Announcements

We are honored to introduce the award committee for the 2024 Tu Youyou Award, composed of distinguished scientists from around the world whose research covers diverse areas of natural product chemistry, pharmacognosy, and drug discovery. Their broad expertise and pioneering contributions have significantly advanced medicinal and natural products research.

Through their collective insights, rigorous evaluation, the committee has carefully selected this year’s award recipients, recognizing exceptional achievements in the field.

We sincerely thank these distinguished scholars for their efforts and dedication to upholding the standards of the Tu Youyou Award.  Below is the list of committee members. For more information about the Tu Youyou Award, please visit https://tuyouyouprize.org/. 

Chair:

Prof. Dr. A. Douglas Kinghorn Ohio State University, USA

Prof. Dr. A. Douglas Kinghorn is a leading expert in pharmacognosy and natural products research. He is recognized for his key contributions to discovering bioactive compounds from plants, especially in anticancer, cancer chemopreventive, and substances with a sweet taste and taste-modifying agents. His prolific contributions include over 590 peer-reviewed works and book chapters and edited or co-edited 40 scientific volumes.

Prof. Angelo Fontana University of Naples “Federico II”, Italy	Angelo Fontana is a Professor of Organic Chemistry at the University of Naples “Federico II” in Italy and serves as Director of the Institute of Biomolecular Chemistry at the National Research Council (CNR). His research focuses on bioactive small molecules derived from marine eukaryotes, with a particular interest on their pharmaceutical applications in immunology and oncology. He also explores their potential as molecular tools for probing and modulating complex biological systems. Prof. Fontana is a co-founder of BioSEArch SRL and has been recognized with numerous grants and honors, including the Apivita Award from the Phytochemical Society of Europe.
Prof. Binghe Wang Georgia State University, USA	Prof. Binghe Wang’s lab works on drug design, drug delivery, click chemistry, chemical biology, new diagnostics, and gaseous signaling molecules such as carbon monoxide and hydrogen sulfide. His interdisciplinary research supports advances in cancer, infectious diseases, organ protection, inflammation, and other areas.
Dr. Diana Pinto University of Aveiro, Portugal	Dr. Diana Pinto, an Associate Professor at the University of Aveiro, specializes in organic synthesis of bioactive heterocyclic compounds, sustainable catalysis (organo-, heterogeneous, and biocatalysis), and natural product research, including isolation, characterization, and total synthesis.
Prof. Hideaki Kakeya Kyoto University, Japan	Prof. Hideaki Kakeya conducts cutting-edge research in chemical biology, high-throughput screening, and biosynthesis of bioactive natural products for system chemotherapy and other therapeutic applications.
Dr. RuAngelie Edrada-Ebel University of Strathclyde, UK	Prof. RuAngelie Edrada-Ebel heads the Natural Products Metabolomics Group (NPMG), specializing in marine natural products discovery and metabolomics-driven drug development. A recognized expert in bioactive metabolites, she collaborates with industry and academia to address antimicrobial resistance and sustainable bioprospecting. She serves on the Editorial Board of Marine Drugs and holds two patents in the field.
Prof. Thomas Prisinzano University of Kentucky, USA	Prof. Thomas Prisinzano combines medicinal and natural product chemistry to explore neurotransmitter systems and develop treatments for drug abuse and pain. He has received several prestigious awards, including the Innovator Award from the College on Problems of Drug Dependence.
Prof. Wei Li University of Tennessee Health Science Center, USA	A distinguished professor and Director of the Drug Discovery Center, Prof. Wei Li is also the founder of SEAK Therapeutics, and the 2025 Chair-Elect of the Drug Discovery and Development Division of the American Society of Pharmacology and Experimental Therapeutics (ASPET). His work focuses on medicinal chemistry and small molecule drug discovery, with over 200 publications and 15 issued US patents.

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an international, peer-reviewed, open access journal of clinical medicine. In order to enhance the academic quality of JCM and expand its dissemination channels, we actively cooperate with clinical-related associations, grasp research dynamics by bringing together professional resources, explore diversified modes of cooperation, and build a wider platform for academic exchange and dissemination to provide better services for medical practitioners. We sincerely appreciate the unwavering support and cooperation of our society partners. We are pleased to present five outstanding publications from society collaborations, in which we offered discount support on the article processing charges. We look forward to continuing this productive partnership and working together to advance clinical research.

To access more information about our society collaborations, please visit the following link: https://www.mdpi.com/journal/jcm/societies.

Hematology remains at the forefront of medical innovation, driving breakthroughs in understanding and treating blood-related disorders that affect millions worldwide. This dynamic field encompasses cutting-edge research in hematopoiesis, hemostasis, transfusion medicine, and the molecular mechanisms underlying conditions ranging from anemia to hematologic malignancies.

MDPI’s cluster of hematology journals has the mission to publish recent advances in this field that have profound implications for a broad spectrum of disorders, including anemia, leukemias, and rare blood conditions. These journals aim to offer the most up-to-date research and discoveries within the field of hematology to the broader scientific community.

