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1,665 Results Found

  • Brief Report
  • Open Access
1 Citations
1,466 Views
10 Pages

21 October 2025

We investigated the occurrence of Radiospongilla inesi in a tilapia aquaculture facility located at the Chavantes Reservoir, Paranapanema River, Brazil. Specimens were collected from both artificial (net cages) and natural substrates along the reserv...

  • Article
  • Open Access
798 Views
17 Pages

Evaluation of Eco-Environmental Quality in the Maceió Metropolitan Region, Alagoas, Brazil

  • Washington Luiz Félix Correia Filho,
  • José Francisco de Oliveira-Júnior and
  • Dimas de Barros Santiago

The Maceió Metropolitan Region (MMR) has undergone significant changes due to public policies that promote urban growth. This has intensified environmental impacts, adversely affecting local communities. The Remote Sensing Ecological Index (RS...

(This article belongs to the Special Issue The Interaction among Environmental, Climatic, and Socioeconomic Aspects and Their Effects on Society)
  • Article
  • Open Access
1,057 Views
20 Pages

Therapeutic Potential of Ambroxol in Osteoarthritis: A Drug Repurposing Study

  • Michelline Joana Tenório Albuquerque Madruga Mesquita,
  • Anne Caroline Silva Nogueira da Cruz,
  • Joana Tenório Albuquerque Madruga Mesquita Meireles Teixeira,
  • Amanda Tissore Forwille Reis and ,
  • Gustavo Medeiro Frota,
  • Taciana Gabrielle Pinheiro de Moura Carvalho,
  • Rafael Antônio Freire Carvalho,
  • Jorge Antônio Meireles Teixeira,
  • Marcelo Souza de Andrade and
  • João Batista Santos Garcia
  • + 11 authors+ 6 authors

27 April 2026

Background/Objectives: Ambroxol is a mucolytic agent widely used in the treatment of respiratory diseases; however, evidence in the literature indicates anti-inflammatory, analgesic, and immunomodulatory properties, suggesting potential for therapeut...

(This article belongs to the Special Issue Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications)
  • Article
  • Open Access
49 Citations
6,085 Views
12 Pages

Chemical Composition of Volatile Compounds in Apis mellifera Propolis from the Northeast Region of Pará State, Brazil

  • Mozaniel Santana de Oliveira,
  • Jorddy Neves Cruz,
  • Oberdan Oliveira Ferreira,
  • Daniel Santiago Pereira and ,
  • Natanael Santiago Pereira,
  • Marcos Enê Chaves Oliveira,
  • Giorgio Cristino Venturieri,
  • Giselle Maria Skelding Pinheiro Guilhon,
  • Antônio Pedro da Silva Souza Filho and
  • Eloisa Helena de Aguiar Andrade
  • + 5 authors+ 0 author

Propolis is a balsamic product obtained from vegetable resins by exotic Africanized bees Apis mellifera L., transported and processed by them, originating from the activity that explores and maintains these individuals. Because of its vegetable and n...

(This article belongs to the Special Issue Essential Oils 2021)
  • Proceeding Paper
  • Open Access
1 Citations
2,480 Views
4 Pages

ID NOW: A NAAT System Solution for the Rapid and Accurate Detection of SARS-CoV-2 with VTM Sampling

  • Susana Bandarra,
  • Célia Neto,
  • Fátima Gil,
  • Lurdes Monteiro and
  • Laura Brum

ID NOW™ COVID-19 is a rapid molecular test for the detection of SARS-CoV-2. According to its instructions for use, this point-of-care test should be performed on dry nasopharyngeal swab (NPS) specimens. However, this method completely consumes...

(This article belongs to the Proceedings of The 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health)
  • Proceeding Paper
  • Open Access
1 Citations
4,863 Views
4 Pages

Performance of ID NOW Influenza A&B 2

  • Susana Bandarra,
  • Célia Neto,
  • Lurdes Monteiro and
  • Laura Brum

ID NOW™ INFLUENZA A&B 2 is a point-of-care assay for rapid molecular diagnosis of Influenza A and B. The present study aims to evaluate the performance of ID NOW™ INFLUENZA A&B 2 compared to a reference RT-PCR assay. A total of 67...

(This article belongs to the Proceedings of The 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health)
  • Proceeding Paper
  • Open Access
2,197 Views
2 Pages

Detection of the SARS-CoV-2 UK Variant in Portugal

  • Susana Bandarra,
  • Lurdes Monteiro and
  • Laura Brum

At the end of 2020, a new highly transmissible variant of SARS-CoV-2 was discovered in the United Kingdom (UK). This work aims to identify potential cases of the UK variant in Portugal using routine diagnostic samples. A total of 26 out of 43 positiv...

(This article belongs to the Proceedings of The 5th International Congress of CiiEM (IC CiiEM))
  • Proceeding Paper
  • Open Access
2,283 Views
9 Pages

The prediction of fog is a challenging task in operational weather forecast. Due to its dependency on small-scale processes, numerical weather models struggle to deal with under scale features, resulting in uncertainties in the fog forecast. Unawaren...

