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Recent Advances in Endocrine Surgery—2nd Edition
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Recent Advances in Endocrine Surgery—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 848

Special Issue Editor

Dr. Gregorio Scerrino

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Guest Editor
Department of Surgical, Oncological and Oral Sciences, University of Palermo (UNIPA), Palermo, Italy
Interests: endocrine surgery; thyroid; thyroid cancer; thyroid diseases; surgical oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue, entitled "Recent Advances in Endocrine Surgery—2nd Edition". We published six papers in the first volume and are excited to launch this second edition. For more details, please visit

https://www.mdpi.com/journal/jcm/special_issues/IXK44E678V

Endocrine surgery has evolved rapidly in little more than three decades, from a super-specialty performed by a few specially trained general surgeons to a truly autonomous branch of surgery. The widespread interest in endocrine surgery is due to the complexity of the metabolic mechanisms, requiring discussion among surgeons, endocrinologists, oncologists, and nuclear physicians, and the level of precision and ability that the surgery requires. There is also a growing interest in more advanced technological applications that are being employed in endocrine surgery. The aim of this Special Issue is to update our knowledge on the pathogenesis and clinical management of endocrine diseases. Particular emphasis will be placed on recent technological advances that have significantly improved outcomes. We invite scientists with expertise in this area to contribute relevant articles. We welcome clinical, experimental, and review articles offer new insights in the field of endocrine surgery and will provide our readers with an up-to-date overview of thyroid, parathyroid, and adrenal surgery. We also encourage the submission of contributions in the field of neuroendocrine disorders of the hepatobiliary and gastrointestinal tracts.

Dr. Gregorio Scerrino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endocrine surgery
  • thyroid
  • thyroid cancer
  • parathyroid
  • parathyroidectomy
  • adrenal glands
  • disorders of hepatobiliary and gastrointestinal tract

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Related Special Issue

Published Papers (1 paper)

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Review

29 pages, 1737 KB  
Review
Predictors of Hungry Bone Syndrome After Parathyroidectomy in Secondary Hyperparathyroidism: A Narrative Review of Bone Turnover Biomarkers and Risk Prediction Tools
by Adina Coman, Cristi Tarta, Alexandru Isaic, Marco Marian, Sorin Olariu, Andrei Ardelean, Anca-Monica Macovei-Oprescu, Fazakas Roland, Gheorghe-Nanu Pupca, Silviu Latcu, Cristian Silviu Suciu and Marius Murariu
J. Clin. Med. 2025, 14(21), 7849; https://doi.org/10.3390/jcm14217849 - 5 Nov 2025
Viewed by 700
Abstract
Background/Objectives: Secondary hyperparathyroidism (SHPT) affects 30–50% of end-stage renal disease patients. Parathyroidectomy (PTX), while effective for medication-refractory SHPT, carries 20–70% risk of hungry bone syndrome (HBS)—severe sustained hypocalcemia requiring intensive care and prolonged hospitalization. Accurate preoperative risk stratification using biochemical markers and [...] Read more.
Background/Objectives: Secondary hyperparathyroidism (SHPT) affects 30–50% of end-stage renal disease patients. Parathyroidectomy (PTX), while effective for medication-refractory SHPT, carries 20–70% risk of hungry bone syndrome (HBS)—severe sustained hypocalcemia requiring intensive care and prolonged hospitalization. Accurate preoperative risk stratification using biochemical markers and validated prediction tools is critical for optimal preventive management. Methods: We conducted a comprehensive narrative review synthesizing evidence on HBS predictors after PTX in SHPT, evaluating traditional and novel bone turnover markers, clinical risk factors, and multivariate prediction models, through a structured literature search and analysis. Results: Preoperative bone turnover status represents the strongest contributor to HBS risk. Traditional biomarkers—particularly parathyroid hormone (PTH > 1000–2400 pg/mL) and alkaline phosphatase (ALP > 150–300 U/L)—demonstrate moderate-to-strong individual predictive power. Novel bone turnover markers (bone-specific ALP, P1NP, TRAP-5b) offer incremental value, especially in CKD populations where renal clearance affects traditional markers. Combined risk prediction models substantially outperform single biomarkers, achieving area under curve values of 0.87–0.95. The simple NYU 2-point score (ALP > 150 U/L + PTH > 1000 pg/mL) showed 96.8% accuracy, with 100% negative predictive value. More complex tools like nomograms (C-index 0.92–0.94) and machine-learning algorithms (AUC 0.88) provide enhanced discrimination by integrating multiple continuous parameters. Additional clinical factors—younger age (<48 years), prolonged dialysis (≥5 years), low preoperative calcium, high gland weight, and absence of autotransplantation—further refine risk assessment. Postoperative calcium typically reaches nadir at 48–72 h, defining the critical monitoring window. Conclusions: High-turnover bone biomarkers and combined risk models effectively identify high-risk SHPT patients. Risk-stratified protocols (i.e., prophylactic supplementation, intensive monitoring, and selective ICU admission) can substantially reduce HBS-related morbidity. Ongoing efforts should focus on validating these predictive tools across diverse populations and integrating them into clinical practice, thereby facilitating real-time HBS risk assessment and protocol-driven care. Full article
(This article belongs to the Special Issue Recent Advances in Endocrine Surgery—2nd Edition)
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