The four participating journals are as follows:

• Hemato (ISSN: 2673-6357) is an integrative effort to explore the multifaceted nature of hematologic diseases, leukemias, and lymphomas. The journal aims to document scientific advancements and provide insights to enhance patient care. It emphasizes immunologic and genetic biomarkers, while also addressing refractory and early relapsed diseases, covering topics from microscopic morphology to immune therapies, ultimately aiming to improve patient outcomes. Hemato is led by its Editor-in-Chief, Prof. Dr. Antonino Carbone;
• Hematology Reports (ISSN: 2038-8330) investigates the prevention, diagnosis, and management of blood disorders, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials. Hematology Reports is led by its Editor-in-Chief, Dr. Claudio Cerchione;
• Thalassemia Reports (ISSN: 2039-4365) analyzes the pathophysiology, diagnosis, classification, and treatment of thalassemia and related disorders for physicians and medical scientists. The journal publishes clinically relevant information that aims to directly improve the care of patients with thalassemia. Basic science studies of interest to clinicians are also considered for publication, when relevant. Specific case reports are also welcome, particularly those including detailed clinical profiles of patients. Thalassemia Reports is led by its Editor-in-Chief, Prof. Dr. Aurelio Maggio;
• Journal of Clinical Medicine (ISSN: 2077-0383) covers all aspects of clinical and pre-clinical research. JCM is led by its Editors-in-Chief, Prof. Dr. Emmanuel Andrès and Prof. Dr. Kent Doi. The journal also features a Section “Hematology”, which provides novel information and groundbreaking updates on clinical and laboratory hematology, from clinical trials to real-world clinical practice.

	Launch Year	Impact Factor (2023)	CiteScore (2023)	First Decision (Median Days)	APC (CHF)
	2020	0.9	1.3	30.6	1000
	2009	1.1	0.9	39.1	1600
	2011	0.6	/	33.1	1000
	2012	3.0	5.7	16	2600

MDPI mission and values:
As a pioneer in academic open access publishing, MDPI has been serving the scientific community since 1996. Our aim is to foster scientific exchange in all forms and across all disciplines. MDPI's guidelines for disseminating open science are based on the following values and guiding principles:

• Open Access—All our content is published in open access and distributed under a Creative Commons License, providing free access to science and the latest research, allowing articles to be freely shared and content to be re-used with proper attribution;
• Timeliness and Efficiency—The latest research is rapidly published through a thorough editorial process, ensuring that a first decision is provided to authors in under 32 days and that papers are published within 7–10 days upon acceptance;
• Simplicity—We offer user-friendly tools and services in one place to enhance the efficiency of our editorial process;
• High-Quality Service—We support scholars and their work by providing a range of options, such as journal publication at mdpi.com, early publication at preprints.org, and conferences on sciforum.net, to make a positive impact on research;
• Flexibility—We adapt and develop new tools and services to meet the changing needs of the research community, driven by feedback from authors, editors, and readers;
• Rooted in Sustainability—We ensure the long-term preservation of published papers and support the future of science through partnerships, sponsorships, and awards.

By adhering to these values and principles, MDPI remains committed to advancing scientific knowledge and promoting open science practices.

Selected Topics and Special Issues:

• “Advances in Molecular Pathogenesis and Targeted Therapies for Multiple Myeloma”
• “Hematopathology: Rare Hematological Diseases”
• “Anaemia in Focus: Challenges and Solutions in Haematology”
• “Innovative Therapies and Management of Complications in Hemoglobinopathies”

Selected Articles:
Journal of Clinical Medicine
“Imaging of Multiple Myeloma: Present and Future”
J. Clin. Med. 2024, 13(1), 264; https://doi.org/10.3390/jcm13010264

Thalassemia Reports
“CRISPR Gene Therapy: A Promising One-Time Therapeutic Approach for Transfusion-Dependent β-Thalassemia—CRISPR-Cas9 Gene Editing for β-Thalassemia”
Thalass. Rep. 2023, 13(1), 51-69; https://doi.org/10.3390/thalassrep13010006

Hemato
“Artificial Intelligence, Lymphoid Neoplasms, and Prediction of MYC, BCL2, and BCL6 Gene Expression Using a Pan-Cancer Panel in Diffuse Large B-Cell Lymphoma”
Hemato 2024, 5(2), 119-143; https://doi.org/10.3390/hemato5020011

Hematology Reports 
“A 2024 Update on Menin Inhibitors. A New Class of Target Agents against KMT2A-Rearranged and NPM1-Mutated Acute Myeloid Leukemia”
Hematol. Rep. 2024, 16(2), 244-254; https://doi.org/10.3390/hematolrep16020024

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is ranked Q1 in the 2024 Scimago Journal & Country Rank. Given that neurology represents a vast domain within clinical medicine, we are committed to engaging a diverse readership by publishing original research, comprehensive reviews, expert opinions, and articles on best practices and clinical guidelines in the fields of neurology and neuroscience. To date, 2330 papers have been published in the “Clinical Neurology” Section. We invite you to explore our most highly cited papers and discover our open Special Issues.

