Nanotechnology is addressing major urgent needs for cancer treatment. We conducted a study to compare the frequency of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2′-deoxyguanosine...
This study aimed to develop monoclonal antibodies (mAbs) against the gD protein of FHV-1 for rapid and specific virus detection. The gD protein, a highly conserved part of the FHV-1 envelope, is crucial for viral entry into host cells, making it an i...
Background/Objectives: Eye infection with herpes simplex virus type 1 (HSV-1) can result in keratitis, a leading cause of corneal blindness. We evaluated whether an experimental vaccine containing HSV-2 immunogens to prevent genital herpes also prote...
Occupational exposure to wood dust has been estimated to affect 3.6 million workers within the European Union (EU). The most serious health effect caused by wood dust is the nasal and sinonasal cancer (SNC), which has been observed predominantly amon...
The N1-atom of guanosine at position 37 in transfer RNA (tRNA) is methylated by tRNA methyltransferase 5 (Trm5) in eukaryotes and archaea, and by tRNA methyltransferase D (TrmD) in bacteria. The resultant modified nucleotide m1G37 positively regulate...
Molecular mechanisms underlying Hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) pathogenesis are still unclear. Therefore, we analyzed the levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and other oxidative lesions at...
In this work, a preliminary screening of the bioactivities of an ethanolic extract obtained from the leaves of Wollemia nobilis W.G.Jones, K.D.Hill & J.M.Allen was carried out to explore its potential pharmaceutical applications. In particular, t...
Autoantibodies targeting islet antigen 2 (IA2) are critical diagnostic and prognostic markers for type 1 diabetes (T1D). Standard clinical assays do not differentiate between IgG and IgM isotypes, yet these antibodies have distinct roles in the T1D a...
The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the...
We produced a recombinant eel luteinizing hormone (rec-eel LH) analog with high potency in Chinese hamster ovary DG44 (CHO DG44) cells. The tethered eel LH mutant (LH-M), which had a linker comprising the equine chorionic gonadotropin (eLH/CG) β...
A huge amount of waste is produced annually by the food processing industry which must be valorized into high-value products. Therefore, the aim of this work involves the use of such wastes for production of β-glucans from medicinal basidiomycet...
The respiratory syncytial virus (RSV) causes significant respiratory disease in young infants and the elderly. Immune prophylaxis in infants is currently limited to palivizumab, an anti-RSV fusion (F) protein monoclonal antibody (mAb). While anti-F p...
This article presents the design of a low-power low noise amplifier (LNA) implemented in 45 nm silicon-on-insulator (SOI) technology using the
This study aimed to develop a glycoengineered recombinant eel follicle-stimulating hormone (rec-eel FSH) with modified O-linked glycosylation and to establish a stable mammalian cell-based production platform using Chinese hamster ovary DG44 (CHO DG4...
Introduction: Neuroblastoma (NB) is one of the most common extracranial solid malignant tumors in children. The 5-year survival rate of high-risk or refractory NB is less than 50%. Therefore, developing new effective therapeutics for NB remains an ur...
Recently, design methods based on
: The biosynthesis of penicillin G (PG) is compartmentalized, which forces penicillin and its intermediates to cross the membrane barriers. Although many aspects around the penicillin intermediates traffic system remain unclosed, the transmembrane tr...
This work details the optimization and evaluation of a CMOS low-noise amplifier by developing a new algorithm for the
The preamplifier block is crucial in bio-medical signal processing. The power intensive Operational Transconductance Amplifier (OTA) is considered, and the performance of preamplifier is studied. A low noise and low power telescopic OTA is proposed i...
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of approximately 13%, partly because of limited treatment options and resistance to therapies. Although the recently discovere...
In this work, an analog front-end (AFE) circuit for an electrocardiogram (ECG) detection system has been designed, implemented, and investigated in an industry-standard Cadence simulation framework using an advanced technology node of 45 nm. The AFE...
The proposed work introduces a sizing algorithm to achieve a desired linear transconductance in the optimization of operational transconductance amplifiers (OTAs) by applying the
Accurate six-degree-of-freedom (6-DoF) visual localization is a fundamental component for modern mapping and navigation. While recent data-centric approaches have leveraged Novel View Synthesis (NVS) to augment training datasets, these methods typica...
Three-dimensional (3D) reconstruction has become a fundamental technology in applications ranging from cultural heritage preservation and robotics to forensics and virtual reality. As these applications grow in complexity and realism, the quality of...
Pancreas-derived islet amyloid polypeptide (IAPP) crosses the blood–brain barrier and co-deposits with amyloid beta (Aβ) in brains of type 2 diabetes (T2D) and Alzheimer’s disease (AD) patients. Depositions might be related to the ci...
