Announcements

We are pleased to announce that the 2024 Tu Youyou Award has been conferred upon Richard DiMarchi and Rolf Müller, in recognition of their significant contributions to natural products chemistry and medicinal chemistry.

Richard DiMarchi Indiana University, USA	Prof. Richard DiMarchi is a Distinguished Professor of Chemistry and Gill Chair in Biomolecular Sciences at Indiana University, USA. He is a member of the National Academy of Medicine and the National Inventors Hall of Fame. Dr. DiMarchi is a former Group Vice President at Eli Lilly and later at Novo Nordisk. He is recognized for his contributions to the discovery and development of rDNA-derived Humulin®, Humalog®, rGlucagon®, and Forteo®. His academic research has broadened the understanding of glucagon and incretin physiology and pioneered the discovery of single-molecule multi-mechanism agonists for the treatment of diabetes and obesity. The central element to success has been the chemical vision and technology to install within single molecules simultaneous agonism at related G-protein coupled receptors, coupled to the counter-intuitive discovery that glucagon and GIP agonism could synergize the therapeutic efficacy of GLP-1. These peptides and their conceptual approach have transformed the management of excessive body weight to a condition comparable to how hypertension, adult-onset diabetes, and excess cholesterol are medicinally managed.
“Professor DiMarchi was recognized by the 2024 Tu Youyou Award Committee members as being an exceptional leader in the medicinal chemistry of peptides and proteins of natural origin, and as a pioneer in the field of chemical biotechnology. His very important discoveries have led to breakthroughs in new drugs related to the therapy of diabetes and obesity. He has been named as an inventor on a very large number of patents, and he has had initially a highly successful scientific and administrative career in industry, which was followed by over two decades in academia as a distinguished professor.” —Prof. Dr. A. Douglas Kinghorn, Chair of the Award Committee
Rolf Müller Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany; Helmholtz Centre for Infections Research (HZI), Germany; Saarland University, Germany	Prof. Rolf Müller is the Founding and Managing Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and Professor of Pharmaceutical Biotechnology at Saarland University, Germany. Having received his training from the University of Bonn, he held research positions at the University of Washington, USA, and Braunschweig University of Technology, Germany, prior to his appointment as professor to Saarland University. His laboratory has dedicated itself to the exploration of bacterial natural-product biosynthetic pathways for more than 20 years and has extensive experience in working with myxobacteria and other microbial producer strains. Starting from the isolation and characterization of new microorganisms, the scope of work includes microbiology-, biotechnology-, bioinformatics-, and chemistry-based approaches to exploit these isolates as sources of new drugs with a special focus on novel anti-infectives. Müller and his team apply a variety of state-of-the-art analytical methods and biological assays to perform biological and chemical characterizations of the identified compounds. Prof. Müller has received several awards, including the prestigious Gottfried Wilhelm Leibniz Prize, the PHOENIX Pharmacy Research Award, the DECHEMA Prize, and the Inhoffen Medal, as well as being an elected member of acatech, Leopoldina, and the German Academy of Sciences and Literature.
“The 2024 Tu Youyou Award Committee members were highly impressed by the truly outstanding past and ongoing contributions of Professor Müller in both microbial natural products isolation chemistry and in biosynthesis, as well as in the development of lead compounds for their potential in treating human diseases, through his global connections with various major funding agencies. He is also a dedicated teacher who has trained numerous graduate students and postdoctoral fellows, and he has lectured on his research in countries all over the world.” —Prof. Dr. A. Douglas Kinghorn, Chair of the Award Committee

The achievements of Richard DiMarchi and Rolf Müller highlight the transformative impact of natural products chemistry and medicinal chemistry. We congratulate them and invite the global academic community and public to join us in celebrating their significant contributions.

2024 Award Committee
Committee Chair:

• Prof. Dr. A. Douglas Kinghorn, Ohio State University, USA.
  

Committee Members (listed in alphabetical order):

• Prof. Angelo Fontana, University of Naples “Federico II”, Italy;
• Prof. Binghe Wang, Georgia State University, USA;
• Dr. Diana Pinto, University of Aveiro, Portugal;
• Prof. Hideaki Kakeya, Kyoto University, Japan;
• Dr. RuAngelie Edrada-Ebel, University of Strathclyde, UK;
• Prof. Thomas Prisinzano, University of Kentucky, USA
• Prof. Wei Li, University of Tennessee Health Science Center, USA.

About the Tu Youyou Award:
The 2024 Tu Youyou Award includes a total monetary prize of 100,000 Swiss Francs and a medal for each recipient. Established in 2016 to honor the pioneering spirit of Nobel laureate Tu Youyou, the Tu Youyou Award is an international award honoring exceptional scholars dedicated to the fields of natural products chemistry and medicinal chemistry.

