Settlement-relevant load combinations play a critical role in the serviceability design of buildings, particularly for structures on soils with time-dependent deformation behavior. While permanent loads must be fully considered, the contribution of v...
Commercial functions are widely regarded as a key instrument for revitalizing historic cultural districts; however, functional mix decisions are often made on experiential grounds, resulting in heritage erosion, homogenized retail, and weakened distr...
The Bandon Bay blue swimming crab supply chain in Surat Thani Province, Thailand, comprises multiple actor levels and operational activities whose locations do not necessarily correspond to actor labels. This study analyzes supply-chain route structu...
23 August 2019
Scientifically justifiable spatial structure can not only promote the efficient use of regional resources, but can also effectively avoid “urban diseases”, such as traffic congestion, housing shortage, resource scarcity, and so on. It is...
The quality of accounting information of listed companies has always been of great concern for investors, creditors, government departments, and other stakeholders. As the core component of accounting information, earnings information is essential, w...
A new Schiff base compound, 3-(5-bromo-2-hydroxybenzylideneamino)phenol (abbreviated as BHAP) was synthesized and characterized by 1H- and 13C- nuclear magnetic resonance and infrared spectroscopies. DFT/B3LYP/6-311++G(d,p) calculations were undertak...
Retrieval-Augmented Generation (RAG) has become an important paradigm for knowledge-intensive natural language processing, as it enables Large Language Models (LLMs) to access external evidence beyond their parametric memory. However, existing RAG pi...
Clustering is an important mechanism that efficiently provides information for mobile nodes and improves the processing capacity of routing, bandwidth allocation, and resource management and sharing. Clustering algorithms can be based on such criteri...
Multiple ducts in the working shaft and main body of tunnels form a combined tee structure. An efficient and accurate prediction method for the local resistance coefficient is the key to the design and optimization of the maintenance ventilation sche...
Trans-acting splicing factors play a pivotal role in modulating alternative splicing by specifically binding to cis-elements in pre-mRNAs. There are approximately 1500 RNA-binding proteins (RBPs) in the human genome, but the activities of these RBPs...
Architectural proteins play key roles in genome construction and regulate the expression of many genes, albeit the modulation of genome plasticity by these proteins is largely unknown. A critical screening of the architectural proteins in five crop s...
Gram-negative marine bacteria can thrive in harsh oceanic conditions, partly because of the structural diversity of the cell wall and its components, particularly lipopolysaccharide (LPS). LPS is composed of three main parts, an O-antigen, lipid A, a...
Norovirus infections belong to the most common causes of human gastroenteritis worldwide and epidemic outbreaks are responsible for hundreds of thousands of deaths annually. In humans, noroviruses are known to bind to gastrointestinal epithelia via r...
Polyphenols have been extensively studied due to their beneficial effects on human health, particularly for the prevention and treatment of diseases related to oxidative stress. Nevertheless, they are also known to have an anti-nutritional effect in...
Beyond anticoagulation, the therapeutic potential of heparin derivatives and heparan sulfate (HS) mimetics (functionally defined HS mimetics) in oncology is related to their ability to bind and modulate the function of a vast array of HS-binding prot...
Atrial fibrillation (AF) is the most common type of sustained arrhythmia. The numerous gaps concerning the knowledge of its mechanism make improving clinical management difficult. As omics technologies allow more comprehensive insight into biology an...
Legumes are sustainable protein-rich crops with numerous industrial food applications, which give them the potential of a functional food ingredient. Legume proteins have appreciable techno-functional properties (e.g., emulsification, foaming, water...
The rapid expansion of artificial intelligence (AI) research does not automatically imply its structural integration into industry governance systems. In the energy sector, this raises the question of whether a policy-relevant AI regime has already e...
Introduction: The usefulness of neuroimaging in patients with first-episode psychosis (FEP) remains controversial. The aim of this study was to assess the prevalence and types of structural abnormalities on neuroimaging in patients with FEP and ident...
Creative accounting is considered to be a 21st-century phenomenon that has received increased attention after the worldwide economic crisis and budget deficits, particularly the prevention and detection of accounting manipulation. Creative accounting...
Trust and credibility in machine learning models are bolstered by the ability of a model to explain its decisions. While explainability of deep learning models is a well-known challenge, a further challenge is clarity of the explanation itself for re...
This paper presents a novel approach to identify cross-section deformation modes for thin-walled structures by assembling preliminary deformation modes (PDM) considering their participation in free vibration modes. These PDM, defined over the cross-s...
This article gives a comprehensive overview on potentially harmful algae occurring in the built environment. Man-made structures provide diverse habitats where algae can grow, mainly aerophytic in nature. Literature reveals that algae that is potenti...
Astrocytes play a crucial role in maintaining neuronal microenvironment homeostasis and regulating synaptic plasticity within the hippocampus. Magnoflorine (MGN), a naturally occurring isoquinoline alkaloid, has demonstrated biological activity in th...
The Ediacaran–Cambrian rocks on the northeastern edge of the Saghro inlier experienced polycyclic tectono-thermal events, which are reported here based on a multiscale structural analysis, from field measurements to fluid inclusion planes. Thre...
