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80 Results Found

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,904 Views
14 Pages

A Quantitative Model to Evaluate Serendipity in Hypertext

  • Yuri Kim,
  • Bin Han,
  • Jihyun Kim,
  • Jisoo Song and ,
  • Seoyeon Kang and
  • Seongbin Park
  • + 1 author+ 0 author

Serendipity is the phenomenon of people making unexpected and beneficial discoveries. While research on the mechanism and effectiveness of serendipity in information acquisition has been actively conducted, little attempt has been made to quantify se...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
7 Citations
7,295 Views
20 Pages

Design of a Serendipity-Incorporated Recommender System

  • Yuri Kim,
  • Seoyeon Oh,
  • Chaerin Noh,
  • Eunbeen Hong and
  • Seongbin Park

19 February 2025

Unexpected yet advantageous findings, often referred to as serendipitous discoveries, are becoming increasingly significant in the field of computer science. This research aims to examine the impact of factors that could potentially trigger such sere...

  • Article
  • Open Access
10 Citations
5,687 Views
20 Pages

A Serendipity-Oriented Personalized Trip Recommendation Model

  • Rizwan Abbas,
  • Ghassan Muslim Hassan,
  • Muna Al-Razgan,
  • Mingwei Zhang and ,
  • Gehad Abdullah Amran,
  • Ali Ahmed Al Bakhrani,
  • Taha Alfakih,
  • Hussein Al-Sanabani and
  • Sk Md Mizanur Rahman
  • + 4 authors+ 0 author

Personalized trip recommendation attempts to recommend a sequence of Points of Interest (POIs) to a user. Compared with a single POI recommendation, the POIs sequence recommendation is challenging. There are only a couple of studies focusing on POIs...

(This article belongs to the Special Issue Context-Aware Computing and Smart Recommender Systems in the IoT)
  • Article
  • Open Access
26 Citations
6,978 Views
20 Pages

10 February 2020

Online video hosting services have been a highly competitive e-commerce application in recent years. The service providers constantly seek viable ways for users to prolong usage time as a model for sustainable business development. In this study, we...

(This article belongs to the Special Issue Sustainable Technology and Business Innovations: Decision-Making under Uncertainty and Information Asymmetry)
  • Article
  • Open Access
62 Citations
12,563 Views
17 Pages

5 February 2023

Since the COVID-19 outbreak, people have been spending more time in the online world because of restrictions on face-to-face communication due to epidemic prevention controls. This has also brought the issue of Internet addiction, including the overu...

(This article belongs to the Special Issue Mental Health and Well-Being on School Campus in the Post-pandemic Era)
  • Opinion
  • Open Access
1 Citations
2,232 Views
9 Pages

18 July 2023

This essay is a personal insight based on my own experience in the Iberian Pyrenees, which addresses three situations common in paleoecological research, such as the verification of previously devised hypotheses (anticipation), the finding on unknown...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,122 Views
18 Pages

16 November 2023

New families of direct serendipity and direct mixed finite elements on general planar, strictly convex polygons were recently defined by the authors. The finite elements of index r are H1 and H(div) conforming, respectively, and approximate optimally...

(This article belongs to the Special Issue Recent Advances in Finite Element Methods with Applications)
  • Review
  • Open Access
2 Citations
2,825 Views
20 Pages

Serendipity in Neuro-Oncology: The Evolution of Chemotherapeutic Agents

  • Denise Nadora,
  • Shawyon Ezzati,
  • Brandon Bol and
  • Orwa Aboud

The development of novel therapeutics in neuro-oncology faces significant challenges, often marked by high costs and low success rates. Despite advances in molecular biology and genomics, targeted therapies have had limited impact on improving patien...

(This article belongs to the Special Issue The Occurrence, Evolution and Treatment of Glioblastoma: Second Edition)
  • New Book Received
  • Open Access
5,707 Views
2 Pages

2 April 2018

Studio International (Studio International 2018), the now on-line successor to print art magazine The Studio, is planning a late April 2018 50th anniversary reprinting of its Special Issue dedicated to the historic 1968 “Cybernetic Serendipity” techn...

