New Updates in the Area of Pig Genomics and Genetics

Dear Colleagues,

Over the past three years, research into pig molecular genetics and genomics has advanced rapidly due to the widespread application of high-throughput sequencing technologies and integrative multi-omics approaches. Whole-genome sequencing, genome-wide association studies (GWAS), and high-density SNP arrays have enabled the identification of numerous candidate genes and genomic regions associated with economically important traits, including growth rate, feed efficiency, carcass composition, meat quality, fat deposition, and reproductive performance, which have significantly improved the accuracy and efficiency of genomic selection in modern pig breeding programs.

A major breakthrough in recent years has been the development and application of genome-editing technologies, particularly CRISPR/Cas9 and its derivatives, such as base editing and prime editing. These tools allow precise and efficient modification of the pig genome and are increasingly used for functional validation of candidate genes, improvement of disease resistance, and generation of pigs with desirable production traits. In parallel, genome editing has expanded the role of pigs as valuable biomedical models for human diseases.

Recent studies increasingly focus on functional genomics and regulatory mechanisms, including transcriptomics, epigenomics, and the analysis of non-coding RNAs such as lncRNAs and miRNAs. Integrating genomic, transcriptomic, and epigenetic data has improved understanding of complex regulatory networks underlying adipogenesis, muscle development, immune response, and environmental adaptation. Publicly available resources and databases integrating multi-omics data across tissues and breeds further support comparative and functional analyses.

In summary, this Special Issue will present how the progress in pig molecular genetics and genomics reflects a shift toward integrative, systems-level approaches combining genomic selection, functional genomics, and genome editing. These advances provide a strong foundation for sustainable pig breeding, improved animal health and welfare, and expanded applications of pigs in translational and biomedical research.

Dr. Katarzyna Piórkowska
Guest Editor

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