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20,748 Results Found

  • Review
  • Open Access
4 Citations
2,524 Views
13 Pages

18 May 2022

Downstream migration (DSM) of fish through the different types of water intakes is not a random process, but rather a selective removal from the limnetic to the lotic parts of river–lake systems. Selectivity means that the assemblage of migrant...

(This article belongs to the Special Issue Fish Passage at Hydropower Dams 2.0)
  • Article
  • Open Access
3 Citations
953 Views
26 Pages

Sea Ice and Water Segmentation in SAR Imagery Based on Polarization Channel Interaction and Edge Selective Fusion

  • Wei Song,
  • Yixun Chen,
  • Bin Liu,
  • Mengying Ge and ,
  • Yiji Zhou and
  • Huifang Xu
  • + 1 author+ 0 author

20 March 2026

Sea ice segmentation based on Synthetic Aperture Radar (SAR) images has become an important technical means for polar climate change monitoring and navigation safety guarantee. However, the existing methods have limitations in the utilization of SAR...

(This article belongs to the Special Issue Innovative Remote-Sensing Technologies for Sea Ice Observing)
  • Article
  • Open Access
4 Citations
4,641 Views
16 Pages

The Assessment of the Safety Profile of Selective Serotonin Reuptake Inhibitors Versus Other Antidepressants: Drug–Drug Interaction Insights from EudraVigilance

  • Carmen Maximiliana Dobrea,
  • Claudiu Morgovan,
  • Adina Frum,
  • Anca Butuca and ,
  • Adriana Aurelia Chis,
  • Anca Maria Arseniu,
  • Steliana Ghibu,
  • Razvan Constantin Vonica,
  • Felicia Gabriela Gligor and
  • Andreea Loredana Vonica Tincu
  • + 6 authors+ 1 author

12 February 2025

Depression persists as one of the illnesses described relentlessly through the centuries because it affects a large group of people. Background/Objectives: The treatment of depression consists of various therapeutic agents, among which selective sero...

(This article belongs to the Special Issue Chronicity, Multimorbidity, and Medication Appropriateness)
  • Article
  • Open Access
1 Citations
2,010 Views
14 Pages

Complex Hand Interaction Authoring Tool for User Selective Media

  • Bok Deuk Song,
  • HongKyw Choi and
  • Sung-Hoon Kim

9 September 2022

Nowadays, with the advancement of the Internet and personal mobile devices, many interactive media are prevailing, where viewers make their own decisions on the story of the media based on their interactions. The interaction that the user can make is...

(This article belongs to the Section Artificial Intelligence)
  • Article
  • Open Access
2 Citations
1,153 Views
16 Pages

The Interaction Mechanism Between Modified Selective Catalytic Reduction Catalysts and Volatile Organic Compounds in Flue Gas: A Density Functional Theory Study

  • Ke Zhuang,
  • Hanwen Wang,
  • Zhenglong Wu,
  • Yao Dong and ,
  • Yun Xu,
  • Chunlei Zhang,
  • Xinyue Zhou,
  • Yangwen Wu and
  • Bing Zhang
  • + 4 authors+ 0 author

31 July 2025

The overall efficiency of combining denitrification and volatile organic compound (VOC) removal through selective catalytic reduction (SCR) technology is currently mainly limited by the VOC removal aspect. However, existing studies have not studied t...

(This article belongs to the Section Computational Catalysis)
  • Article
  • Open Access
430 Views
15 Pages

Interfacial Interaction and Sintering Mechanism of Cellulose/Polylactic Acid Composites in Selective Laser Sintering: A Molecular Dynamics Simulation

  • Yibing Tian,
  • Xirui Yang,
  • Haoyu Zhang,
  • Runan Gong and ,
  • Li Zou,
  • Hong Zhang and
  • Yanling Guo
  • + 2 authors+ 0 author

29 July 2026

Polylactic acid (PLA) is a biodegradable polymer suitable for selective laser sintering, yet the atomic-level sintering mechanisms of plant-fiber-reinforced PLA remain largely unclear. Here, all-atom molecular dynamics simulations are used to investi...

(This article belongs to the Section Polymer Processing and Engineering)
  • Article
  • Open Access
44 Citations
9,769 Views
17 Pages

2 July 2019

Feature interaction is a newly proposed feature relevance relationship, but the unintentional removal of interactive features can result in poor classification performance for this relationship. However, traditional feature selection algorithms mainl...

