Special Issue "Nanomaterials in Biological Systems: Opportunities and Challenges"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 September 2022 | Viewed by 526

Special Issue Editors

Prof. Dr. Carolina Madeira Lucci
E-Mail Website
Guest Editor
Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasilia 70910-900, Brazil
Interests: biocompatibility; in vitro/in vivo cytotoxicity; in vivo interactions; hyperthermia
Prof. Dr. Ricardo Bentes Azevedo
E-Mail Website
Guest Editor
Department of Genetics and Morphology, Universidade de Brasília, Brasilia 70910-900, Brazil
Interests: nanomedicine; photodynamic therapy; nanoemulsions; cancer treatments

Special Issue Information

Dear Colleagues,

Nanomaterials are a class of materials with unique properties that can be used in a wide range of applications and improve biomedical treatments. The different types of nanomaterials (inorganic and polymeric nanoparticles, liposomes, nanocrystals, nanotubes, dendrimers) can be specifically designed and functionalized to become biocompatible and to serve a specific a biomedical purpose. Numerous nanomaterials are being developed and studied for many applications, such as drug delivery, hyperthermia, imaging agents for diagnosis, and treatment of several conditions. Nanomaterials enable creating new therapeutic approaches and optimizing conventional treatments as they allow the delivery of drugs to the affected organ/tissue in a more specific and controlled way, as well as stimuli-responsive therapeutics. These features facilitate the use of lower doses and promote local rather than systemic action, avoiding or reducing side effects. Nanostructured materials also allow the development of treatments based on hyperthermia, such as thermocytolysis and thermoablation. Nonetheless, while nanomaterials present many potential advantages and open several opportunities for new biomedical and theragnostic applications, their interaction with biological systems still poses several challenges. Their short- and long-term effects on different cell types, organs, and body systems still need to be better understood.

The aim of this Special Issue is to explore the applications of nanostructured materials for biological and/or biomedical applications and the interactivity of these materials with different cells, organs, and biological systems.

Prof. Dr. Carolina Madeira Lucci
Prof. Dr. Ricardo Bentes Azevedo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanostructured materials
  • biomedical applications
  • biocompatibility
  • in vitro/in vivo cytotoxicity
  • in vivo interactions
  • pharmacokinetics
  • clearance in complex biological systems
  • theragnostic
  • nanomedicine

Published Papers (1 paper)

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Fish Oil Nanoemulsion Supplementation Attenuates Bleomycin-Induced Pulmonary Fibrosis BALB/c Mice
Nanomaterials 2022, 12(10), 1683; https://doi.org/10.3390/nano12101683 - 14 May 2022
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Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, [...] Read more.
Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, when associated with a lipid nanoemulsion in an experimental pulmonary inflammatory model. Pulmonary fibrosis is a disease associated with excessive extracellular matrix deposition. We determined to investigate the morphophysiological mechanisms in mice that were pretreated after induction with bleomycin (BLM). The pretreatment was for 21 days with saline solution, sunflower oil (SO), fish oil (FO), and fish oil nanoemulsion (NEW3). The animals received a daily dose of 50 mg/Kg of docosahexaenoic acid DHA and 10 mg/Kg eicosapentaenoic (EPA) (100 mg/Kg), represented by a daily dose of 40 µL of NEW3. The blank group was treated with the same amount daily (40 µL) during the 21 days of pretreatment. The animals were treated with SO and FO, 100 mg/Kg (containing 58 mg/Kg of polyunsaturated fats/higher% linoleic acid) and 100 mg/Kg (50 mg/Kg of DHA and 10 mg/Kg EPA), respectively. A single dose of 5 mg/mL (50 μL) bleomycin sulfate, by the intratracheal surgical method in BALB/cAnNTac (BALB/c). NEW3 significantly reduced fibrotic progression, which can be evidenced by the protection from loss of body mass, increase in respiratory incursions per minute, decreased spacing of alveolar septa, decreased severity of fibrosis, and changes in the respiratory system. NEW3 attenuated the inflammatory changes developed in the experimental model of pulmonary fibrosis, while group SO showed a significant increase in inflammatory changes. This concluded that the presented results demonstrated that is possible to positively modulate the immune and inflamamtory response to an external agressor, by changing the nutitional intake of specific fatty acids, such as omega-3 placed in fish oil. Moreover, these benefits can be improved by the nanoencapsulation of fish oil in lipid nanoemulsions. Full article
(This article belongs to the Special Issue Nanomaterials in Biological Systems: Opportunities and Challenges)
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