The management of atrial fibrillation has evolved significantly over the last ten years with advancements in medical and catheter ablation approaches, but these have limited success when used in isolation. Trends in the management of lifestyle modifi...
The response modification factor R is a fundamental parameter in seismic design, linking the elastic demand expected under strong ground motion to the reduced forces used in practice. It reflects the capacity of well-detailed structures to dissipate...
Lubrication performance dominates the rating life of grease-lubricated pitch bearings. Conventionally, the life modification factor is determined using base oil viscosity, whose validity is rarely verified. This work presents an effective viscosity-b...
The eukaryotic and archaeal translation factor IF5A requires a post-translational hypusine modification, which is catalyzed by deoxyhypusine synthase (DHS) at a single lysine residue of IF5A with NAD+ and spermidine as cofactors, followed by hydroxyl...
Atrial fibrillation (AF) is the most common sustained arrhythmia, contributing to significant morbidity and healthcare burden worldwide. This review evaluates the role of early risk factor modification and timely catheter ablation in preventing AF pr...
The design innovation of high-strength steel frames paired with D-eccentric bracing exhibits remarkable resistance to plastic deformation during seismic events. This method strategically combines regular steel connections (with yield strengths below...
In Pakistan, updated codes covering seismic provisions for reinforced concrete bridges do not exist. The majority of the bridge design uses different versions of AASTHO-LRFD provisions. Response modification factors recommended for usage in these cod...
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This review aims to provide an overview of the factors associated with adherence reported in existing literature on lifestyle modification programs for weight management among the adult population. An electronic search was performed using PubMed, Med...
Cloud and aerosol modification factors are investigated in the spectral range of ultraviolet (UV) to correct for cloud and aerosol extinction effects from clear sky irradiance. The cloud modification factor (CMF) and aerosol modification factor (AMF)...
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joine...
BC is the most commonly diagnosed cancer and the second leading cause of cancer death among women worldwide. Cellular stress is a condition that leads to disrupted homeostasis by extrinsic and intrinsic factors. Among other stressors, hypoxia is a dr...
Fermat’s Factoring Algorithm (FFA) is an integer factorisation methods factoring the modulus N using exhaustive search. The appearance of the Estimated Prime Factor (EPF) method reduces the cost of FFA’s loop count. However, the EPF does not work for...
Accurate prediction of the friction factor is fundamental for designing and calibrating fluid transport systems. While the Colebrook–White equation is the benchmark for precision due to its physical basis, its implicit nature hinders practical...
The combined contributions to mountain freeway safety of pavement performance, weather conditions, and traffic condition indicators have not been thoroughly investigated due to the complexity of their interactions and temporal instability. A cross-se...
Cancer is the second most important non-communicable disease worldwide and disproportionately impacts low- to middle-income countries. Diet in combination with other lifestyle habits seems to modify the risk for some cancers but little is known about...
Automated Speed Enforcement (ASE) has emerged as a prominent speed enforcement practice, attracting policy attention as its adoption has increased. Although ASE has been widely studied on residential streets and urban corridors, empirical evidence re...
Background: Adipogenesis is governed by a complex interplay between transcriptional regulation and epigenetic remodeling. While many transcriptional pathways have been well characterized, less is known about how chromatin-level regulation shapes the...
In this paper, the nuclear modification factors,
The Beam Energy Scan (BES) program at RHIC aims to explore the QCD phase diagram, including the search for the evidence of the 1st order phase transition from hadronic matter to Quark-Gluon Plasma (QGP) and the location of the QCD critical point. One...
The review presents evidence that the main damage to the vascular wall occurs not from the action of “oxidized” LDL, which contain hydroperoxy acyls in the phospholipids located in their outer layer, but from the action of LDL particles w...
The 3D bioprinting of cell-incorporated gels is a promising direction in tissue engineering applications. Collagen-based hydrogels, due to their similarity to extracellular matrix tissue, can be a good candidate for bioink and 3D bioprinting applicat...
Management of atrial fibrillation (AF) requires a comprehensive approach due to the limited success of medical or procedural approaches in isolation. Multiple modifiable risk factors contribute to the development and progression of the underlying sub...
Recent studies about the transcriptome-wide presence of RNA modifications have revealed their importance in many cellular functions. Nevertheless, information about RNA modifications in viral RNA is scarce, especially for negative-strand RNA viruses....
This paper presents a new l1-RLS method to estimate a sparse impulse response estimation. A new regularization factor calculation method is proposed for l1-RLS that requires no information of the true channel response in advance. In addition, we also...
Raspberry fruits are a valuable source of bioactive compounds. The study used the modification of the substrate (coconut fibre), consisting of the use of various organic and mineral additives, in the soilless cultivation of raspberries. The additives...
Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hamp...
Translation is a fundamental process in all living organisms that involves the decoding of genetic information in mRNA by ribosomes and translation factors. The dysregulation of mRNA translation is a common feature of tumorigenesis. Protein expressio...
Globally, hepatocellular carcinoma (HCC) is a significant cause of mortality and morbidity among chronically infected HCV patients. It is established that HCV is a primary risk factor for HCC progression. The treatment of HCV infection has been trans...
Post-translational modification is a prerequisite for the functions of intracellular proteins. Thiol-based oxidative post-translational modifications (OxiPTMs) mainly include S-sulfenylation, S-nitrosation, persulfidation, and S-glutathionylation. Re...
We investigate the possibility of estimating global horizontal irradiance (GHI) in parallel to photovoltaic (PV) power production in India using a radiative transfer model (RTM) called libRadtran fed with satellite information on the cloud and aeroso...
Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs). In addition, their regu...
Intrauterine growth retardation (IUGR), which induces epigenetic modifications and permanent changes in gene expression, has been associated with the development of type 2 diabetes. Using a rat model of IUGR, we performed ChIP-Seq to identify and map...
Modifications of biomaterials based on the combination of physical, chemical, and biological cues for manipulating stem cell growth are needed for modern regenerative medicine. The exploitation of these sophisticated modifications remains a challenge...
Evaluating the lateral bearing behavior of rectangular piles in sloping ground is computationally demanding due to the complex three-dimensional spatial pile-soil interaction. To circumvent the inefficiency of full-scale numerical modeling and the li...
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, impacting approximately 6.1 million adults in the United States, with projections to increase two-fold by 2030. AF significantly increases the risk of stroke and other adverse...
In this paper, the effects of blade trailing edge (TE) profile modification of the suction side on the internal flow and hydraulic performance in a low-specific speed centrifugal pump are investigated through particle image velocimetry (PIV) analysis...
Specific expression of genes is fundamental for defining the identity and the functional state of cells. Sequence-specific transcription factors interpret the information contained in DNA sequence motifs and recruit cofactors to modify chromatin and...
Epigenetics generally involves genetic control by factors other than our own DNA sequence. Recent research has focused on delineating the mechanisms of two major epigenetic phenomena: DNA methylation and histone modification. As epigenetics involves...
The seismic response of base-isolated structures is notably influenced by mechanical properties of isolation devices due to their essential role in structural behavior. Consequently, the variability of such properties should be accounted for in the d...
Epigenetic regulation, particularly post-translational modifications (PTMs) of histones, participates in spermatogonial stem cell (SSCs) differentiation. However, there is a lack of systemic studies of histone PTM regulation during the differentiatio...
We explored the usage of a response modification factor and overstrength factor for analyzing brittle or ductile failure of anchor system. Parametric studies on the tension and shear behaviors of anchor systems were compared in terms of elastic and d...
Filamentous fungi are ubiquitous eukaryotic microorganisms characterized by multicellular architectures and branched hyphal structures. They are used in industrial production for the manufacture of enzyme preparations, various organic acids, and seco...
Genetic studies traditionally focus on DNA as the molecule that passes information on from parents to their offspring. Changes in the DNA code alter heritable information and can more or less severely affect the progeny’s phenotype. While the i...
Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation,...
Pseudomonas aeruginosa is the most common human opportunistic pathogen associated with nosocomial diseases. In 2017, the World Health Organization has classified P. aeruginosa as a critical agent threatening human health, and for which the developmen...
Enhancing crop photosynthesis through genetic engineering technologies offers numerous opportunities to increase plant productivity. Key approaches include optimizing light utilization, increasing cytochrome b6f complex levels, and improving carbon f...
The Buckling Restrained Braced Frame (BRBF), consisting of a ductile steel core in concrete or a steel tube encased in concrete, is constructed to avoid brittle failure modes. The application of ductile materials with improved damping properties, suc...
Background: Tissue factor pathway inhibitors (TFPI1 and TFPI2) are ubiquitously distributed in humans and exhibit inhibitory activity against serine proteinases. TFPI1 inhibits the tissue factor (TF)-dependent extrinsic coagulation pathway, while TFP...
Zinc finger E-box binding homeobox 1 (ZEB1) is a pleiotropic transcription factor frequently expressed in carcinomas. ZEB1 orchestrates the transcription of genes in the control of several key developmental processes and tumor metastasis via the epit...
This paper’s main aim was to explain the process of characterising the structural over-strength factor (R), seismic behaviour factor (Q), and the effective elastic stiffness, Keff, of cantilever-reinforced concrete (RC) urban bridge columns wit...
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