(This article belongs to the Proceedings of The 4th International Electronic Conference on Atmospheric Sciences)
  • Article
  • Open Access
11 Citations
5,584 Views
31 Pages

West Nile Virus in the State of Ceará, Northeast Brazil

  • Flávia Löwen Levy Chalhoub,
  • Eudson Maia de Queiroz-Júnior,
  • Bruna Holanda Duarte,
  • Marcos Eielson Pinheiro de Sá and ,
  • Pedro Cerqueira Lima,
  • Ailton Carneiro de Oliveira,
  • Lívia Medeiros Neves Casseb,
  • Liliane Leal das Chagas,
  • Hamilton Antônio de Oliveira Monteiro and
  • Alex Pauvolid-Corrêa
  • + 40 authors+ 35 authors

In June 2019, a horse with neurological disorder was diagnosed with West Nile virus (WNV) in Boa Viagem, a municipality in the state of Ceará, northeast Brazil. A multi-institutional task force coordinated by the Brazilian Ministry of Health was depl...

(This article belongs to the Special Issue Arboviruses: Diagnostic, Phylogeny and Interactions)
  • Article
  • Open Access
5 Citations
3,523 Views
22 Pages

An Intelligent Multicriteria Model for Diagnosing Dementia in People Infected with Human Immunodeficiency Virus

  • Luana I. C. C. Pinheiro,
  • Maria Lúcia D. Pereira,
  • Evandro C. de Andrade,
  • Luciano C. Nunes and ,
  • Wilson C. de Abreu,
  • Pedro Gabriel Calíope D. Pinheiro,
  • Raimir Holanda Filho and
  • Plácido Rogerio Pinheiro
  • + 3 authors+ 0 author

7 November 2021

Hybrid models to detect dementia based on Machine Learning can provide accurate diagnoses in individuals with neurological disorders and cognitive complications caused by Human Immunodeficiency Virus (HIV) infection. This study proposes a hybrid appr...

(This article belongs to the Special Issue Advances in Clinical Decision Support Systems: Artificial Intelligence, Machine/Deep Learning, Computer-Aided Diagnosis/Detection, and Radiomics)
  • Article
  • Open Access
4 Citations
3,195 Views
17 Pages

Impact on Education and Ecological Footprint as a Consequence of SARS-CoV-2 in the Perception of the Quality of Teaching Engineering Students in the Brazilian Amazon

  • Luiz Maurício Furtado Maués,
  • Felipe de Sá Moreira,
  • Luciana de Nazaré Pinheiro Cordeiro,
  • Raísse Layane de Paula Saraiva and ,
  • Paulo Cerqueira dos Santos Junior and
  • Olga Maria Pinheiro Pinheiro
  • + 1 author+ 0 author

10 August 2022

The world experienced several economic, social and environmental transformations during the COVID-19 pandemic, and today, society assesses all these changes in the different stages of the pandemic process. In this sense, this research aimed to evalua...

  • Article
  • Open Access
10 Citations
2,846 Views
19 Pages

Towards Machine Learning Algorithms in Predicting the Clinical Evolution of Patients Diagnosed with COVID-19

  • Evandro Carvalho de Andrade,
  • Plácido Rogerio Pinheiro,
  • Ana Luiza Bessa de Paula Barros,
  • Luciano Comin Nunes and ,
  • Luana Ibiapina C. C. Pinheiro,
  • Pedro Gabriel Calíope Dantas Pinheiro and
  • Raimir Holanda Filho
  • + 2 authors+ 0 author

6 September 2022

Predictive modelling strategies can optimise the clinical diagnostic process by identifying patterns among various symptoms and risk factors, such as those presented in cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known...

(This article belongs to the Special Issue Applied Machine Learning Ⅱ)
  • Article
  • Open Access
1,604 Views
17 Pages

Impact of SARS-CoV-2 Vaccination on Disease Activity and Severity of COVID-19 Infection in Patients with Systemic Lupus Erythematosus: A Multicenter Cohort Study

  • Natália Sarzi Sartori,
  • Ketty Lysie Libardi Lira Machado,
  • Samira Tatiyama Miyamoto,
  • Flavia Zon Pretti and ,
  • Maria da Penha Gomes Gouveia,
  • Yasmin Gurtler Pinheiro de Oliveira,
  • Vanezia Gonçalves da Silva,
  • Filipe Faé,
  • Ana Paula Neves Burian and
  • Odirlei André Monticielo
  • + 55 authors+ 50 authors

21 October 2025

Background: To prospectively evaluate the safety and clinical impact of SARS-CoV-2 vaccines in patients with systemic lupus erythematosus (SLE). Methods: Subanalysis of the Brazilian multicenter observational study “Safety, Effectiveness and Du...

(This article belongs to the Section COVID-19 Vaccines and Vaccination)
  • Review
  • Open Access
5 Citations
4,104 Views
18 Pages

Mercury Exposure and Health Effects in Indigenous People from the Brazilian Amazon—Literature-Scoping Review

  • Maria da Conceição Nascimento Pinheiro,
  • Fabiana Costa Cardoso,
  • Leonardo Breno do Nascimento de Aviz,
  • José Aglair Barbosa de Freitas Junior and ,
  • Márcia Cristina Freitas da Silva,
  • Margareth Tavares Silva,
  • Dirce Nascimento Pinheiro,
  • Saul Rassy Carneiro,
  • Elaine Rodrigues Pinheiro and
  • Tereza Cristina Oliveira Corvelo
  • + 5 authors+ 0 author

Background and purpose: Indigenous people in the Brazilian Amazon are exposed to mercury by eating methylmercury-contaminated fish. The lack of information on the health effects of prolonged exposure to mercury hinders the implementation of mitigatio...