(This article belongs to the Special Issue The Machine as Art (in the 20th Century))
  • Article
  • Open Access
2 Citations
3,125 Views
28 Pages

Leveraging Interactive Evolutionary Computation to Induce Serendipity in Informal Learning

  • Satoko Inoue,
  • Emmanuel Ayedoun,
  • Hiroshi Takenouchi and
  • Masataka Tokumaru

Serendipitous learning, characterized by the discovery of new insights and unexpected connections, is recognized as a valuable educational experience that stimulates critical thinking and self-regulated learning. While there have been limited efforts...

  • Review
  • Open Access
4 Citations
10,330 Views
10 Pages

Today, all of the states in the United States and many countries screen their newborns for biotinidase deficiency. Biotinidase deficiency meets the major criteria for including a disorder into screening programs. However, rarely do we learn the actua...

  • Review
  • Open Access
23 Citations
7,138 Views
18 Pages

29 February 2020

The poly(ADP-ribose) polymerase (PARP) inhibitor, Rubraca®, was given its first accelerated approval for BRCA-mutated ovarian cancer by the FDA at the end of 2016, and further approval by the FDA, EMA and NICE followed. Scientists at Newcastle Un...

(This article belongs to the Special Issue PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer)
  • Article
  • Open Access
6 Citations
3,511 Views
18 Pages

30 January 2022

Industrial robots were modified over the years. The benefit of robots is making production systems more efficient. Most methods of controlling robots have some limitations, such as stopping the robots. The robot stops by various reasons, such as coll...

  • Review
  • Open Access
31 Citations
14,464 Views
25 Pages

Development of Antiepileptic Drugs throughout History: From Serendipity to Artificial Intelligence

  • María Gabriela Corrales-Hernández,
  • Sebastián Kurt Villarroel-Hagemann,
  • Isabella Esther Mendoza-Rodelo,
  • Leonardo Palacios-Sánchez and ,
  • Mariana Gaviria-Carrillo,
  • Natalia Buitrago-Ricaurte,
  • Santiago Espinosa-Lugo,
  • Carlos-Alberto Calderon-Ospina and
  • Jesús Hernán Rodríguez-Quintana
  • + 4 authors+ 0 author

This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used...

(This article belongs to the Section Neurobiology and Clinical Neuroscience)
  • Article
  • Open Access
2 Citations
2,556 Views
17 Pages

This study examines the psychological mechanisms underlying service stickiness during the mature phase of the AI subscription economy, with particular attention to the paradox of subscription fatigue. To enhance conceptual clarity, AI-driven stimuli&...

(This article belongs to the Special Issue AI-Based Disruption, Innovations, and New Business Models in E-Commerce: Empirical Research, Case Studies and Current Trends)
  • Article
  • Open Access
146 Citations
40,354 Views
28 Pages

Factors Affecting Online Impulse Buying: Evidence from Chinese Social Commerce Environment

  • Umair Akram,
  • Peng Hui,
  • Muhammad Kaleem Khan,
  • Chen Yan and
  • Zubair Akram

30 January 2018

First, the purpose of this study is to examine the impact of situational variables, scarcity and serendipity, on online impulse buying (OIB) in Chinese social commerce (SC) environment. Second, the study further assesses the moderating role of five d...

(This article belongs to the Section Economic and Business Aspects of Sustainability)
  • Short Note
  • Open Access
1,258 Views
5 Pages

Cyclo[Tri(thiomethyl-1,2-phenylmethylene)]

  • Pablo Simón Marqués,
  • Nicolas Bréfuel and
  • Claire Kammerer

21 November 2024

During the purification of a reported compound named 1,3-dihydrobenzo[c]thiophene, we isolated an unexpected molecule in one of the chromatography fractions by serendipity. Structural elucidation using common techniques such as 1D and 2D NMR, and mas...

