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Most Cited

  • Article
  • Open Access
316 Citations
16,073 Views
14 Pages

31 January 2023

Background and aim: Chronic low-grade inflammation is associated with various health outcomes, including cardiovascular diseases (CVDs) and cancers. Systemic immune inflammation index (SII) and system inflammation response index (SIRI) have lately be...

  • Review
  • Open Access
280 Citations
80,807 Views
24 Pages

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

  • Samradhi Singh,
  • Namrata Pal,
  • Swasti Shubham,
  • Devojit Kumar Sarma,
  • Vinod Verma,
  • Francesco Marotta and
  • Manoj Kumar

11 February 2023

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbi...

  • Perspective
  • Open Access
192 Citations
56,817 Views
17 Pages

Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus

  • Juan J. Gorgojo-Martínez,
  • Pedro Mezquita-Raya,
  • Juana Carretero-Gómez,
  • Almudena Castro,
  • Ana Cebrián-Cuenca,
  • Alejandra de Torres-Sánchez,
  • María Dolores García-de-Lucas,
  • Julio Núñez,
  • Juan Carlos Obaya and
  • María José Soler
  • + 2 authors

24 December 2022

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are indicated in type 2 diabetes and obesity for their high efficacy in controlling glycaemia and inducing body weight loss, respectively. Patients may develop gastrointestinal adverse events (GI...

  • Systematic Review
  • Open Access
178 Citations
24,804 Views
13 Pages

A Meta-Analysis of the Global Prevalence of Temporomandibular Disorders

  • Grzegorz Zieliński,
  • Beata Pająk-Zielińska and
  • Michał Ginszt

28 February 2024

Background: This meta-analysis aims to evaluate the proportion of people with TMDs in different studies, considering factors such as geographical region, patient age, and sample size. Methods: The search yielded 6984 articles on the incidence of TMDs...

  • Review
  • Open Access
165 Citations
136,586 Views
23 Pages

2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department

  • Matteo Guarino,
  • Benedetta Perna,
  • Alice Eleonora Cesaro,
  • Martina Maritati,
  • Michele Domenico Spampinato,
  • Carlo Contini and
  • Roberto De Giorgio

28 April 2023

Background: Sepsis/septic shock is a life-threatening and time-dependent condition that requires timely management to reduce mortality. This review aims to update physicians with regard to the main pillars of treatment for this insidious condition. M...

  • Review
  • Open Access
157 Citations
37,018 Views
28 Pages

Understanding and Fostering Mental Health and Well-Being among University Faculty: A Narrative Review

  • Dalal Hammoudi Halat,
  • Abderrezzaq Soltani,
  • Roua Dalli,
  • Lama Alsarraj and
  • Ahmed Malki

30 June 2023

In recent years, there has been increasing recognition of mental health concerns in academia, with stress, burnout, anxiety, and depression being reported among faculty members. The demanding work environment, the need to balance personal and profess...

  • Review
  • Open Access
125 Citations
16,527 Views
21 Pages

Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy

  • Gian Marco Leone,
  • Katia Mangano,
  • Maria Cristina Petralia,
  • Ferdinando Nicoletti and
  • Paolo Fagone

17 February 2023

Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and used in the clinical treatment of autoimmune disorders. Currently, five a...

  • Review
  • Open Access
123 Citations
26,255 Views
20 Pages

Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment

  • Vanina Nicol,
  • Claire Verdaguer,
  • Camille Daste,
  • Hélène Bisseriex,
  • Éric Lapeyre,
  • Marie-Martine Lefèvre-Colau,
  • François Rannou,
  • Alexandra Rören,
  • Julia Facione and
  • Christelle Nguyen

20 February 2023

Chronic low back pain (cLBP) is a public and occupational health problem that is a major professional, economic and social burden. We aimed to provide a critical overview of current international recommendations regarding the management of non-specif...

  • Review
  • Open Access
116 Citations
40,707 Views
11 Pages

Acute Kidney Injury: Medical Causes and Pathogenesis

  • Faruk Turgut,
  • Alaa S. Awad and
  • Emaad M. Abdel-Rahman

3 January 2023

Acute kidney injury (AKI) is a common clinical syndrome characterized by a sudden decline in or loss of kidney function. AKI is not only associated with substantial morbidity and mortality but also with increased risk of chronic kidney disease (CKD)....

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J. Clin. Med. - ISSN 2077-0383