Breast cancer is the most common cancer among women worldwide, and estrogen receptor-positive (ER+) breast cancer accounts for a significant proportion of cases. While various treatments are available, endocrine therapies are often the first-line tre...
11 January 2022
Background: Poor adherence to treatment is a common clinical problem in individuals affected by mental illness and substance use/dependence. In Italy, mental care is organized in a psychiatric service and addiction unit (SERD), characterized by dual...
Estrogen receptor-positive (ER+) is the most common subtype of breast cancer. Endocrine therapy is the fundamental treatment against this entity, by directly or indirectly modifying estrogen production. Recent advances in novel compounds, such as cyc...
This decade has witnessed wide use of data-driven systems, from multimedia to scientific computing, and in each case quality data movement infrastructure is required, many with SerDes as a cornerstone. On the one hand, HPC and machine learning cloud...
A 100 Gb/s quad-lane SerDes receiver with a phase-interpolator (PI)-based quarter-rate all-digital clock and data recovery (CDR) is presented. The proposed CDR utilizes a multi-phase multiplying delay-locked loop (MDLL) to generate the eight-phase re...
A new voltage-controlled oscillator (VCO) topology for serializer–deserializer (SerDes) applications is proposed in this paper. The topology is suitable for SATA, PCI Express, and USB 3 protocols. The VCO is based on two-ring oscillator cores a...
In this brief, we propose a 60 GS/s high-linearity two-stage 8 × 8 time-interleaved track-and-hold circuit where it is possible to tune the static non-linearities of the second-stage buffer by applying a proper bias voltage. This allows us to m...
Wide field Raman imaging using the integral field spectroscopy approach was used as a fast, one shot imaging method for the simultaneous collection of all spectra composing a Raman image. For the suppression of autofluorescence and background signals...
Endocrine therapy (ET) of selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and aromatase inhibitors (AIs) has been used as the gold standard treatment for hormone-receptor-positive (HR+) breast cance...
All rotating shafts, even in the absence of external load, deflect during rotation. The magnitude of the deflection depends upon the stiffness of the shaft, its supports and also upon the load level. In this paper, a complete study of the effect of s...
Through this work, an experimental setup and pre-processing method for obtaining fluorescence and quasi-noise-free Raman spectra of minerals for in situ mineral identification in an underground environment is proposed. It uses a combination of method...
With a lifetime risk estimated to be 1 in 8 in industrialized countries, breast cancer is the most frequent type of cancer among women worldwide and the second leading cause of cancer deaths in women. More importantly, current evidence suggests that...
Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. Howev...
This paper describes recent engineering designs that allow full-duplex SerDes connectivity between a number of cascaded Xilinx radio frequency system-on-chip (RF-SoC) and VCU FPGA systems. The design allows for unlimited scalability with all-to-all c...
Introduction: The optimal treatment of estrogen receptor-positive (ER +) metastatic breast cancer (MBC) after progression on cyclin-dependent 4/6 kinase inhibitors (CDK4/6i) is unknown. Methods: We conducted a systematic review and network meta-analy...
High-speed PAM-4 SerDes and wireline interconnects used in data-center, artificial intelligence (AI), high-performance computing (HPC), chip-to-chip, and high-speed networking applications require low-power and hardware-efficient clock and data recov...
The hormone receptor-positive (HR+) type is the most frequently identified subtype of breast cancer. HR+ breast cancer has a more positive prognosis when compared to other subtypes, such as human epidermal growth factor protein 2-positive disorder an...
This study presents an inductance capacitance (LC) phase-locked loop (PLL) with a dual voltage-controlled oscillator (VCO) and a noise-reduced low-dropout (LDO) regulator, which was used in four-lane multiprotocol serial link applications. The dual V...
The rise of cyclin-dependent kinase (CDK)4/6 inhibitors has rapidly reshaped treatment algorithms for hormone receptor (HR)-positive metastatic breast cancer, with endocrine treatment (ET) plus a CDK4/6-inhibitor currently representing the standard o...
This work presents the design and simulation of a time-interleaved successive approximation register (SAR) analog-to-digital converter (ADC) implemented in GlobalFoundries’ 22 nm Fully Depleted Silicon-on-Insulator (FD-SOI) CMOS process. Motiva...
Background/Objectives: Pharmacological prevention is an evidence-based strategy to reduce the incidence of hormone receptor-positive breast cancer in high-risk women. Despite strong data from randomized trials, clinical uptake remains low. This revie...
Recently, with the development of automobile technologies such as advanced driver assistance systems (ADASs), the performance and number of cameras and displays required for a vehicle have significantly increased. Therefore, the need for in-vehicle h...
The past decade has witnessed an unprecedented transformation in breast cancer management, driven by parallel advances in targeted therapies, immunomodulation, drug-delivery technologies, and molecular diagnostic tools. This review summarizes the key...
This paper presents a dedicated digital signal process (DSP) for four pulse amplitude modulation (PAM4) SerDes receivers. It is targeted to implement data recovery and adaptive equalization under ultra-high-speed and large channel attenuation with a...
Background and Objectives: The aims of this study are to: describe the sociodemographic characteristics and typology of drug addiction among people who use drugs that attend the Servizio per le Dipendenze (SerD), and evaluate the competence and abili...