(This article belongs to the Section Organic Synthesis and Biosynthesis)
  • Review
  • Open Access
43 Citations
11,064 Views
31 Pages

Background/Objectives: The dual forces of structured inquiry and serendipitous discovery have long shaped neuropsychiatric research, with groundbreaking treatments such as lithium and ketamine resulting from unexpected discoveries. However, relying o...

(This article belongs to the Section Neurobiology and Clinical Neuroscience)
  • Article
  • Open Access
2 Citations
3,939 Views
31 Pages

Collective and Informal Learning in the ViewpointS Interactive Medium

  • Philippe Lemoisson,
  • Stefano A. Cerri,
  • Vincent Douzal,
  • Pascal Dugénie and
  • Jean-Philippe Tonneau

23 April 2021

Collective learning has been advocated to be at the source for innovation, particularly as serendipity seems historically to have been the driving force not only behind innovation, but also behind scientific discovery and artistic creation. Informal...

(This article belongs to the Collection Knowledge Graphs for Search and Recommendation)
  • Article
  • Open Access
4 Citations
3,276 Views
11 Pages

Serendipitous Discovery of a Competitive Inhibitor of FraB, a Salmonella Deglycase and Drug Target

  • Pankajavalli Thirugnanasambantham,
  • Sravya Kovvali,
  • Austin Cool,
  • Yuan Gao and ,
  • Anice Sabag-Daigle,
  • Erin F. Boulanger,
  • Mark Mitton-Fry,
  • Angela Di Capua,
  • Edward J. Behrman and
  • Venkat Gopalan
  • + 8 authors+ 3 authors

26 September 2022

Although salmonellosis, an infectious disease, is a significant global healthcare burden, there are no Salmonella-specific vaccines or therapeutics for humans. Motivated by our finding that FraB, a Salmonella deglycase responsible for fructose-aspara...

  • Editorial
  • Open Access
2 Citations
2,682 Views
5 Pages

The Quest for Psychiatric Advancement through Theory, beyond Serendipity

  • Robert E. Kelly,
  • Anthony O. Ahmed,
  • Matthew J. Hoptman,
  • Anika F. Alix and
  • George S. Alexopoulos

31 December 2021

Over the past century, advancements in psychiatric treatments have freed countless individuals from the burden of life-long, incapacitating mental illness. These treatments have largely been discovered by chance. Theory has driven advancement in the...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
2,369 Views
17 Pages

31 December 2024

Eight-node quadrilateral isoparametric elements of the serendipity type have frequently been used in finite-element analyses of two-dimensional seepage problems. The shape functions for these elements are quadratic. Hence, nonlinear variation in the...

  • Review
  • Open Access
10 Citations
6,270 Views
31 Pages

10 June 2022

In the 1960s, a world-wide change in electronic devices was about to occur with the invention of integrated circuits. The chip was upon us, which instantly created the need for a revolution in visual communication displays. From the watch to the comp...

(This article belongs to the Special Issue State-of-the-Art Liquid Crystals Research in UK)
  • Review
  • Open Access
2 Citations
2,662 Views
35 Pages

A Review: The Beauty of Serendipity Between Integrated Circuit Security and Artificial Intelligence

  • Chen Dong,
  • Decheng Qiu,
  • Bolun Li,
  • Yang Yang and ,
  • Chenxi Lyu,
  • Dong Cheng,
  • Hao Zhang and
  • Zhenyi Chen
  • + 3 authors+ 0 author

7 August 2025

Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circu...

(This article belongs to the Collection Integrated Circuits and Systems for Smart Sensor Applications)
  • Feature Paper
  • Article
  • Open Access
6 Citations
3,728 Views
25 Pages

Can Serendipity Still Hold Any Surprises in the Coordination Chemistry of Mixed-Donor Macrocyclic ligands? The Case Study of Pyridine-Containing 12-Membered Macrocycles and Platinum Group Metal ions PdII, PtII, and RhIII

  • Alessandra Garau,
  • Giacomo Picci,
  • Massimiliano Arca,
  • Alexander J. Blake and ,
  • Claudia Caltagirone,
  • Greta De Filippo,
  • Francesco Demartin,
  • Francesco Isaia,
  • Vito Lippolis and
  • M. Carla Aragoni
  • + 7 authors+ 2 authors

27 February 2021

This study investigates the coordination chemistry of the tetradentate pyridine-containing 12-membered macrocycles L1-L3 towards Platinum Group metal ions PdII, PtII, and RhIII. The reactions between the chloride salts of these metal ions and the thr...