1. “The Transorbital Approach: A Comprehensive Review of Targets, Surgical Techniques, and Multiportal Variants”
by Matteo De Simone, Cesare Zoia, Anis Choucha, Doo-Sik Kong and Lucio De Maria
J. Clin. Med. 2024, 13(9), 2712; https://doi.org/10.3390/jcm13092712
Full text available online: https://www.mdpi.com/2077-0383/13/9/2712

2. “Epidural Spinal Cord Stimulation for Spinal Cord Injury in Humans: A Systematic Review”
by J. I. Chalif, V. S. Chavarro, E. Mensah, B. Johnston, D. P. Fields, E. J. Chalif, M. Chiang, O. Sutton, R. Yong, R. Trumbower et al.
J. Clin. Med. 2024, 13(4), 1090; https://doi.org/10.3390/jcm13041090
Full text available online: https://www.mdpi.com/2077-0383/13/4/1090

3. ”Evolution, Current Trends, and Latest Advances of Endoscopic Spine Surgery”
by Sharvari Gunjotikar,  Malcolm Pestonji, Masato Tanaka, Tadashi Komatsubara, Shashank J. Ekade, Ahmed Majid Heydar and Huynh Kim Hieu
J. Clin. Med. 2024, 13(11), 3208; https://doi.org/10.3390/jcm13113208
Full text available online: https://www.mdpi.com/2077-0383/13/11/3208

4. ”Intraoperative Neurophysiological Monitoring in Neurosurgery”
by Giusy Guzzi, Riccardo Antonio Ricciuti, Attilio Della Torre, Erica Lo Turco, Angelo Lavano, Federico Longhini and Domenico La Torre
J. Clin. Med. 2024, 13(10), 2966; https://doi.org/10.3390/jcm13102966
Full text available online: https://www.mdpi.com/2077-0383/13/10/2966

5. ”Advances and Challenges of Endoscopic Spine Surgery”
by Daniel Burkett and Nathaniel Brooks
J. Clin. Med. 2024, 13(5), 1439; https://doi.org/10.3390/jcm13051439
Full text available online: https://www.mdpi.com/2077-0383/13/5/1439

6. “Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives”
by Katharine A. Seton, José A. Espejo-Oltra, Karen Giménez-Orenga, Rik Haagmans, Donia J. Ramadan and Jesper Mehlsen on behalf of the European ME Research Group for Early Career Researchers (Young EMERG)
J. Clin. Med. 2024, 13(2), 325; https://doi.org/10.3390/jcm13020325
Full text available online: https://www.mdpi.com/2077-0383/13/2/325

7. “Mild Cognitive Impairment Progression and Alzheimer’s Disease Risk: A Comprehensive Analysis of 3553 Cases over 203 Months”
by Nevra Öksüz, Reza Ghouri, Bahar Taşdelen, Derya Uludüz and Aynur Özge
J. Clin. Med. 2024, 13(2), 518; https://doi.org/10.3390/jcm13020518
Full text available online:  https://www.mdpi.com/2077-0383/13/2/518

8. “A Long-Term Comparative Analysis of Endovascular Coiling and Clipping for Ruptured Cerebral Aneurysms: An Individual Patient-Level Meta-Analysis Assessing Rerupture Rates”
by Johannes Wach, Martin Vychopen, Agi Güresir, Alexandru Guranda, Ulf Nestler and Erdem Güresir
J. Clin. Med. 2024, 13(6), 1778; https://doi.org/10.3390/jcm13061778
Full text available online: https://www.mdpi.com/2077-0383/13/6/1778

9. “Treating Trigeminal Schwannoma through a Transorbital Approach: A Systematic Review”
by Matteo De Simone, Anis Choucha, Guillaume Dannhoff, Doo-Sik Kong, Cesare Zoia and Giorgio Iaconetta
J. Clin. Med. 2024, 13(13), 3701; https://doi.org/10.3390/jcm13133701
Full text available online: https://www.mdpi.com/2077-0383/13/13/3701

World Malaria Day, observed annually on 25 April, is a global reminder of the urgent need to stay focused on the fight against malaria—a preventable and treatable disease that still threatens millions of lives, especially in vulnerable communities. Despite considerable progress over the past two decades, malaria continues to take a heavy toll, particularly in sub-Saharan Africa, where children under five remain at most risk.

The theme for 2025, “Malaria Ends with Us: Reinvest, Reimagine, Reignite”, is a powerful call to action. It is a strong reminder that the fight against malaria is not over, and that the power to end it lies with all of us.

In recognition of this vital cause, MDPI is spotlighting impactful research across a selection of its journals, highlighting contributions that advance the understanding, prevention, and treatment of malaria. Featured journals include Cells, Insects, Journal of Clinical Medicine (JCM), Metabolites, Parasitologia, Pathogens, Pharmaceuticals, Reports, and TropicalMed. By bringing these articles to the forefront, MDPI reaffirms its commitment to open access knowledge and global health equity.

Prof. Tu Youyou was awarded the Nobel Prize in Physiology or Medicine in 2015 for discovering artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from malaria.

To honor Prof. Tu Youyou’s remarkable contributions and to continue with her achievements, MDPI established the Tu Youyou Award in 2016. This award aims to acknowledge exceptional scholars committed to the research fields of natural products chemistry and medicinal chemistry.

The winners of the 2024 Tu Youyou Award will be announced on 30 April. Visit the award website for the latest updates!

