The daily rhythm of mammalian energy metabolism is subject to the circadian clock system, which is made up of the molecular clock machinery residing in nearly all cells throughout the body. The clock genes have been revealed not only to form the mole...
Aiming at the problems of misdetection, leakage, and low recognition accuracy caused by numerous surface defects and complex backgrounds of laser nozzles, this paper proposes DEC-YOLO, a novel detection model centered on the DEC Module (DenseNet-expl...
Various imide derivatives of 1,7,8,9-tetramethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2) have been reported and shown to exhibit an anxiolytic activities [1].[...]
Zonal day-ahead (DA) electricity markets followed by redispatch (RD) markets for congestion management are vulnerable to the strategic bidding behavior known as Inc-Dec gaming. Although previous literature has demonstrated the effects of Inc-Dec gami...
Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutation in the dystrophin gene. Currently there is no cure for DMD. We introduced a novel human Dystrophin Expressing Chimeric (DEC) cell therapy of myoblast origin and confirmed the sa...
Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in...
(1) Background: Pathogenic Escherichia coli are divided into two groups: diarrheagenic (DEC) and extraintestinal pathogenic (ExPEC) E. coli. ExPEC causing urinary tract infections (UTIs) are termed uropathogenic E. coli (UPEC) and are the most common...
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorder...
A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active again...
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various kinds of canc...
The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The ef...
Cardiac fibrosis is a major cause of cardiac dysfunction in hypertrophic hearts. Differentiated embryonic chondrocyte gene 1 (Dec1), a basic helix–loop–helix transcription factor, has circadian expression in the heart; however, its role i...
This study characterized the effects of a deficiency of the hypoxia-responsive gene, differentiated embryonic chondrocyte gene 1 (Dec1), in attenuating the biological function of orthodontic tooth movement (OTM) and examined the roles of ribosomal pr...
The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune syste...
Dendritic cell (DC) targeting by DEC205+ cells effectively promotes the internalization of antigens that may trigger a specific immune response. In this study, we evaluated the ability of a recombinant antibody, anti-DEC205 (rAb ZH9F7), to trigger ce...
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are believed to b...
The use of geological models for mine production scheduling, planning, and design is a common aspect of current digital mine construction. Establishing a mapping relationship from digital geological resources to mining process simulation and then to...
Various imide derivatives of 10-Oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione have been reported and shown to exhibit a wide spectrum of biological activities including antitumor properties [1].[...]
Decentralized partially observable Markov decision process (DEC-POMDP) models sequential decision making problems by a team of agents. Since the planning of DEC-POMDP can be interpreted as the maximum likelihood estimation for the latent variable mod...
Activation of the immune system using antigen targeting to the dendritic cell receptor DEC205 presents great potential in the field of vaccination. The objective of this work was to evaluate the immunogenicity and protectiveness of a recombinant mous...
Wireless sensor networks (WSN) have found more and more applications in remote control and monitoring systems. Energy management in the network is crucial because all nodes in the WSN are energy constrained. Therefore, the design and implementation o...
Accurately reproducing the mechanical and dynamic behavior of fractured rock masses remains a key challenge in rock engineering, especially in marble quarry environments where discontinuity networks, excavation geometry, and topographic effects induc...
Air moving-target detection is crucial for national defense, civil aviation, and airspace supervision. Spaceborne synthetic aperture radar (SAR) provides high-resolution, continuous observations for this task, but faces challenges including target at...
Despite scientific efforts, there is no cure for Duchenne muscular dystrophy (DMD), a lethal, progressive, X-linked genetic disorder caused by mutations in the dystrophin gene. DMD leads to cardiac and skeletal muscle weakness, resulting in premature...
Conventional dendritic cells (cDCs) cannot be infected by porcine reproductive and respiratory syndrome virus (PRRSV) but respond to infection via cytokine production, indicating a possible role in initiation/regulation of the immune response against...
A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine couplin...
A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound 3 by Suzuki coupling of 3,5-difluorophenyl boronic acid with tert-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspir...
Sodium-ion batteries are a promising class of secondary power sources that can replace some of the lithium-ion, lead–acid, and other types of batteries in large-scale applications. One of the critical parameters for their potential use is high...
Computer vision and deep learning are essential in diverse fields such as autonomous driving, medical imaging, face recognition, and object detection. However, enhancing low-light remote sensing images remains challenging for both research and real-w...