(This article belongs to the Special Issue Exclusive Feature Papers in Inorganic Chemistry)
  • Article
  • Open Access
2 Citations
3,515 Views
17 Pages

Exploring Mental Health during the Initial COVID-19 Lockdown in Mumbai: Serendipity for Some Women

  • Lisa R. Roberts,
  • Shreeletha Solomon,
  • Solomon J. Renati and
  • Susanne Montgomery

Background: This study explored how low-income women already distressed by reproductive challenges were affected during the initial lockdown conditions of the COVID-19 pandemic in Mumbai, India. Methods: Women with reproductive challenges and living...

(This article belongs to the Section Mental Health)
  • Case Report
  • Open Access
1 Citations
5,100 Views
8 Pages

Serendipity in Medicine-Elevated Immunoglobulin E Levels Associated with Excess Alcohol Consumption

  • Stephen D. H. Malnick,
  • Ali Abdullah,
  • Fadi Ghanem,
  • Sheral Ohayon Michael and
  • Manuela G. Neuman

25 March 2024

Making a diagnosis of alcoholic liver disease is not always easy. There are problems in obtaining an accurate and reliable history of alcohol consumption. Laboratory findings and hepatic imaging studies are neither sensitive or specific, and newer te...

  • Case Report
  • Open Access
1,570 Views
7 Pages

Chest Wound Gunshot Management Aided by Cardiopulmonary Bypass: Interdisciplinary Teamwork or “Serendipity”?

  • Valentina Tassi,
  • Roland Peraj,
  • Roberto Cirocchi,
  • Valentino Borghetti and
  • Mark Ragusa

13 November 2025

Background and clinical significance. Penetrating cardiothoracic wounds require prompt treatment in order to decrease mortality and morbidity. Surgical therapy, aimed at bleeding control and removal of damaged tissue, varies widely from the direct su...

  • Feature Paper
  • Article
  • Open Access
749 Views
20 Pages

This paper explores the intricate relationship between novel paleo-hydrological settings and the sustainability of ancient human societies in the Sahara Desert, focusing on the sandstone massifs of Tassili n’Ajjer, Tadrart Acacus, and Messak Se...

(This article belongs to the Section Surface Waters and Groundwaters)
  • Article
  • Open Access
8 Citations
3,510 Views
23 Pages

Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action

  • Nithyananda Thorenoor,
  • David S. Phelps,
  • Padma Kala,
  • Radhika Ravi and ,
  • Andreas Floros Phelps,
  • Todd M. Umstead,
  • Xuesheng Zhang and
  • Joanna Floros
  • + 3 authors+ 0 author

Innate immune molecules, SP-A1 (6A2, 6A4) and SP-A2 (1A0, 1A3), differentially affect young mouse survival after infection. Here, we investigated the impact of SP-A variants on the survival of aged mice. hTG mice carried a different SP-A1 or SP-A2 va...

(This article belongs to the Special Issue Innate Immunity against Bacterial Infections)
  • Feature Paper
  • Article
  • Open Access
13 Citations
4,858 Views
19 Pages

30 June 2017

A comparative investigation of the coordination assemblies formed between Co(NCS)2 and two monotopic 4,2’:6’,4’’-terpyridine (4,2’:6’,4”-tpy) ligands or two related ditopic ligands is reported. Crystals were grown by layering MeOH solutions of Co(NCS...