“Blood Source and Anesthetics Effects on the Maintenance of Anopheles darlingi in the Lab-Rearing Condition”
by José Daniel Costa Pontual, Natália Vitória Coelho, Najara Akira Costa dos Santos, Alessandra da Silva Bastos, Jéssica Evangelista Araújo, Alice Oliveira Andrade, Jansen Fernandes Medeiros and Maisa da Silva Araujo
Insects 2025, 16(3), 281; https://doi.org/10.3390/insects16030281

“Identification of Bioactive Metabolites of Capirona macrophylla by Metabolomic Analysis, Molecular Docking, and In Vitro Antiparasitic Assays”
by Joseph Evaristo, Elise de Laia, Bruna Tavares, Esdras Mendonça, Larissa Grisostenes, Caroline Rodrigues, Welington do Nascimento, Carolina Garcia, Sheila Guterres, Fábio Nogueira et al.
Metabolites 2025, 15(3), 157; https://doi.org/10.3390/metabo15030157

“Duplication of a Type-P5B-ATPase in Laverania and Avian Malaria Parasites and Implications About the Evolution of Plasmodium”
by Mark F. Wiser
Parasitologia 2025, 5(1), 6; https://doi.org/10.3390/parasitologia5010006

“Effect of Health Education Intervention on Knowledge and Adherence to Intermittent Preventive Treatment of Malaria in Pregnancy Among Women”
by Pauline N. Atser, Gommaa Hayat and Uchenna B. Okafor
Healthcare 2025, 13(2), 105; https://doi.org/10.3390/healthcare13020105

“Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy”
by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi and Francesco Saccoliti
Pharmaceuticals 2025, 18(1), 28; https://doi.org/10.3390/ph18010028

“Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis”
by Alicia Comino Garcia-Munoz, Isabelle Varlet, Georges Emile Grau, Teodora-Adriana Perles-Barbacaru and Angèle Viola
Pathogens 2024, 13(12), 1042; https://doi.org/10.3390/pathogens13121042

“Prophylaxis Failure and Successful Management of Delayed-Onset Malaria with Renal Complications: A Case Report with Oral Artemether-Lumefantrine Treatment”
by Ilir Tolaj, Gramoz Bunjaku, Murat Mehmeti and Yllka Begolli
Reports 2023, 6(4), 53; https://doi.org/10.3390/reports6040053

“Sensitivity Assessment of a Multiplex and Real-Time PCR Protocols for the Detection of Malaria in External Quality Control Samples in the Malaria Reference Center in Greece”
by Nikolaos Tegos, Christos Goumenopoulos, Anastasia Mpimpa, Vasilios Papavasilopoulos, Stavroula Beleri and Eleni Patsoula
Parasitologia 2024, 4(2), 150-161; https://doi.org/10.3390/parasitologia4020013

“Prevention of Malaria in Pregnant Women and Its Effects on Maternal and Child Health, the Case of Centre Hospitalier de Kingasani II in the Democratic Republic of the Congo”
by Japhet Kabalu Tshiongo, Trésor Zola Matuvanga, Patrick Mitashi, Vivi Maketa, Henk D. F. H. Schallig, Petra F. Mens, Hypolite Muhindo Mavoko and Junior Matangila Rika
Trop. Med. Infect. Dis. 2024, 9(5), 92; https://doi.org/10.3390/tropicalmed9050092

“An Epidemiological Survey of Malaria Infection in Espírito Santo State, Brazil, from 2007 to 2017”
by Nayna Carvalho Oliveira, Lais Rosa Boscalha, Cinthia Emerich Toledo, Felipe Sarlo Pezzin, Bruno Costanza Cisari, Suellen Rodrigues Maran, Laís Rodrigues Diniz, Pedro Henrique Schultz Corcino Freitas, Adenilton Cruzeiro, Frederico Eutropio et al.
Parasitologia 2023, 3(3), 215-222; https://doi.org/10.3390/parasitologia3030022

“Low Prevalence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions—A Multiregional Study in Central and West Africa”
by Tina Krueger, Moses Ikegbunam, Abel Lissom, Thaisa Lucas Sandri, Jacques Dollon Mbama Ntabi, Jean Claude Djontu, Marcel Tapsou Baina, Roméo Aimé Laclong Lontchi, Moustapha Maloum, Givina Zang Ella et al.
Pathogens 2023, 12(3), 455; https://doi.org/10.3390/pathogens12030455

“Impact of the COVID-19 Pandemic on Malaria Control in Africa: A Preliminary Analysis”
by Liping Gao, Qi Shi, Zhiguo Liu, Zhenjun Li and Xiaoping Dong
Trop. Med. Infect. Dis. 2023, 8(1), 67; https://doi.org/10.3390/tropicalmed8010067

World Immunization Week, celebrated annually during the last week of April, is a global health awareness initiative highlighting the critical role of vaccines in protecting people of all ages against vaccine-preventable diseases.

On this momentous occasion, we are thrilled to present a thoughtfully selected compilation of articles and Special Issues that focus on the pioneering research and cutting-edge strategies in immunology and vaccination. We encourage readers to delve into these scholarly contributions and stand with us in our commitment to preserving and enhancing global immunization health.

Join us as we explore the latest findings and innovative methods that are shaping the future of immunization. Together, we can strive towards a world where every individual has access to the life-saving benefits of vaccines.

We hope that the established journals in the fields of biology life sciences and medicine and pharmacology at MDPI will provide a communication platform for innovative ideas regarding prevention and treatment.