  • Article
  • Open Access
3 Citations
2,759 Views
15 Pages

Immunogenicity of SARS-CoV-2 Vaccination Schedules Including a Booster Dose in Patients with Systemic Lupus Erythematosus: Data from a Prospective Multicenter Study

  • Natália Sarzi Sartori,
  • Ketty Lysie Libardi Lira Machado,
  • Samira Tatiyama Miyamoto,
  • Flávia Zon Pretti and ,
  • Maria da Penha Gomes Gouveia,
  • Yasmin Gurtler Pinheiro de Oliveira,
  • Vanezia Gonçalves da Silva,
  • Filipe Faé,
  • Ana Paula Neves Burian and
  • Odirlei André Monticielo
  • + 55 authors+ 50 authors

27 January 2025

Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus in a multicenter cohort design. Methods: Data for this analysis were obtained from the Study of Safety, Effectiveness an...

(This article belongs to the Special Issue Immunogenicity, Safety, and Coverage of Vaccines in Patients with Autoimmune Diseases)
  • Article
  • Open Access
422 Views
17 Pages

Analyzing Fiber Supports by Portuguese Artists (1915–1986) with Micro-Infrared Spectroscopy to Promote the EU’s Sustainable Development Goals

  • Susana Duarte,
  • Paula Nabais,
  • Sofia Pessanha,
  • Agnès Le Gac and ,
  • Carlos Chastre,
  • Emília Ferreira,
  • João Lopes and
  • Maria J. Melo
  • + 3 authors+ 0 author

1 July 2026

Cellulose has been integral to a range of essential applications throughout history and remains relevant today. This research highlights an important topic: the study of cellulose-based and wood-derived supports in works by Portuguese artists from th...

(This article belongs to the Special Issue Interdisciplinary Applications of Spectroscopic Techniques for Heritage Conservation)
  • Article
  • Open Access
3 Citations
1,712 Views
11 Pages

Economic Viability of Raffia in Black Pepper Crops: An Analysis Based on IRR, NPV, and Payback

  • Job Teixeira de Oliveira,
  • Fernando França da Cunha,
  • Sávio Cazelli Torezani,
  • Cassio Henrique Almeida Alves and
  • Kaliu Batista Gonçalves Santos

Black pepper (Piper nigrum) stands out as one of the most valued spices in the global market, with Brazil occupying a strategic position in production, especially in Espírito Santo, being the largest producing state in the country. This study...

(This article belongs to the Section Horticultural Economics, Policy, Business Management and Marketing)
  • Article
  • Open Access
3 Citations
3,446 Views
12 Pages

Validation of Challenges for the Development of the Marketing Plan for Startups Considering the Post-COVID-19 Reality: An Exploratory Analysis of the Brazilian Context Using Lawshe’s Method

  • Ana Carla Magalhães Nascimento,
  • Nathália de Kassia Galdino Oliveira,
  • Verônica de Menezes Nascimento Nagata,
  • Reimison Moreira Fernandes and
  • Vitor William Batista Martins

20 August 2023

Background: The post-COVID-19 scenario has demonstrated the increasing importance of marketing for organizations, as retailers and entrepreneurs have had to adapt to new ways of selling their products and services. In this regard, this research aimed...

  • Article
  • Open Access
16 Citations
6,997 Views
25 Pages

Polishing the Therapy of Onychomycosis Induced by Candida spp.: Amphotericin B–Loaded Nail Lacquer

  • Aleph M. S. Souza,
  • Renato C. A. Ribeiro,
  • Gleyse K. L. O. Pinheiro,
  • Francisco I. Pinheiro and ,
  • Wógenes N. Oliveira,
  • Luanda B. F. C. Souza,
  • André L. Silva,
  • Lucas Amaral-Machado,
  • Éverton N. Alencar and
  • Eryvaldo S. T. Egito
  • + 6 authors+ 1 author

Onychomycosis induced by Candida spp. has several limitations regarding its treatment. Nail lacquers display the potential to overcome these drawbacks by providing therapeutic compliance and increasing local drug bioavailability. Thus, this work aime...

(This article belongs to the Special Issue Antifungal and Antiparasitic Drug Delivery Volume II)
  • Article
  • Open Access
10 Citations
6,036 Views
28 Pages

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

  • Rosana Tomazi,
  • Ângela Costa Figueira,
  • Adriana Maciel Ferreira,
  • Diego Quaresma Ferreira and ,
  • Gisele Custódio de Souza,
  • Wandson Braamcamp de Souza Pinheiro,
  • José Rodrigues Pinheiro Neto,
  • Geilson Alcantara da Silva,
  • Henrique Barros de Lima and
  • Sheylla Susan Moreira da Silva de Almeida
  • + 8 authors+ 3 authors

26 August 2021

Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant is used as a hypoglycemic agent and to lose weight. This study aimed to evaluate the eff...