For further information about the award and the winners, please visit the Tu Youyou Award website.

Conference: ESC Congress 2025
Date: 29 August–1 September 2025
Location: Madrid, Spain

We will be attending the ESC Congress 2025 together with the World Congress of Cardiology as an exhibitor. The event will take place in Madrid, Spain, from 29 August to 1 September 2025.

Organized by the European Society of Cardiology, the ESC Congress 2025 will focus on the theme “Cardiology Beyond Borders – Global Health”, highlighting the evolving role of cardiovascular disease within the broader global health landscape.

The following Open Access journals will be represented:

• JCM;
• JCDD;
• Healthcare;
• Biomedicines;
• Cardiogenetics;
• IJTM;
• Hearts;
• Medicina;
• IJERPH;
• Diseases;
• Genes;
• EJIHPE;
• JPM;
• Clinics and Practice;
• Tomography.

If you are attending this conference, please feel free to start an online conversation with us. Our delegates look forward to meeting you in person at booth #B206 and answering any questions you may have. For more information about the conference, please visit the following website: https://www.escardio.org/Congresses-Events/ESC-Congress.

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an open access journal that covers all topics related to clinical and pre-clinical practices. In this issue, we are delighted to share some highly cited papers on inflammatory bowel disease and recommend open Special Issues for you to submit your recent research to.

1. “Drug Clearance in Patients with Inflammatory Bowel Disease Treated with Biologics”
by Tina Deyhim, Adam S. Cheifetz and Konstantinos Papamichael
J. Clin. Med. 2023, 12(22), 7132; https://doi.org/10.3390/jcm12227132
Full text available online: https://www.mdpi.com/2077-0383/12/22/7132

2. “The Optimal Management of Inflammatory Bowel Disease in Patients with Cancer”
by Panu Wetwittayakhlang, Paraskevi Tselekouni, Reem Al-Jabri, Talat Bessissow and Peter L. Lakatos
J. Clin. Med. 2023, 12(6), 2432; https://doi.org/10.3390/jcm12062432
Full text available online: https://www.mdpi.com/2077-0383/12/6/2432

3. “Systematic Review and Meta-Analysis of Observational Studies on the Effectiveness and Safety of Ustekinumab among Patients with Inflammatory Bowel Disease in Eastern and Western Countries”
by He Zhou, Fang Wang, Jian Wan, Song Su, Yanting Shi, Xiaofei Li, Tong Wu and Jie Liang
J. Clin. Med. 2023, 12(5), 1894; https://doi.org/10.3390/jcm12051894
Full text available online: https://www.mdpi.com/2077-0383/12/5/1894

4. “Time Trends of Environmental and Socioeconomic Risk Factors in Patients with Inflammatory Bowel Disease over 40 Years: A Population-Based Inception Cohort 1977–2020”
by Panu Wetwittayakhlang, Lorant Gonczi, Petra A. Golovics, Zsuzsanna Kurti, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Laszlo Lakatos and Peter L. Lakatos
J. Clin. Med. 2023, 12(8), 3026; https://doi.org/10.3390/jcm12083026
Full text available online: https://www.mdpi.com/2077-0383/12/8/3026

5. “Efficacy and Safety of Vedolizumab in Patients with Inflammatory Bowel Disease in Association with Vedolizumab Drug Levels”
by Eva Hüttemann, Anna Muzalyova, Katharina Gröhl, Sandra Nagl, Carola Fleischmann, Alanna Ebigbo, Johanna Classen, Julia Wanzl, Friederike Prinz, Patrick Mayr et al.
J. Clin. Med. 2024, 13(1), 140; https://doi.org/10.3390/jcm13010140
Full text available online: https://www.mdpi.com/2077-0383/13/1/140

6. “The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients”
by Oana Belei, Diana-Georgiana Basaca, Laura Olariu, Manuela Pantea, Daiana Bozgan, Anda Nanu, Iuliana Sîrbu, Otilia Mărginean and Ileana Enătescu
J. Clin. Med. 2024, 13(5), 1361; https://doi.org/10.3390/jcm13051361
Full text available online: https://www.mdpi.com/2077-0383/13/5/1361

7. “Crohn’s Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities”
by Zhou Zhou, Laura F. Ouboter, Koen C. M. J. Peeters, Lukas J. A. C. Hawinkels, Fabian Holman, Maria F. Pascutti, Marieke C. Barnhoorn and Andrea E. van der Meulen-de Jong
J. Clin. Med. 2023, 12(2), 466; https://doi.org/10.3390/jcm12020466
Full text available online:  https://www.mdpi.com/2077-0383/12/2/466