(This article belongs to the Special Issue Symmetry in Engineering Sciences)
  • Feature Paper
  • Article
  • Open Access
1,698 Views
17 Pages

5 April 2026

Collective cell migration plays essential roles in morphogenesis, wound healing, angiogenesis, and cancer invasion, yet quantitative measurement of leader–follower interaction strength and range remains challenging due to the lack of direct and...

(This article belongs to the Special Issue Advanced Biomaterials, Biodevices, and Their Application)
  • Article
  • Open Access
12 Citations
6,025 Views
23 Pages

5 October 2024

Project portfolio selection is essential for a company to achieve its strategic goals. Due to constraints such as budget and manpower, companies cannot undertake all projects simultaneously and must prioritize those offering the highest value. Projec...

(This article belongs to the Special Issue System of Systems Engineering)
  • Article
  • Open Access
1 Citations
2,257 Views
29 Pages

Mechanisms Maintaining Mitochondrial DNA Polymorphisms: The Role of Mito-Nuclear Interactions, Sex-Specific Selection, and Genotype-by-Environment Interactions in Drosophila subobscura

  • Pavle Erić,
  • Marija Savić Veselinović,
  • Aleksandra Patenković,
  • Marija Tanasković and ,
  • Bojan Kenig,
  • Katarina Erić,
  • Boris Inđić,
  • Stefan Stanovčić and
  • Mihailo Jelić
  • + 4 authors+ 0 author

15 April 2025

Experimental mito-nuclear introgression lines (MNILs) were established by backcrossing isofemale lines of D. subobscura originating from the same populations. MNILs were subjected to a series of life-history experiments designed to test the fitness o...

(This article belongs to the Section Insect Molecular Biology and Genomics)
  • Article
  • Open Access
13 Citations
7,893 Views
18 Pages

The modes of interaction (e.g., mouse and touch) between maps and users affect the effectiveness and efficiency of transmitting cartographic information. Recent advances in eye tracking technology have made eye trackers lighter, cheaper and more accu...

(This article belongs to the Special Issue Eye-Tracking in Cartography)
  • Article
  • Open Access
2 Citations
527 Views
28 Pages

Software defect prediction (SDP) aims to identify defect-prone modules before testing, but severe class imbalance and redundant software metrics often limit prediction performance. Many conventional feature selection methods estimate feature relevanc...

(This article belongs to the Special Issue Next-Generation Imbalanced Learning: Trustworthiness, Scalability, and Representation: A Special Issue Dedicated to the Memory of Prof. Barbara Pes)
  • Article
  • Open Access
1 Citations
1,821 Views
15 Pages

22 September 2025

The primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we...

(This article belongs to the Section Biological Membranes)
  • Article
  • Open Access
1 Citations
3,201 Views
23 Pages

17 March 2025

As part of the so-called interfacial separation techniques, selective particle agglomeration is one of the few options that are suitable for the separation of heterogeneous, multicomponent systems of particles smaller than 1 μm. In this regard, th...

(This article belongs to the Collection Multidimensional Particle Properties: Characterization, Description, Separation)
  • Article
  • Open Access
8 Citations
3,492 Views
24 Pages

17 May 2019

Sustainable supplier selection has become a strategic activity to enhance the competitiveness of sustainable supply chain management. Research on sustainable supplier selection is considering increasingly more practical factors, such as the uncertain...

(This article belongs to the Section Economic and Business Aspects of Sustainability)
  • Article
  • Open Access
8 Citations
3,423 Views
15 Pages

9 January 2023

Drug-target interaction prediction provides important information that could be exploited for drug discovery, drug design, and drug repurposing. Chemogenomic approaches for predicting drug-target interaction assume that similar receptors bind to simi...

  • Article
  • Open Access
7 Citations
5,769 Views
16 Pages

In supply chain management, selecting the right supplier is one of the most important decision-making processes for improving corporate competitiveness. In particular, when a buyer considers selecting multiple suppliers, one should consider the issue...

(This article belongs to the Special Issue Multiple-Criteria Decision-Making (MCDM) Techniques for Business Processes Information Management)
  • Review
  • Open Access
1 Citations
6,431 Views
12 Pages

2 March 2012

Bacterial interactions with eukaryotic hosts are complex processes which vary from pathogenic to mutualistic. Identification of bacterial genes differentially expressed in the host, promises to unravel molecular mechanisms driving and maintaining suc...