“Lifestyle and Biochemical Parameters That May Hamper Immune Responses in Pediatric Patients After Immunization with the BNT162b2 mRNA COVID-19 Vaccine”
by Anthie Damianaki, Antonios Marmarinos, Margaritis Avgeris, Dimitrios Gourgiotis, Elpis-Athina Vlachopapadopoulou, Marietta Charakida, Maria Tsolia and Lydia Kossiva
Diseases 2025, 13(3), 78; https://doi.org/10.3390/diseases13030078

“Evaluating the Potential of Herbal Extracts as Treatment in Immune Thrombocytopenia: A Review of Evidence and Limitations”
by Russell W. Wiggins, Jihoo Woo, John Nicholas Cauba and Shizue Mito
Appl. Biosci. 2025, 4(1), 1; https://doi.org/10.3390/applbiosci4010001

“Immunotherapeutic Strategies for the Treatment of Glioblastoma: Current Challenges and Future Perspectives”
by Ilaria Salvato and Antonio Marchini
Cancers 2024, 16(7), 1276; https://doi.org/10.3390/cancers16071276

“Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies”
by Konstantinos Manganas, Aikaterini Xydaki, Angeliki Kotsiafti, Olympia Papakonstantinou and Sophia Delicou
Thalass. Rep. 2024, 14(2), 26-32; https://doi.org/10.3390/thalassrep14020004

“Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches”
by Natalie Fuchs, Longfei Zhang, Laura Calvo-Barreiro, Katarzyna Kuncewicz and Moustafa Gabr
J. Pers. Med. 2024, 14(1), 68; https://doi.org/10.3390/jpm14010068

“Vaccine-Induced Immune Thrombotic Thrombocytopenia: Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders”
by Yi Zhang, Anna-Lise Bissola, Jared Treverton, Michael Hack, Mark Lychacz, Sarah Kwok, Addi Arnold and Ishac Nazy
J. Clin. Med. 2024, 13(4), 1012; https://doi.org/10.3390/jcm13041012

“Immune Response to Respiratory Viral Infections”
by Antonella Gambadauro, Francesca Galletta, Alessandra Li Pomi, Sara Manti and Giovanni Piedimonte
Int. J. Mol. Sci. 2024, 25(11), 6178; https://doi.org/10.3390/ijms25116178

“Neutrophil Extracellular DNA Traps in Response to Infection or Inflammation, and the Roles of Platelet Interactions”
by William A. Chen and Danilo S. Boskovic
Int. J. Mol. Sci. 2024, 25(5), 3025; https://doi.org/10.3390/ijms25053025

“Host Immune Regulation in Implant-Associated Infection (IAI): What Does the Current Evidence Provide Us to Prevent or Treat IAI?”
by Zulipikaer Maimaiti, Zhuo Li, Chi Xu, Jun Fu, Li-Bo Hao, Ji-Ying Chen and Wei Chai
Bioengineering 2023, 10(3), 356; https://doi.org/10.3390/bioengineering10030356

“Airborne Pollen Calendar of Toluca City, Mexico”
by Maria Cid del Prado, Osvaldo Zarco-Cid del Prado, Hilda Adriana Guerrero-Parra and Karla Elisa Juárez Contreras
Aerobiology 2023, 1(1), 54-69; https://doi.org/10.3390/aerobiology1010005

“Innovative Therapies and Management of Complications in Hemoglobinopathies”	“Peptide-Based Vaccines: An Efficient Alternative to Combat Infectious Diseases and Drug Resistance”
“Immunotherapy in the Management of Hematologic Malignancy”	“Feature Review for Applied Biosciences”
“Advances in Transfusion Medicine and Immunological Research”	“Advancements in Artificial Intelligence for Bioaerosol Detection, Characterization, and Modeling”

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an international, peer-reviewed, and open access journal on clinical and pre-clinical research. Under the guidance of the Section Editor-in-Chief, Dr. Huiberdina Lena Koek, we have established a new Section: “Geriatric Medicine”.

A message from the Section Editor-in-Chief. Dr. Huiberdina Lena Koek:
It is with pleasure that we introduce a new Section named “Geriatric Medicine”. The target articles are manuscripts with a focus on diagnostics, therapeutics, and prognostication in geriatric patients. This Section will focus on papers presenting innovative results that improve medical care for older people. This Section will publish original and review articles within the field of geriatric medicine. We hope that we will attract manuscripts on geriatric medicine of the best scientific quality.

I would like to thank all contributors for supporting our journal, which is currently thriving and expected to have an ever-increasing impact on the scientific community. I would also like to thank the editors and the Editorial Office for their excellent work in strengthening our journal’s handling of manuscripts, as well as their tireless work to increase our journal’s visibility and impact. Together, we endeavor to increase evidence-based, innovative knowledge of clinical medicine for the scientific and medical community.

Section Information:
Geriatric medicine is a crucial branch of clinical medicine that focuses on the etiology, diagnosis, treatment, and prognosis of health conditions affecting older adults. As the global population ages, the demand for specialized clinical care for the elderly continues to grow. The “Geriatric Medicine” Section of the Journal of Clinical Medicine will provide a platform for clinical research focused on the medical care and clinical management of elderly patients. This Section will cover both general geriatric care as well as specialized treatments for age-related diseases and chronic conditions commonly seen in older adults.