(This article belongs to the Special Issue Zebrafish as a Powerful Tool for Drug Discovery 2021)
  • Article
  • Open Access
6 Citations
4,765 Views
17 Pages

Seascape Ethnomapping on the Inner Continental Shelf of the Brazilian Semiarid Coast

  • Lidriana Pinheiro,
  • Antônio Rodrigues Ximenes Neto,
  • Francisco Assis Aquino Bezerra Filho,
  • Cassia Rosane Silveira Pinto and ,
  • Laldiane de Souza Pinheiro,
  • Paulo Pessoa,
  • Regimário Lima Filho,
  • Regina Balbino da Silva,
  • Jáder Morais and
  • Sergio Rossi
  • + 7 authors+ 2 authors

17 February 2023

Seascape mapping is critical to understanding ecosystem services and managing areas with potential for fishing, power generation, mining, and tourism. Despite advances in marine geophysics, the necessary equipment to make underwater cartography can b...

(This article belongs to the Special Issue Implementation of Biodiversity and Ecosystem Services in Marine Ecosystem Management, Volume II)
  • Article
  • Open Access
12 Citations
3,390 Views
18 Pages

Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models

  • Andréia C. Pinheiro,
  • Alicia S. Ombredane,
  • Willie O. Pinheiro,
  • Laise R. Andrade and ,
  • Vitória R. P. Silva,
  • Gisela J. Felice,
  • Débora S. Alves,
  • Aryanne F. Albernaz,
  • Ariane P. Silveira and
  • Graziella A. Joanitti
  • + 16 authors+ 11 authors

30 November 2022

Pequi oil (Caryocar brasiliense) contains bioactive compounds capable of modulating the inflammatory process; however, its hydrophobic characteristic limits its therapeutic use. The encapsulation of pequi oil in nanoemulsions can improve its biodistr...

(This article belongs to the Special Issue Nanomaterials in Biological Systems: Opportunities and Challenges)
  • Article
  • Open Access
3 Citations
4,076 Views
18 Pages

Removal of N-Terminal Peptide Impacts Structural Aspects of an IgE-Reactive Recombinant Der p 5

  • Camilo J. B. Vieira,
  • Raphael C. Silva,
  • Elisânia F. Silveira,
  • Antônio M. S. Fernandes and ,
  • Dumar A. Jaramillo-Hernández,
  • Luis F. S. Garcés,
  • Larissa M. S. Fonseca,
  • Bruna A. S. Machado,
  • Jamille S. Fernandes and
  • Eduardo S. da Silva
  • + 12 authors+ 7 authors

18 September 2023

(1) Background: Modification of the structural elements of allergens is widely used in the field of allergies. The goal of the present research was to express, purify, and characterize the shortened recombinant group 5 allergen of Dermatophagoides pt...

  • Article
  • Open Access
15 Citations
4,757 Views
25 Pages

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

  • Monalisa de Alencar Lucena,
  • Igor Frederico da Silveira Ramos,
  • Maurycyo Silva Geronço,
  • Ricardo de Araújo and ,
  • Francisco Lopes da Silva Filho,
  • Luís Manuel Lopes Rodrigues da Silva,
  • Rayran Walter Ramos de Sousa,
  • Paulo Michel Pinheiro Ferreira,
  • Josy Anteveli Osajima and
  • Marcilia Pinheiro da Costa
  • + 8 authors+ 3 authors

17 June 2022

The present work aimed to characterize the exopolysaccharide obtained from water kefir grains (EPSwk), a symbiotic association of probiotic microorganisms. New findings of the technological, mechanical, and biological properties of the sample were st...

(This article belongs to the Special Issue Polymers in Biomedical Applications)
  • Article
  • Open Access
2 Citations
2,448 Views
15 Pages

Sapo-34 Obtained from Amazonian Flint Kaolin: Influence of Impurities of “Oxidized Fe/Ti” in Synthesis and Its Application in the Removal of Cationic Dye from Water

  • Darllan R. Pinheiro,
  • Alice P. Pinheiro,
  • Fabio A. Pontes,
  • João Vitor K. Soares and ,
  • Roberto F. Neves and
  • Simone P. A. Paz
  • + 1 author+ 0 author

22 February 2023

Non-processed kaolin (flint kaolin) from a mine located in the Capim area (Amazon region, northern Brazil), usually considered as waste, was selected as a source of silicon and aluminum in the synthesis of SAPO-34. This is a molecular sieve and catio...

(This article belongs to the Special Issue Various Adsorbents for Water Purification Processes, Volume II)
  • Article
  • Open Access
4 Citations
2,683 Views
21 Pages

Prediction of Leachate Characteristics via an Analysis of the Solubilized Extract of the Organic Fraction of Domestic Solid Waste from the Municipality of Belém, PA

  • Diogo Oliveira Pereira,
  • Fernanda Paula da Costa Assunção,
  • Jéssica Cristina Conte da Silva,
  • Jorge Fernando Hungria Ferreira and ,
  • Raise Brenda Pinheiro Ferreira,
  • Ádila Lima Lola,
  • Ísis Costa Pereira do Nascimento,
  • Jean Pinheiro Chaves,
  • Mel Safira Cruz do Nascimento and
  • Nélio Teixeira Machado
  • + 9 authors+ 4 authors

30 October 2023

This work aimed to predict the physical–chemical characteristics of leachate according to the analysis of the solubilized extract from urban household solid waste (UHSW), on a laboratory scale, in the city of Belém/PA, Brazil. The neighb...

