2025 December-1 - 354 articles
Recent advances in neuromodulation are opening new pathways for treating chronic pain, with spinal cord stimulation (SCS) poised for substantial transformation in the coming years. Evolving technologies and a deeper understanding of pain mechanisms a...
Intracranial cavernous malformations (CMs) are angiographically occult, slow-flow vascular lesions composed of dilated, mulberry-like capillary clusters lacking intervening brain parenchyma. CMs typically have a low annual hemorrhage risk and are oft...
Background: Systemic inflammation plays a pivotal role in heart failure (HF) progression, yet no meta-analysis has synthesized prospective cohort data on interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and neutrophil-to-lymphocyte...
Background/Objectives: International guidelines recommend the use of antibiotic prophylaxis for lung transplantation (LT). Although multiplex PCR (mPCR) has been shown to hasten antibiotic adaptation during pneumonia, its use to guide antibiotic prop...
Background: Group-based dance interventions (GBDIs) have emerged as a promising approach to rehabilitation for neurological disorders. This pilot study evaluated the feasibility and preliminary effects of a GBDI on motor function, cognition, fatigue,...
Background/Objectives: Data on the long-term outcomes of hypoplastic left heart syndrome (HLHS) patients compared to other single-ventricle patients reaching adolescence after Fontan surgery is limited. This study analyzes the outcomes of HLHS patien...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons; respiratory problems are the leading cause of death and hospital admissions and are secondary to progressive weakness of the respiratory muscle...
As surgeries using multifocal intraocular lenses (IOLs) to correct both cataracts and presbyopia have become common, it has become essential for clinicians to understand their basic optical characteristics to select the optimal lens for their patient...
Introduction: This systematic review aimed to evaluate the effectiveness of preoperative home-based exercise training on clinical outcomes in patients undergoing pulmonary surgery. Methods: A comprehensive literature search was conducted on 25 Octobe...
Background: Accurately predicting difficult airways is essential to ensuring patient safety in anesthesiology and emergency medicine. However, traditional assessment tools often lack sufficient sensitivity and specificity, particularly in high-pressu...
Background/Objectives: Takayasu’s arteritis (TAK) is an inflammatory vascular disease, but atherosclerotic mechanisms may also contribute to vascular injury in TAK. This study aimed to evaluate the clinical and imaging characteristics of TAK pa...
Background: The relationship between sagittal malocclusion, temporomandibular disorders (TMD), and musculoskeletal pain remains uncertain. Methods: Cross-sectional study (April 2020–August 2021) in Małopolska, Poland. Ninety participants (...
Background/Objectives: We describe the real-world survival and utilization of lung biopsy in Medicare patients with unresected stage I-IIB (N0) non-small-cell lung cancer (NSCLC) receiving primary stereotactic body radiotherapy (SBRT) in the US. Meth...
Background: Hip fractures in older adults are sentinel events linked to high mortality and functional decline. Few studies have quantified long-term survival probabilities, standardized mortality ratios (SMRs), and risks of new nursing home admission...
Background: Biomechanical disorders may result from joint deformities. The purpose of this prospective research was to assess total load distribution over the lower limbs and balance in individuals before and after an hemiepiphysiodesis procedure per...
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, immune-mediated conditions that significantly affect quality of life (QoL). The disease can cause extraintestinal manifestations, the mo...
Sickle cell disease (SCD) is the most common monogenic disorder worldwide and remains a major cause of morbidity and mortality. Sickle cell anemia (SCA), the homozygous HbSS genotype, represents the most severe and frequent form within the spectrum o...
Background: Acne vulgaris is a common inflammatory disorder with significant clinical and psychosocial impacts. Medium-depth chemical peels are increasingly used to manage both active acne lesions and atrophic acne scars. This study aimed to quantita...
Hypertrophic cardiomyopathy (HCM) is the most prevalent hereditary cardiovascular disorder characterized by unexplained left ventricular hypertrophy, sarcomeric hypercontractility, and dynamic left ventricular outflow tract (LVOT) obstruction in appr...
Background/Objectives: Evaluating glenoid changes in rotator cuff tear arthropathy (RCTA) is crucial for preoperative planning. MRI with zero echo time (ZTE) sequence, which produces CT-like images, allows for the assessment of osseous morphology as...
Background: Immune-related adverse events (irAEs) represent a considerable complication associated with the use of immune checkpoint inhibitors (ICIs) in oncology patients. Assessing causality is particularly challenging in patients administered mult...
Background: Generative AI and synthetic media have enabled realistic human Embodied Conversational Agents (ECAs) or avatars. A subset of this technology replicates faces and voices to create realistic likenesses. When combined with avatars, these met...
Background/Objectives: Different disease subtypes in neovascular age-related macular degeneration (nAMD) influence treatment burden, yet existing classifications such as the pachychoroid neovasculopathy (PNV)/non-PNV dichotomy may not fully capture c...
Background/Objectives: Temperature control after cardiac arrest remains a recommended component of post-cardiac arrest care, yet substantial practice variability persists. Conflicting evidence regarding optimal temperature targets and mixed interpret...