Severely energy-restricted diets (SERDs) are an effective treatment for obesity, however, adherence to such diets is often perceived as poor by healthcare professionals. This investigation evaluated adherence to a 12-week SERD in participants with cl...
Understanding how indigenous people manage their natural resources can provide a basis for formulating appropriate policies for natural resources management that benefits them while preserving their cultural beliefs. The objective of this study is to...
The efficacy and side effects of endocrine therapy in breast cancer (BC) depend largely on estrogen receptor alpha (ERα) expression, the specific drug administered, and treatment scheduling. Although the benefits of endocrine therapy outweigh any adv...
Fungal melanins represent a resource for important breakthroughs in industry and medicine, but the characterization of their composition, synthesis, and structure is not well understood. Raman spectroscopy is a powerful tool for the elucidation of mo...
Purpose of review: Due to the findings of current studies and the approval of novel substances for the therapy of hormone-receptor-positive breast cancer patients, the established standards of endocrine treatment are changing. The purpose of this rev...
Breast cancer (BC) is the most commonly diagnosed cancer in women, constituting one-third of all cancers in women, and it is the second leading cause of cancer-related deaths in the United States. Anti-estrogen therapies, such as selective estrogen r...
In this article, we show a 60 GS/s two-stage 8 × 8 time-interleaved sampling circuit, where the second-stage nonlinearity can be controlled by using the voltage that optimizes the static distortions of the sampler. A calibration algorithm can e...
Identification of chemical properties in the inner tissues of fresh produce would enable us to identify major issues plaguing the agriculture supply chain, like off-flavors and core rot since these are caused by or accompanied by known chemical eleme...
In this paper we present a low-noise, high-frame-rate global shutter CMOS image sensor with UHD resolution (3840 × 2160), targeting high-speed machine vision applications. The sensor (ForzaFAST581) supports video capture at up to 1141 FPS at 12...
Mutations in the hotspot ligand-binding domain of the estrogen receptor (ER) gene ESR1 have recently been recognized as mechanisms of endocrine resistance in endocrine receptor-positive metastatic breast cancer (MBC). Accumulating data suggest these...
This study presents a high-speed, 9-bit integrating-mode phase interpolator (IMPI) in a 12 nm FinFET process. The proposed slew-rate-tolerant design accepts bandwidth-limited inputs, relaxing the stringent need for high-slew-rate clocks found in prio...
Front-line therapy for advanced and metastatic hormone receptor positive (HR+), HER2 negative (HER−) advanced or metastatic breast cancer (mBC) is endocrine therapy with a CDK4/6 inhibitor (CDK4/6i). The introduction of CDK4/6i has dramatically...
As the PCIe 6.0 specification places higher requirements on signal integrity and transmission latency, it becomes especially important to improve signal transmission performance at the physical layer of the transceiver interface. Retimer circuits are...
A referenceless digital clock and data recovery (D-CDR) circuit using a half-rate jitter-tolerant frequency detector (FD) and a multi-bit decimator is presented. For a referenceless configuration, we introduced a half-rate jitter-tolerant digital qua...
Background: Several novel oral estrogen receptor (ER) degraders have been shown to modestly improve progression-free survival (PFS) compared to standard endocrine therapy (ET) in patients carrying ESR1 mutations. However, whether overall survival (OS...
Breast cancer (BC) is a major global public health problem. Classical therapies have limited success on the treatment of BC; therefore, new therapeutic options are needed. Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that...
Background: This study analyzes data related to Hospital (HOS), Public Treatment Service Dedicated to Drug Addicts (SERD), or Community Mental Health Center (CMHC) clients with a first diagnosis of Pathological Gambling (PG) in the period 2000/2016 i...
Single-use plastics reduction is the primary mission of SDG promotion in Thailand. This study discusses the implementation and challenges of plastics reduction campaigns through interviews and field investigations focusing on stakeholder participatio...
Background: People who inject drugs (PWID) are the largest group at risk for HCV infection. Despite the direct acting antivirals (DAA) advancements, HCV elimination has been hindered by real-life difficulties in PWID. Aims: This study aimed to assess...
A high-speed, high-depth pre-interleaver in the proposed symbol pre-interleaving Bit MUX (PBM) was implemented to mitigate decision feedback equalizer (DFE) error propagation in a 400 G Ethernet Serializer–Deserializer (SerDes) interface. Based...
Shrimp farming often suffers due to high mortalities and poor growth. Mycotoxins can be one of the causes but often underestimated. BIŌNTE® QUIMITŌX® AQUA PLUS, an anti-mycotoxin additive (AMA) was tested to assess its efficacy and...
Understanding the factors affecting the policy process of quality assurance is important for assessing the development of higher education. Here, we used a qualitative research approach, along with an analysis of policies and a literature review, to...
In 2009, the tropical cyclonic storm Aila hit 11 southwestern coastal districts in Bangladesh, which triggered migration. Many studies were conducted on the impact of Aila on southwestern coastal communities; however, no comparative study was done on...
Targeting selective estrogen subtype receptors through typical medicinal chemistry approaches is based on occupancy-driven pharmacology. In occupancy-driven pharmacology, molecules are developed in order to inhibit the protein of interest (POI), and...
In the rapidly growing economies of Southeast Asia, energy consumption and energy costs in buildings continue to increase. Over the past decade, energy consumption from the commercial building sector in Thailand has increased at an average of 4% per...
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