Duchenne Muscular Dystrophy (DMD) is a lethal, X-linked disorder leading to muscle degeneration and premature death due to cardiopulmonary complications. Currently, there is no cure for DMD. We previously confirmed the efficacy of human Dystrophin-Ex...
Chimerism-based strategies represent a pioneering concept which has led to groundbreaking advancements in regenerative medicine and transplantation. This new approach offers therapeutic potential for the treatment of various diseases, including inher...
The molecular structures of (E)-non-2-enoic acid (C9) and (E)-dec-2-enoic acid (C10) are reported. The title compounds were crystallized by slow evaporation of ethanolic solutions at −30 °C. C9 crystallizes in the monoclinic space group P21/c and C10...
Due to COVID-19 barriers, the needs of international container ports have become more important than in the past. Therefore, it is very critical and essential for the scientific developments of port-logistics. To gain the scientific developments of p...
The title compound 1 was synthesized by the coupling reaction of 6,7,8,10-tetra-O-benzyl-1,2,3,4-tetradeoxy-α-D-gluco-dec-5-ulopyranose (2) with 2,3,4,6-tetra-O-benzyl-D-glucopyranose (3) in the presence of 5 mol% bismuth(III) triflate in dichloromet...
Colon diseases, such as colorectal cancer (CRC), are multifactor diseases that affect more than one million people per year; recently, the microbiota has been associated with an etiologic factor, specifically bacterial cyclomodulin positivity (CM+)....
The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible associat...
Background and Objectives: Oral cancer remains a critical global health concern, with oral squamous cell carcinoma (OSCC) being the most prevalent form. Oral potentially malignant disorders (OPMDs), such as oral leukoplakia (OLK), oral lichen planus...
To confront the related problems of environmental protection, energy saving, and carbon reduction, sustainability has been a prominent issue for enterprises seeking to meet the requirements of the Earth Summit’ sustainable development goals (SD...
This work investigates the impact of scatter correction on photon-counting dual-energy chest radiography using a moving block method, focusing on quantifying improvements with the IEC 62220-2-1 dual-energy metrics. A modified LucAl-based chest phanto...
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for...
The prolyl-hydroxylase inhibitor (PHI), used effectively in several countries for the treatment of renal anemia, activates the multifunctional hypoxia-inducible factors (HIFs). While hypoxic conditions in tumors are known to affect the response to ra...
Targeting dendritic cells (DCs) by means of monoclonal antibodies (mAbs) capable of binding their surface receptors (DEC205 and DCIR2) has previously been shown to enhance the immunogenicity of genetically fused antigens. This approach has been repea...
In 2011, an outbreak of hemorrhagic colitis and hemolytic uremic syndrome (HUS) was reported in Europe that was related to a hybrid STEAEC of Escherichia coli (E. coli) O104:H4 strain. The current study aimed to analyze strains of E. coli O104 and O9...
The catalytic [4π + 2π]-cycloaddition of monosubstituted and disubstituted 1,2-dienes to 1,3,5-cyclooctatriene under the action of Co(acac)2(dppe)/Zn/ZnI2 was performed for the first time to produce substituted tricyclo[4.2.2.02,5]dec-7-enes.
The catalytic effects of 1,1,3,3-Tetramethylguanidine (TMG), 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), 7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), and 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) in the r...
People are increasingly open to using online education mainly to break the distance and time barriers of presential education. This type of education is sustainable at all levels, and its relevance has increased even more during the pandemic. Consequ...
(1) Background: Hybrid uropathogenic Escherichia coli (UPEC) strains carry virulence markers of the diarrheagenic E. coli (DEC) pathotypes, which may increase their virulence potential. This study analyzed the frequency and virulence potential of hyb...
Chiral 4,8-diphenyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (DiPh-TBD) was synthesized and applied to a ring-opening polymerization of rac-lactide (rac-LA). The chiral DiPh-TBD promoted the synthesis of isotactic enriched polylactides (PLAs) with control...
Analysis of the stability of slopes in fractured rock masses is not trivial and is fraught with uncertainty and risk. A DFN-DEC model (Discrete Fracture Network-Distinct Element Code) based on the MATLAB platform is developed to evaluate the stabilit...
Defect inspection is an important issue in the field of industrial automation. In general, defect-inspection methods can be categorized into supervised and unsupervised methods. When supervised learning is applied to defect inspection, the large vari...
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