Next Article in Journal
Levels of Furaneol in Msalais Wines: A Comprehensive Overview of Multiple Stages and Pathways of Its Formation during Msalais Winemaking
Next Article in Special Issue
A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen
Previous Article in Journal
A 7-Hydroxybenzoxazinone-Containing Fluorescence Turn-On Probe for Biothiols and Its Bioimaging Applications
Previous Article in Special Issue
Venoms of Iranian Scorpions (Arachnida, Scorpiones) and Their Potential for Drug Discovery
Open AccessArticle

Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2

1
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy
2
Department of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
3
Department of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy
4
Department of Environmental Biology, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy
5
Department of Chemistry and Technology of Drugs, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Enrique Barrajon
Molecules 2019, 24(17), 3103; https://doi.org/10.3390/molecules24173103
Received: 31 July 2019 / Revised: 18 August 2019 / Accepted: 22 August 2019 / Published: 27 August 2019
(This article belongs to the Special Issue Natural Product Pharmacology and Medicinal Chemistry)
Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from the peel of Dente di Cavallo DC2 pomegranate (PGE) and characterized to contain 4% w/w of ellagic acid, has been evaluated for its hypoglycemic, antiglycation, and antioxidative cytoprotective properties, in order to provide possible evidence for future nutraceutical applications. The α-amylase and α-glucosidase enzyme inhibition, interference with advanced glycation end-products (AGE) formation, and metal chelating abilities were studied. Moreover, the possible antioxidant cytoprotective properties of PGE under hyperglycemic conditions were assayed. Phenolic profile of the extract was characterized by integrated chromatographic and spectrophotometric methods. PGE resulted able to strongly inhibit the tested enzymes, especially α-glucosidase, and exerted chelating and antiglycation properties. Also, it counteracted the intracellular oxidative stress under hyperglycemic conditions, by reducing the levels of reactive oxygen species and total glutathione. Among the identified phenolics, rutin was the most abundant flavonoid (about 4 % w/w). Present results suggest PGE to be a possible remedy for hyperglycemia management and encourage further studies to exploit its promising properties. View Full-Text
Keywords: vegetable waste; phenolics; hyperglycemia-induced oxidative stress; α-glucosidase; α-amylase; antioxidant activity; inhibition of advanced glycation end-products; chelating activity vegetable waste; phenolics; hyperglycemia-induced oxidative stress; α-glucosidase; α-amylase; antioxidant activity; inhibition of advanced glycation end-products; chelating activity
Show Figures

Figure 1

MDPI and ACS Style

Di Sotto, A.; Locatelli, M.; Macone, A.; Toniolo, C.; Cesa, S.; Carradori, S.; Eufemi, M.; Mazzanti, G.; Di Giacomo, S. Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2. Molecules 2019, 24, 3103.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop