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Journal of Clinical Medicine, Volume 14, Issue 22

November-2 2025 - 369 articles

Cover Story: Topical tretinoin is a first-generation retinoid with well-established efficacy in acne and photoaging. Its pleiotropic actions on epidermal differentiation, inflammation, pigmentation and collagen remodeling support a broad range of dermatologic uses. This review summarizes evidence from clinical trials and prospective studies published between 2000 and 2025, including FDA-approved indications and expanding off-label applications. Beyond acne and photoaging, tretinoin shows potential benefits in melasma, post-inflammatory hyperpigmentation, acanthosis nigricans, striae distensae, scarring, flat warts, alopecia, actinic keratosis and field cancerization. Overall, tretinoin remains a versatile, well-tolerated therapy with growing relevance in modern dermatology. View this paper
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Articles (369)

  • Review
  • Open Access
612 Views
18 Pages

20 November 2025

Preoperative anemia and non-anemic iron deficiency are common in cardiac surgery patients. Both are frequently caused by absolute iron deficiency or are associated with chronic diseases and inflammation. Multiple studies have shown an association bet...

  • Article
  • Open Access
372 Views
19 Pages

Associations Between Health-Related Quality of Life and Clinical Factors in Lumbar Disc Herniation: Evidence from a Romanian Cohort Using the SF-36

  • Mădălina Duceac (Covrig),
  • Salim Camer,
  • Irina Luciana Gurzu,
  • Alina Pleșea-Condratovici,
  • Liviu Stafie,
  • Letiția Doina Duceac,
  • Lucian Eva,
  • Bogdan Gurzu,
  • Mădălina Nicoleta Matei and
  • Ciprian Adrian Dinu
  • + 2 authors

20 November 2025

Background: Lumbar disc herniation (LDH) has a substantial impact on health-related quality of life (HRQoL), mainly through pain, reduced mobility, and functional limitations. To better reflect these outcomes, we utilized the SF-36 survey, a well-est...

  • Perspective
  • Open Access
616 Views
15 Pages

Upper Gastrointestinal Crohn’s Disease: Shedding Light on the Obscure L4 Classification Meaning

  • Francesca Lusetti,
  • Cristina Bezzio,
  • Alice De Bernardi,
  • Michele Puricelli,
  • Gianpiero Manes and
  • Simone Saibeni

20 November 2025

Background/Objectives: Upper gastrointestinal Crohn’s disease (UGI-CD) is inconsistently defined and often underrecognized, obscuring epidemiology, complicating diagnosis, and delaying tailored care. The absence of a unified, operational defini...

  • Article
  • Open Access
362 Views
12 Pages

Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses

  • Sarah Hinterberger,
  • Cornelia Artmayr,
  • Karanpreet Multani,
  • Kamran M. Riaz,
  • Seth M. Pantanelli,
  • Klemens P. Kaiser,
  • Achim Langenbucher,
  • Matthias Bolz and
  • Jascha A. Wendelstein

20 November 2025

Background/Objectives: To investigate visual acuity, refractive outcomes and the predictive accuracy of modern intraocular lens (IOL) power calculation formulas in eyes implanted with two presbyopia-correcting IOLs: trifocal Zeiss AT LISA TRI and the...

  • Review
  • Open Access
1,039 Views
37 Pages

The Development of Novel Therapies for Chronic Lymphocytic Leukaemia in the Era of Targeted Drugs

  • Tadeusz Robak,
  • Elżbieta Iskierka-Jażdżewska,
  • Anna Puła,
  • Pawel Robak and
  • Bartosz Puła

20 November 2025

Over the past decade, chronic lymphocytic leukaemia (CLL) treatment has shifted from chemoimmunotherapy to targeted oral agents, predominantly Bruton’s tyrosine kinase inhibitors (BTKis) and the BCL-2 inhibitor venetoclax. These therapies have...

  • Case Report
  • Open Access
324 Views
8 Pages

20 November 2025

Background: Although rarely performed, sternal resection for chondrosarcoma presents considerable anesthetic challenges, particularly in both immediate and long-term pain management. Method: This case study details the anesthetic protocol adopted for...

  • Review
  • Open Access
771 Views
14 Pages

20 November 2025

Background: Intracranial aneurysm (IA) rupture is a devastating event in neurosurgery and a leading cause of subarachnoid hemorrhage. Although aneurysm size has been traditionally emphasized, recent research has highlighted multifactorial mechanisms...

  • Article
  • Open Access
914 Views
14 Pages

Algorithm-Guided Management of Thumb Amputation: A 20-Year Retrospective Review and Outcome Analysis

  • Maja Smorąg,
  • Piotr Węgrzyn,
  • Marta Jagosz,
  • Michał Chęciński,
  • Szymon Manasterski,
  • Jędrzej Króliński,
  • Marcin Syrko,
  • Patryk Ostrowski,
  • Katarzyna Kościelska-Kasprzak and
  • Dorota Kamińska
  • + 1 author

20 November 2025

Background: The thumb accounts for 40–50% of hand function. Traumatic amputation of the thumb results in significant disability and necessitates a structured approach to management. Methods: We conducted a retrospective review of 144 patients t...

  • Review
  • Open Access
371 Views
31 Pages

Are Image-Based Deep Learning Algorithms of Kidney Volume in Polycystic Kidney Disease Ready for Clinical Deployment? A Systematic Review and Meta-Analysis

  • Emil Colliander,
  • Sebastian Tupper,
  • Mira Lansner Kielberg,
  • Marie Louise Liu,
  • Enrique Almar-Munoz,
  • Agnes Mayr and
  • Rebeca Mirón Mombiela

20 November 2025

Objectives: In patients with autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV) is the gold standard biomarker for assessing the risk of progression and the need for drug therapy. However, it is a time-consuming process....

  • Review
  • Open Access
774 Views
20 Pages

From Mesh to Modern Therapies: An Updated Narrative Review on Urogenital Prolapse

  • Diana Pop-Lodromanean,
  • Radu Chicea,
  • Dan-Georgian Bratu,
  • Livia-Mirela Popa,
  • Paula Anderco,
  • Nicolae Grigore and
  • Adrian Hașegan

20 November 2025

Urogenital prolapse (UP), a manifestation of pelvic organ prolapse (POP), is prevalent and burdensome, impairing urinary, bowel, sexual and psychosocial health. This review synthesizes evidence on epidemiology, mechanisms, clinical evaluation and tre...

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J. Clin. Med. - ISSN 2077-0383