Recent discoveries have indicated the importance of developing modern strategies for vaccinations, more ethical research models, and effective alternatives to antibiotic treatment in farm animals. Chickens (Gallus gallus) play a crucial role in this...
Although enormous efforts have been made to prepare tasty and soluble steviol glycosides (SGs), the structure–property relationship of SGs still remains unclear, neither in experiment fact nor in the mechanism, such as the influence of linkage...
Environmental enrichment (EE) has emerged as a promising strategy for improving the welfare and post-release fitness of hatchery-reared fish. The large yellow croaker (Larimichthys crocea) has considerable economic value in China’s fishery indu...
Malaria parasites have their Achilles' heel; they are vulnerable in small parts of their relevant molecules where they can be wounded and killed. These are sporozoite and merozoite protein conserved high activity binding peptides (cHABPs), playing a...
The facial and submental regions are supplied by complicated neurovascular networks; therefore, facial aesthetic injections may be associated with serious adverse events such as skin necrosis and blindness. Pre-injection localization of neurovascular...
Accurate implementation of weight reduction for the development of innovative safety-relevant components, such as suspension assemblies, requires a careful evaluation of the structural resistance. The validation of these critical parts usually employ...
Kiwicha (Amaranthus caudatus L.) is an Andean pseudocereal recognized for its nutritional composition and growing potential as a functional food ingredient. Beyond its high-quality proteins, dietary fiber, unsaturated lipids, and antioxidant compound...
Rho GTPase signaling promotes proliferation, invasion, and metastasis in a broad spectrum of cancers. Rho GTPase activity is regulated by the deleted in liver cancer (DLC) family of bona fide tumor suppressors which directly inactivate Rho GTPases by...
Human DNA is continuously exposed to endogenous and exogenous agents that generate over 100,000 lesions per cell each day. In addition to damage to nucleobases, deoxyribose, and phosphate groups, a particularly harmful class of lesions involves non-c...
Background: Organic cation transporter 2 (OCT2) mediates the renal uptake of cisplatin and is a principal contributor to its dose-limiting nephrotoxicity. Despite reports of OCT2 inhibition by various phytochemicals, the structure–activity rela...
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions characterized by impairments in social interaction and communication and restricted patterns of behavior, interests, and activities. Although the etiopathogen...
Agmatine is the product of the decarboxylation of L-arginine by the enzyme arginine decarboxylase. This amine has been attributed to neurotransmitter functions, anticonvulsant, anti-neurotoxic, and antidepressant in mammals and is a potential therape...
Graph neural networks have shown strong potential for learning structural representations of biological networks. However, repeated message passing may blur local structural signals that are relevant for motif- and graphlet-based analysis. This paper...
The study of human protoporphyrinogen oxidase (hPPO) inhibition can contribute significantly to a better understanding of some pathogeneses (e.g., porphyria, herbicide exposure) and the development of anticancer agents. Therefore, we prepared new pot...
As a common emerging environmental pollutant, microplastics (MPs) have been detected in a variety of environmental media and human bodies. The potential toxic effects and mechanisms of MPs need to be revealed urgently. MPs can be deposited in the kid...
One interesting aspect of antioxidant organic molecules is their use as probes for the detection and quantitation of biologically relevant reactive oxidant species (ROS). In this context, a small library of dihydroterphenyl derivatives has been synth...
Ion channels are validated drug targets, but they remain difficult to study as their pharmacology is influenced by rapid gating, conformational state transitions, cell-type-specific expression, and narrow safety margins. Recent advances in cryo-elect...
In contrast to larger species, little is known about the flight of the smallest flying insects, such as thrips and fairyflies. These tiny animals range from 300 to 1000 microns in length and fly at Reynolds numbers ranging from about 4 to 60. Previou...
This study examines research trends and identifies key gaps relevant to the field of structural safety and resilience; additionally, a systematic literature review (SLR) guided by the PRISMA methodology was conducted, analyzing 4188 documents ranging...
Bacterial colonization of implanted biomedical devices is the main cause of healthcare-associated infections, estimated to be 8.8 million per year in Europe. Many infections originate from damaged skin, which lets microorganisms exploit injuries and...
Thermal modification (TM) is an ecological and low-cost pretreated method to improve the dimensional stability and decay resistance of wood. This study systematically investigates the relevance between the evolution of chemical structure and the phys...
Background/Objectives: The human larynx exhibits marked sexual dimorphism and undergoes age-related structural remodeling, both of which influence voice characteristics and have important implications for diagnostic assessment. While sex-related diff...
Transition metal dichalcogenides, especially molybdenum disulfide (MoS2), exhibit exceptional properties that make them suitable for a wide range of applications. However, the interaction between MoS2 and technologically relevant substrates, such as...
Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human di...
Aminopeptidase P (APPro, E.C 3.4.11.9) cleaves N-terminal amino acids from peptides and proteins where the penultimate residue is proline. This metal-ion-dependent enzyme shares a similar fold, catalytic mechanism, and substrate specificity with meth...
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