(This article belongs to the Special Issue Metal Organic Framework Materials)
  • Article
  • Open Access
5 Citations
4,929 Views
18 Pages

Understanding the Role of the Diagnostic ‘Reflex’ in the Elimination of Human African Trypanosomiasis

  • Jennifer J. Palmer,
  • Caroline Jones,
  • Elizeous I. Surur and
  • Ann H. Kelly

To successfully eliminate human African trypanosomiasis (HAT), healthcare workers (HCWs) must maintain their diagnostic acuity to identify cases as the disease becomes rarer. HAT experts refer to this concept as a ‘reflex’ which incorpora...

(This article belongs to the Special Issue Human African Trypanosomiasis (Sleeping Sickness): The Road to Elimination Revisited—Achievements and Remaining Challenges)
  • Hypothesis
  • Open Access
3 Citations
5,375 Views
12 Pages

16 December 2019

In many fields of fundamental and applied ecology, the transition or edge between two distinct biological communities is known as ‘ecotone’. The ecotone concept was first introduced in the early 20th century, describing the edge between t...

(This article belongs to the Section Social Ecology and Sustainability)
  • Article
  • Open Access
6 Citations
3,854 Views
32 Pages

On Serendipitous Campus Meetings: A User Survey

  • Sascha Naomi Jansz,
  • Mark Mobach,
  • Terry van Dijk,
  • Esther de Vries and
  • Roeland van Hout

With campuses opening up and stimulating interactions among different campus users more and more, we aim to identify the characteristics of successful meeting places (locations) on campus. These can help practitioners such as campus managers and dire...

(This article belongs to the Section Environmental Science and Engineering)
  • Article
  • Open Access
1 Citations
2,992 Views
29 Pages

15 November 2022

Although network management tasks are highly automated using big data and artificial intelligence technologies, when an unforeseen cybersecurity problem or fault scenario occurs, administrators sometimes directly analyze system data to make a heurist...

(This article belongs to the Special Issue Human Computer Interaction in Emerging Technologies)
  • Opinion
  • Open Access
13 Citations
4,354 Views
6 Pages

Artificial Intelligence and Anticancer Drug Development—Keep a Cool Head

  • Caroline Bailleux,
  • Jocelyn Gal,
  • Emmanuel Chamorey,
  • Baharia Mograbi and
  • Gérard Milano

Artificial intelligence (AI) is progressively spreading through the world of health, particularly in the field of oncology. AI offers new, exciting perspectives in drug development as toxicity and efficacy can be predicted from computer-designed acti...

(This article belongs to the Special Issue In Silico Drug Testing and Optimization, Coupling Physical-Based Modeling and Machine Learning)
  • Review
  • Open Access
27 Citations
22,270 Views
26 Pages

Popularity Bias in Recommender Systems: The Search for Fairness in the Long Tail

  • Filippo Carnovalini,
  • Antonio Rodà and
  • Geraint A. Wiggins

19 February 2025

The importance of recommender systems has grown in recent years, as these systems are becoming one of the primary ways in which we access content on the Internet. Along with their use, concerns about the fairness of the recommendations they propose h...

(This article belongs to the Special Issue Applications of Information Extraction, Knowledge Graphs, and Large Language Models)
  • Article
  • Open Access
10 Citations
4,996 Views
16 Pages

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

  • Andrea Astolfi,
  • Francesca Milano,
  • Deborah Palazzotti,
  • Jose Brea and ,
  • Maria Chiara Pismataro,
  • Mariangela Morlando,
  • Oriana Tabarrini,
  • Maria Isabel Loza,
  • Serena Massari and
  • Maria Letizia Barreca
  • + 6 authors+ 1 author

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and furt...

(This article belongs to the Special Issue Kinase Inhibitor for Cancer Therapy)
  • Article
  • Open Access
1,775 Views
20 Pages

I-driven recommendation systems are widely assumed to ease decision-making in online hotel booking, yet little is known about whether two of their defining characteristics—perceived serendipity (unexpected but relevant suggestions) and perceive...

  • Editorial
  • Open Access
10 Citations
4,202 Views
10 Pages

15 August 2019

From the past, we know how much “serendipity” has played a pivotal role in scientific discoveries. The definition of serendipity implies the finding of one thing while looking for something else. The most known example of this is the disc...