(This article belongs to the Topic Wastewater Treatment by Physical, Chemical, Photochemical, and Biological Processes, and Their Combinations)
  • Article
  • Open Access
5 Citations
2,462 Views
16 Pages

Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus

  • Livia Furtado Ximenes,
  • Henety Nascimento Pinheiro,
  • José Vilemar de Araújo Filho,
  • Weibson Paz Pinheiro André and ,
  • Flávia Oliveira Monteiro da Silva Abreu,
  • Mayrla Rocha Lima Cardial,
  • Debora de Souza Colares Maia Castelo-Branco,
  • Ana Carolina Fonseca Lindoso Melo,
  • Francisco Flávio da Silva Lopes and
  • Claudia Maria Leal Bevilaqua
  • + 7 authors+ 2 authors

26 March 2024

The present study aimed to evaluate the effect of nanoemulsions using combined synthetic anthelmintics, thiabendazole (TBZ), levamisole (LEV), and ivermectin (IVM), with carvacryl acetate (CA) against Haemonchus contortus, and also tested the presenc...

(This article belongs to the Section Veterinary Clinical Studies)
  • Article
  • Open Access
62 Citations
28,247 Views
18 Pages

New Trifluoromethyl Triazolopyrimidines as Anti-Plasmodium falciparum Agents

  • Núbia Boechat,
  • Luiz C. S. Pinheiro,
  • Thiago S. Silva,
  • Anna C. C. Aguiar and ,
  • Alcione S. Carvalho,
  • Monica M. Bastos,
  • Carolina C. P. Costa,
  • Sergio Pinheiro,
  • Angelo C. Pinto and
  • Antoniana U. Krettli
  • + 10 authors+ 5 authors

10 July 2012

According to the World Health Organization, half of the World’s population, approximately 3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are associated with the disease. Control of the disease in humans still r...

(This article belongs to the Section Medicinal Chemistry)
  • Feature Paper
  • Article
  • Open Access
978 Views
18 Pages

Integrated Biomarker Assessment for Prognosis in Canine Mammary Carcinomas: Complementary Roles of Serum CA 15-3 and Immunohistochemistry Ki-67, and COX-2

  • Breno Queiroz Pinheiro,
  • Marcely Braga de Albuquerque,
  • Francisco Emanuel Pinheiro Cavalcante,
  • Isabela Reis Barroso do Nascimento and ,
  • Fernanda Rezende Souza,
  • Augusto Manuel Rodrigues Faustino and
  • Lúcia Daniel Machado da Silva
  • + 2 authors+ 0 author

16 July 2026

CMTs are biologically heterogeneous neoplasms for which reliable prognostic biomarkers remain limited. This study investigated the clinical significance of serum cancer antigen 15-3 (CA 15-3) and the immunohistochemical expression of Ki-67 and cycloo...

(This article belongs to the Special Issue Tumors in Companion Animals: Detection, Diagnosis, Prognosis and Treatment)
  • Article
  • Open Access
1 Citations
984 Views
16 Pages

Melt Electrowriting-Based Hybrid Fabrication of Biodegradable Cog Threads: Design and Mechanical Evaluation for Pelvic Floor Repair

  • Fábio Pinheiro,
  • Henrique Leon Bastos,
  • Ana Telma Silva,
  • Nuno Miguel Ferreira and ,
  • Joana Pinheiro Martins,
  • Maria Francisca Vaz,
  • António Augusto Fernandes,
  • Ana Colette Maurício,
  • Nuno Alves and
  • Maria Elisabete Silva
  • + 5 authors+ 0 author

6 March 2026

Additive manufacturing (AM) offers new opportunities for biomedical device design; however, its translation to soft-tissue reinforcement remains challenging, particularly in pelvic organ prolapse (POP) applications requiring mechanical performance an...

(This article belongs to the Special Issue Advances in Additive Manufacturing: Processes, Systems, and Emerging Horizons)
  • Review
  • Open Access
1,193 Views
21 Pages

Low-Cost and Scalable Nanomanufacturing Processes for Obtaining Carbon Nanotube-Based Devices

  • Luciano José Barbosa Quaresma,
  • Rosielem Silva Dias Quaresma,
  • Leandro José Sena Santos,
  • Sabrina Ribeiro Magno and ,
  • Luiza de Marilac Pantoja Ferreira,
  • Alberto Solari Silva,
  • Pedro Paulo Rodrigues Pinheiro Filho,
  • Paula Fabíola Pantoja Pinheiro and
  • Marcos Allan Leite dos Reis
  • + 4 authors+ 0 author

The increasing demand for materials with enhanced properties and high-performance devices has driven substantial research into nanomanufacturing, particularly using carbon nanotubes (CNTs), because of their exceptional properties and high sensitivity...