8. “Considering Histologic Remission in Ulcerative Colitis as a Long-Term Target”
by Christopher Pavel, Mircea Mihai Diculescu, Alex-Emilian Stepan, Gabriel Constantinescu, Vasile Sandru, Cristian George Ţieranu, Luiza Tomescu, Alexandru Constantinescu, Cristina Patoni, Oana-Mihaela Plotogea et al.
J. Clin. Med. 2024, 13(1), 289; https://doi.org/10.3390/jcm13010289
Full text available online: https://www.mdpi.com/2077-0383/13/1/289

With the improvements in cancer prognosis thanks to advances in anti-cancer treatment protocols and new targeted therapies and immunotherapies, we are witnessing an increase in survival; however, at the same time, an increase in morbidity has also been observed among cancer survivors as a consequence of the increased cardiovascular adverse effects of anti-cancer drugs.

This is often the consequence of mechanisms that are still partially unknown, which prevent the development of preventative and curative therapies that target the specific cardio- and vasculotoxic effects of anti-cancer therapies. 

In this webinar, we will discuss the new frontiers of cardio-oncology research, the mechanisms and implications of hidden cytotoxicity, and the metabolic roots of anthracycline-induced cardiotoxicity. These topics will be covered by world-class experts in the field. 

This webinar will be introduced by an opening greeting from Prof. Dr. Rosalinda Madonna, together with the co-chair, Prof. Dr. Luca Liberale. 

Date: 07 July 2025 at 4:00 p.m. CEST | 10:00 a.m. EDT | 10:00 p.m. CST Asia
Webinar ID: 844 5419 3422
Webinar website: https://sciforum.net/event/JCM-16 

Register now for free! 

After registering, you will receive a confirmation email containing information on how to join this webinar. Registrations with academic institutional email addresses will be prioritized. 

Unable to attend? Register anyway and we will inform you when the recording is available. 

Webinar Chairs and Keynote Speakers:

• Prof. Dr. Rosalinda Madonna (Chair), Cardiology Division, Department of Pathology, University of Pisa, Italy;
• Prof. Dr. Luca Liberale (Chair), Department of Internal Medicine and Medical Specialties – DIMI, University of Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy;
• Prof. Dr. Pietro Ameri, Department of Internal Medicine and Medical Specialties – DIMI, University of Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy;
• Prof. Dr. Peter Ferdinandy, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary;
• Prof. Dr. Emilio Hirsch, Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Torino, Italy. 

Relevant Special Issue:
“Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond”
Guest Editor: Prof. Dr. Rosalinda Madonna
Deadline for manuscript submissions: 10 July 2025

MDPI is excited to collaborate with Toronto Metropolitan University to host an engaging Scientific Publishing Workshop aimed at empowering scholars with the knowledge and tools needed to succeed in academic publishing. This workshop will delve into the key aspects of MDPI’s open access publishing framework, offering an in-depth exploration of journal selection, the editorial workflow, and the essentials of publication ethics. Participants will also gain practical advice on improving their scientific writing and effectively addressing reviewer comments, with guidance from an experienced professional. This session promises to equip attendees with valuable skills to elevate their publishing journey.

Workshop Highlights:

• Learn How to Better Write and Structure a Research Article;
• How to Choose Where to Publish Academic Work;
• How to Respond to Reviewer Comments;
• Reasons for Rejection During Pre-Check;
• How to Navigate Through Ethics and AI Use.

Date: 15 May 2025
Time: 12:00–1:30 p.m.
Venue: Toronto Metropolitan University

Program:

International Nurses Day (IND) is an international day observed around the world on 12 May (the anniversary of Florence Nightingale’s birth) each year, to mark the contributions that nurses make to society. The vital role of nurse’s work to raise the level of nursing in the region; to create evidence-based knowledge on nursing; and to influence national policies that will lead to the provision of high-quality, accessible, equitable, efficient and sensitive health services.

Building on the success of the 2024 IND theme, “The Economic Power of Care”, which demonstrated how strategic investment in nursing can bring significant economic and societal benefits, the 2025 theme shifts focus to the health and wellbeing of nurses. This theme underscores the critical role a healthy nursing workforce plays in strengthening economies, improving health systems, and ensuring better outcomes for communities worldwide.

In recognition of this important day, we recommend the following related articles, Special Issues, and journals spanning multidisciplinary fields, including clinical medicine. We believe that promoting such research contributes to enhanced public awareness of nursing.

