Dent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function mutations in CLCN5 (DD1) and OCRL genes. CLCN5 encodes the ClC-5 antiporter that in proximal tubules (PT) participates in the receptor-mediated endocytosis of low...
Torque-limiting mechanisms are safety-critical elements in mechanical, automotive, robotic, aerospace and medical systems, where controlled torque transmission is required to avoid overload failure. However, the influence of dent–slot geometry...
Dent is a common form of defect on oil and gas pipeline. Some dents will undergo elastic or plastic recovery due to changes in internal pressure, also known as springback. To analyze the springback law of an API X60 pipeline with a dent defect, the s...
External corrosion dent is a common type of compound dent. On the one hand, this type of compound dent reduces the bearing area and bearing capacity of the pipeline. On the other hand, it leads to an increase in the stress–strain concentration...
Dent disease type 1 is a rare X-linked recessive inherited renal disorder affecting mainly young males, generally leading to end-stage renal failure and for which there is no cure. It is caused by inactivating mutations in the gene encoding ClC-5, a...
This study is dedicated to the experimental characterisation and phenomenological modeling of the bake hardening effect of a thin steel sheet, to predict the static dent resistance and perform an experimental validation on a bulged part. In a first s...
Dent disease is a rare renal tubular disorder that appears almost exclusively in males. The diagnosis is still challenging, and therefore Dent disease is occasionally misdiagnosed. We report a case of a 45-year-old man with Dent disease who developed...
Due to climate change, corrosive conditions, and hydrogen-rich environments, steel energy pipelines inevitably develop a variety of defects. These deficiencies compromise pipeline safety and reliability, and neglecting them may result in pipeline lea...
The detonation properties of nonideal explosives are highly dependent on charge diameter and existence and properties of confinement. In this study, the effect of different confinements on the detonation velocity of ANFO explosives was experimentally...
Mechanical damage in form of dents, cracks, gouges, and scratches are common in pipelines. Sometimes, these damages form in proximity of each other and act as one defect in the pipe wall. The combined defects have been found to be more injurious than...
Mutations in the OCRL gene are associated with both Lowe syndrome and Dent-2 disease. Patients with Lowe syndrome present congenital cataracts, mental disabilities and a renal proximal tubulopathy, whereas patients with Dent-2 disease exhibit similar...
The rolling element bearing is a fundamental component of any rotating machinery. During operation, wear debris and lubricant impurities create dents and bumps on the bearing raceway surfaces. Such localized defects produce transient vibration impuls...
Dent disease (DD) is an X-linked renal tubulopathy characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis and progressive renal failure. Two-thirds of cases are associated with inactivating variants in th...
Background/Objectives: To date, approximately 360 pathogenic variants of the OCRL gene have been reported, including frameshift, substitution, gross inversion, nonsense, and missense mutations. These genetic alterations have been associated with a br...
Kidney stones are becoming increasingly common, affecting up to 10% of adults. A small percentage are of monogenic origin, such as Dent’s disease (DD). DD is a syndrome that causes low-molecular-weight proteinuria, hypercalciuria, nephrolithias...
Many ship panels may be subjected to operational or accidental impact loads, and increased crashworthiness is a desirable design feature. A designer may reach this goal using different structural configurations that are available nowadays. However, t...
Dent disease-1 (DD-1) is a rare X-linked tubular disorder characterized by low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrolithiasis and nephrocalcinosis. This disease is caused by inactivating mutations in the CLCN5 gene which encodes...
Dent disease (DD1) is a rare tubulopathy caused by mutations in the CLCN5 gene. Glomerulosclerosis was recently reported in DD1 patients and ClC-5 protein was shown to be expressed in human podocytes. Nephrin and actin cytoskeleton play a key role fo...
Deepwater sandwich pipes (SPs) offer high collapse resistance and thermal insulation, making them promising for hydrocarbon transport under high-pressure and low-temperature conditions. However, mechanical damage such as local dents increases cross-s...
Detection and localization of the dents on a vehicle body that occurs during manufacturing is critical to achieve the appearance quality of a new vehicle. This study proposes a region-based convolutional neural network (R-CNN) to detect and localize...
Dent disease is a rare X-linked renal tubulopathy due to CLCN5 and OCRL (DD2) mutations. OCRL mutations also cause Lowe syndrome (LS) involving the eyes, brain and kidney. DD2 is frequently described as a mild form of LS because some patients may pre...
7 November 2026
To address the safety of buried oil pipelines in mountainous areas subjected to rockfall impact, this study investigates API X65 steel pipelines containing pre-existing constrained dent defects. A three-dimensional coupled rockfall–soil–p...
To explore the effect of dents on the tribological behavior of the “washers-cage-rollers” system of rolling element bearings (REBs), the friction and wear properties of dents textured thrust cylindrical roller bearings (81107TN) with diff...
This paper presents the results of fatigue tests performed on dented steel pipeline specimens that were tested under different environmental conditions and subjected to cyclic internal pressure. Thirty-three pipe specimens were divided into three gro...