  • Article
  • Open Access
846 Views
17 Pages

Seed Transmission of Cowpea Mild Mottle Virus in Common Beans in Brazil

  • Bruna Pinheiro-Lima,
  • Andreza H. Vidal,
  • Gustavo P. Felix,
  • Dione M. T. Alves-Freitas and ,
  • Cristiano Lacorte,
  • Josias C. Faria,
  • Emanuel F. M. Abreu,
  • Patricia Valle Pinheiro,
  • Fernando L. Melo and
  • Simone G. Ribeiro
  • + 5 authors+ 0 author

7 July 2026

Cowpea mild mottle virus (CPMMV) is a carlavirus that is transmitted by whiteflies and can also be spread through seeds in cowpea, soybean, and common bean. Seed transmission of CPMMV has been described in various countries; however, it was only rece...

(This article belongs to the Special Issue Biosecurity and Plant Viruses: A Call to Action for a Sustainable Future)
  • Article
  • Open Access
483 Views
22 Pages

Structural Characterization of a Proto-Type Galectin from Cinachyrella sp. and Evaluation of Its Selective Bacterial Glycan Recognition and Antibiofilm Activity

  • Juliana Sampaio Nogueira Marques,
  • Francisco Regivânio Nascimento Andrade,
  • Renato Cézar Farias Torres,
  • Israel Ferreira Barbosa Junior and ,
  • Gloria Steffanne Damasio da Silva,
  • Renata Pinheiro Chaves,
  • Ellen Araújo Malveira,
  • Elielton Nascimento,
  • Ulisses Pinheiro and
  • Alexandre Holanda Sampaio
  • + 9 authors+ 4 authors

Marine sponges represent a rich source of lectins with diverse biological activities and biotechnological potential. In this study, we report the purification and comprehensive biochemical and structural characterization of a lectin (CspL) from the m...

(This article belongs to the Special Issue Glycans, Microbiomes and Host Immunity)
  • Article
  • Open Access
2 Citations
3,563 Views
13 Pages

Toxocara spp. Infection Influences on Eosinophil Levels: An Immunological Indicator of Severe Asthma and Allergy

  • Raphael Chagas Silva,
  • Márcia Barbosa da Silva,
  • Alana Alcantara Galvão,
  • Jamile Souza Fernandes and ,
  • Gabriela Pimentel Pinheiro,
  • Álvaro A. Cruz,
  • Carina da Silva Pinheiro and
  • Neuza Maria Alcântara-Neves
  • + 3 authors+ 0 author

Background/Objectives: Toxocara spp. infection has been associated with severe asthma and allergic manifestations due to the activation of eosinophils by the release of Th2 cell cytokines. The aim of this study was to investigate the association betw...

(This article belongs to the Section Asthma/Respiratory)
  • Article
  • Open Access
18 Citations
17,129 Views
10 Pages

The Effect of Continuous Low-Intensity Exposure to Electromagnetic Fields from Radio Base Stations to Cancer Mortality in Brazil

  • Nádia Cristina Pinheiro Rodrigues,
  • Adilza Condessa Dode,
  • Mônica Kramer de Noronha Andrade,
  • Gisele O’Dwyer and ,
  • Denise Leite Maia Monteiro,
  • Inês Nascimento Carvalho Reis,
  • Roberto Pinheiro Rodrigues,
  • Vera Cecília Frossard and
  • Valéria Teresa Saraiva Lino
  • + 4 authors+ 0 author

Background: this study aims to estimate the rate of death by cancer as a result of Radio Base Station (RBS) radiofrequency exposure, especially for breast, cervix, lung, and esophagus cancers. Methods: we collected information on the number of deaths...

  • Review
  • Open Access
76 Citations
7,729 Views
26 Pages

Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin

  • Rúben G. R. Pinheiro,
  • Marina Pinheiro and
  • Ana Rute Neves

9 October 2021

Quercetin is a flavonol present in many vegetables and fruits. Generally, quercetin can be found in aglycone and glycoside forms, mainly in leaves. The absorption of this compound occurs in the large and small intestine, where it suffers glucuronidat...

(This article belongs to the Special Issue Nanoparticles for Medical Applications: Progress in Surface Modification)
  • Review
  • Open Access
11 Citations
3,568 Views
20 Pages

Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

  • Marcos Antonio Pereira de Lima,
  • Álife Diêgo Lima Silva,
  • Antônio Carlos Silva do Nascimento Filho,
  • Thiago Lima Cordeiro and ,
  • João Pedro de Souza Bezerra,
  • Maria Aline Barroso Rocha,
  • Sally de França Lacerda Pinheiro,
  • Roberto Flávio Fontenelle Pinheiro Junior,
  • Maria do Socorro Vieira Gadelha and
  • Cláudio Gleidiston Lima da Silva
  • + 5 authors+ 0 author

4 November 2021

Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-a...

(This article belongs to the Section Viral Pathogens)
  • Review
  • Open Access
46 Citations
13,136 Views
23 Pages

Voisin Rational Grazing as a Sustainable Alternative for Livestock Production

  • Luiz C. Pinheiro Machado Filho,
  • Hizumi L. S. Seó,
  • Ruan R. Daros,
  • Daniel Enriquez-Hidalgo and ,
  • Adenor V. Wendling and
  • Luiz C. Pinheiro Machado
  • + 1 author+ 0 author

8 December 2021

Current livestock practices do not meet current real-world social and environmental requirements, pushing farmers away from rural areas and only sustaining high productivity through the overuse of fossil fuels, causing numerous environmental side eff...

