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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Myasthenia Gravis

edited by Shingo Konno

submission deadline 13 Nov 2025 | 3 articles | Viewed by 4611 | Submission Open

Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Cardiovascular Interventions

edited by

Tomasz Tokarek

submission deadline 14 Nov 2025 | 10 articles | Viewed by 13492 | Submission Open

Keywords: coronary artery disease; myocardial infarction; cardiovascular imaging; microvascular disease; heart failure; atrial fibrillation; ventricular arrhythmias; cardiac implantable electronic device; valvular heart disease and treatment; peripheral arterial disease

(This special issue belongs to the Section Cardiology)

New Advances in Wound Healing and Skin Wound Treatment

edited by Hajime Matsumura

submission deadline 15 Nov 2025 | 7 articles | Viewed by 12114 | Submission Open

Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Advances in Catheter Ablation: Current Challenges and Future Perspectives

edited by

Gabriel Cismaru

and Raluca Tomoaia

submission deadline 15 Nov 2025 | 3 articles | Viewed by 3699 | Submission Open

Keywords: catheter ablation; three-dimensional mapping; arrhythmia; wolf– parkinson– white syndrome; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Clinical Applications of Artificial Intelligence (AI) in Surgery: Future Trends and Challenges

edited by

Michał H. Strzelecki

and

Rafał Obuchowicz

submission deadline 15 Nov 2025 | 2 articles | Viewed by 2887 | Submission Open

Keywords: artificial intelligence; surgical planning; surgical medical robots; machine learning in surgery; AI-supported post-operative care

(This special issue belongs to the Section General Surgery)

Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies

edited by

H. Christian Weber

submission deadline 15 Nov 2025 | Viewed by 214 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Mechanisms and Management of Intracerebral Hemorrhage

edited by Emanuela Crobeddu

submission deadline 15 Nov 2025 | Viewed by 169 | Submission Open

Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions

(This special issue belongs to the Section Clinical Neurology)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 20 Nov 2025 | 6 articles | Viewed by 45234 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Association Between Sleep Disorders and Diabetes

edited by

Patrizio Tatti

and Desiderio Passàli

submission deadline 20 Nov 2025 | 3 articles | Viewed by 23557 | Submission Open

Keywords: diabetes; OSAS; complications; insulin; resistance

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in Vascular and Endovascular Surgery

edited by Toshifumi Kudo

submission deadline 20 Nov 2025 | 11 articles | Viewed by 22497 | Submission Open

Keywords: aortic aneurysm; peripheral arterial disease; chronic limb-threatening ischemia; endovascular aneurysm repair; endovascular treatment; non-invasive blood flow measurements; varicose veins; deep venous thrombosis

(This special issue belongs to the Section Vascular Medicine)

Thromboembolic Disease and Antithrombotic Therapy

edited by Prahlad Ho

submission deadline 20 Nov 2025 | 6 articles | Viewed by 22147 | Submission Open

Keywords: thrombosis; pulmonary embolism; manticoagulation; DOAC (direct oral anticoagulants); DVT (deep vein thrombosis); novel anticoagulants (factor XIa inhibitors); thrombin; fibrin generation; risk stratification; biomarkers; Virchow’ s triad; post thrombotic syndrome

(This special issue belongs to the Section Hematology)

Advances in Trauma and Orthopedic Surgery: 2nd Edition

edited by

Christian von Rüden

submission deadline 20 Nov 2025 | 12 articles | Viewed by 21738 | Submission Open

Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease

edited by Joseph B. Selvanayagam and

Sivabaskari Pasupathy

submission deadline 20 Nov 2025 | 10 articles | Viewed by 18994 | Submission Open

Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 Nov 2025 | 7 articles | Viewed by 17968 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

New Clinical Advances in Chronic Asthma

edited by Vitaliano Nicola Quaranta

submission deadline 20 Nov 2025 | 6 articles | Viewed by 14492 | Submission Open

Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids

(This special issue belongs to the Section Respiratory Medicine)

Sports Injury Treatment: Innovations in Pain Management, Recovery, and Performance Optimization

edited by Antonio P. Veloso and Javad Sarvestan

submission deadline 20 Nov 2025 | 2 articles | Viewed by 11355 | Submission Open

Keywords: sports injury treatment; pain management; recovery optimization; performance enhancement; advanced rehabilitation; injury prevention; biomechanics; neuromechanics; novel pain relief modalities; performance recovery strategies; wearable technology

(This special issue belongs to the Section Sports Medicine)