Background/Objectives: With the increasing use of immune checkpoint inhibitors (ICIs), their administration in pregnant patients is expected to become more frequent. Although immunotherapy has transformed melanoma treatment, its use during pregnancy...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterized by the degeneration of upper and lower motor neurons. This degeneration leads to a gradual muscle weakness, dysarthria, dysphagia, respiratory insufficienc...
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD) globally. Beyond metabolic and haemodynamic stress, the complement system has emerged as a contributor to glomerular and tubulointerstitial injury. In type 1 diabetes mell...
Background/Objectives: In today’s reality, the mobile phone accompanies people in almost every area of life. Technological progress offers a range of conveniences, facilities, and opportunities. At the same time, researchers observe new phenome...
Background/Objectives: Posterior vitreous detachment (PVD) is an age-related physiological process, yet the clinical and biometric factors influencing its progression remain incompletely characterized in adults undergoing routine ophthalmic evaluatio...
Background/Objectives: Rickets is a pediatric disorder caused by impaired mineralization of the growth plate, primarily due to deficiencies in vitamin D, calcium, or phosphate. Lower limb deformities are among the most clinically relevant skeletal ma...
Background: The clinical utility of risk scores predicting shunt dependency after aneurysmal subarachnoid hemorrhage (aSAH) remains limited due to scarce validation data. This multicenter pooled analysis aimed to assess the predictive accuracy of exi...
Background/Objectives: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by persistent social-communication deficits and repetitive behaviors. While genetic factors play a major role, prenatal environmental...
Background: Bereavement often elicits complex emotional and cognitive reactions, including guilt, unresolved relational concerns, and repetitive negative thinking. Although grief-specific rumination is recognized as a key process that can intensify p...
Background: Chronic cutaneous wounds such as diabetic foot ulcers, venous leg ulcers, pressure injuries, and burns remain a global clinical burden. These wounds are often arrested in inflammatory or ischemic stages due to impaired angiogenesis and gr...
Background/Objectives: A medical–government conflict in South Korea in 2024 led to the collective resignation of resident physicians, causing severe workforce shortages in tertiary hospitals. This study aimed to investigate temporal changes in...
Extramammary Paget’s disease is a rare malignant tumor that frequently presents in areas rich in apocrine glands, most often affecting the skin of the perianal area: the labia minora, clitoris, scrotum, penis, skin of the lower abdomen, and ing...
Objective: This study systematically evaluates the association between breast arterial calcifications (BACs) on mammography and systemic vascular calcifications detected by computed tomography (CT) in female lung transplant recipients, representing t...
Background/Objectives: The utility and value of graduated compression stockings (gCS) as an adjunct to pharmacological thromboprophylaxis, with and without low-molecular-weight heparins (LMWH) and other anticoagulants, in avoiding any thromboembolic...
Background/Objectives: Inflammatory bowel disease (IBD), including Crohn’s Disease and Ulcerative Colitis, requires complex treatment and active patient participation. Health literacy (HL), defined as the ability to access, understand, and appl...
Eosinophilic esophagitis (EoE) is an emerging disease characterized by chronic inflammation of the esophagus. EoE is a multifactorial disorder, likely resulting from the combination of genetic predisposition, epithelial barrier dysfunction, environme...
Background: Caustic ingestion represents a severe clinical emergency, leading to variable and often unpredictable outcomes. The severity depends on the nature of the corrosive agent, the amount ingested, and the timing of management. Summary: This re...
Surgical navigation is a rapidly advancing area of innovation that has extended from its roots as a tool based on rigid anatomical landmarks into the complex domain of soft-tissue surgery. Three complementary technologies—fluorescence-guided su...
Background: High-chloride solutions such as 0.9% saline are widely used for medication dilution in intensive care units (ICUs) and are an underrecognized source of hyperchloremia and acid–base disturbances. Excess chloride reduces the strong io...
Background/Objectives: Accurate diagnosis of otitis media (OM) using otoscopic images is often challenging, particularly for non-specialists. Artificial intelligence (AI), especially deep learning-based methods, has shown promising results in support...
Fungi are one of the major causes of opportunistic infections in people living with HIV/AIDS. Pneumocystis jirovecii, Cryptococcus neoformans, Histoplasma capsulatum, and Candida spp. are especially more likely to affect HIV-infected individuals. Int...
Efficient oxygen transport and accurate anemia diagnostics remain significant medical challenges, as current therapies suffer from stability limitations, immunogenic risks, and inadequate sensitivity. Cucurbiturils (CB[n]), a family of pumpkin-shaped...
Background: Non-Communicable Diseases (NCDs) are the leading cause of adult mortality worldwide, accounting for 74% of deaths. In Sri Lanka, assessing NCD mortality trends is essential for public health planning. This study evaluated trends in total...
Background/Objectives: Smith–Lemli–Opitz syndrome (SLOS) is a genetic metabolic disorder characterized by impaired cholesterol synthesis and a wide range of developmental anomalies. This article presents a case of a girl with SLOS, diagno...
Background/Objectives: There is limited information on the interplay between passive joint motion and joint kinematics from three-dimensional gait analysis (3DGA) and its longitudinal evolution in cerebral palsy (CP). We aimed to associate clinical m...
Coronary artery disease remains the leading cause of cardiovascular morbidity and mortality worldwide, affecting millions of individuals each year. Coronary artery calcification is a common finding in patients with advanced atherosclerosis and repres...
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