2025 November-2 - 369 articles
Preoperative anemia and non-anemic iron deficiency are common in cardiac surgery patients. Both are frequently caused by absolute iron deficiency or are associated with chronic diseases and inflammation. Multiple studies have shown an association bet...
Background: Lumbar disc herniation (LDH) has a substantial impact on health-related quality of life (HRQoL), mainly through pain, reduced mobility, and functional limitations. To better reflect these outcomes, we utilized the SF-36 survey, a well-est...
Background/Objectives: Upper gastrointestinal Crohn’s disease (UGI-CD) is inconsistently defined and often underrecognized, obscuring epidemiology, complicating diagnosis, and delaying tailored care. The absence of a unified, operational definition w...
Background/Objectives: To investigate visual acuity, refractive outcomes and the predictive accuracy of modern intraocular lens (IOL) power calculation formulas in eyes implanted with two presbyopia-correcting IOLs: trifocal Zeiss AT LISA TRI and the...
Over the past decade, chronic lymphocytic leukaemia (CLL) treatment has shifted from chemoimmunotherapy to targeted oral agents, predominantly Bruton’s tyrosine kinase inhibitors (BTKis) and the BCL-2 inhibitor venetoclax. These therapies have...
Background: Although rarely performed, sternal resection for chondrosarcoma presents considerable anesthetic challenges, particularly in both immediate and long-term pain management. Method: This case study details the anesthetic protocol adopted for...
Background: Intracranial aneurysm (IA) rupture is a devastating event in neurosurgery and a leading cause of subarachnoid hemorrhage. Although aneurysm size has been traditionally emphasized, recent research has highlighted multifactorial mechanisms...
Background: The thumb accounts for 40–50% of hand function. Traumatic amputation of the thumb results in significant disability and necessitates a structured approach to management. Methods: We conducted a retrospective review of 144 patients t...
Objectives: In patients with autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV) is the gold standard biomarker for assessing the risk of progression and the need for drug therapy. However, it is a time-consuming process....
Urogenital prolapse (UP), a manifestation of pelvic organ prolapse (POP), is prevalent and burdensome, impairing urinary, bowel, sexual and psychosocial health. This review synthesizes evidence on epidemiology, mechanisms, clinical evaluation and tre...
Background/Objective: Glucocorticoids (GC) have anti-inflammatory effects, but long-term use can suppress bone formation and cause osteoporosis. The impact of inflammatory environments, such as periodontitis, on alveolar bone metabolism remains insuf...
Background: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease, characterized by cholestasis and fibrosis. Ursodeoxycholic acid (UDCA) is the first-line treatment for normalizing markers, slowing progression, and improving outcom...
Background: Acute kidney injury (AKI) is a frequent complication following congenital heart surgery and is associated with increased morbidity and mortality. Early recognition is crucial, yet standard clinical biomarkers result in delayed detection....
Background/Objectives: The increasing number and complexity of cardiac and neurosurgical procedures underscore the importance of effective perioperative care. One of the most serious postoperative complications is delirium, which prolongs hospitaliza...
Background/Objectives: This pragmatic randomized controlled trial evaluated the efficacy of ultrasound-guided supraclavicular nerve (SCLN) block compared to standard pain management in patients with acute displaced clavicle fractures (CFs) in an emer...
Background/Objectives: Arrhythmic recurrence is a common issue affecting a significant percentage of patients undergoing transcatheter ablation (TCA) of Atrial Fibrillation (AF). The use of artificial intelligence (AI) for the identification of elect...
Background/Objectives: Projected augmented reality (PAR) enables real-time projection of digital surgical information directly onto the operative field. This offers a hands-free, headset-free platform that is universally visible to all members of the...
Background: Postoperative sagittal imbalance, including hyperextension and flexion contracture after total knee arthroplasty (TKA), adversely affects long-term outcomes. Conventional techniques depend on surgeons’ visual estimation, which may v...
Background/Objectives: Radiotherapy (RT) induces oxidative stress and structural damage in solid tissues, including the liver. This study aimed to investigate the histological and immunohistochemical effects of dexmedetomidine (DEX) and amifostine on...
Background/Objectives: Superior cerebellar artery (SCA) infarction is a rare but clinically significant subtype of posterior circulation stroke. Extensive swelling in the SCA territory may cause downward brainstem compression and appear as brainstem...
Background/Objectives: Cochlear implantation (CI) has been shown to be effective in children with inner ear malformations (IEMs). However, outcomes vary with malformation type and anatomical complexity. Advances in radiological classification may imp...
Background: Spontaneous ventilation with intubation (SVI) during video-assisted thoracoscopic surgery (VATS) has been introduced as a hybrid technique that combines the physiological benefits of spontaneous breathing with the safety of a secured airw...
Background: Breast cancer mortality and long-term survival are influenced by the unpredictability of recurrences, which cause significant diagnostic and therapeutic challenges for oncology teams. The risk of local and distant recurrence is higher in...
Background: Respiration-synchronized hypoglossal nerve stimulation (HGNS) is an effective treatment option for selected patients with obstructive sleep apnea (OSA). While literature on the standardization of the post-implant care pathway for patients...
