Special Issue "Nanoparticles for Medical Applications: Progress in Surface Modification"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 21 December 2020.
Interests: Bioactive glasses/glass-ceramics; antibacterial materials; composites; magnetic materials; inorganic nanoparticles.
Interests: biomaterials; bioactive glasses; antibacterial materials; surface functionalization; magnetic materials; nanomaterials
Special Issues and Collections in MDPI journals
In the last years, nanoparticles attracted the researchers interest due to their exclusive chemical and physical properties. In medical applications, different kind of nanoparticles have been investigated, such as magnetic, metallic, polymeric, silica, fluorescent (quantum dots) and biologically derived nanoparticles; moreover, several progresses have been made regarding their synthesis method. However, more efforts are still required to improve and tailor the nanoparticles surface properties.
Surface features are extremely important since they can influence nanoparticles dispersion, biocompatibility, solubility, interaction with biomolecules and cellular internalization. Functionalization with small molecules, surfactants, dendrimers and polymers, is one of the most used strategy to protect nanoparticles against agglomeration, improve their biocompatibility, tailor the biodegradability and impart desired properties. Another strategy to modify the nanoparticles surface features is to coat them with thin organic or inorganic layers.
The specific challenge of this special issue is to survey and outline the progress on the nanoparticles surface optimization, focusing the attention on the interaction between nanoparticles and chemical moieties, and their characterization in physiological conditions. For this reason, it is with immense pleasure that we invite authors to submit original research paper or reviews for this Special Issue.
Potential topics concern, but are not limited to:
- Nanoparticles surface functionalization
- Nanoparticles organic/inorganic coating
- Nanoparticles interaction with biomolecules
- Interaction between nanoparticles and biological systems
- Role of nanoparticles surface in the cell internalization
- Biocompatibility of nanoparticles
- Nanoparticles surface functionalization
- Nanoparticles coatings
- Nanoparticles-cells interaction
- Inorganic nanoparticles
- Organic Nanoparticles
- Biologically derived nanoparticles
- Therapy and diagnosis
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Tumor targeting by monoclonal antibody functionalized magnetic nanoparticles
Authors: Oltolina F, Colangelo D, Miletto I, Clemente N, Miola M, Verné E, Prat M and Follenzi A
Abstract: Several magnetic nanoparticles (MNPs) were analysed as potential tumor-targeted drug-loaded nanocarriers after functionalization with anti-MET/HGFR monoclonal antibody (mAb) and Doxorubicin (DOXO). The simplest silica- and calcium-free mAb-loaded MNPs were the most cytocompatible (MTT assay), the most stable, showed the best immunocompetence and specificity (immunoprecipitation, confocal immunofluorescence)]. The presence of the mAbs on DOXO-MNPs increased significantly their cytotoxicity on MET/HGFR+ cells, while no such effect was detectable on MET/HGFR- cells (real time toxicity). Bare MNPs were biocompatible in vivo; mAb presence on MNPs induced a better dispersion within the tumor mass when injected in situ in MET/HGFR+ xenotumors in γ-null mice.
Title: Interaction of biadhesive molecules based-nanotools with the “sweet” side of cancer cells: implication in cancer- and immune-therapy
Authors Name: Bloise Nora,1,2,* Sehrish Farooq,1 Galliano Monica1 and Visai Livia1,2
1 Department of Molecular Medicine, Center for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, Italy
2 Department of Occupational Medicine, Toxicology and Environmental Risks, ICS Maugeri, IRCCS, Pavia, Italy
* Correspondence: [email protected]
Abstract: Malignant transformation is accompanied by profound alterations in glycosylation. After a short excursus on the role of glycosylation and its main characteristics, the review aimed to summarize the recent progress relating to nanomedicine strategies to targeting aberrant glycosylation by involving the functionalization of nanoparticles with biological molecules owing bioadhesive properties. We will focus on the current adhesive molecules based-nanotools (e.g. natural lectins and antibodies), describing also the possible mechanism of action and its challenges and perspective in cancer immunotherapies.