Niemann–Pick disease type C (NPC) is an autosomal recessive disorder caused by the mutation of cholesterol-transporting proteins. In addition, early treatment is important for good prognosis of this disease because of the progressive neurodegen...
In the model system for genetics, Drosophila melanogaster, sexual differentiation and male courtship behavior are controlled by sex-specific splicing of doublesex (dsx) and fruitless (fru). In vitro and in vivo studies showed that female-specific Tra...
This paper generalizes the structural Markov properties for undirected decomposable graphs to arbitrary ones. This helps us to exploit the conditional independence properties of joint prior laws to analyze and compare multiple graphical structures, w...
Two novel phlorotannins with a molecular weight of 974, temporarily named 974-A and 974-B, were isolated from the polyphenol powder prepared from the edible marine brown alga Ecklonia kurome Okamura, and their chemical structures were determined by s...
To date, in-cell NMR has elucidated various aspects of protein behaviour by associating structures in physiological conditions. Meanwhile, current studies of this method mostly have deduced protein states in cells exclusively based on ‘indirect...
The heterogeneous empirical evidence in the vast literature on capital structure determinants is puzzling to scholars and practitioners. Various leverage measurements, in conjunction with the inconclusiveness of the significant firm-related capital s...
Sugarcane molasses-assisted combustion was employed to synthesize two LaFeO3 perovskite formulations (ELF-4 and ELF-6). X-ray diffraction and Rietveld refinement supported the formation of the orthorhombic Pnma structure, while vibrational spectrosco...
The main aim of the paper is to examine the interdependence of corporate financing structure on selected determinants in the energy and mining sectors of the economy. In addition, a comparison of the results between these economic sectors is made. In...
Powder X-ray diffraction (XRD) and solid-state NMR spectroscopy are complementary techniques for investigating the structural properties of solids, and there are considerable opportunities and advantages to applying these techniques synergistically t...
The aim of the study is to identify the main determinants of the capital structure of energy industry companies in the European Union. The study was based on a panel of 6122 companies from 25 EU countries, operating between 2011 and 2018. The study u...
The crystal structures of red and blue-black tin(II) oxide, SnO, have been determined for the first time by single-crystal X-ray diffraction. Blue-black SnO crystallizes in the tetragonal space group P4/nmm, representing a layer structure consisting...
China is endowed with a large quantity of residual coal resources that require upward mining. The stability of interburden strata structures and accurate determination are crucial for safe mining. Therefore, we established a mechanical model of distu...
Conotoxins are short, cysteine-rich peptides of great interest as novel therapeutic leads and of great concern as lethal biological agents due to their high affinity and specificity for various receptors involved in neuromuscular transmission. Curren...
Determining the crystal structure of semi-crystalline polymers is still quite the challenge, especially when relying on powder X-ray diffraction (PXRD) alone [...]
The Venusian geological features are poorly gravity-resolved, and the state of the core is not well constrained, preventing an understanding of Venus’ cooling history. The EnVision candidate mission to the ESA’s Cosmic Vision Programme consists of a...
Protein homo-oligomerization is a very common phenomenon, and approximately half of proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority of such assemblies possess internal symmetry which can be either exploited...
State-level COVID-19 vaccination rates among older adults have been uneven in the United States. Due to the immunocompromised nature of older adults, vaccine hesitancy increases the risk of morbidity and mortality. This study aims to determine the as...
Uniformly 13C- and 15N-labeled samples ensure fast and reliable nuclear magnetic resonance (NMR) assignments of proteins and are commonly used for structure elucidation by NMR. However, the preparation of uniformly labeled samples is a labor-intensiv...
Single-crystal X-ray diffraction analysis has emerged as the most reliable method for determining the structures of organic molecules. However, numerous analytes, such as liquid organic molecules, pose challenges in crystallization, making their stru...
3D electron diffraction (3D ED), also known as micro-crystal electron diffraction (MicroED), is a rapid, accurate, and robust method for structure determination of submicron-sized crystals. 3D ED has mainly been applied in material science until 2013...
Influence lines are indispensable tools for visualizing and analyzing the dynamic variations in force factors induced by external loads within structural systems. Among these methods, the energetic approach stands as a widely employed technique, root...
Three novel metal complexes of the tridentate ligand 4-nitro-2-(quinolin-8-yliminomethyl)phenol (NQP) were synthesized and fully characterized using elemental analysis, TGA, magnetic susceptibility, FT-IR, NMR, and UV–Vis spectroscopy. Stoichio...
Globally, the rise in car ownership and usage has intensified parking challenges, particularly within central business districts (CBDs) of many developed cities. Scarce parking infrastructure and escalating land values have further exacerbated these...
Background/Objectives: This study analyzes how Health and Fitness Awareness influences quality of life (QOL), mediated by Health Behavior Action and Safety Behavior Practice, within the Social Determinants of Health (SDH) framework. Methods: Accordin...
17 August 2021
Social-epidemiology that excludes Aboriginal voices often fails to capture the full and complex social worlds of Aboriginal people. Using data from an existing co-designed Victorian government Adolescent Health and Wellbeing Survey (2008/9), we worke...