Pelvic Organ Prolapse: Current Progress and Clinical Challenges

edited by

Riccardo Lombardo

and Cosimo De Nunzio

submission deadline 20 Nov 2025 | 5 articles | Viewed by 10256 | Submission Open

Keywords: pelvic organ prolapse (POP); postmenopausal; urinary dysfunction; minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical mesh

(This special issue belongs to the Section Obstetrics & Gynecology)

Complex Orthopedic Trauma: Diagnosis, Treatment, Managing Complications and Rehabilitation

edited by Philip-Christian Nolte and Benedict Swartman

submission deadline 20 Nov 2025 | 6 articles | Viewed by 9788 | Submission Open

Keywords: orthopedic trauma; fracture; complications; infection; bone; rehabilitation

(This special issue belongs to the Section Orthopedics)

Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)

edited by

Jacek Matys

Kinga Grzech-Lesniak

and

Tomasz Gedrange

submission deadline 20 Nov 2025 | 6 articles | Viewed by 9212 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; dentistry; biological safety

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

The Association Between Sleep Disorders and Metabolic and Mental Health

edited by

Filip Franciszek Karuga

Piotr Bialasiewicz

and

Marcin Sochal

submission deadline 20 Nov 2025 | 5 articles | Viewed by 8903 | Submission Open

Keywords: sleep medicine; sleep apnea; hypoxia; metabolism; mental health; women’ s health

(This special issue belongs to the Section Mental Health)

Cardiac Imaging in the Diagnosis and Management of Heart Failure

edited by Mahi Lakshmi Ashwath and Allen S. Anderson

submission deadline 20 Nov 2025 | 2 articles | Viewed by 7346 | Submission Open

Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain

(This special issue belongs to the Section Cardiology)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6327 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Cardiopulmonary Resuscitation—from Research to Clinical Implementation

edited by

Endre Zima

submission deadline 20 Nov 2025 | 4 articles | Viewed by 5354 | Submission Open

Keywords: cardiopulmonary resuscitation; cardiac arrest; basic life support; advanced life support; special circumstances; target temperature management; eCPR-ECLS; survival

(This special issue belongs to the Section Emergency Medicine)

Current State of Breast Reconstruction

edited by

Il-Kug Kim

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4862 | Submission Open

Keywords: breast reconstruction; silicone implant; autologous tissue; acellular dermal matrix; seroma; outcome; complication; patient satisfaction

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Advances in Orthopedic Infections

edited by

Hyonmin Choe

submission deadline 20 Nov 2025 | 4 articles | Viewed by 4741 | Submission Open

Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management

(This special issue belongs to the Section Orthopedics)

Advances in the Diagnosis and Treatment of Heart Failure

edited by

Noel Lorenzo-Villalba

and

Manuel Montero-Perez-Barquero

submission deadline 20 Nov 2025 | 4 articles | Viewed by 4418 | Submission Open

Keywords: heart failure; diagnosis; treatment; elderly; pluripathology

(This special issue belongs to the Section Cardiology)

Clinical Updates in Lung Ultrasound

edited by

Lior Fuchs

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3879 | Submission Open

Keywords: lung ultrasound; intensive care; imaging; ARDS; POCUS

(This special issue belongs to the Section Respiratory Medicine)

PET Imaging in Bone and Non-Bone Diseases

edited by

Tanuj Puri

and

Glen Blake

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3818 | Submission Open

Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Perspectives in Reconstructive Urethral Surgery

edited by Krishnan Venkatesan

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3622 | Submission Open

Keywords: urethral reconstruction; urethroplasty; urethral stricture; bladder neck stenosis; urinary fistula

(This special issue belongs to the Section Nephrology & Urology)

Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies

edited by

Minzhong Yu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3255 | Submission Open

Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment

(This special issue belongs to the Section Ophthalmology)

Updates on Cardiac Pacing and Electrophysiology

edited by

Axel Brandes

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3236 | Submission Open

Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation

(This special issue belongs to the Section Cardiology)

New Advances in Uterus and Ovarian Transplantation: 2nd Edition

edited by

Elliott G. Richards

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3200 | Submission Open

Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3056 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Aortic Valve Implantation: Recent Advances and Future Prospects

edited by Suvitesh Luthra and Richard Jabbour

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3002 | Submission Open

Keywords: aortic valve replacement; aortic stenosis; paravalvular leak; coronary and structural interventional cardiology; percutaneous coronary artery interventions

(This special issue belongs to the Section Cardiology)

