ECSOC-25 - 111 articles
Online | 15–30 November 2021
Volume Editors:
Julio A. Seijas, Universidad of Santiago De Compostela, Spain
M. Pilar Vázquez-Tato, Universidad of Santiago De Compostela, Spain
Due to the presence of two acrylonitrile fragments, 3,5-di(α-cyanostyryl)-1,2,4-thiadiazoles are prone to react under Radziszewski reaction conditions (oxidative hydrolysis of nitriles to amides) with the simultaneous epoxidation and formation...
Heterocyclic compounds are abundant in natural products and bioactive compounds and play a huge role in the present repertoire of medicinal chemists due to their potential capability to modulate physicochemical properties. As a result, chemists have...
Purpurogallin or (6E,8Z)-2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one is a benzotropolone possessing a dienic system and known to inhibit the TLR1/TLR2 activation pathway. We have recently described the easy green synthesis of purpurogallin from pyr...
Various chronic inflammatory diseases have become a problem, especially in the Western world. Whether it concerns inflammation of visceral organs, joints, bones, etc., it is always a physiological reaction of the body, which always tries to eradicate...
Solanum glaucophyllum is a species of the Solanaceae family that causes enzootic calcinosis by vitamin D3 intoxication in breeding cattle grazing in Argentina. Inspired by thrusting forward the study of the biosynthetic pathway of vitamin D3 in S. gl...
Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β-amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. Th...
In search of new thermotropic, photoswitchable materials, a number of 4′-alkoxy-4-(ω-cinnamoylalkoxy)azobenzenes were prepared. The synthetic procedure included O-alkylation of 4-nitrophenol, followed by reduction of the nitro group (H2,...
Imidazole derivatives are known for their varied biological applications, such as antibacterial, antifungal, antioxidant, antiviral, antiparasitic and anticancer compounds, among others. Therefore, numerous imidazole derivatives have been synthesized...
The synthesis of three alkoxy alcohols with different chains was carried out from eugenol oxirane. These derivatives were evaluated against their effect on the viability of the insect cell line Sf9 (Spodoptera frugiperda). The molecules under study d...
In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions. Thus, the reaction of 2-(hydroxy(phenylamin...
Fluorescent carbon dots (C-dots) were directly synthesized by a sustainable and ecofriendly one-pot microwave-assisted hydrothermal carbonization method from coffee grounds waste. The coffee grounds obtained from automatic coffee machines, after bein...
Unsubstituted (2E)-N-phenyl-3-[2-(trifluoromethyl)phenyl]prop-2-enamide and six other ortho- or para-halogen-substituted anilides of 2-(trifluoromethyl)cinnamic acid were prepared. As the benzene nucleus of cinnamic acid itself is substituted in C(2)...
In 1995, Noyori and co-workers made a breakthrough with their design of practical ruthenium-based catalysts, which combined the homochiral TsDPEN ligand with a Ru(II) arene [...]
A simple method for the synthesis of new derivatives of isoindoline-1,3-dione is developed in this study, which consists of the interaction of N-arylbenzenecarboximidamides with phthalic anhydride in benzene at reflux. It was found that carrying out...
Interest in the possible use of EAN in electronic devices has increased in recent years. EAN can be used directly as an electrolyte, but its application could potentially be optimized by mixing with a metal salt such as Al(NO3)3. Although ionic liqui...
Currently, mitochondria are considered as an attractive universal target in the development of new anticancer drugs. These organelles are essential in energy production, the regulation of cell death pathways, the generation of reactive oxygen species...
Through the reaction of fullerenylazide with terminal acetylenes, previously undescribed 1-butyl-2-triazolylfullerenes, in which the heterocyclic fragment was directly attached to the fullerene backbone, were synthesized for the first time. Water-sol...
The Bingel–Hirsch reaction was used to synthesize two new hexamethanofullerenes containing six quadricyclane fragments. Preliminary experiments have established that the synthesized compounds have a high antitumor effect in combination with cis...
In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, foll...
Hydrazine derivatives are known as a group of organic compounds containing C=N-N=C functional groups. This π-conjugated system enables electronic excitation in the visible and near-ultraviolet regions. This is of particular interest for many appli...
Several computational studies have been published to predict the behaviour of naphthalenediimides (NDI) in the transport of electrons in batteries, as well as their physical properties. This communication compares NDI with their analogues resulting f...
In this work, we present a novel spiropyran–containing photochromic pyrrolidinofullerene as a promising agent for the photodynamic therapy of cancer.
It is interesting to know the behavior of Protic Ionic Liquids (PILs) within the binary mixture of molecular solvents, since it is usual to carry out processes such as organic and inorganic synthesis, or liquid–liquid extractions in the presenc...
For polar Diels–Alder (DA) reactions, one of the most relevant aspects is its dependence on the reaction media; thus, in this work, the objective is to analyze the effect of aqueous micellar systems on the synthesis of compounds of biological i...
A water-soluble pentamethine cyanine dye was synthesized for further conjugation with peptides. The dye preparation was accomplished by solution-phase chemistry and the synthesized compounds were characterized by the usual techniques (nuclear magneti...
A BODIPY derivative bearing a benzimidazole unit at position 2 and an electron donor group (anthracene) at the meso position was synthetized and characterized by the usual spectroscopic techniques. The evaluation of the compound as a colorimetric che...