“Exploring Applications of Artificial Intelligence in Critical Care Nursing: A Systematic Review”
by Elena Porcellato, Corrado Lanera, Honoria Ocagli and Matteo Danielis
Nurs. Rep. 2025, 15(2), 55; https://www.mdpi.com/2039-4403/15/2/55

“European Nurses’ Burnout before and during the COVID-19 Pandemic and Its Impact on Patient Safety: A Scoping Review”
by Goitseone Mogomotsi and Jennifer Creese
Hospitals 2024, 1(2), 151–171; https://www.mdpi.com/2813-4524/1/2/13

“Potential of Assistive Robots in Clinical Nursing: An Observational Study of Nurses' Transportation Tasks in Rural Clinics of Bavaria, Germany”
by Domenic Sommer, Jakob Kasbauer, Dietmar Jakob, Sebastian Schmidt and Florian Wahl
Nurs. Rep. 2024, 14(1), 267–286; https://www.mdpi.com/2039-4403/14/1/21

“Moral Resilience Reduces Levels of Quiet Quitting, Job Burnout, and Turnover Intention among Nurses: Evidence in the Post COVID-19 Era”
by Petros Galanis, Ioannis Moisoglou, Aglaia Katsiroumpa, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou and Daphne Kaitelidou
Nurs. Rep. 2024, 14(1), 254–266; https://www.mdpi.com/2039-4403/14/1/20

“Association between Organizational Support and Turnover Intention in Nurses: A Systematic Review and Meta-Analysis”
by Petros Galanis, Ioannis Moisoglou, Ioanna V. Papathanasiou, Maria Malliarou, Aglaia Katsiroumpa, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou and Daphne Kaitelidou
Healthcare 2024, 12(3), 291; https://www.mdpi.com/2227-9032/12/3/291

“Association between Workplace Bullying, Job Stress, and Professional Quality of Life in Nurses: A Systematic Review and Meta-Analysis”
by Petros Galanis, Ioannis Moisoglou, Aglaia Katsiroumpa and Maria Mastrogianni
Healthcare 2024, 12(6), 623; https://www.mdpi.com/2227-9032/12/6/623

“Quiet Quitting among Nurses Increases Their Turnover Intention: Evidence from Greece in the Post-COVID-19 Era”
by Petros Galanis, Ioannis Moisoglou, Maria Malliarou, Ioanna V. Papathanasiou, Aglaia Katsiroumpa, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou  and Daphne Kaitelidou
Healthcare 2024, 12(1), 79; https://www.mdpi.com/2227-9032/12/1/79

“A Moderated Mediation Model of the Influence of Cynical Distrust, Medical Mistrust, and Anger on Vaccination Hesitancy in Nursing Staff”
by Athanasios Tselebis, Christos Sikaras, Charalampos Milionis, Eleni Paraskevi Sideri, Konstantinos Fytsilis, Styliani Maria Papageorgiou, Ioannis Ilias and Argyro Pachi
Eur. J. Investig. Health Psychol. Educ. 2023, 13(11), 2373–2387; https://www.mdpi.com/2254-9625/13/11/167

“Can Vitality and Mental Health Influence Upper Extremity Pain? A Prospective Cohort Study of 1185 Female Hospital Nurses”
by Rodrigo Núñez-Cortés, Ander Espin, Joaquín Calatayud, Sofía Pérez-Alenda, Carlos Cruz-Montecinos, Rubén López-Bueno, Jonas Vinstru, Markus D. Jakobsen and Lars Louis Andersen
Eur. J. Investig. Health Psychol. Educ. 2023, 13(10), 2192–2201; https://www.mdpi.com/2254-9625/13/10/154

“The Impact of Transformational Leadership in the Nursing Work Environment and Patients' Outcomes: A Systematic Review”
by Line Miray Kazin Ystaas, Monica Nikitara, Savoula Ghobrial, Evangelos Latzourakis, Giannis Polychronis and Costas S. Constantinou
Nurs. Rep. 2023, 13(3), 1271–1290; https://www.mdpi.com/2039-4403/13/3/108

“Increased Job Burnout and Reduced Job Satisfaction for Nurses Compared to Other Healthcare Workers after the COVID-19 Pandemic”
by Petros Galanis, Ioannis Moisoglou, Aglaia Katsiroumpa, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou, Evangelia Meimeti and Daphne Kaitelidou
Nurs. Rep. 2023, 13(3), 1090–1100; https://www.mdpi.com/2039-4403/13/3/95

“Nurses' Organization of Work and Its Relation to Workload in Medical Surgical Units: A Cross-Sectional Observational Multi-Center Study”
by Federica Maria Pia Ferramosca, Maddalena De Maria, Dhurata Ivziku, Barbara Raffaele, Marzia Lommi, Maria Ymelda Tolentino Diaz, Graziella Montini, Barbara Porcelli, Anna De Benedictis, Daniela Tartaglini et al.
Healthcare 2023, 11(2), 156; https://www.mdpi.com/2227-9032/11/2/156

Celebrated on 8 May, International Thalassaemia Day is dedicated to raising awareness among the general public and decision-makers about thalassaemia, supporting the lifelong and challenging journey of patients living with this severe blood disease, and honouring the memory of those we have lost, while renewing our commitment to finding a final cure.

