser/Thr protein kinase that regulates cytoskeletal reorg...

(This article belongs to the Collection Recent Advances in Protein Phosphorylation)
  • Review
  • Open Access
94 Citations
14,498 Views
20 Pages

Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 (DM1) and 2 (DM2). Current disease models for DM1 and DM2 propose a common p...

(This article belongs to the Special Issue Myotonic Dystrophy: From Molecular Pathogenesis to Therapeutics)
  • Article
  • Open Access
2 Citations
3,078 Views
13 Pages

We investigated the relationship between diabetes family conflict and parental conflict on problem recognition in illness self-management (PRISM) among individuals with type 1 diabetes mellitus (T1DM). We employed a descriptive research design. Parti...

(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
  • Article
  • Open Access
306 Views
22 Pages

Asteroseismology of Neutron Stars with Axionlike Particle-Mediated Dark Matter

  • Pinku Routaray,
  • Rudra N. Sahoo,
  • Bharat Kumar and
  • M. Bhuyan

8 October 2026

We examine the impacts of dark matter (DM) on the observables of the neutron star (NS). The interaction of DM with nucleons is mediated by axionlike particles (ALPs), and the DM-admixed NS (DNS) is formulated in the framework of the relativistic mean...

(This article belongs to the Topic Dark Matter, Dark Energy and Cosmological Anisotropy)
  • Article
  • Open Access
6 Citations
2,490 Views
8 Pages

The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism

  • Diana Oliveira,
  • Teresa Brito,
  • Catarina Elias,
  • Marta Carreira and ,
  • Mariana Serino,
  • Inês Guerreiro,
  • Helena Magalhães,
  • Sara Coelho,
  • Sara Ferreira and
  • Patrícia Lourenço
  • + 7 authors+ 2 authors

30 October 2020

Diabetes mellitus (DM) predicts ominous outcomes in acute pulmonary embolism (PE). The influence of gender on the prognostic impact of DM in PE is unknown. We did a retrospective analysis of a cohort of patients hospitalized with PE between 2006 and...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
4 Citations
2,578 Views
16 Pages

Effect of Type-2 Diabetes Mellitus on the Expression and Function of Smooth Muscle ATP-Sensitive Potassium Channels in Human Internal Mammary Artery Grafts

  • Jovana Rajkovic,
  • Miodrag Peric,
  • Jelena Stanisic,
  • Milos Gostimirovic and ,
  • Radmila Novakovic,
  • Vladimir Djokic,
  • Snezana Tepavcevic,
  • Jelena Rakocevic,
  • Milica Labudovic-Borovic and
  • Ljiljana Gojkovic-Bukarica
  • + 5 authors+ 0 author

Here we have shown for the first time altered expression of the vascular smooth muscle (VSM) KATP channel subunits in segments of the human internal mammary artery (HIMA) in patients with type-2 diabetes mellitus (T2DM). Functional properties of vasc...

(This article belongs to the Special Issue Potassium Channels as Novel Therapeutic Targets)
  • Article
  • Open Access
15 Citations
4,477 Views
21 Pages

Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of Aspalathus linearis for Type-2 Diabetes Care

  • Ayesha Akoonjee,
  • Athika Rampadarath,
  • Christiana Eleojo Aruwa,
  • Taibat Arinola Ajiboye and ,
  • Abdulwakeel Ayokun-nun Ajao and
  • Saheed Sabiu
  • + 1 author+ 0 author

24 October 2022

The medicinal herb Aspalathus linearis (rooibos) is globally recognized in type-2 diabetes mellitus (T2DM) treatment due to its known and distinctive compounds. This work utilized network pharmacology (NP) coupled with molecular dynamics simulation i...