  • Article
  • Open Access
20 Citations
3,161 Views
23 Pages

18 December 2019

Picture fuzzy numbers (PFNs), as the generalization of fuzzy sets, are good at fully expressing decision makers’ opinions with four membership degrees. Since aggregation operators are simple but powerful tools, this study aims to explore some a...

(This article belongs to the Special Issue Fuzzy Sets, Fuzzy Logic and Their Applications)
  • Article
  • Open Access
15 Citations
4,210 Views
20 Pages

Penalized Variable Selection for Lipid–Environment Interactions in a Longitudinal Lipidomics Study

  • Fei Zhou,
  • Jie Ren,
  • Gengxin Li,
  • Yu Jiang and ,
  • Xiaoxi Li,
  • Weiqun Wang and
  • Cen Wu
  • + 2 authors+ 0 author

3 December 2019

Lipid species are critical components of eukaryotic membranes. They play key roles in many biological processes such as signal transduction, cell homeostasis, and energy storage. Investigations of lipid–environment interactions, in addition to...

(This article belongs to the Special Issue Statistical Methods for the Analysis of Genomic Data)
  • Article
  • Open Access
11 Citations
12,330 Views
16 Pages

Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database

  • Carmen Maximiliana Dobrea,
  • Adina Frum,
  • Anca Butuca,
  • Claudiu Morgovan and ,
  • Laurentiu Stoicescu,
  • Adriana Aurelia Chis,
  • Anca Maria Arseniu,
  • Luca Liviu Rus,
  • Felicia Gabriela Gligor and
  • Andreea Loredana Vonica-Tincu
  • + 5 authors+ 0 author

26 September 2024

As the most common psychiatric symptom, depression represents a subject of high interest for the medical community. Background/Objectives: International guidelines consider selective serotonin reuptake inhibitors (SSRIs) the first-line treatment of d...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
465 Views
14 Pages

Understanding the adsorption mechanisms of anions onto functional monomers is crucial for various applications in environmental remediation and chemical separation. In this study, we investigated the interactions of ReO4−, Cl−, SO42&minus...

(This article belongs to the Section Materials Science)
  • Article
  • Open Access
16 Citations
4,815 Views
16 Pages

13 October 2018

Overlapping structures of protein–protein interaction networks are very prevalent in different biological processes, which reflect the sharing mechanism to common functional components. The overlapping community detection (OCD) algorithm based...

(This article belongs to the Special Issue Computational Analysis for Protein Structure and Interaction)
  • Feature Paper
  • Review
  • Open Access
11 Citations
6,105 Views
12 Pages

Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy

  • Erik K. Larsen,
  • Cristina Olivieri,
  • Caitlin Walker,
  • Manu V.S. and ,
  • Jiali Gao,
  • David A. Bernlohr,
  • Marco Tonelli,
  • John L. Markley and
  • Gianluigi Veglia
  • + 4 authors+ 0 author

3 August 2018

Protein-protein interactions (PPIs) regulate a plethora of cellular processes and NMR spectroscopy has been a leading technique for characterizing them at the atomic resolution. Technically, however, PPIs characterization has been challenging due to...

(This article belongs to the Special Issue NMR as a Tool to Investigate Biomolecular Structure, Recognition and Dynamics)
  • Review
  • Open Access
157 Views
33 Pages

22 October 2026

Faces and voices in live remote interactions are often treated as identity evidence, but advances in synthetic media generation weaken that inference. An attacker needs one feasible route to an incorrect identity or action decision; a defense must co...

(This article belongs to the Special Issue Emerging Research Trends and Technologies in Intrusion Detection Systems (IDSs) and Artificial Intelligence (AI) Utilization)
  • Article
  • Open Access
14 Citations
4,528 Views
15 Pages

Selective Interaction of Sugarcane eIF4E with VPgs from Sugarcane Mosaic Pathogens

  • Zongtao Yang,
  • Meng Dong,
  • Guangyuan Cheng,
  • Shuxian Liu and ,
  • Hai Zhang,
  • Heyang Shang,
  • Yingshuan Zhou,
  • Guoqiang Huang,
  • Muqing Zhang and
  • Jingsheng Xu
  • + 6 authors+ 1 author

22 March 2021

Eukaryotic translation initiation factor 4E (eIF4E) plays a key role in the infection of potyviruses in susceptible plants by interacting with viral genome-linked protein (VPg). Sugarcane (Saccharum spp.) production is threatened by mosaic disease ca...