Thalassaemia is more than just a disease. It transcends numbers and statistics, touching the lives of real people with real challenges and lived experiences. This year, we proudly embrace the theme, “Together for Thalassaemia: Uniting Communities, Prioritizing Patients”, and stand united under the powerful slogans “#WeAre1” and “PatientsFirst”.

In recognition of this important day, we recommend the following related articles, Special Issues, and journals spanning multidisciplinary fields, including clinical medicine. We believe that promoting such research contributes to enhanced public awareness and a greater understanding of thalassaemia.

“Childhood Anemia in Mozambique: A Multilevel Mixed-Effects Analysis of 2011–2022/23 Population-Based Surveys”
by Réka Maulide Cane, Rornald Muhumuza Kananura, Ronald Wasswa, Maria Patrícia Gonçalves, Luís Varandas and Isabel Craveiro
Healthcare 2025, 13(6), 635; https://doi.org/10.3390/healthcare13060635

“Challenges of Iron Chelation in Thalassemic Children”
by Alkistis Adramerina and Marina Economou
Thalass. Rep. 2024, 14(1), 1-9; https://doi.org/10.3390/thalassrep14010001

“A Case Report of Hyperhemolytic Syndrome in Sickle Cell Disease, with a Special Focus on Avoiding the Use of Transfusions”
by Omar Obajed Al-Ali, György Pfliegler, Ferenc Magyari, Fanni Borics, László Imre Pinczés, Árpád Illés and Boglárka Brúgós
Thalass. Rep. 2024, 14(1), 18-25; https://doi.org/10.3390/thalassrep14010003

“Vamifeport: Monography of the First Oral Ferroportin Inhibitor”
by Federica Pilo and Emanuele Angelucci
J. Clin. Med. 2024, 13(18), 5524; https://doi.org/10.3390/jcm13185524

“Prognostic Role of Multiparametric Cardiac Magnetic Resonance in Neo Transfusion-Dependent Thalassemia”
by Antonella Meloni, Laura Pistoia, Paolo Ricchi, Aurelio Maggio, Valerio Cecinati, Filomena Longo, Francesco Sorrentino, Zelia Borsellino, Alessandra Salvo, Vincenza Rossi et al.
J. Clin. Med. 2024, 13(5), 1281; https://doi.org/10.3390/jcm13051281

“Pancreatic T2* Magnetic Resonance Imaging for Prediction of Cardiac Arrhythmias in Transfusion-Dependent Thalassemia”
by Antonella Meloni, Laura Pistoia, Paolo Ricchi, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Valerio Cecinati, Giuseppe Messina, Elisabetta Corigliano, Rosamaria Rosso et al.
J. Clin. Med. 2023, 12(18), 6015; https://doi.org/10.3390/jcm12186015

“Health-Related Quality-of-Life Profile of Pediatric Patients with β Thalassemia after Hematopoietic Stem Cell Transplantation”
by Olga Mulas, Fabio Efficace, Maria Grazia Orofino, Antonio Piroddi, Eugenia Piras, Adriana Vacca, Susanna Barella, Alessandro Costa, Johannes M. Giesinger, Giorgio La Nasa et al.
J. Clin. Med. 2023, 12(18), 6047; https://doi.org/10.3390/jcm12186047

“Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis”
by Shahad Saif Khandker, Nurani Jannat, Deepannita Sarkar, Alif Hasan Pranto, Ismoth Ara Hoque, Jemema Zaman, Md. Nizam Uddin and Ehsan Suez
Thalass. Rep. 2023, 13(3), 195-205; https://doi.org/10.3390/thalassrep13030018

“Bone Marrow Transplantation in Nonmalignant Haematological Diseases: What Have We Learned about Thalassemia?”
by Luca Castagna, Stefania Tringali, Giuseppe Sapienza, Roberto Bono, Rosario Di Maggio and Aurelio Maggio
Thalass. Rep. 2023, 13(2), 122-130; https://doi.org/10.3390/thalassrep13020011

“Emerging Therapies and Strategies in Thalassemia: Toward a New Era in Management—2nd Edition”	“Feature Papers in Thalassemia Reports”

World Asthma Day is held on the first Tuesday in May, aiming to improve asthma awareness and care around the world. World Asthma Day is organized by the Global Initiative for Asthma (GINA), a World Health Organization collaborative organization founded in 1993. In celebration of World Asthma Day 2025, GINA has chosen the theme “Make Inhaled Treatments Accessible for All”. GINA emphasizes the need to ensure that people with asthma can access inhaled medications that are essential both for controlling the underlying disease and treating attacks.