(This article belongs to the Special Issue The Role of Nonmainstream Approach in Science Discoveries)
  • Article
  • Open Access
6 Citations
6,650 Views
28 Pages

Short video applications have gained increasing prominence as pivotal channels for information acquisition and knowledge dissemination, capturing the attention of scholars. Despite the increasing interest in this area, a general investigation of the...

  • Article
  • Open Access
11 Citations
3,988 Views
10 Pages

Metabolic Serendipities of Expanded Newborn Screening

  • Raquel Yahyaoui,
  • Javier Blasco-Alonso,
  • Montserrat Gonzalo-Marín,
  • Carmen Benito and ,
  • Juliana Serrano-Nieto,
  • Inmaculada González-Gallego,
  • Pedro Ruiz-Sala,
  • Belén Pérez and
  • Domingo González-Lamuño
  • + 4 authors+ 0 author

29 August 2020

Incidental findings on newborn screening (NBS) are results that are not the target of screening within a given NBS program, but rather are found as a result of the screening and resulting diagnostic workup for that target. These findings may not have...

(This article belongs to the Special Issue The Value of Genetics in the Identification of Treatable Rare Diseases. The Paradigm of Inborn Errors of Metabolism)
  • Article
  • Open Access
6 Citations
4,627 Views
18 Pages

Serendipity-oriented recommendation systems have been widely applied in major e-commerce and social platforms. Platform managers aim to enhance user satisfaction and increase platform sales by creating serendipitous encounters with information. Previ...

(This article belongs to the Topic Online User Behavior in the Context of Big Data)
  • Article
  • Open Access
9 Citations
5,384 Views
30 Pages

16 November 2019

The present work focuses on the formulation and numerical assessment of a family of C0 quadrilateral plate elements based on the refined zigzag theory (RZT). Specifically, four quadrilateral plate elements are developed and numerically tested: The cl...

(This article belongs to the Special Issue Feature Papers in Journal of Composites Science in 2019)
  • Article
  • Open Access
9 Citations
3,627 Views
13 Pages

5 January 2022

Coworking spaces are “serendipity accelerators” designed to host creative people and entrepreneurs. While recent literature has started exploring the indirect effects of coworking spaces on the local context, little is still known on how...

(This article belongs to the Special Issue Competitiveness, Attractiveness and Socio-Economic Development of Highly Peripheral and Marginal Regions: Qualitative, Quantitative, and Mixed Approaches)
  • Review
  • Open Access
15 Citations
7,958 Views
23 Pages

24 February 2023

The finite element method (FEM) is widely used in many engineering applications. The popularity of FEM led to the development of several variants of formulations, and hexahedral meshes surged as one of the most computationally effective. After briefl...

(This article belongs to the Section Robotics, Mechatronics and Intelligent Machines)
  • Proceeding Paper
  • Open Access
3,008 Views
6 Pages

Development and Optimization of the Multi-Gram Synthesis of the Antiviral 18-(Phthalimide-2-yl)ferruginol

  • Francisco Javier Miquel-Leal,
  • Natalia González-Zapata,
  • Orlando José Jimenez-Jarava,
  • Yaneth M. Brand and ,
  • Liliana Betancur-Galvis,
  • Maria Luisa Marín and
  • Miguel A. González-Cardenete
  • + 2 authors+ 0 author

13 November 2021

Virus-induced diseases are very common in our society, and we continuously need new treatments for these challenging infections. We discovered by serendipity some years ago that the molecule 18-(Phthalimide-2-yl)ferruginol, an analogue of the natural...

(This article belongs to the Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry)
  • Review
  • Open Access
3 Citations
4,636 Views
18 Pages

Why Search for Alternative GPCR Agonists?

  • Jean A. Boutin and
  • Jérôme Leprince

4 January 2023

Intuitively, it is easy to understand why we search for G protein-coupled receptor (GPCR) antagonists. It is obviously to block a functionality of a specific receptor potentially linked to some aspects of disease. Whether by focused research or by se...

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