27 May 2020
Adherence to HIV antiretroviral therapy (ART) is a crucial factor in health outcomes for people living with HIV (PLWH). Interventions to support ART adherence are increasingly focused on the household as a source of social support. This review aims t...
The weights and structure determination (WASD) neuronet (or neural network) is a single-hidden-layer feedforward neuronet that exhibits an excellent approximation ability, despite its simple structure. Thanks to its strong generalization, fast speed,...
Based on economic considerations, in order to fully utilize the land use and landscape functions behind a shore connection project, the sea side is often designed as a low-rise structure, which is prone to wave energy concentration and water retentio...
During the last two decades, three-dimensional electron diffraction (3D ED) has undergone a renaissance, starting with the introduction of precession (Precession Electron Diffraction Tomography, PEDT) that led to variations on the idea of collecting...
Recent technological breakthroughs in machine-learning-based AlphaFold2 (AF2) are pushing the prediction accuracy of protein structures to an unprecedented level that is on par with experimental structural quality. Despite its outstanding structural...
In this paper, the ternary system La2O3-TiO2-Nb2O5 is studied to find new ternary phases with useful electrical properties. The solid solution La3−xTi5−3xNb10−2xO39.5−12.5x was recently identified, and this study focuses on th...
14 August 2025
Tuberculosis (TB) remains a critical public health issue in Johannesburg, South Africa, driven by a complex interplay of individual, social, and structural factors. This study assessed the syndemic relationship between these determinants to understan...
The design and optimization of executive compensation structure to reduce the risk-taking of banks is one of the core topics of corporate governance theory. Especially after the 2008 global financial crisis, due to the characteristics of banks, such...
For decades, high-resolution 1H NMR spectroscopy has been routinely utilized to analyze both naturally occurring steroid hormones and synthetic steroids, which play important roles in regulating physiological functions in humans. Because the 1H signa...
Two single-crystal X-ray structure determinations of 2-aminopyrimidinium hydrogen tri oxofluorophosphate, (C4H6N3)+·(HFO3P)−, (I), and bis(2-aminopyrimidinium) trioxofluorophosphate, 2(C4H6N3)+·(FO3P)2−, (II), as well as the...
LC-SPE/cryo NMR and MS methodologies have been developed and employed for a rapid structure determination of 4″-tetrahydrofurfuryl macrozone reaction mixture components. Macrozones, novel conjugates of azithromycin, and thiosemicarbazones have shown...
Organic farming has gained increasing relevance worldwide due to its environmental benefits and its prominent role in sustainable food systems; however, the persistence of organic farms remains uneven across regions, particularly within the European...
Pericosines are unique C7 cyclohexenoid metabolites of Periconia byssoides OUPS-N133 fungus that was originally isolated from the sea hare, Aplysia kurodai. Pericosines show significant in vitro cytotoxicity against P388 lymphocytic leukemia cells. P...
1 May 2025
Health disparities among populations across geographic regions, demographic and socio-economic groups are well documented; however, ecological studies which visually demonstrate health disparities associated with structural racism among racialized po...
Single crystals of Sn6O4(OH)4 have been grown over a period of more than a decade in hermetically sealed flasks of various triorganotin(IV)-trihydrides in toluene/N,N-dimethylformamide and those of Pb6O4(OH)4 on a petri dish within some days from the...
Exploring the determinants of biological community structure is important not only for understanding the formation of the community, but also for promoting its biodiversity conservation. We monitored butterfly communities in a grassland and woodland...
A number of studies have shown that glycosylation of proteins plays diverse functions in the lives of organisms, has crucial biological and physiological roles in pathogen–host interactions, and is involved in a large number of biological event...
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of...
Bacteriophages produce endolysins that target and cleave the hosts peptidoglycan to release their progeny at the end of the infection cycle. These proteins can be used for the eradication of pathogenic bacteria, but also for their detection. Endolysi...
TRPA1 is a transmembrane cation channel, one of the most promising targets in the context of respiratory diseases. Its general structure has already been experimentally resolved, but the binding site of TRPA1 antagonists such as HC-030031, a model me...
Structural pounding between adjacent, insufficiently separated buildings, or bridge segments, has been repeatedly observed during seismic excitations. Such earthquake-induced collisions may cause severe structural damage or even lead to the collapse...
Coarse-grained molecular simulation models can provide significant insight into the complex behavior of protein systems, but suffer from an inherently distorted description of dynamical properties. We recently demonstrated that, for a heptapeptide of...
Ag+ pollution is of great harm to the human body and environmental biology. Therefore, there is an urgent need to develop inexpensive and accurate detection methods. Herein, lignin-derived structural memory carbon nanodots (CSM-dots) with outstanding...
A series of new fluorinated quinoline analogs were synthesized using Tebufloquin as the lead compound, 2-fluoroaniline, ethyl 2-methylacetoacetate, and substituted benzoic acid as raw materials. Their structures were confirmed by 1H NMR, 13C NMR, and...
A forest’s structure changes as it progresses through developmental stages from establishment to old-growth forest. Therefore, the vertical structure of old-growth forests will differ from that of younger, managed forests. Free, publicly available sp...
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