- Perspective
Embodied Neuroplasticity: Exploring Biological and Molecular Pathways of Inner Development for Planetary Health
- Karen B. Kirkness
Understanding how inner development capacities are embodied at biological levels remains an underexplored dimension of planetary health research. The aim of this viewpoint is to provide transdisciplinary integration across neuroscience, cell biology, education, and social systems toward addressing planetary health challenges. Despite growing recognition of the Inner Development Goals (IDG) framework as complementary to the UN Sustainable Development Goals, the biophysical dynamics underlying personal and collective transformation remain largely unexplored. This viewpoint presents key molecular pathways that may underpin the Embodied Neuroplastic Resilience Model (ENRM) via calcium signaling and hyaluronan (the CHA axis). This viewpoint explores educational and therapeutic implications while simultaneously illuminating how socioeconomic inequalities constrain access to neuroplasticity-supporting practices. Four key conclusions emerge: (1) The CHA axis provides a compelling mechanistic framework for understanding how bodily experiences can reshape neural circuits through calcium signaling and hyaluronic acid matrix dynamics; (2) Mapping molecular mechanisms to complex human inner development capacities remains provisional, requiring further interdisciplinary investigation; (3) Socioeconomic inequality creates structural barriers to neuroplasticity and inner development, necessitating an integrated approach that connects mechanistic understanding with equitable access to transformative practices; (4) Enhanced understanding of embodied neuroplasticity must serve compassion and systemic transformation, moving beyond individual optimization toward collective well-being. By bridging neuroscience and sustainability frameworks, this viewpoint calls for a nuanced understanding of inner development that transcends individual optimization and emphasizes collective transformation.
30 January 2026



![The IDG framework is increasingly recognized as a foundational tool for educators, leaders, and organizations aiming to bridge the gap between inner growth and global sustainability goals. Structured around five key dimensions (Being, Relating, Collaborating, Thinking, and Acting), the framework identifies 23–25 skills deemed essential for sustainable transformation. Reproduced with permission from the Inner Development Goals Initiative (https://innerdevelopmentgoals.org/) URL accessed on 25 November 2025 under a Creative Commons license for non-commercial educational use [17].](https://mdpi-res.com/cdn-cgi/image/w=470,h=317/https://mdpi-res.com/challenges/challenges-17-00006/article_deploy/html/images/challenges-17-00006-ag-550.jpg)