Subject areas (including but not limited to those below):

• Age-related diseases;
• Chronic disease management in the elderly;
• Clinical geriatric pharmacology;
• Geriatric psychiatry;
• Geriatric neurology;
• Frailty and mobility;
• Rehabilitation and physical therapy in aging populations;
• End-of-life care and palliative medicine in the elderly;
• Nutrition and aging in the elderly;
• Acute care for the elderly;
• Preventive care and screening for older adults;
• Geriatric oncology;
• Surgery in the elderly;
• Cardiology in the elderly;
• Nephrology in the elderly;
• Orthopedics in the elderly;
• Infectious diseases in the elderly;
• Pulmonary diseases in the elderly;
• Endocrinology in the elderly;
• Gastroenterology in the elderly;
• Urogenital diseases in the elderly.

Please find more details at https://www.mdpi.com/journal/jcm/sections/geriatric_medicine.

The “Geriatric Medicine” Section is currently recruiting Guest Editors for Special Issues, which provide a platform for collaborative research on innovative geriatric medicine topics; relevant information can be found at https://www.mdpi.com/special_issues_guidelines. We are actively looking for scholars in this field to join the peer review and editorial procedures as volunteer reviewers. We provide reviewer benefits; for further details, kindly visit https://www.mdpi.com/reviewers#5_Volunteer_Reviewers.

If you are interested in the latest publications in geriatric medicine, please visit https://www.mdpi.com/search?journal=jcm&section=2634.

On 17 April 2025, the global bleeding disorders community will come together to celebrate World Hemophilia Day. This year’s theme is “Access for all: Women and girls bleed too”.

Currently, women and girls with bleeding disorders (WGBDs) are still underdiagnosed and underserved. The global bleeding disorders community has the power—and the responsibility—to change this. Through recognition, diagnosis, treatment, and care, the quality of life of women and girls will improve, strengthening the community as a whole.

We would like to recommend some related articles, Special Issues, and MDPI journals as suitable communication platforms and believe that sharing research like this can help raise awareness of Hemophilia Day.

“Managing Surgical Risks in Hemophilic Elbow Arthropathy: An In-Depth Case Study and Literature Review”
by Gianluigi Pasta, Salvatore Annunziata, Roberta Ruggieri, Dario Abruzzi, Paolo Arrigoni, Eugenio Jannelli, Francesco Benazzo, Luisella Pedrotti, Erika Maria Viola, Emérito Carlos Rodriguez-Merchan and Mario Mosconi
Healthcare 2024, 12(17), 1776; https://doi.org/10.3390/healthcare12171776

“Better Communication for Better Management of Persons with Hemophilia: Results from a Patients’-Clinicians’ Project to Address the New Therapeutic Landscape”
by Laura Banov, Silvia Linari, Luigi Ambroso, Enrico Ferri Grazzi, Samanta Gallo, Patrizio Pasqualetti and Maria Elisa Mancuso
J. Clin. Med. 2024, 13(2), 568; https://doi.org/10.3390/jcm13020568

“Six-Year, Real-World Use of Prophylaxis with Recombinant Factor IX–Albumin Fusion Protein (rIX-FP) in Persons with Hemophilia B: A Single-Center Retrospective–Prospective Study”
by Antonio Coppola, Gianna Franca Rivolta, Gabriele Quintavalle, Annalisa Matichecchia, Federica Riccardi, Rossana Rossi, Anna Benegiamo, Paola Ranalli, Valeria Coluccio and Annarita Tagliaferri
J. Clin. Med. 2024, 13(5), 1518; https://doi.org/10.3390/jcm13051518

“Thalassemia: Pathophysiology, Diagnosis, and Advances in Treatment”
by Idris Zubairu Sadiq, Fatima Sadiq Abubakar, Hauwa Salisu Usman, Aliyu Dantani Abdullahi, Bashiru Ibrahim, Babangida Sanusi Kastayal, Maryam Ibrahim and Hassan Aliyu Hassan
Thalass. Rep. 2024, 14(4), 81-102; https://doi.org/10.3390/thalassrep14040010

“Haemophilia A: A Review of Clinical Manifestations, Treatment, Mutations, and the Development of Inhibitors”
by Sarmiento Doncel, Samuel, Gina Alejandra Díaz Mosquera, Javier Mauricio Cortes, Carol Agudelo Rico, Francisco Javier Meza Cadavid and Ronald Guillermo Peláez
Hematol. Rep. 2023, 15(1), 130-150; https://doi.org/10.3390/hematolrep15010014

“Ultrasound Evaluation of Tendinopathy in Hemophiliac Patients for the Purpose of Rehabilitation Indications”
by Danilo Donati, Paolo Spinnato, Lelia Valdrè, Lydia Piscitelli, Giuseppina Mariagrazia Farella, Enrico Pagliarulo and Maria Grazia Benedetti
J. Clin. Med. 2023, 12(13), 4513; https://doi.org/10.3390/jcm12134513

“Safe and Successful Surgical Outcome in Persons with Hemophilia A with and without Inhibitors Treated with Emicizumab: A Large, Single Center, Real-World Experience”
by Giancarlo Castaman, Silvia Linari, Lisa Pieri, Christian Carulli, Paolo Prosperi, Paolo Tonelli, Francesco Demartis, Rajmonda Fjerza, Monica Attanasio, Mirella Coppo and Francesca Salvianti
J. Clin. Med. 2023, 12(6), 2317; https://doi.org/10.3390/jcm12062317