(This article belongs to the Special Issue Identification and Therapeutic Properties of Secondary Metabolites of Medicinal Plants)
  • Article
  • Open Access
17 Citations
8,456 Views
14 Pages

Polar Cooling Effect Due to Increase of Phytoplankton and Dimethyl-Sulfide Emission

  • Ah-Hyun Kim,
  • Seong Soo Yum,
  • Hannah Lee,
  • Dong Yeong Chang and
  • Sungbo Shim

1 October 2018

The effects of increased dimethyl-sulfide (DMS) emissions due to increased marine phytoplankton activity are examined using an atmosphere-ocean coupled climate model. As the DMS emission flux from the ocean increases globally, large-scale cooling occ...

(This article belongs to the Special Issue Aerosol-Cloud Interactions)
  • Article
  • Open Access
918 Views
19 Pages

14 February 2026

We theoretically investigate the influence of uniaxial distortion on the stability of square skyrmion crystals, which are described as double-Q spin textures composed of two orthogonal spiral modulations, in noncentrosymmetric magnets. An effective s...

(This article belongs to the Section Inorganic Crystalline Materials)
  • Article
  • Open Access
549 Views
15 Pages

Associations of Diabetes Mellitus Status and Geriatric Nutritional Risk Index with the Gut Microbiota in Nursing-Home Residents

  • Teresa Gisinger,
  • Luise Bellach,
  • Christina Fastl,
  • Cátia Pacífico and ,
  • Marion Nehr,
  • Athanasios Makristathis,
  • Alexandra Kautzky-Willer and
  • Thomas E. Dorner
  • + 3 authors+ 0 author

18 June 2026

Background/Objectives: Malnutrition and diabetes mellitus (DM) have been linked to gut microbial perturbations, yet data are scarce for the aging population, especially in a nursing-home setting. As this group is generally at risk for malnutrition, w...

(This article belongs to the Special Issue Gut Microbiota–Diet Interactions in Obesity and Metabolic Regulation)
  • Article
  • Open Access
14 Citations
3,781 Views
18 Pages

Molecular Insight into the Pharmacological Potential of Clerodendrum minahassae Leaf Extract for Type-2 Diabetes Management Using the Network Pharmacology Approach

  • Fatimawali,
  • Trina Ekawati Tallei,
  • Billy Johnson Kepel,
  • Widdhi Bodhi and ,
  • Aaltje Ellen Manampiring and
  • Firzan Nainu
  • + 1 author+ 0 author

26 October 2023

Background and Objectives: The increasing occurrence and prevalence of type-2 diabetes mellitus (T2DM) have led to a growing interest in researching available treatment alternatives. Clerodendrum minahassae, a native plant species of North Sulawesi,...

(This article belongs to the Section Pharmacology)
  • Review
  • Open Access
135 Citations
18,259 Views
26 Pages

The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

  • Chae Bin Lee,
  • Soon Uk Chae,
  • Seong Jun Jo,
  • Ui Min Jerng and
  • Soo Kyung Bae

Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM); however, its mechanism of modulating glucose metabolism is elusive. Recent advances have identified the gut as a potential target of metformin. As patients with...

(This article belongs to the Special Issue Tissue-Specific Direct and Indirect Effects of Metformin and Its Application)
  • Article
  • Open Access
21 Citations
3,778 Views
22 Pages

The Impact of Asymmetric Dark Matter on the Thermal Evolution of Nucleonic and Hyperonic Compact Stars

  • Edoardo Giangrandi,
  • Afonso Ávila,
  • Violetta Sagun,
  • Oleksii Ivanytskyi and
  • Constança Providência

27 February 2024

We investigate the impact of asymmetric fermionic dark matter (DM) on the thermal evolution of neutron stars (NSs), considering a scenario where DM interacts with baryonic matter (BM) through gravity. Employing the two-fluid formalism, our analysis r...

  • Article
  • Open Access
18 Citations
6,116 Views
19 Pages

Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 Diabetes: Randomised Placebo-Controlled Clinical Trial

  • Chompoonut Teparak,
  • Juntanee Uriyapongson,
  • Jatuporn Phoemsapthawee,
  • Orathai Tunkamnerdthai and ,
  • Ploypailin Aneknan,
  • Terdthai Tong-un,
  • Charnchai Panthongviriyakul,
  • Naruemon Leelayuwat and
  • Ahmad Alkhatib
  • + 4 authors+ 0 author

21 March 2025

Background: Antioxidants and prebiotics are popular functional foods known for their distinct physiological ameliorating benefits on type 2 diabetes mellitus (T2DM). Whether and how a combined antioxidant-prebiotic supplement affects primary and seco...