(This article belongs to the Special Issue Feed and Water Resources, Climate Changes, and Environmental Impact: Challenges and Opportunities for the Sustainable Development of the Animal Production Systems)
  • Article
  • Open Access
3 Citations
3,138 Views
15 Pages

Genomic Variability of Hepatitis B Virus Circulating in Brazilian Western Amazon

  • Tárcio Peixoto Roca,
  • Livia Melo Villar,
  • Felipe Souza Nogueira Lima,
  • Mariana Pinheiro Alves Vasconcelos and ,
  • Lourdes Maria Pinheiro Borzacov,
  • Eugênia de Castro e Silva,
  • Bárbara Vieira do Lago,
  • Mayara Torquato Lima da Silva,
  • Luan Felipo Botelho Souza and
  • Deusilene Souza Vieira
  • + 7 authors+ 2 authors

22 September 2022

The emergence of clinically relevant mutations in the hepatitis B virus (HBV) genome has been a matter of great debate because of the possibility of escape from the host’s immune system, the potential to cause more severe progression of liver d...

(This article belongs to the Special Issue Viral Hepatitis in Brazil)
  • Article
  • Open Access
13 Citations
3,578 Views
10 Pages

Hydroalcoholic Leaf Extract of Punica granatum, alone and in Combination with Calcium Hydroxide, Is Effective against Mono- and Polymicrobial Biofilms of Enterococcus faecalis and Candida albicans

  • Monica Naufel Sousa,
  • Alessandra Teixeira Macedo,
  • Gabriella Freitas Ferreira,
  • Haryne Lizandrey Azevedo Furtado and ,
  • Aruanã Joaquim Matheus Costa Rodrigues Pinheiro,
  • Lídio Gonçalves Lima-Neto,
  • Valéria Costa Fontes,
  • Rayana Larissa Pinheiro Soares Ferreira,
  • Cristina Andrade Monteiro and
  • Julliana Ribeiro Alves Santos
  • + 11 authors+ 6 authors

Failures in endodontic treatments are mostly associated with the difficulty in eradicating microbes of the root canal system, highlighting the need to develop novel effective antimicrobials. Punica granatum (pomegranate) leaf hydroalcoholic extract m...

(This article belongs to the Section Plant-Derived Antibiotics)
  • Review
  • Open Access
260 Citations
18,947 Views
22 Pages

Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?

  • Rúben G. R. Pinheiro,
  • Ana Joyce Coutinho,
  • Marina Pinheiro and
  • Ana Rute Neves

28 October 2021

The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategi...

(This article belongs to the Collection Feature Papers in Materials Science)
  • Article
  • Open Access
4 Citations
3,989 Views
16 Pages

Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study

  • Marisa Zenaide Ribeiro Gomes,
  • Douglas Quintanilha Braga,
  • Debora Otero Britto Passos Pinheiro,
  • Renata Cristina Amorim Silveira Verduc and ,
  • Letícia Vellozo dos Reis,
  • Elisangela Martins de Lima,
  • Newton Dias Lourenço,
  • Patrícia Aquen Cid,
  • Debora Souza Beck and
  • Saint Clair dos Santos Gomes Junior
  • + 26 authors+ 21 authors

A clinical–epidemiological score to predict CR-GNB sepsis to guide empirical antimicrobial therapy (EAT), using local data, persists as an unmet need. On the basis of a case–case–control design in a prospective cohort study, the pre...

(This article belongs to the Special Issue Antibiotics Resistance in Gram-Negative Bacteria)
  • Article
  • Open Access
1,787 Views
12 Pages

Fermentative Potential of Industrial Saccharomyces cerevisiae Strains for Mead Production from Semi-Arid Brazilian Honeys

  • Rayssa Karla Silva,
  • Jamerson Domingos de França,
  • Henri Adson Ferreira Medeiros,
  • Walter de Paula Pinto Neto and ,
  • Luciana Leite de Andrade Lima Arruda,
  • Hélio Fernandes de Melo,
  • Daniela Maria do Amaral Ferraz Navarro,
  • Paulo Milet-Pinheiro,
  • Andrelina Maria Pinheiro Santos and
  • Rafael Barros de Souza
  • + 6 authors+ 1 author

This study evaluated the fermentative potential of eight industrial strains of Saccharomyces cerevisiae for producing mead from honeys originating from the Caatinga Biome in the semi-arid region of Pernambuco, Brazil. Despite presenting similar ethan...

(This article belongs to the Special Issue Bioactive Compounds in Fermented Beverages)
  • Article
  • Open Access
575 Views
23 Pages

Antimicrobial Activity of Stryphnodendron adstringens (Mart.) Coville, Baccharis crispa Spreng, and Azadirachta indica Against Bacteria Causing Bovine Mastitis and Phytochemical Profiling Determined by PS-MS

  • Gian Carlos Nascimento,
  • Melina Laura Moretti Pinheiro,
  • Brenda Veridiane Dias,
  • Raphael Ocelli Pinheiro and ,
  • Maria Aparecida Vasconcelos Paiva Brito,
  • Afonso Henrique de Oliveira Júnior,
  • Lara Louzada Aguiar,
  • Rodinei Augusti,
  • Julio Onesio-Ferreira Melo and
  • Ana Cardoso Clemente Filha Ferreira de Paula
  • + 6 authors+ 1 author

Medicinal plants have attracted increasing scientific interest due to the diversity of bioactive compounds reported across different species. They may represent complementary sources of bioactive compounds alongside conventional antimicrobials, which...