“A Retrospective Analysis of the American Thrombosis and Hemostasis Network Dataset Describing Outcomes of Dental Extractions in Persons with Hemophilia”
by Heather Messenger, Roshni Kulkarni, Michael Recht and Chunla He
J. Clin. Med. 2023, 12(5), 1839; https://doi.org/10.3390/jcm12051839

“Laboratory Rat Thrombi Lose One-Third of Their Stiffness When Exposed to Large Oscillating Shear Stress Amplitudes: Contrasting Behavior to Human Clots”
by Ursula Windberger, Veronika Glanz and Leon Ploszczanski
Int. J. Transl. Med. 2022, 2(3), 332-344; https://doi.org/10.3390/ijtm2030026

As artificial intelligence (AI) technology advances at a rapid pace, clinical researchers are vigorously delving into diverse AI applications within clinical medicine. Their ultimate aim is to bring greater benefits to patients and chart new courses for the medical field.

We invite you to read the highly cited papers on artificial intelligence published in the Journal of Clinical Medicine (JCM, ISSN: 2077-0383). These papers present the latest insights and findings, and we trust they will infuse fresh inspiration and innovative thinking into your new research endeavors. Furthermore, several Special Issues centered around this topic are currently open for submissions.

1. “Face the Future—Artificial Intelligence in Oral and Maxillofacial Surgery”
by Maximilian F. Miragall, Samuel Knoedler, Martin Kauke-Navarro, Rakan Saadoun, Alex Grabenhorst, Florian D. Grill, Lucas M. Ritschl, Andreas M. Fichter, Ali-Farid Safi and Leonard Knoedler
J. Clin. Med. 2023, 12(21), 6843; https://doi.org/10.3390/jcm12216843
Full text available online: https://www.mdpi.com/2077-0383/12/21/6843

2. “Evolving the Era of 5D Ultrasound? A Systematic Literature Review on the Applications for Artificial Intelligence Ultrasound Imaging in Obstetrics and Gynecology”
by Elena Jost, Philipp Kosian, Jorge Jimenez Cruz, Shadi Albarqouni, Ulrich Gembruch, Brigitte Strizek and Florian Recker
J. Clin. Med. 2023, 12(21), 6833; https://doi.org/10.3390/jcm12216833
Full text available online: https://www.mdpi.com/2077-0383/12/21/6833

3. “Artificial Intelligence and Machine Learning in the Diagnosis and Management of Stroke: A Narrative Review of United States Food and Drug Administration-Approved Technologies”
by Anirudha S. Chandrabhatla, Elyse A. Kuo, Jennifer D. Sokolowski, Ryan T. Kellogg, Min Park and Panagiotis Mastorakos
J. Clin. Med. 2023, 12(11), 3755; https://doi.org/10.3390/jcm12113755
Full text available online: https://www.mdpi.com/2077-0383/12/11/3755

4. “Using Generative Artificial Intelligence Tools in Cosmetic Surgery: A Study on Rhinoplasty, Facelifts, and Blepharoplasty Procedures”
by Bryan Lim, Ishith Seth, Skyler Kah, Foti Sofiadellis, Richard J. Ross, Warren M. Rozen and Roberto Cuomo
J. Clin. Med. 2023, 12(20), 6524; https://doi.org/10.3390/jcm12206524
Full text available online: https://www.mdpi.com/2077-0383/12/20/6524

5. “Revolutionizing Spinal Care: Current Applications and Future Directions of Artificial Intelligence and Machine Learning”
by Mitsuru Yagi, Kento Yamanouchi, Naruhito Fujita, Haruki Funao and Shigeto Ebata
J. Clin. Med. 2023, 12(13), 4188; https://doi.org/10.3390/jcm12134188
Full text available online: https://www.mdpi.com/2077-0383/12/13/4188

6. “Using Artificial Intelligence to Predict Mechanical Ventilation Weaning Success in Patients with Respiratory Failure, Including Those with Acute Respiratory Distress Syndrome”
by Tamar Stivi, Dan Padawer, Noor Dirini, Akiva Nachshon, Baruch M. Batzofin and Stephane Ledot
J. Clin. Med. 2024, 13(5), 1505; https://doi.org/10.3390/jcm13051505
Full text available online: https://www.mdpi.com/2077-0383/13/5/1505

7. “Artificial Intelligence (AI) versus POCUS Expert: A Validation Study of Three Automatic AI-Based, Real-Time, Hemodynamic Echocardiographic Assessment Tools”
by Eyal Gohar, Amit Herling, Mor Mazuz, Gal Tsaban, Tomer Gat, Sergio Kobal and Lior Fuchs
J. Clin. Med. 2023, 12(4), 1352; https://doi.org/10.3390/jcm12041352
Full text available online: https://www.mdpi.com/2077-0383/12/4/1352

8. “Development of Bleeding Artificial Intelligence Detector (BLAIR) System for Robotic Radical Prostatectomy”
by Enrico Checcucci, Pietro Piazzolla, Giorgia Marullo, Chiara Innocente, Federico Salerno, Luca Ulrich, Sandro Moos, Alberto Quarà, Gabriele Volpi, Daniele Amparore et al.
J. Clin. Med. 2023, 12(23), 7355; https://doi.org/10.3390/jcm12237355
Full text available online: https://www.mdpi.com/2077-0383/12/23/7355