(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
  • Article
  • Open Access
14 Citations
5,770 Views
20 Pages

Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles

  • José M. Espejo-Román,
  • Belén Rubio-Ruiz,
  • Victoria Cano-Cortés,
  • Olga Cruz-López and ,
  • Saúl Gonzalez-Resines,
  • Carmen Domene,
  • Ana Conejo-García and
  • Rosario M. Sánchez-Martín
  • + 3 authors+ 0 author

Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44), acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular stimuli for tumor growth, angiogenesis, invasion, and metas...

(This article belongs to the Section Nanomedicine and Nanotechnology)
  • Article
  • Open Access
15 Citations
8,993 Views
21 Pages

Selective Interaction of a Cationic Polyfluorene with Model Lipid Membranes: Anionic versus Zwitterionic Lipids

  • Zehra Kahveci,
  • María José Martínez-Tomé,
  • Rocío Esquembre,
  • Ricardo Mallavia and
  • C. Reyes Mateo

13 March 2014

This paper explores the interaction mechanism between the conjugated polyelectrolyte {[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene}bromide (HTMA-PFP) and model lipid membranes. The study was carried out using different biophysical tec...

  • Article
  • Open Access
11 Citations
8,254 Views
13 Pages

Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID

  • Yukiko Kamiya,
  • Yuuki Takeyama,
  • Tomonari Mizuno,
  • Fuminori Satoh and
  • Hiroyuki Asanuma

Small interfering RNA (siRNA) has been recognized as a powerful gene-silencing tool. For therapeutic application, chemical modification is often required to improve the properties of siRNA, including its nuclease resistance, activity, off-target effe...

(This article belongs to the Special Issue Designer Biopolymers: Self-Assembling Proteins and Nucleic Acids 2020)
  • Article
  • Open Access
923 Views
18 Pages

30 April 2026

Background/Objectives: Selective inhibition of JAK1 remains a major challenge in cytokine-signaling therapeutics due to the high structural similarity of the JAK family. Here, we present an integrated computational framework that combines large-scale...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
13 Citations
3,800 Views
11 Pages

29 September 2021

Highly cis-1,4 selective (up to 98%) coordination–insertion polymerization of 1,3-butadiene (BD) has been achieved herein using acenaphthene-based α-diimine cobalt complexes. Due to the presence of intra-ligand π-π stacking interactions, the complexe...

(This article belongs to the Special Issue Polymers Synthesis and Characterization)
  • Article
  • Open Access
8 Citations
3,134 Views
15 Pages

15 December 2023

In this study, GX2 was applied as a new high-efficiency chalcopyrite depressant to selectively separate molybdenite from Cu-Mo sulfide ores. The flotation performance and its interaction mechanisms with chalcopyrite and molybdenite were investigated...

(This article belongs to the Section Mineral Processing and Extractive Metallurgy)
  • Article
  • Open Access
2 Citations
2,327 Views
13 Pages

28 December 2023

In this study, the performance of 2-hydroxy-3-naphthylmethyl hydroxamic acid (NHA) in cassiterite flotation was investigated. The aim was to understand the mechanism of action of NHA for the first time. The effect of NHA as a collector in the flotati...

(This article belongs to the Section Mineral Processing and Extractive Metallurgy)
  • Review
  • Open Access
10 Citations
4,667 Views
19 Pages

The Interaction between Oral Bacteria and 3D Titanium Porous Surfaces Produced by Selective Laser Melting—A Narrative Review

  • Tatiane Cristina Dotta,
  • Simonetta D’Ercole,
  • Giovanna Iezzi,
  • Vinicius Pedrazzi and ,
  • Rodrigo Galo and
  • Morena Petrini
  • + 1 author+ 0 author

The interaction between oral bacteria and dental implant surfaces is a critical factor in the success and longevity of dental implants. With advancements in additive manufacturing technologies, selective laser melting (SLM) has emerged as a prominent...

(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 3rd Edition)
  • Article
  • Open Access
162 Views
19 Pages

OSPIR-DETR: Object-Selective Proxy Interaction and Gain-Guided Scale Alignment for Remote Sensing Object Detection

  • Gaoshan Song,
  • Kan Chen,
  • Guoqiang Chu,
  • Song Ming and ,
  • Chen Zhao and
  • Qian Sun
  • + 1 author+ 0 author

14 October 2026

Remote sensing imagery is characterized by complex backgrounds, substantial scale variation, and numerous small targets, placing greater demands on semantic modeling of high-spatial-resolution features and feature integration across multiple scales....