The present work is devoted to the synthesis of imidazo[2,1-b][1,3]thiazine derivatives as possible anti-inflammatory agents. The synthetic approach to (2-pyridinyloxy) substituted imidazo[2,1-b][1,3]thiazines based on the interaction of the polysubs...
The synthesis of five new bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described. Then, on the main protease MPro (PDB: 6lu7) from the SARS-CoV-2, the synthesi...
N,N-Dimethyl-4-amino-2,1,3-benzothiadiazole (BTDNMe2) was synthesized from the commercially available 2,1,3-benzothiadiazole (BTD) by nitration in a sulfonitric mixture, followed by a reduction of the nitro group and subsequent methylation with iodom...
Since several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections, especially in tropical countries. In the present study, we have s...
According to WHO, sugar intake rates should be reduced due to the connection between sugar and diseases. However, reducing sugar in foods is a challenge both for food manufacturers and consumers. Therefore, sweet-tasting proteins may solve this probl...
Specific structural modifications in eugenol molecules can simultaneously improve the biological activity and reduce side effects of the respective analogues. The esterification of eugenol by two different experimental procedures, and subsequently th...
Pectin is a natural structural polymer that is extensively used in the food industry and in medicinal and pharmaceutical fields. Considering potential applications, in this study, microwave-assisted and conventional extraction were evaluated for the...
Our group described a green, “P-ligand-free”, Pd(OAc)2- or NiCl2-catalyzed synthesis under MW conditions. The reactivity of a few aryl derivatives in the Pd(OAc)2-catalyzed, “P-ligand-free” P–C coupling reactions under M...
Twenty-five novel imidazole analogs of 26(a–r) and 27(a–g) were designed, based on Quantitative Structure Activity Relationship (QSAR)studies. The designed compounds were subjected to molecular docking studies and predictive Absorption, D...
Anti-HIF flavonoids have been described for their antitumor activity by interfering with a presumed antioxidant mechanism through direct and indirect ways of overexpression of the hypoxia inducible factor (HIF-1α). The aryl hydrocarbon receptor...
A method for the synthesis of 3R-substituted and norbornane-annelated 1H-phospholan oxides has been developed. The method is based on the in situ substitution of the Al atom by the P atom in five-membered cyclic alumolanes using phosphorus trichlorid...
With the aim of investigating the development of an easily synthesized dansyl-based fluorescent probe for detecting heavy-metal-based nanomaterials in aqueous solution, we synthetized and characterized a Schiff-base ligand, which we named H3L. It was...
Ricinine is an alkaloid of Ricinus communis that displays numerous biological properties. Ricinine (4-methoxy-1-methyl-2-oxo-dihydropyridine-3-carbonitrile)) and new N-analogues of Ricinine were obtained by the reaction of ethyl α-ethoxyethylid...
Differences in the functional groups of the ligands can change the properties of the cyclometallated compounds and modify their suitability for various applications, such as catalysis and biomedicine. Herein, we report the synthesis and characterizat...
In the current research work, the title compounds 5-ethoxy-benzimidazole, were synthesized by nitration of phenacetin with concentrated nitric acid it gives N-(2-nitro-5-ethoxyphenyl) acetamide (I), which on reduction with alcohol gives 5-ethoxy-2-ni...
The condensation products of cyanothioacetamide with aldehydes—(E)-arylmethylenecyanothioacetamides—have proven to be readily available and multifunctional starting reagents in the chemistry of S,N-containing compounds. We decided to stud...
One approach creating and to tuning the energy levels of small band gap polymers or molecules is alternating donor-like (electron donating) and acceptor-like (electron withdrawing) monomers. Polymer for solar cells need to maintain a low highest occu...
Although the most common types of secondary structures in proteins are helices and sheets, other types of structures also form, such as turns and loops. Turns play an important role, both structurally and functionally. With regard to the structural a...
The reactivity of R–CH=N–(C6H4–2–SMe) with R = 4–Br–C6H5, R = 3–Br–C6H5, R = 2–Cl–C6H5 with palladium (II) salts was investigated in this study. We were able to prepare and characterize the...
The yellow-legged Asian hornet (AH) (Vespa velutina Lepeletier 1836 (Hymenoptera: Vespidae)) is naturally distributed in China, Southeast Asia, and India; however, it has been detected outside of its native area, confirmed as being established in Sou...
A new β-turn inducer peptidomimetic incorporating 1-amino-1-aminomethylcyclohexane (compound 3) was synthetized and structurally studied. It was established that there is a rapid conformational equilibrium between the expected β-turn induce...
A composite based on three components including PMMA (polymethyl metacrylate), HA (hydroxyl apatite) and LDH (layered double hydroxide) was prepared, characterized and applied as bone cement. Bone cement is a biomaterial used in clinical applications...
In order to find alternative pesticides, a series of benzamide derivatives was synthesized. An in silico inverted virtual screening protocol considering the 13 common insecticide protein targets was used to evaluate the potential insecticide activity...
Benedict’s Reagent is commonly used in identifying reducing sugars through a redox process where a Cu(I) species is generated. Despite the simplicity of this reaction, this has barely been investigated as a copper (I) source for catalytic proce...
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