9. “An Artificial Intelligence-Enabled ECG Algorithm for Predicting the Risk of Recurrence in Patients with Paroxysmal Atrial Fibrillation after Catheter Ablation”
by Junrong Jiang, Hai Deng, Hongtao Liao, Xianhong Fang, Xianzhang Zhan, Wei Wei, Shulin Wu and Yumei Xue
J. Clin. Med. 2023, 12(5), 1933; https://doi.org/10.3390/jcm12051933
Full text available online: https://www.mdpi.com/2077-0383/12/5/1933

Special Issues:
“Artificial Intelligence (AI)-Based Diagnosis in Clinical Practice” Guest Editor: Dr. Takao Fujisawa Submission deadline: 24 July 2025	“Machine Learning and Artificial Intelligence in Neurosurgery” Guest Editors: Dr. Jan Oliver Neumann and Dr. Paul Naser Submission deadline: 31 July 2025
“Surgical Precision: The Impact of AI and Robotics in General Surgery” Guest Editor: Dr. Tamara M. H. Gall Submission deadline: 25 August 2025	“Artificial Intelligence and Eye Disease” Guest Editors: Prof. Dr. Andrzej Grzybowski, Dr. Louis Arnould and Prof. Dr. Haoyu Chen Submission deadline: 30 September 2025

We are delighted to share some highly cited papers that were published in the Section “Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine” of the Journal of Clinical Medicine (JCM, ISSN: 2077-0383) in 2024. In addition, some Special Issues in this topic are currently open for submission. The following is a list of articles and Special Issues that we believe will interest you:

1. “Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients”
by Giuseppe Consorti, Gabriele Monarchi, Mariagrazia Paglianiti, Enrico Betti and Paolo Balercia
J. Clin. Med. 2024, 13(4), 922; https://doi.org/10.3390/jcm13040922
Full text available online: https://www.mdpi.com/2077-0383/13/4/922

2. “Prevention of Breast Cancer-Related Lymphedema: An Up-to-Date Systematic Review of Different Surgical Approaches”
by Domenico Pagliara, Federica Grieco, Silvia Rampazzo, Nicola Pili, Pietro Luciano Serra, Roberto Cuomo and Corrado Rubino
J. Clin. Med. 2024, 13(2), 555; https://doi.org/10.3390/jcm13020555
Full text available online: https://www.mdpi.com/2077-0383/13/2/555

3. “Needle-Free Jet Injection of Poly-(Lactic Acid) for Atrophic Acne Scars: Literature Review and Report of Clinical Cases”
by Nark-Kyoung Rho, Hyun-Jo Kim, Hyun-Seok Kim and Won Lee
J. Clin. Med. 2024, 13(2), 440; https://doi.org/10.3390/jcm13020440
Full text available online: https://www.mdpi.com/2077-0383/13/2/440

4. “Three-Dimensional Printing in Breast Reconstruction: Current and Promising Applications”
by Horacio F. Mayer, Alejandro Coloccini and José F. Viñas
J. Clin. Med. 2024, 13(11), 3278; https://doi.org/10.3390/jcm13113278
Full text available online: https://www.mdpi.com/2077-0383/13/11/3278

5. “Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series”
by Maarten Verbist, Anne-Laure Vandevelde, Joris Geusens, Yi Sun, Eman Shaheen and Robin Willaert
J. Clin. Med. 2024, 13(10), 2805; https://doi.org/10.3390/jcm13102805
Full text available online: https://www.mdpi.com/2077-0383/13/10/2805

6. “Bioactive Dressing: A New Algorithm in Wound Healing”
by Gianmarco Polverino, Francesca Russo and Francesco D’Andrea
J. Clin. Med. 2024, 13(9), 2488; https://doi.org/10.3390/jcm13092488
Full text available online: https://www.mdpi.com/2077-0383/13/9/2488

7. “Our Experience in Diagnosing and Treating Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)”
by Gon Shoham, Oriana Haran, Roei Singolda, Ehab Madah, Ada Magen, Orit Golan, Tehillah Menes, Ehud Arad and Yoav Barnea
J. Clin. Med. 2024, 13(2), 366; https://doi.org/10.3390/jcm13020366
Full text available online: https://www.mdpi.com/2077-0383/13/2/366

8. “A Multidisciplinary Approach to End-Stage Limb Salvage in the Highly Comorbid Atraumatic Population: An Observational Study”
by Karen R. Li, Christian X. Lava, Monique B. Neughebauer, Rachel N. Rohrich, Jayson Atves, John Steinberg, Cameron M. Akbari, Richard C. Youn, Christopher E. Attinger and Karen K. Evans
J. Clin. Med. 2024, 13(8), 2406; https://doi.org/10.3390/jcm13082406
Full text available online: https://www.mdpi.com/2077-0383/13/8/2406

9. “Ultrasound in Microsurgery: Current Applications and New Frontiers”
by Rachel Cowan, Gursimran Mann and Ara A. Salibian
J. Clin. Med. 2024, 13(12), 3412; https://doi.org/10.3390/jcm13123412
Full text available online: https://www.mdpi.com/2077-0383/13/12/3412

10. “Challenges in Autologous Breast Reconstruction: A Review of Recommendations”
by Lauren M. Sinik and Meredith S. Collins
J. Clin. Med. 2024, 13(4), 971; https://doi.org/10.3390/jcm13040971
Full text available online: https://www.mdpi.com/2077-0383/13/4/971