Asthma is one of the most common chronic non-communicable diseases that affects over 260 million people and is responsible for over 450,000 deaths each year worldwide. Most of these deaths are preventable. Inhaled corticosteroid-containing medications prevent asthma attacks by treating the underlying inflammation that causes asthma. Doctors and allied health care professionals are called upon to ensure that every person with asthma is prescribed evidence-based, essential, inhaled corticosteroid-containing medication in addition to (or in combination with) reliever medication, to prevent the continuing but avoidable morbidity and mortality from asthma.

In celebration of this day, we invite you to explore a curation of insightful articles, journals, and Special Issues across various fields, including human diseases and conditions, human nutrition, children’s health, and personalized medicine. By sharing these findings, we hope to call on everyone to increase our efforts in managing asthma to reduce and prevent attacks.

“Burden and Economic Impact of Respiratory Viral Infections in Adults Aged 60 and Older: A Focus on RSV”
by Adrián Peláez, Sara Jimeno Ruiz, Mercedes Villarreal, Manuel Gil, Inés Gutiérrez, Marta Sanz and Silvina Natalini Martínez
Diseases 2025, 13(2), 35; https://doi.org/10.3390/diseases13020035

“Long-Term Greenness Effects of Urban Forests to Reduce PM10 Concentration: Does the Impact Benefit the Population Vulnerable to Asthma?”
by Jinsuk Jeong, Chaewan Kim, Sumin Choi, Hong-Duck Sou and Chan-Ryul Park
Int. J. Environ. Res. Public Health 2025, 22(2), 167; https://doi.org/10.3390/ijerph22020167

“Sinonasal Outcomes Obtained after 2 Years of Treatment with Benralizumab in Patients with Severe Eosinophilic Asthma and CRSwNP: A “Real-Life” Observational Study”
by Eugenio De Corso, Dario Antonio Mele, Angela Rizzi, Camilla Spanu, Marco Corbò, Serena Pisciottano, Rodolfo Francesco Mastrapasqua, Silvia Baroni, Davide Paolo Porru, Gabriele De Maio et al.
J. Pers. Med. 2024, 14(9), 1014; https://doi.org/10.3390/jpm14091014

“Current Challenges in Pediatric Asthma”
by Andrija Miculinić, Iva Mrkić Kobal, Tin Kušan, Mirjana Turkalj and Davor Plavec
Children 2024, 11(6), 632; https://doi.org/10.3390/children11060632

“Prediction of Asthma Exacerbations in Children”
by Evangelia Sarikloglou, Sotirios Fouzas and Emmanouil Paraskakis
J. Pers. Med. 2024, 14(1), 20; https://doi.org/10.3390/jpm14010020

“Characterization and Factors Associated with Poor Asthma Control in Adults with Severe Eosinophilic Asthma”
by Clara Padró-Casas, María Basagaña, María Luisa Rivera-Ortún, Ignasi García-Olivé, Carlos Pollan-Guisasola, Aina Teniente-Serra, Eva Martínez-Cáceres, José-Tomás Navarro, Jorge Abad-Capa, Antoni Rosell et al.
J. Pers. Med. 2023, 13(7), 1173; https://doi.org/10.3390/jpm13071173

“Association between Single Nucleotide Polymorphisms Related to Vitamin D Metabolism and the Risk of Developing Asthma”
by Susana Rojo-Tolosa, Laura Elena Pineda-Lancheros, José María Gálvez-Navas, José Antonio Sánchez-Martínez, María Victoria González-Gutiérrez, Andrea Fernández-Alonso, Concepción Morales-García, Alberto Jiménez-Morales and Cristina Pérez-Ramírez
Nutrients 2023, 15(4), 823; https://doi.org/10.3390/nu15040823

“Racial Disparities and Common Respiratory Infectious Diseases in Children of the United States: A Systematic Review and Meta-Analysis”
by Elizabeth A. K. Jones, Amal K. Mitra and Shelia Malone
Diseases 2023, 11(1), 23; https://doi.org/10.3390/diseases11010023

“Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma”
by José Valverde-Molina and Luis García-Marcos
Nutrients 2023, 15(3), 486; https://doi.org/10.3390/nu15030486

“Effect of Disease Severity, Age of Child, and Clinic No-Shows on Unscheduled Healthcare Use for Childhood Asthma at an Academic Medical Center”
by Pavani Rangachari, Imran Parvez, Audrey-Ann LaFontaine, Christopher Mejias, Fahim Thawer, Jie Chen, Niharika Pathak and Renuka Mehta
Int. J. Environ. Res. Public Health 2023, 20(2), 1508; https://doi.org/10.3390/ijerph20021508

“Pulmonary Function in Children with Respiratory Symptoms” Guest Editors: Dr. Paraschiva Cherecheș-Panța and Prof. Dr. Sorin Claudiu Man Deadline for manuscript submissions: 5 August 2025	“Mechanisms of Airway Inflammation in Asthma” Guest Editor: Dr. Kathleen Haley Deadline for manuscript submissions: 20 November 2025

In 2024, 7808 papers covering medical research were published in Journal of Clinical Medicine (JCM, ISSN: 2077-0383), an open access journal with a CiteScore of 5.7. We have 36 Sections open for submission. This announcement is an extension of the previous 2024 Most Downloaded Papers, and we hope to share a collection of popular articles with you.

If you would like to know more about our journal statistics and journal history, please click the following links:

• https://www.mdpi.com/journal/jcm/stats;
• https://www.mdpi.com/journal/jcm/history.

1. “Emergencies in Hematology: Why, When and How I Treat?”
by Andrea Duminuco, Vittorio Del Fabro, Paola De Luca, Dario Leotta, Miriana Carmela Limoli, Ermelinda Longo, Antonella Nardo, Gabriella Santuccio, Alessandro Petronaci, Gaia Stanzione et al.
J. Clin. Med.2024, 13(24), 7572; https://doi.org/10.3390/jcm13247572
Full text available online: https://www.mdpi.com/2077 - 0383/13/24/7572

2. “IgA Vasculitis (Henoch–Schönlein Purpura): An Update on Treatment”
by Santos Castañeda, Patricia Quiroga-Colina, Paz Floranes, Miren Uriarte-Ecenarro, Cristina Valero-Martínez, Esther F. Vicente-Rabaneda and Miguel A. González-Gay
J. Clin. Med.2024, 13(21), 6621; https://doi.org/10.3390/jcm13216621
Full text available online: https://www.mdpi.com/2077 - 0383/13/21/6621

3. “Chest Tubes and Pleural Drainage: History and Current Status in Pleural Disease Management”
by Claudio Sorino, David Feller-Kopman, Federico Mei, Michele Mondoni, Sergio Agati, Giampietro Marchetti and Najib M. Rahman
J. Clin. Med.2024, 13(21), 6331; https://doi.org/10.3390/jcm13216331
Full text available online: https://www.mdpi.com/2077-0383/13/21/6331

4. “The Management of Interstitial Lung Disease in the ICU: A Comprehensive Review”
by Zehra Dhanani and Rohit Gupta
J. Clin. Med.2024, 13(22), 6657; https://doi.org/10.3390/jcm13226657
Full text available online: https://www.mdpi.com/2077-0383/13/22/6657

5. “A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches”
by Francesco Giangregorio, Emilio Mosconi, Maria Grazia Debellis, Stella Provini, Ciro Esposito, Matteo Garolfi, Simona Oraka, Olga Kaloudi, Gunel Mustafazade, Raquel Marín-Baselga et al.
J. Clin. Med.2024, 13(19), 5880; https://doi.org/10.3390/jcm13195880
Full text available online: https://www.mdpi.com/2077-0383/13/19/5880

6. “Echocardiography in the Ventilated Patient: What the Clinician Has to Know”
by Fiorella Chiara Delle Femine, Diego D’Arienzo, Biagio Liccardo, Maria Concetta Pastore, Federica Ilardi, Giulia Elena Mandoli, Simona Sperlongano, Alessandro Malagoli, Matteo Lisi, Giovanni Benfari et al.
J. Clin. Med.2025, 14(1), 77; https://doi.org/10.3390/jcm14010077
Full text available online: https://www.mdpi.com/2077-0383/14/1/77

7. “Clinical Recommendations for Managing Genitourinary Adverse Effects in Patients Treated with SGLT-2 Inhibitors: A Multidisciplinary Expert Consensus”
by Juan J. Gorgojo-Martínez, José L. Górriz, Ana Cebrián-Cuenca, Almudena Castro Conde and María Velasco Arribas
J. Clin. Med.2024, 13(21), 6509; https://doi.org/10.3390/jcm13216509
Full text available online: https://www.mdpi.com/2077-0383/13/21/6509

