Understanding Drug Disposition: The Interplay of Absorption, Distribution, and Excretion Processes, and Transport Mechanisms
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 821
Special Issue Editors
Interests: ABC transporters; bioavailability; drug resistance; parasitology; Chagas disease; bromodomain factors; cell biology; cell and tissue engineering
Interests: ABC transporters; intestinal barrier; MRP2 (ABCC2); P-glycoprotein (ABCB1); BCRP (ABCG2); xenobiotic absorption and excretion, pathophysiological regulation
Interests: acetaminophen; hepatotoxicity; ABC transporters; bioavailability; drug interactions; drug resistance; nuclear localization; P-glycoprotein
Special Issue Information
Dear Colleagues,
Drug disposition is governed by the complex interplay of absorption, distribution, metabolism, and excretion processes, in which membrane transporters constitute a fundamental regulatory component. These proteins, expressed in biological interfaces such as the intestinal epithelium, hepatocytes, renal tubules, and the blood–brain barrier, influence drug pharmacokinetics by modulating intracellular drug concentrations and tissue exposure. Both efflux and uptake transporters have emerged as critical determinants of drug efficacy and safety, prompting their inclusion in regulatory frameworks and drug development pipelines. Importantly, studies of these processes in non-mammalian organisms have likewise provided valuable insights into evolutionary conservation and species-specific adaptations.
This Special Issue invites authors to submit original research and reviews, addressing the roles of absorption, distribution, and excretion processes and transporter mechanisms in therapeutic drug disposition. Topics of interest include, but are not limited to, the regulation of transporter expression and function, transporter-mediated drug interactions, species-specific and disease-related variability, and advanced experimental models. By fostering a comprehensive and multidisciplinary perspective, this Issue aims to advance the understanding of how absorption, distribution, and excretion processes and transporters collectively shape drug behavior in the body, thereby informing rational drug design, enabling individualized therapy, and improving clinical outcomes.
Dr. Virginia Perdomo
Dr. Silvina Villanueva
Dr. Carolina Inés Ghanem
Guest Editors
Manuscript Submission Information
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Keywords
- transporters
- drug disposition
- absorption
- drug interactions
- drug therapy
- pharmacokinetics
- bioavailability
- multidrug resistance
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