Dents are among the most common deformation defects in buried transmission pipelines, significantly influencing structural integrity and internal flow behaviour. This study examines the occurrence of turbulence in dented pipe sections using time&ndas...
Dents are a common geometric deformation defect in pipelines where the dented section becomes susceptible to local buckling, significantly threatening the integrity and reliability of the pipeline. This paper developed a novel finite element (FE) mac...
In the field of oil and gas transportation, X80 pipelines are susceptible to localized plastic deformation caused by mechanical impact or geological activity. This leads to the formation of dents and the introduction of pre-strain, thereby affecting...
The residual strength of denting- and fracture-damaged box girders were experimentally and numerically investigated. The experiments were conducted under a pure bending moment using the four-point bending test method. The load, deflection, and strain...
In this paper, we study three kinds of dentabilities and present their important applications in the geometric theory of Banach spaces. First, the relations between weak-denting points and extreme points are established. Moreover, we characterize str...
Mechanical damage is recognized as a problem that reduces the performance of oil and gas pipelines and has been the subject of continuous research. The artificial neural network in the spotlight recently is expected to be another solution to solve th...
The search for dents is a consistent part of the aircraft inspection workload. The engineer is required to find, measure, and report each dent over the aircraft skin. This process is not only hazardous, but also extremely subject to human factors and...
Lowe syndrome and Dent II disease are X-linked monogenetic diseases characterised by a renal reabsorption defect in the proximal tubules and caused by mutations in the OCRL gene, which codes for an inositol-5-phosphatase. The life expectancy of patie...
In the study, experimental and theoretical studies were carried out to assess the influence of the shapes of dents in the tank wall on the stress-strain state of the defect zone. By testing fragments of a cylindrical tank, it was found that the most...
Impact indentation is believed to be an effective indication of low-velocity impact (LVI) damage for polymer matrix composites. However, it has been discovered that an indentation can partially rebound over time. Impact indentation and its rebound be...
Maize, one of the most cultivated crops worldwide, has multiple uses, one of which is human food. Maize flour intended for human consumption is preferably produced from var. indurata. This maize variety, although it has some desirable traits, general...
Cone-beam computed tomography (CBCT) allows for more accurate 3D study of the craniofacial region and the development of a very precise treatment plan. The present pilot study aims to evaluate the skeletal outcomes of the rapid maxillary expander (RM...
This study examines the behaviors of structural members in their most vulnerable state (fixed along their weak axes) against sudden loads such as impact loads. To do so, eight supported rectangular hollow steel beam samples were constructed, and a ci...
Dilated Composite Odontoma also known as Dens invaginatus, “dens in dente”, or “tooth within tooth” is a rare dental anomaly resulting from enamel organ infolding during tooth development, often leading to complications like c...
Subsea pipelines subjected to impacts are prone to generating significant deformations and residual stresses, which could reduce their structural integrity and increase the risk of failure. This paper introduces analytical and numerical frameworks ai...
Fracture toughness determination of dual-phase DP450 steel using the essential work of fracture (EWF) methodology is the major focus of this research work. The EWF method is used for the determination of fracture toughness of thin sheets in a plane s...
Background/Objectives: Orthodontic treatment planning software with artificial intelligence has been introduced into practice in recent years. They allow the simulation of the results of orthodontic treatment in several scenarios. The aim of the stud...
Dent disease type 1 is characterized by pathogenic CLCN5 gene variants and impaired receptor-mediated endocytosis in proximal tubules. However, mutation-related abnormalities in proximal tubules have not yet been described. Here, we present three pat...
The characterization of ductile fracture in thin metallic sheets is challenging due to extensive plastic deformation and stable crack growth under plane-stress conditions. This study investigates the applicability of the load separation criterion as...
Carbonized elastomer-based composites (CECs) possess a number of attractive features in terms of thermomechanical and electromechanical performance, durability in aggressive media and facile net-shape formability, but their relatively low ductility a...
Panoramic radiography is vital in dentistry, where accurate detection and segmentation of diseased regions aid clinicians in fast, precise diagnosis. However, the current methods struggle with accuracy, speed, feature extraction, and suitability for...
To improve the lubrication stability of centrifugal pump mechanical seals under high-speed and high-pressure conditions, a composite texture combining elliptical dimples and herringbone grooves is proposed. The Hybrid Groove–Ellipse (HGE) confi...
The purpose of this study was to assess the impact of food texture, oral processing, bolus characteristics, and in vitro digestive conditions on the starch and protein digestibility of al dente and soft-cooked commercial red lentil pasta. For that, s...
I would like to comment on an article by Thomson [1] recently published in Dentistry Journal.[...]
Panoramic radiography remains a cornerstone diagnostic tool in dentistry; however, its two-dimensional nature limits the visualisation of complex maxillofacial anatomy. Three-dimensional reconstruction from single panoramic images addresses this limi...
Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from the peel of Dente di Cavallo DC2 pomegran...
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