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New Insights into Orthodontic Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 713

Special Issue Editors


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Guest Editor
Private Practice Limited to Periodontics, Oral Implants and Adult Orthodontics, Rome, Italy
Interests: orthodontics; orthodontic materials; airways; malocclusions; ODO; PAOO

E-Mail Website
Guest Editor
Postgraduate School of Orthodontics, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy
Interests: orthodontics; clear aligners; growing patients; digital dentistry; digital scanner

Special Issue Information

Dear Colleagues,

The integration of cone beam computed tomography (CBCT), digital workflows, and artificial intelligence (AI) is changing orthodontic clinical practice. CBCT provides detailed 3D imaging of craniofacial structures and periodontal architecture, enhancing treatment planning and an interdisciplinary approach. Intraoral scanners are improving efficiency and patient comfort, as well as growing patients. AI algorithms analyze dental superimpositions, predicting tooth movement and optimizing clear aligner therapy even in cases requiring maxillofacial surgery. These new insights are especially beneficial for growing patients, where timely interventions can guide proper development. The synergy among orthodontists, radiologists, and periodontists is crucial for harnessing these technologies effectively. We invite you to contribute to this Special Issue focusing on the state-of-the-art applications of CBCT and digital technologies in orthodontics.

The present Special Issue aims to highlight the new insights in this field, promoting the production of relevant scientific literature with research articles or reviews on new digital techniques or clinical assessments in orthodontics, such as the following:

  • The use of CBCT in orthodontic diagnosis, treatment planning, and stability assessment.
  • Airway and craniofacial development evaluations.
  • Digital orthodontic workflows in maxillofacial surgery.
  • AI applications in orthodontics.
  • Clear aligner therapy suitable for growing patients and those with periodontal disease.

We await your esteemed contributions with great interest, confident that they will enrich and advance the field of “third-millennium” orthodontics.

Dr. Federico Brugnami
Dr. Simonetta Meuli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digital orthodontics
  • clear aligners
  • artificial intelligence
  • digital superimpositions
  • cone beam computed tomography
  • growing patients
  • periodontal patients
  • maxillofacial surgery
  • long-term stability
  • prediction of orthodontic movements

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Published Papers (1 paper)

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Research

9 pages, 780 KB  
Article
Long-Term Stability and Histologic Evaluation of Orthodontically Driven Osteogenesis (ODO): A Preliminary Retrospective Study
by Federico Brugnami, Simonetta Meuli, Valentina Ventura and Davide Gentile
J. Clin. Med. 2025, 14(19), 6896; https://doi.org/10.3390/jcm14196896 - 29 Sep 2025
Cited by 1 | Viewed by 533
Abstract
Background: Orthodontically driven osteogenesis (ODO) is a surgical tunnel modification of periodontally accelerated osteogenic orthodontics (PAOO), combining selective corticotomy with bone grafting in sequential and/or segmental fashion. This is a minimally invasive approach that enhances periodontal health and allows orthodontic tooth movement [...] Read more.
Background: Orthodontically driven osteogenesis (ODO) is a surgical tunnel modification of periodontally accelerated osteogenic orthodontics (PAOO), combining selective corticotomy with bone grafting in sequential and/or segmental fashion. This is a minimally invasive approach that enhances periodontal health and allows orthodontic tooth movement beyond the original alveolar envelope. Considering the lack of long-term three-dimensional data on orthodontically driven osteogenesis (ODO), this study aims to quantitatively assess the long-term stability of alveolar bone and buccal cortical thickness following ODO, using CBCT imaging. The null hypothesis is that ODO does not result in significant changes in alveolar bone volume or cortical thickness over a seven-year follow-up period. Methods: Twenty patients (13 females, 7 males; mean age 27.4 ± 5.3 years) who had undergone orthodontically driven osteogenesis (ODO) using a minimally invasive tunnel approach and segmental corticotomy protocol followed by clear aligner therapy were retrospectively evaluated. The mean follow-up period after treatment was 7 years (range: 5–15 years). Cone beam computed tomography (CBCT) scans were obtained at one year postoperatively (T1) and again at the long-term follow-up visit (T2). Buccal bone thickness measurements were taken at standardized levels (3 mm, 5 mm, and 7 mm apical to the cementoenamel junction) and compared between T1 and T2 to evaluate bone stability over time. In addition, histologic evaluation of the previously grafted area was performed in two patients: one sample was collected during an alveolar ridge augmentation procedure six months after ODO, and the other during orthognathic surgery eight months after ODO. The samples were analyzed to assess new bone formation and integration of graft material. Results: Radiographic analysis showed long term stability of the new bone support. Histologic examination showed newly formed lamellar and reticular bone. Bone marrow showed no inflammatory infiltration, and bone particles were still detectable but incorporated in the newly created bone. Conclusions: Based on these findings, ODO appears to be a promising technique that could induce stable bone osteogenesis. A larger cohort study can enhance the evidence of these promising results to popularize this technique. Full article
(This article belongs to the Special Issue New Insights into Orthodontic Treatment)
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