(This article belongs to the Special Issue Effects of Nutrition and Physical Activity Lifestyle Interventions on Childhood Obesity)
  • Article
  • Open Access
6 Citations
1,828 Views
18 Pages

Type 2 Diabetes Mellitus Impairs the Reverse Transendothelial Migration Capacity (rTEM) of Inflammatory CD14+CD16− Monocytes: Novel Mechanism for Enhanced Subendothelial Monocyte Accumulation in Diabetes

  • Dilvin Semo,
  • Adama Sidibé,
  • Kallipatti Sanjith Shanmuganathan,
  • Nicolle Müller and ,
  • Ulrich A. Müller,
  • Beat A. Imhof,
  • Rinesh Godfrey and
  • Johannes Waltenberger
  • + 3 authors+ 0 author

9 October 2025

Background: Type 2 diabetes mellitus (DM) is a major cardiovascular risk factor that induces monocyte dysfunction and contributes to their accumulation in atherosclerotic lesions. Monocyte recruitment and accumulation in the tissues contribute to chr...

(This article belongs to the Section Cells of the Cardiovascular System)
  • Article
  • Open Access
6 Citations
7,951 Views
32 Pages

In this work, an interactive optimisation framework—a combination of a low fidelity flow solver, Athena Vortex Lattice (AVL), and an interactive Multi-Objective Particle Swarm Optimisation (MOPSO)—is proposed for aerodynamic shape design...

  • Article
  • Open Access
1 Citations
1,013 Views
11 Pages

Severity of Leaf Spots Caused by Bipolaris maydis and Cercospora fusimaculans on Panicum maximum Forages Under Phosphate Fertilization and Limestone

  • Néstor Eduardo Villamizar Frontado,
  • Gelson dos Santos Difante,
  • Alexandre Romeiro de Araújo,
  • Manuel Claudio Motta Macedo and ,
  • Denise Baptaglin Montagner,
  • Marcio Martinello Sanches,
  • Celso Dornelas Fernandes,
  • Hitalo Rodrigues da Silva,
  • Gustavo de Faria Theodoro and
  • Adrián Gonzalez
  • + 8 authors+ 3 authors

2 December 2025

The study evaluated the severity of leaf spots caused by Bipolaris maydis and Cercospora fusimaculans in Panicum maximum subjected to different liming and phosphate fertilization levels. A randomized block design was used in a 6 × 2 × 5 f...

(This article belongs to the Section Crop Protection, Diseases, Pests and Weeds)
  • Article
  • Open Access
17 Citations
7,117 Views
15 Pages

Association of Canonical Wnt/β-Catenin Pathway and Type 2 Diabetes: Genetic Epidemiological Study in Han Chinese

  • Jinjin Wang,
  • Jingzhi Zhao,
  • Jianfeng Zhang,
  • Xinping Luo and ,
  • Kaiping Gao,
  • Ming Zhang,
  • Linlin Li,
  • Chongjian Wang and
  • Dongsheng Hu
  • + 4 authors+ 0 author

15 June 2015

We aimed to investigate the associations of polymorphisms in Canonical Wnt/β-catenin pathway (WNT) signaling genes (including low-density lipoprotein-related protein 5 [LRP5] and transcription factor 7-like 2 [TCF7L2] gene) and the downstream gene g...

  • Review
  • Open Access
2 Citations
774 Views
24 Pages

Background/Objective: Emotion regulation (ER) is closely linked to decision-making (DM). Although executive functions (EF) are often suggested as a key mechanism underlying this relationship, evidence from different clinical conditions remains fragme...

(This article belongs to the Special Issue Reviews in Neuropsychology: Advances and Future Directions)

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