(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
  • Feature Paper
  • Article
  • Open Access
383 Views
33 Pages

14 August 2026

We develop a tensor-based dynamical framework for monetary flows in multi-sector, multi-agent economies and quantify the information destroyed when the monetary state is reduced to a scalar aggregate. The state is a third-order tensor encoding capita...

(This article belongs to the Section Multidisciplinary Applications)
  • Article
  • Open Access
30 Citations
4,627 Views
13 Pages

Effects of Harvest Time and Hydrodistillation Time on Yield, Composition, and Antioxidant Activity of Mint Essential Oil

  • Samara de Paula Pinheiro Menezes Marques,
  • Rafaela Oliveira Pinheiro,
  • Rafael Alves do Nascimento,
  • Eloísa Helena de Aguiar Andrade and
  • Lênio José Guerreiro de Faria

14 November 2023

In this study, we assessed the effects of different harvest times (9 a.m., 1 p.m., and 5 p.m.) and hydrodistillation times (60, 90, and 120 min) on the yield, chemical composition, and antioxidant activity of the spearmint (Mentha spicata L.) essenti...

  • Review
  • Open Access
6 Citations
2,146 Views
25 Pages

Fishways in Portugal: Status, Main Findings and Research Needs

  • José M. Santos,
  • Ana L. Quaresma,
  • Filipe Romão,
  • Susana D. Amaral and ,
  • Daniel Mameri,
  • Marta Santo,
  • Jorge Bochechas,
  • Ana Telhado,
  • Francisco N. Godinho and
  • Paulo Branco
  • + 12 authors+ 7 authors

7 October 2025

Anthropogenic barriers fragment Portuguese rivers, threatening endemic freshwater fish communities. This study compiled national inventories and peer-reviewed research (2002–2024) to quantify fishway implementation, evolution and typology, whil...

(This article belongs to the Section Ecohydrology)
  • Review
  • Open Access
13 Citations
5,764 Views
60 Pages

An Overview of Orchidaceae from Brazil: Advances and Shortfalls After 400 Years of Studies

  • Edlley M. Pessoa,
  • Adriane M. Araújo,
  • Felipe F. V. A. Barberena,
  • João A. N. Batista and ,
  • Adarilda P. Benelli,
  • João S. P. Bento,
  • Eduardo L. Borba,
  • Antônio Edmilson Camelo-Júnior,
  • Patrick C. Cantuária and
  • Cássio van den Berg
  • + 39 authors+ 34 authors

18 November 2025

The historical background of studies on Brazilian Orchidaceae dates back almost 400 years. In this review, we provide an overview of the current knowledge on Brazilian Orchidaceae across three thematic axes: 1. diversity, distribution, and endemism;...

(This article belongs to the Special Issue New Perspectives on Plant Biogeography, Systematics, and Taxonomy)
  • Article
  • Open Access
1,737 Views
14 Pages

In Vitro Antifungal Effect of Selected Essential Oils Against Clinical Isolates Causing Fungal Keratitis: A Preliminary Pharmacological Evaluation

  • Elijah Akegbe,
  • Nuno Mesquita,
  • Célia Cabral,
  • Emília Pereira and ,
  • Luís Fernandes,
  • Anália do Carmo,
  • Rui Tomé,
  • Dolores Pinheiro,
  • João Pinheiro-Costa and
  • Elisa J. Campos
  • + 6 authors+ 1 author

Background/Objectives: Fungal keratitis (FK) is a current challenge in ophthalmology due to its association with severe visual impairment and the limitations of current antifungal therapies. We aim to evaluate the antifungal activity of essential oil...

(This article belongs to the Special Issue Novel Therapeutic Agents and Innovative Treatment Strategies Against Infectious Diseases)
  • Article
  • Open Access
1,548 Views
14 Pages

Synthesis, In Vitro Antitumor Activity, and In Silico ADMET Evaluation of β-Lapachone-Based Thiosemicarbazones

  • Elizabete Silva de Sousa,
  • Edilane Almeida da Silva,
  • Délis Galvão Guimarães,
  • Ingrid Louise Santos de Souza and ,
  • Arlan de Assis Gonsalves,
  • Paulo Michel Pinheiro Ferreira,
  • Rayran Walter Ramos de Sousa,
  • Marcília Pinheiro da Costa and
  • Cleônia Roberta Melo Araújo
  • + 4 authors+ 0 author

Background/Objectives: β-Lapachone and triapine are compounds with recognized antitumor potential—the former is an ortho-naphthoquinone, and the latter a thiosemicarbazone inhibitor of ribonucleotide reductase. This study aimed to synthesi...

(This article belongs to the Section Medicinal Chemistry and Preliminary Screening)

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