Challenges in Fertility Preservation

edited by

Loris Marin

and Guido Ambrosini

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2862 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Arthritis: From Diagnosis to Treatment

edited by Andrea Di Matteo and

Kulveer Mankia

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2762 | Submission Open

Keywords: rheumatoid arthritis; psoriatic arthritis; imaging; ultrasound; DMARDs; differential diagnosis; difficult to treat rheumatoid arthritis; prevention

(This special issue belongs to the Section Immunology & Rheumatology)

Challenges and Opportunities in Geriatric Nephrology and Urology

edited by Giulio Romano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1943 | Submission Open

Keywords: kidney disease; elderly patient; epidemiology; pharmacological therapy; lifestyle diet

(This special issue belongs to the Section Nephrology & Urology)

Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy

edited by

Takuhei Shoji

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1538 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; visual field testing; glaucoma surgery; MIGS; structure– function relationship in glaucoma

(This special issue belongs to the Section Ophthalmology)

Current Status and Future Directions in Cardiac Surgery

edited by Marie-Elisabeth Stelzmüller and Randolph H.L. Wong

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1439 | Submission Open

Keywords: innovations; AI; minimally invasive; endoscopic; novel technologies in electrophysiology; hybrid procedures; inno-vative approaches in cardiac surgery and patient care

(This special issue belongs to the Section Cardiology)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1415 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Advances in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis

edited by

Roberto Carbone

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1368 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; idiopathic pulmonary fibrosis; heart failure; mitral valve disease

(This special issue belongs to the Section Respiratory Medicine)

Latest Advances in Glaucoma, Cataract and Refractive Surgery: Expert Views, 2nd Edition

edited by

Jose Angel Fernandez-Vigo

and

Enrique Santos-Bueso

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1364 | Submission Open

Keywords: refractive surgery; glaucoma; cataract; intraocular lenses; diagnostic imaging

(This special issue belongs to the Section Ophthalmology)

State-of-the-Art Research on Thoracic Surgery

edited by

Russell Seth Martins

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1183 | Submission Open

Keywords: 3D imaging; surgical process optimization; robotic surgery; immunotherapy and targeted therapy; novel cancer detection methods; personalized treatment

(This special issue belongs to the Section General Surgery)

Research Progress in Pediatric Endocrinology

edited by

Federico Baronio

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1071 | Submission Open

Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening

(This special issue belongs to the Section Clinical Pediatrics)

Acute Ischemic Stroke Management Strategies

edited by

Marta Iacobucci

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1061 | Submission Open

Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra

(This special issue belongs to the Section Clinical Neurology)

Skin Wound Healing: Clinical Updates and Perspectives

edited by

András Bánvölgyi

and

Norbert Kiss

submission deadline 20 Nov 2025 | 1 articles | Viewed by 855 | Submission Open

Keywords: dermatology; wound care; diagnosis; biomaterials; negative pressure wound therapy

(This special issue belongs to the Section Dermatology)

Clinical Insights in Maternal–Fetal Medicine

edited by Moti Gulersen

submission deadline 20 Nov 2025 | 1 articles | Viewed by 818 | Submission Open

Keywords: preterm birth; antenatal corticosteroids; preeclampsia; ultrasound; fetal growth; congenital anomalies; infection; maternal morbidity; diabetes; multiple gestation

(This special issue belongs to the Section Obstetrics & Gynecology)

Diagnosis and Treatment of Ocular Surface Diseases

edited by

Stuti Misra

and

Sònia Travé-Huarte

submission deadline 20 Nov 2025 | 1 articles | Viewed by 814 | Submission Open

Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care

(This special issue belongs to the Section Ophthalmology)

Low Back Pain: Clinical Treatment and Management

edited by

Raffaello Pellegrino

and

Angelo Di Iorio

submission deadline 20 Nov 2025 | 1 articles | Viewed by 786 | Submission Open

Keywords: exercise; rehabilitation; weight loss; telerehabilitation; pain; physical therapy; treatment; conservative treatment; intervertebral disk displacement; low back pain; sciatica

(This special issue belongs to the Section Clinical Neurology)

Clinical Procedures for Diagnosis and Treatment of Cardiovascular Diseases

edited by Ahmad Jabri, Mohammad Alqarqaz, Qais Radaideh and Ahmad Al-Abdouh

submission deadline 20 Nov 2025 | 1 articles | Viewed by 659 | Submission Open

Keywords: cardiovascular disease; diagnostic imaging; minimally invasive procedures; precision medicine; artificial intelligence; interventional cardiology; surgical innovations; patient outcomes; preventive cardiology

(This special issue belongs to the Section Cardiovascular Medicine)

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