(This article belongs to the Special Issue Artificial Intelligence in Computer Vision: Advances and Applications)
  • Article
  • Open Access
5 Citations
3,456 Views
15 Pages

The Roles of Precursor-Induced Metal–Support Interaction on the Selective Hydrogenation of Crotonaldehyde over Ir/TiO2 Catalysts

  • Aiping Jia,
  • Hantao Peng,
  • Yunshang Zhang,
  • Tongyang Song and ,
  • Yanwen Ye,
  • Mengfei Luo,
  • Jiqing Lu and
  • Weixin Huang
  • + 3 authors+ 0 author

9 October 2021

Various supported Ir/TiO2 catalysts were prepared using different Ir precursors (i.e., H2IrCl6, (NH4)2IrCl6 and Ir(acac)3) and tested for vapor phase selective hydrogenation of crotonaldehyde. The choice of Ir precursor significantly altered the Ir-T...

(This article belongs to the Special Issue Metal-Support Interactions for Advanced Catalysis)
  • Review
  • Open Access
228 Citations
14,324 Views
23 Pages

16 September 2021

Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers...

(This article belongs to the Special Issue Sample Preparation-Quo Vadis: Current Status of Sample Preparation Approaches-2nd Edition)
  • Article
  • Open Access
13 Citations
4,740 Views
25 Pages

The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies

  • Aleksandra Szopa,
  • Karolina Bogatko,
  • Mariola Herbet,
  • Anna Serefko and ,
  • Marta Ostrowska,
  • Sylwia Wośko,
  • Katarzyna Świąder,
  • Bernadeta Szewczyk,
  • Aleksandra Wlaź and
  • Ewa Poleszak
  • + 13 authors+ 8 authors

12 February 2021

The purpose of the study was to investigate whether the co-administration of Mg2+ and Zn2+ with selective A1 and A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, and spontaneous locomotor motilit...

(This article belongs to the Section Bioactives and Nutraceuticals)
  • Article
  • Open Access
14 Citations
4,449 Views
17 Pages

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation

  • Nolan M. Dvorak,
  • Cynthia M. Tapia,
  • Aditya K. Singh,
  • Timothy J. Baumgartner and ,
  • Pingyuan Wang,
  • Haiying Chen,
  • Paul A. Wadsworth,
  • Jia Zhou and
  • Fernanda Laezza
  • + 4 authors+ 0 author

17 December 2021

Voltage-gated Na+ (Nav) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Nav channel α subunit that have been described (Nav1.1-Nav1.9), Nav1.1, Nav1.2, and Nav1.6 are the primary isoforms e...

(This article belongs to the Special Issue Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications)
  • Article
  • Open Access
330 Views
27 Pages

A Ranked Sparsity Extension to the Bayesian Information Criterion: A Tool for Selecting Variables from Multiple Data Modalities

  • Ryan A. Peterson,
  • Sarah M. Bird,
  • Logan M. Harris,
  • Patrick J. Breheny and
  • Joseph E. Cavanaugh

22 August 2026

The concept of ranked sparsity, originally introduced in the context of penalized regression, arises in modeling applications when an expected disparity exists in the quality of information between different feature sets. Its presence can cause tradi...

(This article belongs to the Special Issue Statistical Planning, Inference, and Decision Making in High-Dimensional Data Analysis)
  • Article
  • Open Access
9 Citations
6,367 Views
19 Pages

1 November 2017

The Kv1.2 channel plays an important role in the maintenance of resting membrane potential and the regulation of the cellular excitability of neurons, whose silencing or mutations can elicit neuropathic pain or neurological diseases (e.g., epilepsy a...

(This article belongs to the Special Issue Toxins in Drug Discovery and Pharmacology)
  • Article
  • Open Access
5,269 Views
10 Pages

This paper introduces organic phases with aligned carbonyl groups derived from l-aspartic acid, l-glutamic acid, and l-α-aminoadipic acid; their stationary phases are denoted as Sil-Asp-2Cn, Sil-Glu-2Cn, and Sil-Adi-2Cn, respectively. The stationary...

  • Article
  • Open Access
2 Citations
1,855 Views
18 Pages

ITap: Index Finger Tap Interaction by Gaze and Tabletop Integration

  • Jeonghyeon Kim,
  • Jemin Lee,
  • Jung-Hoon Ahn and
  • Youngwon Kim

30 April 2025

This paper presents ITap, a novel interaction method utilizing hand tracking to create a virtual touchpad on a tabletop. ITap facilitates touch interactions such as tapping, dragging, and swiping using the index finger. The technique combines gaze-ba...