Background/Objectives: Conventional radiographic methods, although considered the gold standard for dental implantology, are not exempt from certain limitations, including their two-dimensional nature, the exposure to ionizing radiation and the inabi...
Background: Current ESC guidelines recommend the use of oral anticoagulant therapy in patients with atrial fibrillation to reduce the risk of arterial embolization. Recently, Factor XIa inhibitors were investigated as an alternative to the commonly u...
Background: Retinal dystrophies are often challenging to diagnose. At early stages, they may resemble benign retinal pigment epithelium alterations and drusen present in otherwise healthy individuals. With the increased incidence of autoimmunity-rela...
Background/Objectives: The perioperative management of a patient’s blood values involves the optimization of anemia management in the pre-, intra-, and postoperative periods to avoid blood transfusions. The purpose of this study was to determin...
Background: Osteochondral fractures (OCFs) following acute patellar dislocation significantly influence treatment decisions and long-term prognosis, yet reliable risk stratification remains elusive. This study aimed to identify demographic and trochl...
Background/Objectives: Preterm infants are at risk for developmental delays due to immature brain development and increased sensitivity to environmental stress. Genetic factors, such as polymorphisms in *OXTR* rs2268490, *COMT* rs4818, and *GRIN2B*,...
Objectives: Alexander disease (AxD) is a rare neurodegenerative disorder that represents a group of leukodystrophies with severe disability and premature death, mostly with an infancy/childhood onset. In rare cases of late-onset phenotypes, symptoms...
Background: Gastrointestinal (GI) sarcoidosis is a rare manifestation of systemic disease, with limited evidence to guide diagnosis and treatment. Methods: A 75-item international survey was completed by 132 clinicians from multiple specialties and h...
Background/Objectives: Osteoporotic vertebral fractures (OVFs) are a growing global health burden, often managed surgically with vertebroplasty or kyphoplasty. However, long-term outcomes such as refracture and mortality remain poorly characterized a...
Background: Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that shares histological features with Kaposi’s sarcoma. It usually occurs in infancy or early childhood and is seldom reported in adults. The most c...
Background: Oral and cardiovascular health share inflammatory and behavioral pathways. Chronic oral inflammation leading to tooth loss may reflect systemic vascular injury. The relationship between tooth loss and cardiovascular risk among patients wi...
Background/Objectives: Intravitreal anti–vascular endothelial growth factor (anti-VEGF) therapy is the standard treatment for neovascular age-related macular degeneration (nAMD), but concerns remain regarding its potential effects on optic nerv...
Background: Chronic subdural hematoma (cSDH) is a common condition, particularly in individuals over 65 years of age. Its pathophysiology involves traumatic and inflammatory processes, culminating in hematoma formation. Although surgical drainage is...
Background: This multicenter retrospective study evaluated the long-term outcomes of functional dyspepsia (FD) and factors associated with treatment resistance over a 3-year period after treatment initiation. Methods: A total of 111 patients diagnose...
Background/Objectives: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective treatment modalities for patients with peritoneal carcinomatosis (PC), though splenectomy is frequently required and its impact on...
Objectives: This study aimed to compare survival and outcomes between robotic-assisted and conventional sternotomy myxoma resection. Methods: This retrospective single-center study included 16 consecutive patients undergoing left atrial myxoma resect...
Background/Objectives: Cerebral aneurysms affect 3–5% of the population and carry a risk of rupture. Post-treatment imaging is essential to detect residual or recurrent filling. Digital subtraction angiography (DSA) is the gold standard, but it...
Background: Encephalitis is a severe and potentially life-threatening inflammatory disorder of the central nervous system. Without prompt diagnosis and appropriate treatment, it often results in poor clinical outcomes. The study aimed to develop an a...
Angiography-derived physiology (ADP) has emerged as a validated, wire-free method for the functional assessment of coronary artery disease (CAD). By avoiding pressure-wire instrumentation and hyperemic agents, ADP reduces procedure time, radiation ex...
In published publication [...]
Background: The success of orthopaedic surgery is fundamentally biological, yet the synergistic effect of smoking and comorbidities on surgical outcomes is not well quantified. We hypothesised that active smoking multiplies the risk conferred by comm...
Background/Objectives: Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous malignancy with variable outcomes. Accurate risk prediction at diagnosis remains essential to guide treatment and follow-up strategies. In thi...
Background: Discontinuing mechanical ventilation during cardiopulmonary bypass (CPB) is common but may adversely affect postoperative pulmonary function. This study aimed to evaluate the impact of stopping ventilation during CPB on postoperative gas...
Background/Objectives: Osteoarthritis, the principal indication for joint arthroplasty, has doubled in incidence since 1990. Advances in surgical techniques, combined with an ageing population, have driven a substantial rise in arthroplasty procedure...
Background/Objectives: Familial hypercholesterolemia (FH) is an inherited lipid disorder that markedly elevates lifetime risk of premature cardiovascular disease (CVD), yet remains under-recognized globally. We aimed to estimate the prevalence of phe...
Introduction: The da Vinci Single-Port (SP) robotic system represents a newer minimally invasive surgical development with greater articulation and reduced surgical footprint through the use of a single incision. While originally applied in urology a...
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