Analog design is an inherently intricate process comprising many trade-offs; as a result, it is an iterative time-consuming operation. A low dropout voltage regulator (LDO) is an example of such analog blocks that involve a myriad of trade-offs. In t...
Herpes simplex virus-1 (HSV-1), like all herpesviruses, is a large complex DNA virus containing up to 16 different viral membrane proteins in its envelope. The assembly of HSV-1 particles occurs by budding/wrapping at intracellular membranes producin...
HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent prot...
Agile product development cycles and re-configurable Industrial Internet of Things (IIoT) allow more flexible and resilient industrial production systems that can handle a broader range of challenges and improve their productivity. Reinforcement Lear...
In individuals who have once developed humoral immunity to an infectious/foreign antigen, the antibodies present in their body can mediate instant protection when the antigen re-enters. Such antigen-specific antibodies can be readily detected in the...
The Golgi complex undergoes dynamic remodeling during the cell cycle, as ribbon unlinking in G2 is required for proper mitotic progression. Failure to fragment the ribbon leads to G2 arrest, whereas forced mitotic entry with intact ribbons results in...
Background/Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition with not fully understood causes, though evidence points to immune system involvement and possible autoimmunity. ME/CFS could be triggered...
When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells. When μ chains were paired...
Less defective, nitrogen-doped 3-dimensional graphene (N3DG) and defect-rich, nitrogen-doped 3-dimensional graphene (N3DG-D) were made by the thermal CVD (Chemical Vapor Deposition) process via varying the carbon precursors and synthesis temperature....
A series of Fe2O3-anchored three-dimensional graphene (3DG) composites are synthesized via hydrothermal and annealing methods. The Fe2O3 nanocrystals in composites display nanocubes, one-dimensional (1D) nanorods and ellipsoids at hydrothermal temper...
Fetal alcohol spectrum disorder (FASD) is the most common preventable cause of neurodevelopmental defects, and white matter is a major target of ethanol neurotoxicity. Therapeutic interventions with choline or dietary soy could potentially supplement...
The increasing penetration of Distributed Generators (D.G.) into the existing power system has brought some real challenges regarding the transient response of electrical systems. The injection of D.G.s and abrupt load changes may cause massive power...
Angiotensin-converting enzyme (ACE) inhibitors are one of the most active classes for cardiovascular diseases and hypertension treatment. In this regard, developing active and non-toxic ACE inhibitors is still a continuous challenge. Furthermore, the...
Metabotropic glutamate receptor 5 (mGlu5) plays a fundamental role in synaptic plasticity, potentially serving as a therapeutic target for various neurodevelopmental and psychiatric disorders. Previously, we have shown that mGlu5 can also signal from...
A highly reconfigurable open-loop analog baseband circuitry with programmable gain, bandwidth and filter order are proposed for integrated linear frequency modulated continuous wave (LFMCW) radar receivers in this paper. This analog baseband chain al...
Analog design productivity remains a challenge in the digitally driven semiconductor chip design field. Knowledge-based and simulation-based analog automation approaches have not achieved widespread acceptance in the analog design community. Systemat...
This work presents a comprehensive analytical and simulation-based comparison between bulk-driven (BD) and gate-driven (GD) operational transconductance amplifiers (OTAs) operating in the deep-subthreshold ultra-low-voltage regime. While BD technique...
In this paper, a novel smart outage management system considering Emergency Demand Response Programs (EDRPs) and Distributed Generations (DGs) denoted as
To meet the demand for high-capacity indoor wireless access in future 6G systems, we propose and experimentally demonstrate a photonics-aided D-band wireless transmission scheme operating at 138 GHz. At the transmitter, two external-cavity lasers tog...
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Lipotoxic stress from saturated fatty acids compromises the mitochondria of human adipose-derived mesenchymal stem cells (hAdMSCs) and, with them, their regenerative capacity. We exposed hAdMSCs to sodium palmitate at 250 and 500 µM for 24 h an...
Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in...
Depletion of fossil fuel deposits is the main current issue related to the world’s power generation. Renewable energy sources integrated with energy efficiency represent an effective solution. The electrification of end-use coupled with renewable pow...
Anaemia caused by iron deficiency has long been reported in dairy calves. This study investigated iron deficiency anaemia on UK dairy farms feeding whole milk and evaluated the effect of iron supplementation on the daily weight gain (DG) and haemoglo...
It is anticipated that many of the future forest mapping applications will be based on three-dimensional (3D) point clouds. A comparison study was conducted to verify the explanatory power and information contents of several 3D remote sensing data so...
A proposal to control the structural pounding hazard imposed on multistory reinforced concrete (RC) structures is presented. The main goal is to guarantee the seismic performance of a structure with an acceptable (predefined) risk-targeted parameter...
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