(This article belongs to the Section Biomedical Sensors)
  • Article
  • Open Access
10 Citations
4,325 Views
12 Pages

Voice as a Mouse Click: Usability and Effectiveness of Simplified Hands-Free Gaze-Voice Selection

  • Darisy G. Zhao,
  • Nikita D. Karikov,
  • Eugeny V. Melnichuk,
  • Boris M. Velichkovsky and
  • Sergei L. Shishkin

9 December 2020

Voice- and gaze-based hands-free input are increasingly used in human-machine interaction. Attempts to combine them into a hybrid technology typically employ the voice channel as an information-rich channel. Voice seems to be “overqualified&rdq...

(This article belongs to the Special Issue User Experience for Advanced Human–Computer Interaction)
  • Article
  • Open Access
57 Citations
1,691 Views
15 Pages

Eye Movements in Gaze Interaction

  • Emilie Møllenbach,
  • John Paulin Hansen and
  • Martin Lillholm
J. Eye Mov. Res.2013, 6(2), 1-15;https://doi.org/10.16910/jemr.6.2.1 
(registering DOI)

9 May 2013

Gaze, as a sole input modality must support complex navigation and selection tasks. Gaze interaction combines specific eye movements and graphic display objects (GDOs). This paper suggests a unifying taxonomy of gaze interaction principles. The taxon...

  • Article
  • Open Access
2 Citations
973 Views
20 Pages

Structural Determinants of PARP1 Selectivity from Molecular Dynamics Analysis of PARP1 and PARP2 Complexes

  • Dmitrii O. Shkil,
  • Natalia A. Chesnokova,
  • Andrey A. Ivashchenko,
  • Elena V. Petersen and
  • Philipp Y. Maximov

Selective inhibition of poly(ADP-ribose) polymerase 1 (PARP1) may reduce the hematologic toxicity associated with dual PARP1/PARP2 inhibition. We performed molecular dynamics simulations for five selective inhibitors in complexes with PARP1 and PARP2...

(This article belongs to the Section Computational and Theoretical Chemistry)
  • Article
  • Open Access
27 Citations
3,772 Views
20 Pages

Development and Proof-of-Concept Application of Genome-Enabled Selection for Pea Grain Yield under Severe Terminal Drought

  • Paolo Annicchiarico,
  • Nelson Nazzicari,
  • Meriem Laouar,
  • Imane Thami-Alami and ,
  • Massimo Romani and
  • Luciano Pecetti
  • + 1 author+ 0 author

Terminal drought is the main stress limiting pea (Pisum sativum L.) grain yield in Mediterranean environments. This study aimed to investigate genotype × environment (GE) interaction patterns, define a genomic selection (GS) model for yield und...

(This article belongs to the Special Issue Legume Genetics and Biology: From Mendel's Pea to Legume Genomics)
  • Article
  • Open Access
6 Citations
5,655 Views
19 Pages

29 January 2021

Gene-environment (G×E) interaction is critical for understanding the genetic basis of complex disease beyond genetic and environment main effects. In addition to existing tools for interaction studies, penalized variable selection emerges as a...

  • Article
  • Open Access
4 Citations
2,288 Views
19 Pages

11 November 2024

Selection is a fundamental interaction element in virtual reality (VR) and 3D user interfaces (UIs). Raycasting, one of the most common object selection techniques, is known to have difficulties in selecting small or distant objects. Meanwhile, recen...

(This article belongs to the Section Sensing and Imaging)
  • Article
  • Open Access
14 Citations
3,314 Views
11 Pages

NMR Investigation of the Interaction of Three Non-Steroidal Anti-Inflammatory Drugs with Human Serum Albumin

  • Federica Aiello,
  • Gloria Uccello-Barretta,
  • Claudio Picchi,
  • Samuele Nazzi and ,
  • Alessandra Recchimurzo and
  • Federica Balzano
  • + 1 author+ 0 author

6 October 2022

The understanding of the interaction between non-steroidal anti-inflammatory drugs and human serum albumin plays a fundamental role in the development of new drugs and new therapeutic strategies. Several studies have been performed, nevertheless, the...

(This article belongs to the Special Issue Bioorganic Chemistry: Current and Future Perspectives)

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