8. “A Comprehensive Review of Catheter-Related Thrombosis”
by Marina López-Rubio, Marta-Olimpia Lago-Rodríguez, Lucía Ordieres-Ortega, Crhistian-Mario Oblitas, Sergio Moragón-Ledesma, Rubén Alonso-Beato, Luis-Antonio Alvarez-Sala-Walther and Francisco Galeano-Valle
J. Clin. Med.2024, 13(24), 7818; https://doi.org/10.3390/jcm13247818
Full text available online: https://www.mdpi.com/2077-0383/13/24/7818

9. “Vasopressor Therapy”
by Jean-Louis Vincent and Filippo Annoni
J. Clin. Med.2024, 13(23), 7372; https://doi.org/10.3390/jcm13237372
Full text available online: https://www.mdpi.com/2077-0383/13/23/7372

10. “Urgent Reversal of Direct Oral Anticoagulants in Critical and Life-Threatening Bleeding: A Multidisciplinary Expert Consensus”
by Anabela Rodrigues, Luciana Ricca Gonçalves, Tiago Gregório, Cilénia Baldaia, Gustavo C. Santo and João Gouveia
J. Clin. Med.2024, 13(22), 6842; https://doi.org/10.3390/jcm13226842
Full text available online: https://www.mdpi.com/2077-0383/13/22/6842

11. “OMI/NOMI: Time for a New Classification of Acute Myocardial Infarction”
by Martiola Kola, Naltin Shuka, Harvey Pendell Meyers, Elizana Zaimi (Petrela) and Stephen W. Smith
J. Clin. Med.2024, 13(17), 5201; https://doi.org/10.3390/jcm13175201
Full text available online: https://www.mdpi.com/2077-0383/13/17/5201

12. “Diagnosis of Pulmonary Embolism: A Review of Evidence-Based Approaches”
by Sneha E. Thomas, Ido Weinberg, Robert M. Schainfeld, Kenneth Rosenfield and Gaurav M. Parmar.
J. Clin. Med.2024, 13(13), 3722; https://doi.org/10.3390/jcm13133722
Full text available online: https://www.mdpi.com/2077-0383/13/13/3722

On 16 May 2025, MDPI and the Journal of Clinical Medicine (JCM, ISSN: 2077-0383) will host a webinar entitled “Acute Kidney Injury: A Global Challenge”. It will highlight the different aspects of care for patients with acute kidney injury in both resource-rich and resource-limited settings.

During this webinar, Dr. Jorge Cerda, a world-renowned scientist focused on optimizing AKI care in underprivileged areas, discusses differences in AKI care based on resource availability. Then, Dr. Sina Menon, an avid investigator and extraordinary clinician, discusses AKI care within the pediatric population and alludes to differences in AKI between children and adults globally. Dr. Mitra Nadim, a thought leader in nephrology, particularly in kidney–liver crosstalk, will discuss the paradigm shift in care for patients with liver disease who are experiencing AKI. Finally, Dr. Vedran Premužić, a global leader in advanced treatment options for AKI, discusses the nuances of extracorporeal blood purification strategies and their potential impacts in terms of patient care. This webinar will provide attendees with an excellent opportunity to interact with these experts, as we plan to host a Q&A section following the aforementioned presentations.

Please note that this webinar is associated with a Special Issue in the Journal of Clinical Medicine entitled “Acute Kidney Injury: Latest Advances and Prospects”.

Date: 16 May 2025
Time: 3:00 p.m. CEST |9:00 a.m. EDT
Webinar ID: 868 2766 6050
Webinar Secretariat: journal.webinar@mdpi.com
Webinar announcement: https://sciforum.net/event/JCM-15

Register now for free!

After registering, you will receive a confirmation email containing information on how to join the webinar. Registrations with academic or institutional email addresses will be prioritized.

If you are unable to attend, feel free to register nonetheless; we will inform you once a recording of the webinar becomes available.

Webinar Chair and Keynote Speakers:

• Prof. Dr. Kianoush B. Kashani, ¹ Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; ² Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA;
• Prof. Dr. Jorge Cerda, Albany Medical College, Albany, NY 12208, USA;
• Dr. Shina Menon, Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford Children’s Health, USA;
• Prof. Dr. Mitra K. Nadim, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA;
• Prof. Dr. Vedran Premužić, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
  

Relevant Special Issue:
“Acute Kidney Injury: Latest Advances and Prospects”
Guest Editors: Dr. Emanuele de Simone and Dr. Kianoush Kashani
Deadline for manuscript submission: 30 June 2025